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Publications
Publications (55)
This interdisciplinary work communicates the identification and quantification of elements
responsible for the bioactive potency of leaves from pointed gourd, trichosanthes dioica, using laser-
induced breakdown spectroscopy (LIBS). Calibration-free LIBS determines the presence of various
trace and major elements, their concentrations, and ratios i...
This interdisciplinary work communicates identification and quantification of elements responsible for the bioactive potency of leaves from pointed gourd, trichosanthes dioica,using laser induced breakdown spectroscopy (LIBS). Calibration-free LIBS determines the presence of various trace and major elements, their concentrations, and ratios in whic...
Although plants have long been a major source of medicine, there is renewed interest in studying the phytochemistry and use of herbal formulations. This paper reports spectroscopic analysis using Laser Induced Breakdown Spectroscopy (LIBS) of a polyherbal formulation, whose antidiabetic activity has also been demonstrated on rat models. LIBS analys...
For centuries now, antioxidants have been known to provide better health by neutralizing the free radicals which are continuously produced in the human body. In normal circumstances, self-antioxidant defense system of the human body is capable of quantitatively managing the free radicals. However, in certain cases, which are at the threshold of dev...
Objective:
To evaluate the antioxidant activity of aqueous extract of Moringa oleifera (M. oleifera) young leaves by in vivo as well as in vitro assays.
Methods:
In vitro study included estimation of total phenolic, total flavonol, total flavonoid and total antioxidant power (FRAP assay). In addition, in vivo study was done with the identified m...
The present study was undertaken to scientifically validate the antidiabetic activity of aqueous fruit extract of Trichosanthes dioica Roxb. (Family: Cucurbitaceae) which has been traditionally used for managing diabetes mellitus. This plant commonly known as "Sespadula" in English has not been explored scientifically so far for its glycemic potent...
The demand for interdisciplinary research is increasing in the new millennium to help us understand complex problems and find solutions by integrating the knowledge from different disciplines. The present review is an excellent example of this and shows how unique combination of physics, chemistry, and biological techniques can be used for the eval...
The demand for interdisciplinary research is increasing in the new millennium to help us understand complex problems and find solutions by integrating the knowledge from different disciplines. The present review is an excellent example of this and shows how unique combination of physics, chemistry, and biological techniques can be used for the eval...
Psoralea corylifolia (PC), a medicinal plant, is used in traditional medicine to treat diabetes. Purpose of the research was to examine the antidiabetic and antilipemic potential of PC and to determine the relationship between its antidiabetic potential and the trace elements present. Wistar rats (150–200 g) with fasting blood glucose (FBG) of 80–1...
Impurity-free, controlled synthesis of iron oxide nanoparticle, in ultrapure water and chitosan, using laser ablation technique and its application for type II diabetes management through oral delivery of insulin-loaded iron oxide-chitosan nanocomposite is presented. The purity of the nanoparticle is monitored by laser-induced breakdown spectroscop...
This paper reports, the Laser Induced Breakdown Spectroscopy (LIBS) studies and structure elucidation of compounds isolated
from the fruit extract of Moringa oleifera and also deals with their possible effects on some bacterial strains viz. Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli and Pseudomonas aeruginosa. The extract was fou...
A highly green and expeditious route to alpha-mercapto-gamma-lactams from masked mercapto acids viz. 2-phenyl-2-methyl-1,3-oxathiolan-5-ones, and tosyl aziridines in an excellent yield (82-93%) is reported. The synthetic protocol involves regioselective opening of the terminal aziridine ring and mercaptoacetylative cyclisation cascades in a one-pot...
The effectiveness of various trace element concentrations in medicinal plants in the cure of various diseases can be determined by their quantitative estimation. Elemental concentrations of aqueous extract of F. religiosa leaves were measured by Laser-induced breakdown spectroscopy (LIBS). LIBS is a very powerful and efficient analytical tool for d...
The present study was designed to investigate the ameliorating effect of aqueous extract of C. dactylon on carbofuran induced oxidative stress (OS) and alterations in the activity of acetylcholinesterase (AChE) in the brain of rats. Vitamin C was used as a positive control. Wistar rats were administered with single sub-acute oral dose (1.6 mgkg-1 b...
The present study is a systematic and scientific evaluation of antioxidant potential of aqueous extract of Trichosanthes dioica fruits on diabetes induced oxidative stress of severely diabetic rats. Its effect on gene expression level of the tissue—specific cytochrome P450 (CYP) was also studied. The dose of 1000mg/kg bw of T. dioica extract was ad...
Many plants have been explored scientifically and systematically and claimed to be useful for the treatment of diabetes mellitus by various research groups worldwide. The present study is a further effort in the direction of developing a novel oral antidiabetic agent of high potential with minimal or no side effects.
This study screened the glycemi...
In India, Trichosanthes dioica is known as pointed gourd (in English), parwal (in Hindi) and potol (in Oriya) it is distributed in equatorial and subtropical regions and widely found in northern India. The present study is a unique example of interdisciplinary research as it deals not only with the phytochemical investigation of Trichosanthes dioic...
The aim of the study was to determine the effect of the elements of the extract of seed from Emblica officinalis on antioxidant enzymes and osmotic fragility of erythrocytes membrane in normal as well as streptozotocin-induced severely
diabetic albino Wister rats. The results revealed that the untreated diabetic rats exhibited increase in oxidative...
The present study deals with the scientific evaluation of antioxidant potential of aqueous extract of Trichosanthes dioica fruits on diabetes-induced oxidative stress of diabetic rats. The most effective dose of mg/kg bw of fruit aqueous extract was given orally to diabetic rats for 30 days. Different oxidative stress parameters were analyzed in va...
The study deals with the effect of ethanolic extract of Withania coagulans fruits on normal and streptozotocin-induced diabetic models. The maximum reduction of 39.2% in fasting blood glucose at 4 h and 39.9% during oral glucose tolerance test at 2 h was observed with the dose of 750 mg/kg in normal rats, whereas the reduction observed was 47.1 and...
The study evaluated the hypolipidaemic and hepatoprotective effects of unripe Psidium guajava fruit peel aqueous extract in streptozotocin (STZ) induced severely diabetic rats by assaying their triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) cholesterol, alkaline phosphatase (ALKP), asperate amino transeferase (AST), alani...
This study deals with the effects of freeze dried rhizome powder of Curcuma longa (C. longa) dissolved in milk on normal as well as diabetic models. Diabetes of type II and type I was within 3 days of a single administration of doses of 45 and 65 mg kg(-1) of streptozotocin respectively. Various parameters such as blood glucose levels, triglyceride...
The scientific evaluation of the antidiabetic efficacy of aqueous extract of Trichosanthes dioica fruits on streptozotocin-induced diabetic rats is being presented. The graded doses of the extract, viz., 500, 750, 1,000,
and 1,250mg/kg body weight (bw), were administered orally, and it was observed that the blood glucose concentration decreased
in...
The present study is an extension of our previous research work and it deals with the scientific evaluation of antioxidant potential of the aqueous extract of Cynodon dactylon on diabetes-induced oxidative stress of diabetic rats. The most effective dose of 500 mg/kg of extract was given orally to diabetic rats for 30 days. Different oxidative stre...
It is estimated that one-third of the world's population is infected with tuberculosis (TB). Though a number of drugs have been introduced in past thirty years but still there are unmet needs to develop more effective novel anti-TB drugs. The selection of Trichosanthes dioica plant for the present study was based on its previously identified bioact...
Erythrocytes are readily available cells and a good model system to study the health status of individuals with pathologic complications. It can also serve as a meaningful target to study toxicant/xenobiotic-induced damages. We have prepared different concentrations of a carbamate pesticide (carbofuran) and carried out experiments to determine its...
Antidiabetic efficacy of medicinal plant cannot be ignored in order to develop drugs without toxicity and side effects. Trace elements present in plant material is responsible for their medicinal nature and hence it is necessary to know the major and minor constituents of the plant material. Laser-induced breakdown spectroscopy (LIBS) is a very eff...
Antioxidants protect the body against oxidative stress by neutralizing free radicals. Plants contain rich amount of polyphenols which are very potent natural antioxidants. The present study was designed to evaluate the relative contribution of different polyphenols such as total phenolics, flavonoids and flavonol contents and their antioxidants act...
The aqueous extract of Emblica officinalis Gaertn. (syn: Phyllanthus emblica L.) (Euphorbiaceae) seeds was investigated for its anti-diabetic activity in animal models. Streptozotocin (STZ)-induced type 2 diabetes models were used for the study. The standardized doses of 100, 200, 300, and 400 mg kg−1 body weight of the extract were administered or...
The aim of the study was to ascertain the role of ethanolic extract of Cynodon dactylon against hepatic complications in streptozotocin (STZ) induced type 2 diabetic models. Effect of the pre identified most effective dose of 500 mg/kg body weight was studied on hepatic injury caused by chemically induced diabetes by 55 mg/kg body weight i.p. injec...
The present study exploits the information based on concentration of trace elements and minerals in understanding the role/mechanism
of action of freeze-dried fruit powder suspended in distilled water of Momordica charantia (family: Cucurbitaceae) in diabetes treatment. Laser-induced break down spectroscopy (LIBS) spectra of plant product was
recor...
In Indian traditional system of medicine, Moringa oleifera Lam. Syn. Moringa pterygosperma Gaerth (Moringaceae) is commonly used as healing herb to treat diabetes.
The purpose of the present study was to assess the effect of M. oleifera leaves aqueous extract therapy on glycemic control, haemoglobin, total protein, urine sugar, urine protein and bo...
Herbal preparations of Ficus bengalensis had been considered as effective, economical and safe ethnomedicines for various ailments in Indian traditional system of medicine.
The present study was aimed to explore scientifically the antidiabetic potential of Ficus bengalensis aerial roots as its bark had already been reported to possess antidiabetic...
This study was undertaken to evaluate the glycaemic potential of aqueous extract of Psidium guajava unripe fruit peel on blood glucose level (BGL) of normal and streptozotocin induced mild and severely diabetic rats as an extension of our previous work carried out on Psidium guajava ripe fruit peel.
The aqueous extract of P. guajava unripe fruits w...
The present study defines the systematic evaluation and the role of minerals in glycemic potential of aqueous extract of Withania coagulans fruits in order to develop an effective and safe alternative treatment for diabetes mellitus. Laser Induced Breakdown Spectroscopy was used for glycemic element detection. The study is based on the results of l...
Wistar rats of 6-8 weeks in age weighing between 120-150 g were exposed to the fixed doses of each of the carbamate pesticides such as cartap (50% LD(50)) and carbofuran (50% LD(50)) as well as a combination of these two with 25% LD(50) of each for one week. The effect of treatments was studied in terms of serum lipid parameters such as high-densit...
Erythrocytes are prone to oxidative stress due to the presence of hemoglobin and polyunsaturated fatty acids. Oxidative stress (OS) is associated with increased osmotic fragility (OF) of erythrocytes. Organophosphate and organocarbamate pesticides are known to cause OS in erythrocytes. We have investigated the effect of a single sub-acute dose of c...
The study defined the scientific evaluation of glycemic elements of extracts of Cynodon dactylon and Musa paradisiaca. A dose of 500 mg/kg body weight (bw) of C. dactylon produced maximum falls of 23.2% and 22.8% in blood glucose levels of normoglycemic rats during studies of fasting blood glucose and glucose tolerance, respectively, whereas the sa...
In continuation of our previous work on Trichosanthes dioica Roxb. (Cucurbitaceae), the aim of this study was to screen the glycemic attributes of an aqueous extract of Trichosanthes dioica leaves in normal as well as various diabetic models. The variable doses of 250, 500, and 750 mg kg− 1 body weight (bw) of the extract were administered orally t...
The present study was designed to investigate the hepatoprotective effect of aqueous extract of Cynodon dactylon, widely used in India as a traditional treatment for diabetes mellitus. Male Albino Wistar rats (180-220 g) were administered with streptozotocin (STZ, 50 mg/kg) intraperitoneally to induce experimental diabetes. Alkaline phosphatase (AL...
Natural remedies from medicinal plants are considered to be effective and safe alternative treatments for diabetes mellitus. The current study deals with the effect of a single oral dose of the aqueous extract of Trichosanthes dioica. Roxb. (Cucurbitaceae) seeds in different diabetic animal models. Evaluation of the antihyperglycemic effect in norm...
In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine prote...
In continuation of our previous work on Trichosanthes dioica [1] the aim was to screen glycemic attributes of aqueous extract of Trichosanthes dioica Roxb. (Cucurbitaceae) leaves in normal as well as various diabetic models. Variable doses of 250, 500, and 750mg kg-1 body weight (bw) of the extract were administered orally to normal and streptozoto...
The present study deals with the evaluation of glycemic profile of aqueous extract of Cajanus cajan leaves in streptozotocin induced type 2 diabetic rats. Single oral administration of graded doses of aqueous extract of Cajanus cajan leaves showed significant increment of 14.3 % in fasting blood glucose levels of normal rats. The sub diabetic and m...
The present study is an extension of our previous work carried out on Cynodon dactylon. This study deals with the critical evaluation of glycemic potential of ethanolic extract of defatted C. dactylon. The doses of 250, 500 and 750 mg kg(-1) bw of the extract were administered orally to normal as well as Streptozotocin-induced diabetic rats to stud...
The present study reveals the effect of Musa paradisiaca stem juice on blood glucose level (BGL) of normal & diabetic rats.
The dose of 500 mg/kg bodyweight produces a significant rise of 28.3% in blood glucose level after 6h of oral administration
in normal rats. Whereas, in sub diabetic rats the same dose produces a rise of 16.4% in blood glucos...
The present study deals with the detection of elements responsible for glycemic potential of ripe and unripe fruit peel aqueous extracts of Psidium guajava (P. guajava). Treatment with the aqueous extract of unripe fruit peel showed a significant fall of 17.5% (p<0.001) in blood glucose levels (BGLs) of normal rats during fasting blood glucose (FBG...
Many plant polysaccharides exhibit hypoglycaemic effect. Though the fruit of Psidium guajava is known to contain free sugars, the fruit extract showed hypoglycaemic effect in alloxan treated mice and human subjects. The present study was aimed to determine the glycaemic potential of P. guajava fruit peel extract on blood glucose level (BGL) of norm...