Prakash S Bisen

• M.Sc., Ph.D., D.Sc., FNASc.
• Professor Emeritus at Jiwaji University

Among the most common medical problems experienced by older adults (over 60 years) are diabetes, Parkinson's disease (PD), and erectile dysfunction (ED). The potential use of Mucuna pruriens in treating type 2 diabetes (T2D), PD, and ED is being investigated. Literature searches were conducted using the PubMed, MEDLINE, and Mendeley databases (1990...

Gastrointestinal (GI) cancer stands as a global health challenge, necessitating effective therapeutic approaches with minimal adverse еffеct. This review delves into the potential of Ganoderma lucidum, a macro fungus, commonly recognized for its medicinal properties, in traditional Chinese medicine. Macro fungus acts as a promising adjunct for trea...

There are many dietary options available to us in nature that can benefit our health and cure metabolic conditions. The aim of this study is to identify cardiometabolic biomarkers that can be modulated by dietary supplements. This study used data from PubMed, Web of Science, Scopus, Mendeley, and Embase from 2000 to Dec. 2023. Studies have found th...

India has a large population of people who live in rural areas. Regional differences prevent every part of the country from being well developed. Among other factors, there are differences in cultural practices, living standards, and ownership of agricultural lands. Closing the gap requires the adoption of technology and a good education. This stud...

Patients with coronavirus disease 2019 (COVID-19) infection can suffer from a variety of neurological disorders; therefore, there is a demand to investigate specific treatments. As a part of this endeavor, academic databases related to clinical, neuropathological, and immunological biomarkers were examined for searching promising drugs to treat neu...

Human cathepsin-L protease is involved in the cleavage of S protein of SARS-Cov2 virus and activates the membrane fusion which mediates the entry of the virus into the host cell. Thus, it suggests the cathepsin-L protease is critical for the entry of SARS-Cov2. Currently, chemically synthesized cathepsin-L inhibitors are present, but, the consumpti...

Nutritional therapy and disease causes have been studied sparingly. It is one of the main objectives of this study to look for a nutritional diet that promotes cardiovascular health. Various electronic databases and scientifically published articles were searched for relevant information for this review. In addition to these parameters, diabetes, b...

The scientific literature indicates that ginger is known for its medicinal properties from ancient times. Ginger is an excellent source of bio-active compounds. It can stimulate the immune system to protect against various types of cancers. In the review, the bio-active compounds of ginger like gingerols, shogaols, paradols, terpenes, camphene, zin...

Ginger is traditionally known for its therapeutic and pharmaceutical properties. It has been used widely to treat various health problems such as high blood pressure, coughs, colds, swelling, nausea, rheumatic disorders, vomiting, bronchitis, indigestion, gastric ulcers, and behavioral problems. Shogaol and Gingerol are anti-inflammatory, anti-feve...

Ginger is traditionally known for its therapeutic and pharmaceutical properties. It has been used widely to treat various health problems such as high blood pressure, coughs, colds, swelling, nausea, rheumatic disorders, vomiting, bronchitis, indigestion, gastric ulcers, and behavioral problems. Shogaol and Gingerol are anti-inflammatory, anti-feve...

Objective Nutritional therapy, integrative and functional medicine, and psychiatry are areas of medicine where there has been limited research on the cause of disease and nutritional therapy. Modern medicine treats the medical cause, not the symptoms. All medicines are toxic in some way. Now, healthcare professionals are recommending food as medici...

This study explores the potential role of cinnamaldehyde from cinnamon to elicit immunity against the pathogens of COVID-19. In the culture of traditional and herbal treatments, it was more valuable than gold. It has been observed that coronavirus infects cells of an organism including innate and adaptive immune cells. Cinnamaldehyde, eugenol, and...

This study explores the potential role of cinnamaldehyde from cinnamon to elicit immunity against the pathogens of COVID-19. In the culture of traditional and herbal treatments, it was more valuable than gold. It has been observed that coronavirus infects cells of an organism including innate and adaptive immune cells. Cinnamaldehyde, eugenol, and...

India is a country of herbs found in forest areas. Most herbs are collected from the forest and sold in the local market. There is a need to cultivate and explore the export potential of demanded herbs. Advance farming is the need of the society and farmers in the developing world. Most farmers are adopting a single cropping pattern in India. A sus...

Mucuna pruriens known as “Velvet Bean,” it is an important herb used in the Indian system of Traditional medicine. It is mainly used as a drug to promote muscle mass and body weight and is advocated as Aphrodisiac. Mucuna pruriens belong to the family Fabaceae and genus Mucuna, a vigorous annual climbing legume with long and slender branches, lance...

Introduction- Many environmental risk factors are associated with some form of chronic inflammation. The spread of COVID-19 across the world has impacted every one of us. The first case of coronavirus was reported on 30 January 2020 in India originating from China. Study Area- India has a tremendous capacity to deal with the coronavirus outbreak be...

There has been a lot of research about the human microbes, some detailed investigations of the gastrointestinal microorganisms and its functions, and the highlighting of complex interactions between the gut, the gut microbiome, and the central nervous system. That acquires the involvement of the microbiome in the pathogenesis of various diseases. T...

There has been a lot of research about the human microbes, some detailed investigations of the gastrointestinal microorganisms and its functions, and the highlighting of complex interactions between the gut, the gut microbiome, and the central nervous system. That acquires the involvement of the microbiome in the pathogenesis of various diseases. T...

Probiotics are the widely explored dietary supplements for a variety of benefits. The most common and known functions include protective effects against gastrointestinal disorders such as irritable bowel syndrome, diarrhea, ulcerative colitis, and many others. Recently, scientists have been very keen on exploring the multiple other aspects of probi...

Probiotics are the widely explored dietary supplements for a variety of benefits. The most common and known functions include protective effects against gastrointestinal disorders such as irritable bowel syndrome, diarrhea, ulcerative colitis and many others. Recently, scientists have been very keen on exploring the multiple other aspects of probio...

Probiotics are the widely explored dietary supplements for a variety of benefits. The most common and known functions include protective effects against gastrointestinal disorders such as irritable bowel syndrome, diarrhea, ulcerative colitis and many others. Recently, scientists have been very keen on exploring the multiple other aspects of probio...

Background: There is an urgent need to devise improved alternatives for the efficient delivery of drugs to develop improved therapeutic interventions against cancers. Nanotechnology based drug delivery vehicles are in-use with obvious issues of toxicity and bio-distribution. Therefore, green synthetic routes are being deployed to replace the conve...

Nanotechnology-based drug delivery vehicles are in-use with obvious issues of toxicity and biodistribution. Therefore, green synthetic routes are being deployed to replace the conventional nanoparticle formulations for effective drug delivery aiming at developing interventional strategies against cancer.

A wide array of fast replicating and mutating endogenous viruses with temporal and spatial variability predominate human and zoonotic genomes with and without disease manifestations. However, knowledge about their composition, complexity, and dynamics is inadequate. To date, high throughput genomic, transcriptomic, and proteomic studies revealed so...

A wide array of fast replicating and mutating endogenous viruses with temporal and spatial variability predominate human and zoonotic genomes with and without disease manifestations. However, knowledge about their composition, complexity, and dynamics is inadequate. To date, high throughput genomic, transcriptomic, and proteomic studies revealed so...

The Lactic Acid Bacteria (LAB) has extensively been used in food industry for the production of varied fermented products such as yoghurt, cheese etc. These are also been used as probiotics for animal as well as human welfare in terms of health and well being. also The present review focuses on available literature, current market status and on the...

Background It has been seen that 90% of municipal solid waste is disposed of unscientifically in open dumps and landfill sites, initiating problems to the environment, and public health in developing countries. Many technological options can convert wastes into various forms of energy. Heat and electricity can be generated and utilized for specific...

Introduction: Tuberculosis (TB) is still one of the major global health threats and delayed diagnosis or misdiagnosis continues to fuel the global epidemic. The conventional diagnostic approaches have shortcomings that might hinder the process of diagnosis of the disease and ultimately affect the prognosis. Area covered: We emphasize on the process...

As we researched the currently available textbooks covering the basic principles, applications, and promises of nanotechnology as it applies to medicine, we noted a dearth of introductory material tailored specifically for students. While a number of comprehensive books exist outlining the promise of nanosciences applicable to medical applications,...

Background India has enormous potential of medicinal and herbal plants but the knowledge of herbs and its uses are not fully explored. Chlorophytum borivilianum (family: Lilliaceae) is one of highest valued medicinal plant found in the Indian forest. Traditionally it is used after delivery by the females in different composition in the form of “Lad...

Abstract: Introduction: Intermediate covalent complex of DNA-Topoisomerase II enzyme is the most promising target of the anticancer drugs to induce apoptosis in cancer cells. Currently, anticancer drug and chemotherapy are facing major challenges i.e., drug resistance, chemical instability and, dose-limiting side effect. Therefore, in this study, n...

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Mycobacterium tuberculosis is a rod shaped acid fast,slow growing bacteria. It is an intracellular pathogen,which cause sever chronic infection to human known as Tuberculosis (TB). TB is an infectious, airborne communicable disease transmitted from one person to other through aerosols. Primilarly it affects respiratory system ( Lungs- Pulmonary TB...

Oral cancer is a heterogeneous group of cancers arising from different parts of the oral cavity, with different predisposing factors, prevalence, and treatment outcomes. The sixth most common cancer reported globally with an annual incidence of over 300,000 cases, of which 62% arise in developing countries like India. Diagnosed in an estimated 30,...

Tropilite Foods Probiotic Project Commercial Operation

Different forms of microbes which are being used as a source of medicinal food.

Human Microbiome analysis of Sputum

Performance metrics as of 20 October 2019

My name is Danielle Cazabon, the Summer Student for the Stars in Global Health program at Grand Challenges Canada. Grand Challenges Canada is proud to have supported your project and we are excited to communicate the results and outcomes of your work. In doing so, we aim to increase the visibility of your work, which we believe will nurture new pa...

GCC 253 Using lipid biochemistry to detect TB Issue Tuberculosis (TB) causes millions of deaths annually worldwide. In 2011 there were 8.7 million new TB cases and 1.4 million TB deaths. The current gold standard for diagnosis by cell culture is slow and may result in further progression and molecular diagnostic techniques are promising, butnot wid...

Introduction Intermediate covalent complex of DNA-Topoisomerase II enzyme is a most promising target of the anticancer drugs to induce apoptosis in cancer cells. Currently, Anticancer drug and chemotherapy are facing major challenges i.e., drug resistance, chemical instability and, dose-limiting side effect. Therefore, in this study, natural therap...

A wide array of therapeutic strategies has been implemented against cancers, yet their clinical benefit is limited. The lack of clinical efficacy of the conventional treatment options might be due to the inept immune competency of the patients. Dendritic cells (DCs) have a vital role in initiating and directing immune responses and have been freque...

Background Jatropha curcas is one of the most suitable plants which seeds are nonedible in nature but rich in oil. Around 350 oil bearing crops are found suitable as potential alternative fuels for diesel engine. Non-edible crop Jatropha curcas has been identified by many experts for biodiesel production in many countries like India. Objective The...

The world population is at major risk of obesity and overweight, leading to various chronic implications at later stages like cardiovascular diseases, diabetes and sometimes cancers. The fatty acid synthase (FASN) protein plays key role in fatty acid synthesis by interacting with Acetyl CoA. It also works in close association with various genes tha...

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This book is an effort to reflect on the new advances in our understanding of the immune system, immune response activation, as well as immunomodulation, and to improve upon the presentation of information to students, teachers, and researchers. As teachers of immunology, we are becoming increasingly aware that assimilating detailed information as...

To remain competitive and survive in the developing economy, farmer has to adopt the scientific and technological approach for farming. Integrated farming with crop diversification is a sustainable agricultural development concept towards accumulation and utilization of cultivable land. Cultivating suitable multiple crop like short term vegetable,...

Jatropha curcas is one of the most suitable plants which seeds are non-edible in nature but rich in oil. In this research, the fatty acid composition of the extracted lipid of jatropha was studied using the gas chromatography with high resolution mass spectrometer. The major fatty acids in jatropha crude oil were the oleic (3.81%), linoleic (50%) a...

Tapping non-conventional renewable energy resources for generation of electricity is the need of the hour, particularly in the developing countries. Renewable energy from photovoltaic, wind turbines and small hydroelectricity plants iseco-friendly and highly desirable for all countries. But, for the developing countries, such as,Sub-Sahara Africa w...

Curcumin and also the products derived from this yellow magic have provided relief to a vast number of arthritis patients worldwide. In order to overcome the problem of poor pharmacokinetic behavior of curcumin, curcumin-like diarylpentanoid, a curcumin analog, suppressed the activities of matrix metalloproteinase, interleukin-6, and cyclooxygenase...

Garlic is a proven potential natural remedy for arthritis. The advancement of medical science and research has made it possible to exploit its various components for the targeted administration of this wonder drug. Making nanoformulations of garlic compounds will help further the easy use and bioavailability for arthritis patients. Also, preclinica...

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The advent of various health care policies and digital revolution has fuelled interest in the direction of food supplements, and as preventive or curative drug containing live non-pathogenic bacteria, probiotics. The widespread usage of probiotics by consumers and in clinical practice has emphatically made to understand the benefits associated with...

Abstract: Background: Breast cancer demands safe adjuvant to overcome the side effects of standard drug tamoxifen. Diet derived bioactive compounds are reported to exhibit modulation of cancer growth leading to cell death. Chickpea is a protein rich edible legume with several bioactive compounds that includes lectin as well. Characterization of chi...

Globally, increased dependence on fossil fuels for manufacturing plastics, scarcity of space for disposal, and ongoing environmental concerns for nonbiodegradable chemical-based plastics have fueled research toward sustainable process development of cost-effective, eco-friendly, and biodegradable polymers. In this context, polyhydroxyalkanoates (PH...

The current study was undertaken to study the effect of Spirulina platensis (Spirulina) extract on enhanced oxidative stress during high glucose induced cell death in H9c2 cells. H9c2 cultured under high glucose (33 mM) conditions resulted in a noteworthy increase in oxidative stress (free radical species) accompanied by loss of mitochondrial membr...

The health promoting effect of various fruits and vegetables is due to the presence of the plethora of bioactive compounds which have preventive and anti-proliferative activity. However, not much has been documented about functional foods in prevention and treatment of cancer. In this chapter, we have reviewed plant based functional foods which hav...

The remarkable properties of nanomaterials, such as their unique electrical, optical, and chemical properties as compared to macromaterials, make them ideal candidates for sensor design. Nanosensors offer unique advantages such as high sensitivity and accuracy, quick response, direct localized detection, and enhanced sensing surface area, which can...

Nanodentistry has evolved as a new science of nanotechnology that helps in diagnosing, treating, preventing oral and dental disease, and improving dental health by using nanomaterials. These nanomaterials include clusters of atoms, grains, fibers, films, crystals, and nanoholes. The orientation of these nanomaterials can be in one dimension, for ex...

Developing countries encounter huge economic losses due to frequent epidemics of infectious diseases. The major contributing factor is the indiscriminate use of antibiotics leading to the emergence of resistant strains that are unaffected by existing antibiotics. Moreover, infectious diseases associated with the formation of biofilms composed of a...

The health promoting effectofvariousfruitsandvegetables isduetothe presence of theplethora of bioactive compounds which have preventive and anti-proliferative activity. However, not much has been documented about functional foods in prevention and treatment of cancer. In this chapter, we have reviewed plant based functional foods which have prevent...

Background: Withania somnifera, a high value medicinal plant is a major source of pharmaceutically important active compounds withanolides. Withania somnifera has been used in ayurveda as health restorative and anabolic agent besides having anti-arthritic, antidepressant, anti-microbial, anti-inflammatory, anti-diabetic, anti-stress, neuroprotectiv...

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Squamous cell carcinoma (SCC) is the most common cancer worldwide. The treatment of locally advanced disease generally requires various combinations of radiotherapy, surgery, and systemic therapy. Despite aggressive multimodal treatment, most of the patients relapse. Identification of molecules that sustain cancer cell growth and survival has made...

Developing countries encounter huge economic losses due to frequent epidemics of infectious diseases. The major contributing factor is the indiscriminate use of antibiotics leading to emergence of resistant strains which are unaffected by existing antibiotics. Moreover, infectious diseases associated with formation of biofilms composed of large num...

Nanodentistry has evolved as a new science of nanotechnology which will help in diagnosing, treating, preventing oral & dental diseases and improving dental health by using nanomaterials, such as atoms, grains, fibers, films, crystals and nanoholes, fullerenes, nanowires, nanobelts, quantum dots, nanorings, nanocapsules. The orientation of these na...

Road transport is accountable for considerable emissions in the atmosphere in the form of carbon content, nitrogen, sulphur and other particulate matter. The average annual concentration of suspended particulate matter is very high in the Indian cities reaching the threshold of the prescribed critical levels set by the WHO. It has been studied that...

The remarkable properties of nano-materials such as their unique electrical, optical and chemical properties as compared to macro-materials make them ideal candidates for sensor design. Nanosensors offer unique advantages such as high sensitivity and accuracy, quick response, direct localized detection and enhanced sensing surface area which can be...