Pradip Gyanwali

• Professor (Assistant) at Institute of Medicine(IOm).kathmandu nepal

Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services. Methods A cross-sectional survey was conducted among healthcare workers employed in 87 hospitals having medical/surgical ICU...

Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services. Methods A cross-sectional survey was conducted among healthcare workers employed in 87 hospitals having medical/surgical IC...

INTRODUCTION Smoking prevalence and age of smoking initiation (AOI) are two important variables for tobacco control programs. The study aimed to compare the prevalence of smoking between three WHO STEPS (STEPwise approach to surveillance) surveys and the AOI between males and females, using the Bayesian approach. METHODS We made three null hy...

Background. Cancer is one of the leading causes of death globally. The low and middle-income countries (LMICs) cover a major share of the global cancer burden; however, most of the LMICs including Nepal still lack national cancer control and prevention strategies. Since 1st January 2018, the Nepal Health Research Council (NHRC) started the populati...

Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services. Methods A cross-sectional survey was conducted among healthcare workers employed in 87 hospitals having medical/surgical ICU...

Background Nepal is one of the high prevalent countries for tobacco use in Southeast Asia regions. Tobacco related cancer share the major burden since a decade, however, population-based estimates is still lacking. This study provides results from population-based cancer registries on tobacco-related cancer (TRCs) burden in Nepal. Methods The data...

Introduction The universal health research ethical principles must be adhered to ensure a balance between science and safeguarding participants' rights, safety and dignity. A cross-sectional study was conducted to assess the knowledge, attitude, and practice of research ethics among researchers in Nepal. Methods The study was carried out among 449...

Measles poses a significant global health threat, exacerbated by the COVID-19 pandemic. Despite the efficacy of two vaccine doses, under-5 mortality rates persist, with over 61 million delayed measles vaccinations worldwide. Nepal, striving to eliminate measles by 2023, faces a resurgence, attributing 1013 cases to inadequate vaccination and health...

Background Background COVID-19 is a highly challenging infectious disease. Research ethics committees (RECs) have challenges reviewing research on this new pandemic disease under a tight timeline and public pressure. This study aimed to assess RECs’ responses and review during the outbreak in seven Asian countries where the Strategic Initiative for...

Background This study aimed to assess the current status of critical care services in 13 districts of Bagmati Province in Nepal, with a focus on access, infrastructure, human resources, and intensive care unit (ICU) services. Methods A cross-sectional survey was conducted among healthcare workers employed in 87 mixed medical/surgical ICUs across Ba...

Background Nepal has been devastated by an unprecedented COVID-19 outbreak, affecting people emotionally, physically, and socially, resulting in significant morbidity and mortality. Approximately 10% of COVID-19 affected people have symptoms that last more than 3–4 weeks and experience numerous symptoms causing an impact on everyday functioning, so...

Objectives Reports from other countries have indicated that severe forms and fatal cases of COVID-19 in older adults and people with underlying comorbidities. The aim of this study was to assess the risk factors associated with COVID-19 mortality in Nepal. Methods A cross-sectional study was conducted from April 12 to July 23, 2021 to identify the...

Essential medicines are those medicines that satisfy the primary health care needs of the citizens. Poor quality of essential medicines can have serious impact on public health. Thus, this study is aimed to assess the quality of essential medicines available in public health care facilities of Nepal. A cross sectional descriptive study was carried...

Antimicrobial resistance (AMR) is increasing and it is a serious public health problem worldwide. Nepal is considered as one of the contributors for rising AMR due to the most prevalent irrational use of antibiotics. In this review, we have assessed the practices of antibiotic prescription and dispensing, and antibiotic resistance of commonly encou...

Background: The worldwide containment strategy for COVID-19 outbreak includes laboratory-confirmed cases, and their isolation and management in health care institutions or at home. The spread of the COVID-19 virus has mandated home isolation for mild cases, as recommended by the Government of Nepal. Isolation is a situation that can have a substan...

The editorial strongly urges Nepal to set up its own Evidence-Based Research Centre to be able to assess high quality published evidence in the context of a resource-poor country such as Nepal.

Introduction: The development of pharmaceutical industry has been adding new knowledge about drugs continuously making it difficult to remember each piece of information. The physicians need to be supplemented with new information using various unbiased and reliable drug information (DI) sources which will promote rationale use of medicines. This s...

Background Antibiotic treatment guidelines have been increasingly recognized as an effective tool to guide appropriate prescriptions and help curtail antibiotic resistance. We aimed to assess the quality of inpatient antibiotic prescribing practices for common infections in a tertiary centre in Kathmandu. Methods We conducted a retrospective monoc...

Introduction: Type 2 diabetes mellitus (T2DM) is a common chronic condition with significant health and socioeconomic consequences. In Nepal, T2DM is a common disease for which people consult ayurvedic (traditional medical system) practitioners and use ayurvedic medicines. Strong concerns remain about the suboptimal T2DM management of many patient...

Presence of Nepal in global clinical trials has been visibly negligible despite the history of conducting large scaled randomized controlled trial on Hepatitis E vaccine decades ago. Majority of the problem is attributed to lack of collaborative work, financial and human resource constrains. COVID-19 pandemics seems to have triggered urgency among...

Background: The novel coronavirus has caused significant global impacts and is still continuing. Social distancing, the use of face mask and sanitizer (SMS) measures have become the prominent security measures to diminish the COVID-19 transmission. Hence, this study aims to assess the general public's compliance towards SMS measures set by the Gov...

Coronavirus Disease 2019 (COVID-19) burden, often underestimated by case-based incidence reports, can be accurately estimated by measuring the population that has developed antibodies following an infection. Here, we report the prevalence of COVID-19 antibodies among health workers in Kathmandu, Nepal. This seroepidemiology of COVID-19 was a longit...

Objective This study aims to determine the prevalence and factors associated with injuries in the adult population of Nepal. Design and participants Secondary analysis of the data from the cross-sectional WHO STEPwise Approach to NCD Risk Factor Surveillance (STEPS) Survey Nepal, 2019. A multistage cluster sample of 5593 adults aged 15–69 years wh...

Background: The clinical presentation, biochemical characteristics, and outcomes of patients infected with SARS-CoV-2 can vary in different populations. The purpose of the study is to assess the clinical presentation and identify predictors of mortality among patients with severe acute respiratory distress syndrome admitted to different critical c...

Objective: This study aimed to determine population-based prevalence of chronic kidney disease (CKD) and its associated factors in Nepal. Study design: The study was a nationwide population-based cross-sectional study. Setting and participants: Cross-sectional survey conducted in a nationally representative sample of 12 109 Nepalese adult from...

Background: Mental disorders account for a large portion of burden of disease. In Nepal, the prevalence of mental disorders has been rising steadily, but national and province level prevalence is not available. This study aims to assess the prevalence of common mental disorders and suicidality in Nepal. Methods: We conducted nationwide descriptive...

Objectives The burden of diabetes mellitus (DM) has increased globally, particularly in low-income and middle-income countries, including Nepal. Population-based nationally representative data on the prevalence of DM is limited. This paper presents the prevalence of DM and its associated risk factors in Nepal. Research designs and methods This pop...

COVID-19 pandemic has created a long-lasting effect on different aspects of peoples' life. Several efforts were made by Nepal for the management of the COVID-19 surge. This study intended to compile the pharmacological efforts adopted for the prevention and management of COVID-19 during its pandemic in Nepal. A comprehensive study was performed fro...

Background: Body Temperature is one of the most common and an important sign of health and disease. Considering the need of keeping physical distance, newer methods have evolved such as; thermal imaging systems which have been used by several countries during epidemics. Therefore, the present study was conducted to compare body temperatures obtain...

Objective: This study aims to determine the prevalence of joint pain and its association with demographic, socioeconomic and behavioural factors in Nepal. Design: The study was a national cross-sectional population-based study. Setting: We used the most recent nationally representative population-based cross-sectional health survey, The WHO ST...

Background The spread of SARS-CoV-2 has become a global public health crisis. Nepal is facing the second wave of COVID-19 pandemic but, there is still a limited data on the genomic sequence of SARS-CoV-2 variants circulating in Nepal. Objective The objective of this study is to sequence the whole genome of SARS-CoV-2 in Nepal to detect possible mut...

Background: The characteristics of research proposals submitted to the Nepal Health Research Council reflect the trend of health-related researches being conducted in Nepal. The objective of the study was to analyze research proposals submitted for the ethical review in Nepal Health Research Council from 2017 to 2019. Methods: A retrospective re...

Executive Summary: Introduction COVID-19 is now a pandemic affecting many countries globally. COVID-19 infection is reported both symptomatic and asymptomatic There are numerous symptoms for COVID-19 which are usually mild and begin gradually. Some people become infected but only have very mild symptoms. Around 1 out of every 6 people who get COVID...

Executive summary: Background The spread of novel coronavirus has resulted in the development of various psychological problems in Nepalese. Patients infected with the disease are also facing stigma and discrimination from their own family, relatives and neighbors, further leading to mental distress such as loneliness, fear, worries, anxiety and de...

Introduction: The practice of medicine is an honorable profession besides being accompanied by a demanding environment. This study aimed to find out the professional quality of life of medical doctors working in Kathmandu valley. Methods: A descriptive cross-sectional study was conducted among 174 Nepalese medical doctors working in different hospi...

Population Based Cancer Registry plays a crucial role in cancer control through identifying cancer incidence, mortality, pattern and trends over time in a particular population. The registry is in a very infancy stage in Nepal. During the process of establishing Population Based Cancer Registry in Nepal, the major challenges include adequate covera...

p> Having an anti-diabetic activity, Aloe Vera (Aloebarbadensis) has been used for medicinal purposes in several cultures for millennia. It has also been proved that aloe vera is having protective activity in nephrotoxic rats.The objective of the pres­ent study was to evaluate the effect of Aloe vera leaves extract on diabetic nephropathy in Strept...

Background: Many countries are having problem of substandard and counterfeit drugs which results in life threatening issues, financial loss of consumers and loss in trust on health system. This study is concerned with the assessment of drugs quality available in the Nepalese market. Methods: A cross sectional survey was carried out in Kathmandu val...