
Pragyan MishraKIIT University | KIIT · School of Biotechnology
Pragyan Mishra
Integrated M.Sc
About
7
Publications
1,284
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Introduction
Currently I am working on the epigenetic regulation during host pathogen infection, particularly during Vibrio infection.
My work basically focuses on knowing the histone PTMs involved during in vitro and in vivo Vibrio infection. Identifying the HATs and HDACs having a role during infection and characterizing them subsequently. Further, elucidating the biological functions carried out by these epigenetic modulators.
Education
August 2008 - July 2013
Publications
Publications (7)
The regulation of gene expression is a dynamic process that is influenced by both internal and external factors. Alteration in the epigenetic profile is a key mechanism in the regulation process. Epigenetic regulators, such as enzymes and proteins involved in posttranslational modification (PTM), use different cofactors and substrates derived from...
Gram negative intracellular pathogen V. parahaemolyticus manifests its infection through a series of effector proteins released into the host via the type III secretion system. Most of these effector proteins alter signalling pathways of the host to facilitate survival and proliferation of bacteria inside host cells. Here, we report V. parahaemolyt...
The key to bacterial virulence relies on an exquisite balance of signals between microbe and hosts. Bacterial toxin–antitoxin (TA) system is known to play a vital role in response to stress adaptation, drug resistance, biofilm formation, intracellular survival, persistence as well as pathogenesis. In the present study, we investigated the role of H...
Purpose
The key differences in cell death mechanisms in the trabecular meshwork (TM) in adult moderate and severe primary glaucoma remain still unanswered. This study explored key differences in cell death mechanisms in the trabecular meshwork (TM) in adult moderate and severe primary glaucoma.
Design
In-vitro laboratory study on surgical specimen...
The human genome encodes around 25,000–30,000 genes, translating to many more proteins resulting from alternate splicing. A number of these proteins are enzymes possessing regulatory function in cellular and biochemical processes. Deregulation of enzyme activity can alter cell fate, often leading to diseased state, thereby presenting an opportunity...
Background
The key differences in cell deathmechanisms in the trabecular meshwork (TM) in adult moderate and severe primary glaucoma remain still unanswered. This studyexplored key differences in cell deathmechanisms in the trabecular meshwork (TM) in adult moderate and severe primary glaucoma.
Methods
Select cell death related proteins differenti...