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43
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Current institution
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July 2022 - present
September 2017 - February 2020
September 2017 - present
Publications
Publications (43)
The development of environmentally friendly pesticides and antibiotics is critical due to increasing resistance to conventional agents and rising concerns about human health and environmental impact. This study aimed to evaluate the nematicidal, phytotoxic, and antibacterial properties of acetone extracts from various parts of Alpinia malaccensis....
Pancreatitis is a prominent and severe type of inflammatory disorder that has grabbed a lot of scientific and clinical interest to prevent its onset. It should be detected early to avoid the development of serious complications, which occur due to long-term damage to the pancreas. The accurate measurement of biomarkers that are released from the pa...
The pesticidal activity of the rhizome and aerial parts of Cautleya spicata (Sm.) Baker was investigated, revealing significant findings. The GC-MS analysis revealed significant compositional variability among the extracts. β-Sitosterol was identified as the dominant compound in all extracts prepared with hexane, acetone, and methanol, while α-humu...
Pancreatitis is a prominent and severe type of inflammatory disorder with has grabbed a lot of scientific and clinical interest to prevent its onset. It should be detected early to avoid the development of serious complications, which occur due to long term damage. The accurate measurement of biomarkers that are released from the pancreas during in...
Three labdane-type diterpenes, namely coronalactoside i, hedychilactone a, and (E)-labda-8(17),12-dien-15(16)-olide, along with the flavonoid glycoside isolinariin a, were isolated from Heydichium coronarium. Structural elucidation employed spectroscopic techniques (iR, mS, nmR, and dEpt) and comparison with literature data. pesticidal and antimicr...
Cerium oxide nanoparticles have now significant presence in biomedical fields due to their wide applications; however, challenges regarding their safety and biocompatibility persist. Polysaccharides based biopolymers have inherent hydroxyl and carboxyl groups, enabling them to govern the surface functionalization of cerium oxide nanoparticles, henc...
Oxides for Medical Applications reviews the most important advances of oxides with optical, magnetic and electronic properties for biomedical applications. Owing to their unusual properties, oxides are expected to play a significant role in the prevention or early treatment of diseases. In addition to catalytically active artificial enzymes based o...
Hedychium coccineum Buch. Ham. ex Sm. is a perennial rhizomatous herb belonging to the family Zingiberaceae. The aim of the present study was to compare the chemical composition and biological activities of H. coccineum rhizome essential oil (HCCRO) and H. coccineum aerial part essential oil (HCCAO). The plant material was subjected to hydro-distil...
Clinicians require simple, and cost-effective diagnostic tools for the quantitative determination of amino acids in physiological fluids for the detection of metabolic disorder diseases. Besides, amino acids also act as biological markers for different types of cancers and cardiovascular diseases. Herein, we applied an in-silico based approach to i...
Here, we report the draft genome sequence of Limosilactobacillus fermentum strain NKN-51, which was isolated from naturally processed yak cheese from the western Himalayas of India. The genome was assembled in 101 contigs with a total length of 1,879,705 bp and a GC content of 53.5%. Genome annotation predicted 1,730 protein-coding genes and 50 tRN...
This study reports covalent immobilization of β-glucosidase (BGL) from Bacillus subtilis PS on magnetically recyclable iron nanoparticles for enhancing robustness, facile recovery and reuse of enzyme. Immobilized BGL iron nanoparticles (BGL-INPs) were characterized by various biophysical techniques viz. TEM, DLS, FTIR and CD spectroscopy. The effic...
Aptamers generated de novo by iterative process of in-vitro selection called Systemic Evolution
of Ligand by EXponential enrichment (SELEX) which mimics Darwinian evolution process.
SELEX is a powerful and yet simple technique that has been used to isolate DNA or RNA
sequences with a function of interest (e.g. ligand-binding or catalysis) from a po...
Antibodies have been known for more than three decades and have proved to be invaluable tool
for rapid and advanced diagnostics. Although, antibodies are used routinely in most of diagnostic
tests as biorecognition elements, however, their high cost of production, shorter-shelf life, animal
requirement for production, stability issues, batch-to-bat...
There is a need to develop effective antibacterial therapies for mitigating bacterial pathogens in food systems. We used a 3D checkerboard assay to ascertain a safe synergistic combination of food-grade components: vitamin C, copper, and the essential oil linalool. Individually, these constituents have to be added in large amounts to exert their an...
A novel protein tyrosine phosphatase like phytase (PTPLP), designated as PhyLf from probiotic bacterium Lactobacillus fermentum NKN51 was identified, cloned, expressed and characterized. The recombinant PhyLf showed specific activity of 174.5 U/mg. PhyLf exhibited strict specificity towards phytate and optimum temperature at 60 °C, pH 5.0 and ionic...
The thermostable, glucose tolerant β-glucosidase gene (bgl) of Glycoside hydrolase family 1, isolated from Bacillus subtilis, was cloned and overexpressed in Escherichia coli. The bgl has open reading frame of 1407 bp, encoding 469 amino acids with predicted molecular weight of 53 kDa. The recombinant protein (BGL) was purified 10.76 fold to homoge...
Infirmity and death from diseases caused by unsafe food are a continual hazard to communal health safety and socio-economic growth throughout the world. Chemical preservatives are associated with health hazards and toxicity issues. In the study reported here, 200 soil isolates from Western Himalayan region in India were screened for potential antib...
Biosensing nitrogenous compounds like urea is required to control the incidents of Economically Motivated Adulteration (EMA). In this study, we report the FluMag Systematic Evolution of Ligands by Exponential Enrichment (FluMag-SELEX) method to isolate a urea specific DNA aptamer with a dissociation constant (Kd) of 232nM. The interaction of DNA ap...
Infectious diseases cause a huge burden on healthcare systems worldwide. Pathogenic bacteria establish infection by developing antibiotic resistance and modulating the host’s immune system, whereas opportunistic pathogens like Pseudomonas aeruginosa adapt to adverse conditions owing to their ability to form biofilms. In the present study, silver na...
Transmission electron micrograph showing citrate-capped silver nanoparticles (CSNPs).
Scanning electron micrograph of untreated Vibrio fluvialis L-15318 at different magnifications (A) 5,000×, (B) 10,000×, and (C) 50,000×.
Scanning electron micrograph of PBSNPs-treated Pseudomonas aeruginosa PAO1 at different magnifications (A) 5,000×, (B) 10,000×, and (C) 50,000×.
Abbreviation: PBSNPs, polymyxin B-capped silver nanoparticles.
Scanning electron micrograph of CSNPs-treated Pseudomonas aeruginosa PAO1 at different magnifications (A) 5,000×, (B) 10,000×, and (C) 50,000×.
Abbreviation: CSNPs, citrate-capped silver nanoparticles.
Scanning electron micrograph of untreated Pseudomonas aeruginosa PAO1 at different magnifications (A) 5,000×, (B) 10,000×, and (C) 50,000×.
Scanning electron micrograph of PBSNPs-treated Vibrio fluvialis L-15318 at different magnifications (A) 20,000× and (B) 50,000×.
Abbreviation: PBSNPs, polymyxin B-capped silver nanoparticles.
Scanning electron micrograph of CSNPs-treated Vibrio fluvialis L-15318 at different magnifications (A) 5,000×, (B) 20,000×, and (C) 50,000×.
Abbreviation: CSNPs, citrate-capped silver nanoparticles.
Phytase-producing bacteria (PPB) is being investigated as plant growth promoting rhizobacteria (PGPR) to improve the phosphorus (P) nutrition and growth of plants grown in soil with high phytate content. Phytate is dominant organic P forms in many soils and must be hydrolyzed to be available for plants. Indian mustard (Brassica juncea) is a plant w...
This article deals with the optimization of the various parameters for production of phytase using Achromobacter sp. PB-01 in submerged fermentation (SmF). A semisynthetic medium containing ingredients of phytase screening media (PSM) supplemented with 2% (w/v) sucrose, 1% (w/v) peptone, and 10% (w/v) wheat bran was found to be the best production...
Questions
Questions (3)
Is it possible a molecule showing high negative docked score may be less catalytically efficient compared to other which has relatively low docked score.And what is possible explanation for it,in case hydrognbonds are also equal.
i have used MVD for docking. please tell moldock which is cumputed is equivalent to binding energy or we need to calculate it?
Thanks in advance for your replies.
