
Prasadi De SilvaUva Wellassa University · Faculty of Animal Science and Export Agriculture
Prasadi De Silva
B.V.Sc. (Sri Lanka), M.Sc. (U.Tokyo, Japan), M.Sc. (J'Pura-Sri Lanka) Ph.D. (U.Tokyo Japan)
About
25
Publications
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Introduction
Immunogenetics and biotherapy, aquatic animal health, microbiology and zebrafish research
Skills and Expertise
Publications
Publications (25)
Antimicrobial resistant (AMR) bacteria including Campylobacter has become an emerging global concern in human and animal health. There are very few researches on AMR Campylobacter conducted in Sri Lanka and none of them studied about AMR genes to the best of our knowledge. The present study focused on the detection of AMR Campylobacter from broiler...
Zebrafish embryo is considered as one of the most suitable alternative to animals in toxicity testings’ due to their special features like transparent embryo, high fecundity (200-250 eggs) and the short period of the embryonic development. The main problem with Zebrafish embryo toxicity model is the manual image inspection. The process is complex a...
Status of Ornamental Zebrafish Varieties in Aquaria in Badulla, Sri Lanka
Water quality deterioration due to inorganic and organic pollutant is a serious issue and the presence of toxic trace metals cause a serious threat to the aquatic ecosystem. Fish embryos have gained interest in risk assessment because of their high sensitivity to pollutants and the ecological relevance. This study investigated the acute toxicity ef...
Swordfish (Xiphias gladius) is a migratory fish commercially exploited due to high export value. Presence of parasites in fish lead to economic losses in the export market and public health issues. This study was conducted to identify the parasite larvae inhabiting swordfish and to determine its phylogenetic origin using ribosomal subunit gene sequ...
Poultry industry is one of the leading protein sources around the world. In Sri Lanka, it has developed rapidly over the years and it is the main contributor for consumed meat. Campylobacter is one of the microorganisms presents in asymptomatic form in poultry which cause zoonotic disease, Campylobacteriosis to human. Due to improper usage of antib...
Cartilaginous fish are the evolutionarily oldest group of animals which possess antibodies, T cell receptors and major histocompatibility complex (MHC). The immunoglobulin novel antigen receptor (IgNAR) found in cartilaginous fish is a heavy chain homodimer which lacks light chain. The presence of non-canonical cysteine molecules and lack of CDR2 r...
Poultry industry in Sri Lanka has developed rapidly in the past decade and it is the main contributor to consumed meat nowadays. Campylobacter is one of the most important food borne bacterial pathogen and this disease, campylobacteriosis is acquired mainly by eating contaminated, undercooked chicken. It mainly causes gastroenteritis and is of majo...
Immunoglobulin novel antigen receptor (IgNAR) is a unique antibody found only in cartilaginous fish. It is a heavy chain homodimer with smallest variable region (around 12 kDa) identified to date. Affinity maturation of IgNAR was tested in few shark species but the results were not always promising. Therefore current study aimed to determine IgNAR...
Immunotherapy particularly in the field of oncology is showing promising results due to high specificity of monoclonal antibodies against target antigens. However due to structural complexity (heavy and light chains) and large molecular size of antibodies limit their functional efficacy. Immunoglobulin novel antigen receptor (IgNAR) is a naturally...
Parasitism leads to severe economic losses to marine fish exports in Sri Lanka. Swordfish is a seasonal species with high demand both locally and internationally. Presence of a parasite in their flesh confuses the suppliers with zoonotic Anisarkis spp. This study is aimed to identify the plerecercoid parasitic larvae found in swordfish and establis...
Pesticides severely affect the balance in biodiversity, but are used worldwide for agriculture to control pests. The effect of this on the life in water bodies has been poorly investigated. The present study investigated the acute toxicity of two widely used pesticides; Diazinon (C 12 H 21 N 2 O 3 PS) and Etofenprox (C 25 H 28 O 3) on zebrafish (Da...
Parasitic infestations cause severe economic loss to the marine fish export industry in Sri Lanka. Present study is to identify the parasites found in fish in order to determine its public health importance. Parasites were isolated from sword fish (Xiphias gladius) muscles. Specimens were fixed in formalin and observed under confocal microscope. Pa...
Zebrafish (Danio rerio) in the family Cyprinidae, is a tropical freshwater fish widely used as a model organism in scientific research. Use of effective and economical anaesthetic is very important when handling fish. Clove oil (active ingredient: eugenol) was identified as a natural product which is safer and economical compared to synthetic chemi...