Prashant Singh

• Researcher at Central Institute of Mining and Fuel Research

In this study, N2,N4‐Bis[4‐(dimethylamino)benzylidene]pyrimidine‐2,4,6‐triamine ligand (DBPT) derived from 4‐(dimethylamino)benzaldehyde, and 2,4,6‐triaminepyrimidine. Mn (II) (M1), Co (II) (M2), Ni (II) (M3), and Co (II) (M4) complexes of DBPT were also prepared together. Different analytical and spectroscopic methods including molar conductance,...

Occupational chromium exposure, especially in electroplating and stainless steel manufacture, can cause respiratory, skin, and lung cancer. The detection of chromium ions is crucial for environmental monitoring, as chromium contamination in water poses significant health risks, including cancer and organ damage. Early and sensitive detection of chr...

Plant viruses, viroids, and phytoplasma have been related to high crop production costs and pose a severe threat to agricultural output globally. The great genetic diversity of plant viruses, viroids, and phytoplasma makes it challenging to create markers that can identify every type of pathogen. The identification and detection of these infections...

The present study examines the interaction between bovine serum albumin (BSA) and dinotefuran utilizing spectroscopic, electrochemical, and computational approaches. The examination of fluorescence spectroscopy demonstrates the formation of a stable complex (protein‐ligand) between dinotefuran and BSA, with a binding coefficient of 3.8 × 10⁸ M⁻¹ an...

Corrosion of metals and alloys is a critical challenge across various industries, leading to substantial financial losses and safety risks. The use of corrosion inhibitors has proven to be an effective strategy in mitigating this issue. This review provides a comprehensive overview of the latest advancements in the use of macrocyclic compounds and...

The rapid growth of industrialisation has led to the discharge of harmful effluents into water bodies, severely disrupting the balance of ecosystems. The detection and removal of dyes from wastewater remains a significant challenge. In this study, we report the synthesis of zinc oxide (ZnO) and its doped derivatives through a facile chemical method...

Recently, molecular photoswitches have garnered significant attention in the realm of research. The photochemistry of the azo (–N = N–) group due to its photodynamic features associated with the reversible (trans–cis-trans) isomerization cycle considers azo compounds as light-driven molecular devices. This research investigates the effect of mordan...

The widespread use of pesticides poses significant threats to both environmental and human health, primarily due to their potential toxic effects. The study investigated the cardiovascular toxicity of selected pesticides, focusing on their interactions with Toll-like receptor 4 (TLR4), an important part of the innate immune system. Using computatio...

The interactions between protein and ligand are crucial to practically every biological function in the body, and investigations of these interactions are critical from the perspective of logical medication development. In this work, several biophysical methods like UV–Visible spectroscopy, fluorescence spectroscopy, and in-silico studies have been...

Ordinary-cemented paste backfill (CPB) has low stiffness and tensile strength. Several studies have reported pre-eminence of polypropylene (PP) fibre in improving such characteristics. The efficacy of PP fibre as a reinforcement for mine tailing-based CPB is widely explored but for coal ash-based CPB is not investigated. Therefore, through present...

Carbon nanotubes are cylindrically shaped with diameters as tiny as one nanometer. Significant research has been carried out in last two decades and have intriguing electrical and mechanical properties, dimensional solids and hold great promise for use as components in a variety of real-world nanoscale technologies.

Developing sustainable energy sources has been crucial in reducing environmental impacts caused by fossil fuel consumption. Production of hydrogen gas and oxygen gas by water splitting utilizing sunlight is one of the promising methods, and it requires photocatalysts to facilitate the reaction. Graphene-based photocatalysts have gained a lot of att...

In recent years, the exceptional characteristics of graphene (Gr)-based photocatalysts have sparked significant interest for their potential applications across various industries. These materials stand out for their capacity to harness solar energy and their promise in addressing environmental issues, making them a focal point of attention for pot...

Indole‐3‐carbaldehyde based novel ligand (E)‐2‐((1‐benzyl‐1H‐indol‐3‐yl)methylene)‐N‐methylhydrazine‐1‐carbothioamide (MBIHC) and their complexes [(MBIHC)2FeCl2]Cl(C1), [(MBIHC‐)2Co] (C2), [(MBIHC‐)2Ni] (C3), and [(MBIHC‐)2Cu] (C4) have been synthesized. All compounds have been characterized by spectroanalytical techniques. The structure of MBIHC w...

The study examined the interactions between a deep eutectic solvent (DES) containing choline chloride (ChCl) along with ethylene glycol (EG) in a molar ratio of 1:3, and three carboxylic acids: acetic acid, propanoic acid and butanoic acid. The structural stability, electrical characteristics and dynamic behavior of these DES-carboxylic acid system...

Acetylene (C2H2) is a colourless and odourless gas, making leak detection challenging. It can react with certain metals, such as copper and silver, to form highly sensitive and explosive compounds. Therefore, designing a highly efficient C2H2 sensor is of paramount importance for environmental and safety reasons. Utilizing deep eutectic solvents (D...

Eutectic mixtures (EMs) are consisted of two or more components with a specific composition and melting point, have received a lot of attention in pharmaceutical research due to their potential to improve the physicochemical properties and oral bioavailability of active pharmaceutical ingredients (APIs). This review summarizes the most recent resea...

The non‐structural protein (nsP2 & nsP3) of the CHIKV is responsible for the transmission of viral infection. The main role of nsp is involved in the transcription process at an early stage of the infection. In this work, authors have studied the impact of nsP2 and nsP3 of CHIKV on hormones present in the human body using a computational approach....

Inspired from the important applications of spirocyclic compounds in medicinal chemistry, a new series of pyrazoline Spiro-oxindole tethered 1,2,3-triazole hybrids was reported via Cu(I)-catalyzed click reaction from isatin–pyrazoline linked terminal alkynes with in situ derived benzyl azides. Antimicrobial evaluation data showed that all hybrids e...

Statistical analysis is essential for minimizing the time, cost, and number of experiments needed to get the maximum output. In this work, the removal of cadmium bivalent (Cd (II)) ions was optimized using Box‐Behnken design methodology. The effects of pH, concentration, time, and temperature were investigated for the removal of cadmium. Maximum re...

There was an emergency call globally when COVID‐19 was detected in December 2019. The SARS‐CoV‐2 virus, a modified virus, is what causes this contagious disease. Although research is being conducted throughout the world, the main target is still to find the promising candidate to target RNA‐dependent RNA polymerase (RdRp) to provide possible drug a...

Energy storage and conversion play a crucial role to maintain a balance between supply and demand, integrating renewable energy sources, and ensuring the resilience of a robust power infrastructure. Carbon-based materials exhibit favorable energy storage characteristics, including a significant surface area, adaptable porosity, exceptional conducti...

This work lies in the growing concern over the potential impacts of pesticides on human health and the environment. Pesticides are extensively used to protect crops and control pests, but their interaction with essential biomolecules like haemoglobin remains poorly understood. Spectrofluorometric, electrochemical, and simulations investigations hav...

Parkinson's disease (PD) is a neurodegenerative condition characterized by both motor and non‐motor symptoms. Although PD is commonly associated with a decline of dopaminergic neurons in the substantia nigra, other diagnostic criteria and biomarkers also exist. In the search for novel therapeutic agents, chromene and pyran derivatives have shown po...

Understanding the intricate interplay between proteins and ligands is pivotal for rational drug development. This study investigates the binding of Ofloxacin to Hb using diverse biophysical techniques: fluorescence spectroscopy, UV‐visible spectroscopy, molecular docking, molecular dynamics simulations, and electrochemical analysis. Spectrophotomet...

A new series of isatin‐Schiff base linked 1,2,3‐triazole hybrids has been synthesized using CuAAC approach from (E)‐3‐(phenylimino)‐1‐(prop‐2‐yn‐1‐yl)indolin‐2‐one derivatives in high yield (73‐91 %). These synthesized derivatives were characterized using FT‐IR, 1H NMR, 13C NMR, 2D‐NMR and HRMS spectral techniques. The in vitro antimicrobial activi...

One of the principal industrial pollutants, SO2 gas is a primary byproduct of the burning of fossil fuels and greenhouse gases. Further, acetylene (C2H2) is a colorless, volatile, and toxic gas that is used in dissolved gas analysis. Therefore, carbon allotropes can provide a low-cost and effective method for its detection and removal. A theoretica...

In the contemporary landscape, anxiety and seizures stand as major areas of concern, prompting researchers to explore potential drugs against them. While numerous drugs have shown the potential to treat these two neurological conditions, certain adverse effects emphasize the need for development of safer alternatives. This study seeks to employ an...

The need for pollution-free energy generation and water treatment is urgent, but more significantly, affordable energy supplies are currently the focus of study. Hydrogen is one of the energy sources that is thought to be pure and clean. This work uses N, F-codoped SnO2 nanoparticles for photocatalytic hydrogen production and dye degradation. At ro...

Solid and liquid waste management is critical to environmental sustainability and public health in urban and rural areas. This chapter overviews the various techniques and applications employed in managing waste in these diverse settings. In urban areas, the exponential growth of populations has led to an ever-increasing volume of waste, necessitat...

The exponential surge of plastic waste, derived from pre- and post-consumer realms, has been well-recognized as a global threat. Current global plastic consumption necessitates rapid sustainable solutions conjugated with technological and scientific advancements to counter plastic waste. Recycling holds a promising green stewardship, economic benef...

Hydrogen cyanide (HCN) gas, a major industrial pollution, is generated as a result of burning fossil fuels and indirectly contributes to the greenhouse effect. Therefore, deep eutectic solvents (DES) can provide a low-cost and effective method for its detection and removal. Density function theory (DFT) computations have been used to conduct a theo...

Numerous chemical pesticides were employed for a long time to manage pests, but their uncontrolled application harmed the health and the environment. Accurately quantifying pesticide residues is essential for risk evaluation and regulatory purposes. Numerous analytical methods have been developed and utilized to achieve sensitive and specific detec...

The limited solubility of graphene in water can be attributed to the existence of π–π bonds connecting its layers. Functionalized graphene or graphene oxide (GO) is frequently produced in order to overcome the shortcomings of graphene. Using density functional theory (DFT) calculation, functionalized graphene with various combinations of hydroxyl,...

Amidst the unprecedented 2019 coronavirus outbreak and the substantial loss of lives due to the scarcity of information about the virus and lack of viable drugs, understanding the impact of the nCoV Main Protease (Mpro) on the endocrine system has emerged as a critical topic to pursue. This study explores the potential interactions between four key...

In the present work, investigation of the choline chloride-urea base deep eutectic solvents (DES) in various solvents has been performed to explore the change in interaction between choline chloride and urea. A comparative study of various thermodynamic and physiochemical properties of DES in different solvents have been conducted. TD-DFT of the de...

The ever-increasing demand for hazardous solvents and catalysts for the easier synthesis of important heterocycles useful for humankind in various fields such as medicine, materials science, agrochemicals, etc., led to...

Metal nanoparticles (MNPs) have been the subject of intense study in a wide variety of disciplines for quite some time now. Various metal nanoparticles like silver and gold, copper, nickel, palladium have been synthesized using plant extracts, flower seeds, polyvinylpyrrolidone, PEG200, egg-white, cellulose nanocrystals, nanosheets, fruit extracts,...

Noscapine is one of the leading antitussive drugs available but it also faces the huge task of solubility. Ionic liquids are found to have high water solubility and stability. The authors have designed ionic liquids of noscapine and studied their interactions using DFT calculations. It was found that both the solubility and stability of noscapine i...

Mine back filling is an integral part of overall mining operation. This paper highlights the progress of underground mine back filling practices in Sukinda region, Odisha. Initially underground stope backfilling started with sand based cemented hydraulic backfilling. Slowly, the transition to other backfill material has also being done. Mine overbu...

Acyclovir, a widely used antiviral medication, is primarily known for its efficacy against viral infections caused by the herpes simplex virus and varicella‐zoster virus. While acyclovir‘s direct effects on viral DNA replication are well‐established, its potential interactions with hormone receptors and influence on hormone functioning remain relat...

In an effort to develop new antimicrobial and antibiofilm agents, we have designed and synthesized a novel class of isatin-thiosemicarbazone-1,2,3-triazoles through the CuAAC approach. All the synthesized hybrids were characterized by several spectral techniques such as FTIR, 1H NMR, 13C NMR, 2D NMR and HRMS. All the derivatives were evaluated for...

Hyperglycemia is one of the diagnostic issues in diabetes mellitus and is considered as a complex metabolic condition. It has been one of the most prevalent illnesses of the twenty-first century and still rising at an alarming rate across the globe and expected to impact 693 million individuals by 2045. Therefore, it is mandatory to develop more ef...

Mn(II) and Cu(II) complexes having the formula [M(L)2]X2 of ligand i.e., 2-acetyl-5-methylfuranthiosemicarbazone were synthesized. Various analytical and spectroscopic techniques described the structure of synthesized complexes. Molar conductance confirmed the electrolytic nature of the complexes. The theoretical study of the complexes explained th...

Cemented paste backfilling (CPB) in underground mines is a widely accepted backfilling technique. It has plenty of scope for application in Indian underground mines. Both the uniaxial compressive strength (UCS) and tensile strength (TS) are the essential CPB design parameters. During adjacent stope extraction, minor principal stresses in the backfi...

Ionic Liquids: Eco-friendly Substitutes for Surface and Interface Applications explores the growing interest in utilizing ionic liquids as sustainable alternatives for various industrial and biological applications. With their unique properties and environmentally friendly nature, ionic liquids have emerged as promising substitutes for toxic and vo...

Noscapine is a proficient anticancer drug active against wide variety of tumors including lung cancer. Over time, several noscapine analogues have been assessed to maximize the efficiency of the drug, amongst which 9-bromo noscapine remains one of the most potent analogues till date. In the present work, we have synthesized 9-bromo noscapine ionic...

Mn(II) and Co(II) complexes of methyl‐(Z)−N′‐carbamothioylcarbamohydrazonate Schiff base ligand were synthesized. The ligand and metal salts were taken in 2 : 1 stoichiometric ratio. All the synthesized complexes were characterized using elemental analysis, molar conductance, magnetic moment and various spectroscopic techniques (FT‐IR, UV/VIS, EPR)...

Paracetamol is a commonly used antipyretic drug and its consumption drastically was increased during the COVID-19 times as fever was one of the symptoms. The excessive usage of paracetamol could harm humans, as the unused accumulated paracetamol can involve in the reaction with many small molecules as well as can interact with several biomolecules....

Noscapine is known to have anti‐cancerous properties as it ceases cell division at metaphase. It is also known for its anti‐antitussive properties. Derivatives of noscapine are also known to have significant potential to act as a drug. As noscapine has low toxicity, high bioactivity and high availability, it is being explored extensively. Poor solu...

The discovery of small organic molecules as new antimicrobial agents is a promising strategy for encountering the problem of multidrug-resistant microbial strains. In an attempt to identify new azole-based antimicrobials, a library of new pyrrole based chalcone linked 1,2,3-triazoles was synthesized via CuAAC reaction of pyrrole-chalcone based term...

Schiff bases are versatile chemical compounds that are frequently utilized and manufactured by reacting various amines with carbonyl compounds (aldehydes/ketones), resulting in the formation of the azomethine/imine (–CN–) group by condensation reaction. Medical science is driven to generate novel drugs with revolutionary bioactivities and function...

Organophosphorus-based chemical warfare nerve agents are the most terrifying weapons for mass destruction of humans. These can be obtained easily and used in comparison of other they are the biggest danger for environment and human life. There is a need for techniques for identification of these organophosphorus-based chemical warfare nerve agents...

Chemical warfare (CW) is undoubtedly one of the most devastating weapons as compared to biological and nuclear warfare of mass destruction invented by humans. They are extremely hazardous chemicals that may be dispersed as aerosol or liquid, gas, and agents. These CW agents are either fatal or inefficient on humans. Many harmful substances are well...

A novel series of 3-sulfenylated oxindole linked 1,2,3-triazole hybrids from 3-sulfenylated oxindoles bearing a terminal alkyne was efficiently synthesized. After establishing the structure of all the synthesized derivatives through various spectral techniques, the antimicrobial properties were evaluated against various bacterial and fungal strains...

Amino acid–surfactant interactions are central to numerous studies because of their increased effectiveness in chemical, biological, household and industrial use. This review will focus on the impact and effect of the physicochemical properties, temperature, pH, and surfactant chain length of the amino acid for detailed exploration of amino acids a...

A new corona virus (nCoV) is aetiological agent responsible for the viral pneumonia epidemic. Three is no specific therapeutic medicines available for the treatment of this condition and also effective treatment choices are few. In this work author tried to investigate some repurposing drug such as 5- fluorouracil, doxorubicin, methotrexate and pac...

The first infection case of new coronavirus was reported at the end of 2019 and after then, the cases are reported in all nations in a very short period. Further, the regular news of mutations in the virus has made life restricted with appropriate behavior. To date, a new strain (Omicron and its new subvariant Omicron XE) has brought fear amongst u...

Graphene oxide is a two-dimensional carbon nanomaterial and has gained huge popularity over the last decade as graphene can be dispersed in water easily and it is one of the most researched two-dimensional materials in the current time. The extraordinary properties shown by graphene oxide (GO) are due to its unique chemical structure; includes vari...

Graphene oxide (GO) has attracted much attention in the past few years because of its interesting and promising electrical, thermal, mechanical, and structural properties. These properties can be altered, as GO can be readily functionalized. Brodie synthesized the GO in 1859 by reacting graphite with KClO3 in the presence of fuming HNO3; the reacti...