Prashanth M K

B. N. M. Institute of Technology | BNMIT · Department of Chemistry

Two new quinazoline derivatives (2a and 2b) were successfully synthesized in this work using the condensation technique in excellent yields. Using spectroscopic techniques and elemental analyses, the compounds were completely characterized. Density functional theory (DFT) computations have been used to examine the title compound's reactive characte...

The promising quinazolinone-based pyridine derivatives (4a-j) were synthesized and subsequently tested for their antimycobacterial activities against the various drug-sensitive and drug-resistant Mycobacterium tuberculosis (Mtb) strains to combat infectious diseases and address growing concerns about the devastating effects of tuberculosis (TB). Ut...

The pyrazolo[1,5-a]pyrimidine core framework is a good starting point for the synthesis of drug-like molecules since the biological activity is determined by the kind and position of the substituents on the heterocyclic center. To develop safer and more effective anticancer medications, pyrazolopyrimidine derivatives (6a-o) were designed and develo...

The ecosystem is being exposed to a huge amount of CO2 as a result of excessive usage of fossil fuels. Global ecological imbalance is a result of this. In addition to being a pollutant, CO2 has the potential to be converted into beneficial carbonaceous products when exposed to light and thereby supporting the two important sectors of energy and the...

The current study reports on the synthesis and anticancer efficacy of novel oxadiazole derivatives (8a-f) as tubulin polymerization inhibitors. NMR, mass, and elemental studies were used to confirm the newly produced compounds. In contrast to the conventional medicine colchicine, compounds 8e and 8f demonstrated stronger sensitivity and improved IC...

Because of the excessive use of fossil fuels, CO2 emissions into the environment are increasing. An efficient method of converting CO2 to useful carbonaceous products in the presence of light is one way to address the issues associated with energy and environmental remediation. In2S3/WS2 heterostructure has been fabricated using the efficient hydro...

In the present investigation, we employed pyrrolo[2,3-d] pyrimidine, potassium amide, and liquid ammonia to synthesize pyrrolo[2,3-d]pyrimidin-2-amine derivatives (4a-n). Spectroscopic techniques and elemental analyses were used to determine the structure of the title compounds. For their in vitro cytotoxic activity against the human cancer cell li...

Pesticide usage is one of the significant issues in modern agricultural practices; hence, monitoring pesticide content and its degradation is of utmost importance. A novel and simple one-pot deep eutectic solvent-based solvothermal method has been developed for the synthesis of FeVO4/reduced graphene oxide (FeV/RGO) nanocomposite. The band gap of F...

Triazine-linked triazole compounds (4a-j) were designed, synthesized, and then examined for their anticonvulsant abilities. Compounds 4e, 4f, 4g, 4i, and 4j displayed significant anticonvulsant activity in both maximum electroshock seizure (MES) and pentylenetetrazole (PTZ) induced seizure during the preliminary screening. The phase II anticonvulsa...

A simple co-precipitation method has been developed to synthesize Nb2O5/reduced graphene oxide nanocomposite (NbO/RGO). The effect of various % of strontium doping on NbO/RGO was studied. The characterization results for its structure; morphology confirms the decoration of NbO with RGO followed by Sr doping resulting in [email protected]/R-wt% nano...

The new triazole linked saccharin derivatives namely, 2-(3-methyl-1H-1,2,4-triazol-5-yl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide (MTD) and 2-(3-isopropyl-1H-1,2,4-triazol-5-yl)benzo[d]isothiazol-3(2H)-one 1,1-dioxide (ITD) were synthesized under microwave irradiation method. The newly synthesized inhibitors were characterized by ¹H NMR, ¹³C NMR, FT...

Upgradation in technology leads to the accumulation of a large amount of electronic waste and causes serious issues in the environment. Discharged dry cells are one such waste that needs proper monitoring. The present work deals with the synthesis of boron-doped reduced graphene oxide (BRGO) from graphite derived from dry cells. Nb2O5 (NbO) nanofla...

Despite combination therapy is effective in treating tuberculosis (TB) caused by susceptible Mycobacterium tuberculosis (Mtb) strains, overcoming multidrug resistance (MDR) remains a problem. As a result, it is critical to continue developing new chemotherapeutic drugs with unique mechanisms of action. A variety of benzimidazole-linked thiazole com...

A green synthetic approach for the synthesis of nanoparticles (NPs) is important to maintain sustainable development. Here we report the synthesis of samarium sesquioxide (Sm2O3) nanoparticles using an eco-friendly and unconventional method that utilizes pineapple peel extract as a reducing agent and stabilizer. The synthesized Sm2O3 NP was charact...

A new, fast and solvent-free method is offers to synthesize thiazoles by condensation of 4-bromoacetylpyridine with substituted N-phenylthiourea under microwave irradiation. This approach delivers good to excellent yields of thiazoles within 5 min without using any catalyst and allows various functionalities. In comparison to the traditional heatin...

The Thermal polycondensation method was used to make sulfur self-doped graphitic-carbon nitride (SCN) sheets that were anchored with samarium vanadate (SmV). The decorating of SmV nanoparticles on sheets of SCN is confirmed by X-ray diffraction, spectroscopic, and microscopic characterizations. When compared to the bandgap of pure SmV (2.16 eV) and...

To explore effective antituberculosis agents, a new class of imidazoles and benzimidazoles linked ethionamide analogs were designed and synthesized. The elemental analysis, ¹H NMR, ¹³C NMR and mass spectral data were used to characterize all of the novel analogs. In vitro activity against Mycobacterium tuberculosis (Mtb) H37Rv was assessed for all...

A new protocol for the N-alkylation of amines with alcohols for the synthesis of tertiary amines in the presence of MnCl2 as a catalyst, under microwave conditions, is described. The advantages of this protocol include stable reaction profiles, a wide substrate variety, excellent yields, low cost, high yields, and easy workup conditions. The antica...

Agriculture is having a major role in solving issues associated with food shortages across the globe. Carbendazim (CZM) is one of the fungicides which is commonly used in agriculture to grow crops in large quantities and fast. Monitoring CZM content is in high demand for environmental remediation. The present work deals with the synthesis of gadoli...

A novel class of penipanoid C-inspired 2-benzoyl-1-methyl-2,3-dihydroquinazolin-4(1H)-ones (3a-3f) and 1-methyl-2-(3,4,5-trihydroxybenzoyl)-2,3-dihydroquinazolin-4(1H)-one derivatives (10-15) was successfully synthesized using the I2/DMSO method. The newly synthesized compounds were characterized and tested for cytotoxicity against three cancer cel...

In medicinal chemistry, the searching for new anticonvulsants with greater selectivity and reduced toxicity is still active. Therefore, multistep reaction sequence has been explored to obtained novel series of S and C-linker thiazole derivatives (7a-h and 8a-d). The final compounds were screened for antimicrobial activity against different microbia...

Two new series of N-substituted [1,2,4]triazolo[4,3-a]pyrazine derivatives, 2a-e and 3a-e were synthesized by coupling substituted acid chlorides/benzyl chlorides with 3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine and investigated for antioxidant, anticonvulsant effect and neurotoxicity. The in vitro antioxidant activity was...

Halloysite nanotube (HNT) is a clay material paving much attention in the field of biological studies. In the present work multifunctional carbon dot (CD) has been synthesized and functionalized with HNT that resulted in HNT-CD nanocomposite. Fabricated HNT-CD nanocomposite has been subjected to analytical and morphological characterization using X...

New thiazole derivatives (2a-l) were synthesized via the reaction of 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid with substituted phenyl amines. The anticancer activity of the synthesized thiazole derivatives was examined against MCF-7 (human breast), MDA-MB-231(mammary carcinomas), HeLa (Cervical cancer), HT-29, HCT 116 (Colon...

A novel series of pteridine derivatives (3a-e) was synthesized, and the structures of these molecules were established using elemental analysis and numerous spectroscopic methods. The disc diffusion technique was used to examine the antimicrobial potential of the newly synthesized molecules. Among the compounds examined, the 3b and 3e compounds wou...

A heterocyclic ligand, 5-(2-(4-chlorophenyl)-1H-benzo[d]imidazol-1-yl)quinolin-8-ol and its Co(II), Ni(II), Cu(II) and Zn(II) complexes were synthesized and characterized by elemental analysis and spectroscopic techniques. According to the spectral analysis, the ligand acts as a bidentate ligand and coordinating through the nitrogen and deprotonate...

A green synthetic route has been developed for the synthesis of Pt doped Titanium dioxide nanocomposite (Pt/TiO2). Mentha arvensis (Mint) leaves extract has been used as a reducing agent to get Pt/TiO2 nanocomposite. Spectroscopic, morphological analysis confirms the doping of Pt to TiO2. High-resolution XPS shows the presence of Ti⁴⁺ and Ti³⁺ mixe...

At present energy and environmental remediation are of highest priority for the well defined sustainability. Multifunctional materials that solve both the issues are on high demand. In the present work, a simple method has been followed to extract carbon spheres fromTamarindus indica(commonly known astamarind fruit) shelland doped with nitrogen (N-...

A novel 5-(2-phenyl-1H-benzo[d]imidazol-1-yl)quinolin-8-ol ligand (PBIQ) ligand was used to synthesize a series of Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes. Elemental analysis, FTIR, 1H NMR, UV-Visible and mass spectra were utilized to characterize the newly synthesized ligand and its transition metal complexes. The antimicrobial activi...

Precipitation assisted facile hydrothermal method has been developed for anchoring nitrogen-doped reduced graphene oxide (NRGO) with tantalum pentoxide (TO) denoted as [email protected] Synthesized materials were characterized using spectroscopic, optical and microscopic techniques and confirm transforming TO from orthorhombic to hexagonal phase (δ...

A Ta2O5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been synthesized and characterized. It was then used as a highly effective nanocatalyst for the synthesis of quinolin-2(1H)-one derivatives through C-O bond functionalization. The special advantage of this heterogeneous solid catalyst is the reusability of the catalyst for up to...

Research in material chemistry is inspiring scholars across the globe in designing multifunctional materials to fight against energy and environmental issues. In this view, the present work defines functionalization of polyaniline (PANI) with boroncarbonitride (BCN) through in-situ polymerization that gives multifunctional hybrid ([email protected]...

Three new imidazole derivatives namely,4-(4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl)phenol (IM1), 4-(4,5-bis(4-methoxyphenyl)-1H-imidazol-2-yl)benzenamine (IM2), 2,4,5-tris(4-methoxy phenyl)-1H-imidazole (IM3) were synthesized using microwave irradiation method. The noteworthy highlights of this method are safe reaction profiles, broad substrate sc...

Using Cu(I)-catalyzed cycloaddition of alkyne and azide reaction (CuAAC), a series of novel 1,2,3-triazole based imidazole derivatives (3a-e) have been synthesized. The synthesized molecules were characterized by spectroscopic techniques such as ¹H NMR, ¹³C NMR, mass and elemental analysis. Antitubercular activity (anti-TB) against Mycobacterium tu...

We herein report a design and synthesis of new 1,3,5-triazine based pyrazole derivatives (5a-i) for anticancer activity targeting epidermal growth factor (EGFR) tyrosine kinase. The newly synthesized compounds were characterized...

New pharmacologically active transition metal complexes of Co(II), Ni (II), Cu (II), and Zn(II) have been synthesized with the ligand 5-(2-(4-methoxyphenyl)-1H-benzo [d] imidazol-1-yl) quinolin-8-ol (2). Different analytical and spectroscopic tools were used to analyze the compounds, including elemental analysis, FTIR, 1H-NMR, mass spectra, electro...

A series of 2,3-disubstituted quinazolin-4(1H)-ones (3a-j) were screened for their antimicrobial activity using the minimum inhibitory concentration method (MIC). The in vitro anti-tubercular (TB) activity of compounds against Mycobacterium tuberculosis (Mtb) H37Rv has been evaluated. Among the screened compounds, 3g and 3h exhibited more potent an...

The current work defines the synthesis of rutile, mesoporous ruthenium oxide (RuO2) decorated with graphene oxide (GO) by a simple hydrothermal method. The formation of RuO2-GO composite was confirmed by X-ray crystallographic studies. The Raman spectroscopic study shows the definite interaction between RuO2 nanostring and GO. The SEM, EDS, TEM and...

In the present study we made an effort to deploy eco-friendly synthesized reduced graphene oxide/Lanthanum Alluminate nanocomposites (RGO-LaAlO3) and Lanthanum Alluminate (LaAlO3) as adsorbents to remove dye from the synthetic media. XRD, SEM, BET surface area and EDX have been used to characterize the above-mentioned adsorbents. The impacts of dif...

Three new 5-fluoro-2- methylthio substituted pyrimidine derivatives have been synthesized and characterized by ¹H NMR spectroscopy and Mass spectrometry. Corrosion inhibition characteristics of the synthesized pyrimidine derivatives have been studied on mild steel (MS) in 0.5 M hydrochloric acid solution at various temperatures (303−333 K) using ma...

The corrosion inhibition ability of three newly synthesized quinazoline derivatives namely, 2-chloro-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) propanamide (Q1), 2-methoxy-N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothioyl) acetamide (Q2) and N-(1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-3-carbonothi...

An efficient one-pot synthesis of 2,3-disubstituted quinazolin-4(1H)-ones has been developed via ruthenium oxide (RuO2) nanoparticle catalyzed cyclocondensation method. Various 2,3-disubstituted quinazolin-4(1H)-ones have been synthesized from N-(4-methoxyphenyl)-2-(methylamino)benzamide with aromatic substituted aldehydes with excellent yields. Ru...

A novel class of 3‐(4‐chlorophenyl)‐2‐(substituted)quinazolin‐4(3H)‐one derivatives were synthesized, and the structure of synthesized compounds was characterized by IR, 1H NMR, and mass spectroscopy. The newly synthesized compounds (4a–g and 6a–g) were tested for their in vitro cyclooxygenase (COX) inhibition activity. The compounds have inhibitor...

Polyaniline–few-layer molybdenum disulfide nanocomposite (PANI–MoS2) has been synthesized by in situ polymerization of aniline over MoS2 using HCl as the dopant. X-ray crystallographic studies show the characteristic peaks of few-layered MoS2 in the PANI matrix. The changes in Raman and UV–Vis spectra have proved that there are definite interaction...

The present work deals with preparation of graphene chemically bonded to TiO2 film (G-TiO2), which gives rise to Ti-O-C bond pattern. The structural and morphological properties of the synthesized G-TiO2 nanocomposite were studied by X-ray diffraction (XRD), Raman spectrospcopy, SEM, TEM, EDAX and Atomic force microscopy (AFM) techniques. Observabl...

Expelling of heavy metal ions into water resource systems is extremely hazardous to the environment. Adsorption is one of the most cost effective and potential methods to remove the heavy metal ions from the effluents. Therefore, an attempt has been made to study the adsorption of metal particles of Cd and Hg from aqueous solution by using reduced...

Graphene oxide–Zinc oxide (GO–ZnO) nanocomposite was prepared by a simple hydrothermal method. SEM and TEM analysis showed the presence of wide size range ZnO nanoparticles, which are distributed and firmly anchored onto the graphene oxide layers. The resulting GO–ZnO nanocomposite showed extraordinary adsorption capacity and fast adsorption rates...

The present work describes the synthesis of covalent composite of graphene with Fe3O4, through the formation of amide bond between chloride functionalized graphene oxide (GO) and amine containing Fe3O4. The synthesized chemically bonded graphene oxide- Fe3O4 (GO-Fe3O4) nanocomposite was used as an adsorbent for the removal of malachite green oxalat...

The kinetics and mechanism of oxidation of Phenylephrine (PHE) by Chloramine-T (CAT) in acid media have been investigated by spectroscopic technique at the temperature of 298 K. It is found that the reaction is of first order with respect to PHE, fractional order with respect to CAT & inverse order with respect to H+. The reaction rate remained unc...

The current study involves the synthesis of novel imidazo[4,5-c]pyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacological activities were determined by the objective to better understand their st...

Copper oxide nanoparticles synthesized via hydrothermal method and used to modify a carbon paste electrode are reported. The structural characterization of nanopowder by XRD clearly shows the formation of monoclinic phase with high crystallinity. The morphological structure is characterized by field emission scanning electron microscope shows the f...

A series of new N-(substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides were designed, synthesized, and evaluated for their anticonvulsant activity. Most of the synthesized compounds exhibited potent anticonvulsant activities in the maximal electroshock (MES) and pentylenetetrazol (PTZ) test. The most promising compound 4c show...

This spectroscopic study presents the kinetics and degradation pathways of oxidation of amoxicillin (AMOX) by chloramines-T (CAT) in acidic medium at a constant ionic strength of 0.105 mol dm-3 at 298 K. Reaction between AMOX and CAT in acidic medium exhibits 1:1 stoichiometry (AMOX:CAT). The reaction is of a first-order in both [CAT] and [AMOX]. T...

A series of piperamides (PA) 8a-j were designed, synthesized and evaluated for their antimicrobial and anticonvulsant activity. Compounds 8a and 8h showed considerable antibacterial activity against B. subtilis with minimum inhibitory concentration (MIC) of 8 and 10 µg/mL, respectively. Compounds 8a and 8h were showed advanced anticonvulsant activi...

Application of a Highly Sensitive UV-spectrophotometric Method for the Determination of Amitriptyline Hydrochloride in Pure and Dosage Forms

A simple, rapid, sensitive and specific high performance liquid chromatograpic (HPLC-UV) method was developed and fully validated for the quantification of midazolam in human plasma. Alprazolam was used as an internal standard. The analyte was extracted from human plasma samples by liquid-phase extraction technique. Analyte was chromatographed on a...

The present paper describes a simple, rapid, reproducible, and highly sensitive spectrophotometric method for the determination of the tricyclic antidepressant drugs: amitriptyline hydrochloride (AMT), imipramine hydrochloride (IMH), clomipramine hydrochloride (CPH) and desipramine hydrochloride (DPH) in pure and in pharmaceutical preparations. The...

Titanium Dioxide (TiO2) nanoparticles were synthesized by the precipitation method. The obtained products were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). As synthesized TiO2 nanoparticles were used for the modification of carbon paste electrode (MCPE). Electrochemical determination of dopamine was carried out u...

In the present study, a series of novel quinazolinones functionalized with urea/thiourea/thiazole derivatives was synthesized and evaluated for their antioxidant and 5-lipoxygenase (5-LOX) inhibition activities. The newly synthesized compounds were characterized using 1H NMR, 13C NMR, IR, Mass spectra and elemental analysis. The antioxidant activit...

A series of novel 1′‐[2‐(difluoromethoxy)benzyl]‐2′H,5′H‐spiro[8‐azabicyclo[3.2.1]octane‐3,4′‐imidazolidine]‐2′,5′‐dione substituted hydantoins (5–32) were synthesized using an appropriate synthetic route and characterized by elemental analysis and spectral data. The novel molecules were screened for anticonvulsant activity in mice by maximal elect...

A simple, rapid, selective and highly sensitive spectrophotometric method is described for the quantitative determination of the tricyclic antidepressant drugs, desipramine hydrochloride (DPH), clomipramine hydrochloride (CPH) and imipramine hydrochloride (IMH) in pure and in pharmaceutical preparations. The proposed method is based on the brominat...

Export Date: 18 October 2014

Argyreia elliptica extracts were prepared with solvents at different polarity (petroleum ether, chloroform, ethyl acetate and methanol) and evaluate their antibacterial, anthelmintic and antioxidant properties first time. An antioxidant activity was analyzed using different in vitro tests namely 2,2-diphenyl-1-picrylhydrazyl (DPPH) and superoxide r...

Various difluoropyridoindoles were synthesized via a palladium-catalyzed intramolecular Heck reaction as a key step. Thus, ortho-bromoanilines and difluoropiperidinone were treated with (PPh3)2PdCl2 and base in pyridine to give the regioselective cyclized heterocycles in modest to satisfactory yields.

New 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives 8-37 were synthesized and their pharmacological activities were determined with the objective to better understand their structure-activity relationship (SAR) for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant activity by...

Condensation of amine 1 with aldehyde 2 gives Schiff base, N-(4-((benzofuran-2-ylmethylene) amino)phenyl)acetamide 3. Schiff base on N-acylation with different substituted acid chlorides in the presence of triethylamine gives the corresponding benzamides, N-acetyl-N-(4-((benzofuran-2-ylmethylene)amino)phenyl)substitutedbenzamide (NABP) 5a-j. The st...

A simple, rapid, selective and highly sensitive spectrophotometric method is described for the quantitative determination of a tricyclic antidepressant drug, amitriptyline hydrochloride (AMT) in pure and in pharmaceutical preparations. The method is based on the bromination of AMT with known excess of bromine. The unreacted bromine is determined ba...

A series of novel 8-amino-3-[2-(4-fluorophenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione derivatives 7–36 was synthesized and their pharmacological activity was determined with the objective to better understand their structure–activity relationship for anticonvulsant activity. All the compounds were evaluated for their possible anticonvulsant ac...

A series of novel glutamine linked 2,3-disubstituted quinazolinone conjugates was synthesized from methyl anthranilate and different substituted acids and acid chlorides. The compounds 5a–l were prepared in good yields. All compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria and for antifungal a...

This study was designed to examine the in-vitro antibacterial and antioxidant activity of the Ajwain seed extract (ASE) and the same in combination with essential trace elements copper(II), iron(III) and zinc(II). The methanol seed extract (MSE) was found to possess strong antibacterial and antioxidant activity, however, other extracts shows modera...