Pramod Kumar Manjhi

All India Institute of Medical Sciences, Patna · Department of Pharmacology

Background: Preeclampsia is a major factor in both maternal and fetal morbidity and mortality. The most widely investigated preeclampsia prevention medication is low dose Aspirin. However, guidelines differ considerably regarding the prophylactic dose of Aspirin for preeclampsia. Objective: The objective is to compare the efficacy of 150mg versus...

Background: Drug allergy (DA) or hypersensitivity is an immunologically mediated reaction producing stereotype symptoms which is challenging for health care providers (HCP). Objective of current study was to assess the knowledge, attitudes and practices of drug allergy among healthcare providers in eastern India. Methods: A 25-item self-administere...

Background: Teneligliptin, a new DPP4 inhibitor, was approved in India in 2019 and has been shown to improve blood glucose and lipid profile. The purpose of this study was to compare the efficacy and safety metformin with teneligliptin combination versus metformin with glimepiride which is the most common combination prescribed in diabetes. Materia...

Introduction: Coronary artery disease (CAD) is one of the most common causes of cardiovascular mortality and morbidity in developing countries like India. Initial management includes use of many anti- anginal drugs. If angina pectoris not managed adequately results in significant morbidity and mortality too due to the complications. Anti-anginal dr...

Coronavirus disease (COVID‑19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2). The clinical spectrum of SARS‑CoV‑2 infection ranges from asymptomatic infection to critical illness. About 80% of COVID‑19 infections are mild or asymptomatic, 15% are associated with severe infection requiring oxygen and...

Background: Fungal infections are the 4th most common skin disease affecting 984 million people. Fungal infections are mostly associated with the use of broad-spectrum antibiotics, corticosteroids, anticancer/immunosuppressant drugs, indwelling catheters and implants, and the emergence of AIDS. The aim of this study was to analyze the rational use,...

Background: This study was conducted to know the students’ views regarding the personal drug (P-drug) concept in the rational prescription of drugs and also to give them training on creating and using personal drug concepts. Methods: The 60 medical students (5th semester) divided into four groups were involved voluntarily three-phase, questionnaire...

Background: Antitussive-expectorants are among the most frequently prescribed drugs by physicians in clinical practice. Upper respiratory tract infections, such as common cold, acute pharyngitis and acute trachea-bronchitis, are the most common of all communicable diseases and significantly increase OPD burden. This study aimed to assess the ration...

Background: There has been a growing interest in ivermectin ever since it was reported to have an in-vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This trial was conducted to test the efficacy of ivermectin in mild and moderate coronavirus disease 19 (COVID-19). Methods: A double blind, parallel, randomised...

Drug - Drug Interactions in patients with COVID-19

Introduction: Coronavirus disease-2019 (COVID-19) is a global pandemic without any specific treatment to date. Drug utilisation plays a vital role in helping the health care system to understand the pattern of drug use. Aim: To assess the prescribing trends among COVID-19 patients admitted to the hospital. Methodology: This was a retrospective coho...

Introduction: Cutaneous Adverse Drug Reactions (CADRs) share significantly to Adverse Drug Reactions (ADRs) comprising 10%-30% of all ADR reporting in India. Multi Drug Therapy for Leprosy (MDT-L) and antimicrobials contribute remarkably to the overall CADRs burden. Aim: To show distinctive pictures of CADRs profile and to assess inter-rater agreem...

Diabetic peripheral neuropathy (DPN) is a common presentation in Type 2 diabetes in the long run. Neuropathic pain is the most common disabling symptom of DPN. Previous studies suggest beneficial role of cannabis in animal model for neuropathic pain. Cannabinoid receptors (CB1 and CB2) are found at sites associated with pain processing and they als...

Background: Main objective of this study was to find out the students’ perception and to obtain feedback towards the use of Animal Simulator to demonstrate drug effects in terms of its acceptability, advantages and disadvantages of Computer Assisted Learning (CAL) in experimental pharmacology practical as an educational tool.Methods: Questionnaire...

Background: Cutaneous drug reactions are most frequent drug related adverse events which lead to early treatment discontinuations, high treatment cost and leading cause of morbidity and mortality. The aim of this study is to analyze the clinical patterns and offending drugs as well as their causality, severity and preventive strategies. Methods: A...

Background: This study was conducted to assess the knowledge, attitude and practice of pharmacovigilance (PV) and adverse drug reaction (ADR) reporting among healthcare professionals in a tertiary care hospital of Bihar. Methods: It was a questionnaire based cross- sectional study carried out for a period of 3 months by a preformed structured quest...

Background: A cardiovascular disease (CVD) is one of the most common causes of mortality and morbidity globally. The drastic change in the lifestyle of population during 21 st century has had a great impact on health especially cardiovascular diseases. Objective of this study was to assess the prescription pattern of fixed dose drug combinations (F...

The objective of the study is to evaluate the prescription pattern of antimicrobial drugs in paediatric outpatient department in a tertiary care teaching hospital. The prescriptions of 140 patients who attended the paediatric outpatient department were analysed and following data were collected - patient demographics, presenting complaints, investi...

Background: The conventionally used topical antiscabetics have poor compliance. Ivermectin, an oral antiparasitic drug, has been shown to be an effective scabicide and could be a useful substitute. This study was designed to compare efficacy of oral ivermectin with commonly used topical antiscabies drugs. Materials and methods: This study was co...