Pius Tshimankinda Mpiana

Pius Tshimankinda Mpiana
University of Kinshasa | UNIKIN · Department of Chemistry

PhD

About

362
Publications
194,590
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4,578
Citations
Additional affiliations
February 1988 - present
University of Kinshasa
Position
  • vice head of department
Description
  • Natural products, medicinal and environmental chemistry Biophysics of Hemoglobin S and antisickling activity of plants

Publications

Publications (362)
Article
Full-text available
Medicinal plants have played and continue to play a very important role as medicines or sources of therapeutic molecules throughout the world. Numerous people in developing countries use their therapeutic virtues to treat their health. Among those plants, Alchornea cordiflia is in a prominent position due to its numerous beneficial effects on both...
Article
Full-text available
Le but de ce travail était d'évaluer le potentiel économique des feuilles de Lippia multiflora dans la partie Ouest de la République démocratique du Congo depuis la cueillette jusqu'à la vente, d'une part et d'autre part d'en évaluer l'activité antifalcémiante in vitro de l'extrait aqueux. Pour ce faire, une enquête a été réalisée auprès de la popu...
Article
Background: The Plant of Jatropha gossypiifolia is known for their many biological activities including anticoagulant, antihypertensive, anti-inflammatory, antibacterial, antiviral, antifungal and other. Aim: To carry out recent informations regarding phytochemistry, ethnopharmacology, bioactivities, toxicology, antiviral and medicinal activities o...
Conference Paper
Full-text available
This study was carried out to assess the concentration and distribution of naturally occurring radionuclides in soils and sediments collected along Luilu and Dilala Rivers, at the mining district of Kolwezi (Lualaba province) in the Democratic Republic of the Congo. Soil and sediment samples were analyzed by gamma-ray spectrometry. The 226Ra averag...
Article
Background: The Plant of Jatropha curcas is known for their many biological activities including antiviral, antifungal and antibacterial. Aim: To provide update knowledge on the phytochemistry, toxicology and antiviral activity of some medically interesting Jatropha curcas. Study Design: Multidisciplinary advanced bibliographic surveys and dissemin...
Article
Objectives: The aim of this work is to carry out a phytochemical study and to evaluate in vitro antibacterial potential of the aqueous extract of Phyllanthus niruri, a plant traditionally used in Kasai Oriental (DR Congo) against various bacteriosis and non-bacterial diseases. Study Design: P. niruri, was selected from a list resulting from an ethn...
Article
Full-text available
The aim of the present work was to review data on the antiviral activities of some fruit plant species and their macronutrient composition. This was done with the aim of promoting these plants for the management of viral diseases, particularly covid-19. Several fruit plant species are mentioned in the literature for their antiviral properties. Thes...
Article
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La présente étude a pour but l'étude ethnobotanique d'une plante alimentaire sauvage, Vitex doniana (Lamiaceae) ainsi que sa vulnérabilité dans la zone péri-urbaine de Gbado-Lite, dans la Province de Nord-Ubangi en République Démocratique du Congo. Il ressort de cette étude que la majorité d'enquêtés sont des hommes (72,2%) contre 27,8% des femmes....
Article
Aims: The objective of this study was to determine the phytochemical profile of Centella asiatica, Citrus grandis and Zanthoxylum gilletii leaves, in solution and the thin layer chromatography chemical screening and to evaluate the antibacterial photodynamic activity of the species extracts. Materials and Methods: The search of the secondary metabo...
Article
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In many suburban municipalities of developing countries, the household drinking water comes mainly from groundwater including, wells, streams and springs. These sources are vulnerable because poor hygienic conditions and sanitation prevail causing persistence and recurrent waterborne diseases. In this research, a survey study on water resource use...
Article
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Solid waste management constitutes a major concern and unresolved problem in most parts of the world, particularly in developing countries where solid waste is disposed in unregulated dumpsites in the public spaces. This practice can lead to contamination of environmental compartments such as soil, surface and groundwater which could negatively imp...
Article
Aims: To carry out a preliminary phytochemical study and to evaluate in vitro the antibacterial activities of aqueous extracts of different parts of P. muellerianus, a plant widely used traditionally in Kasai Oriental to treat various pathologies including several bacteriosis. Study Design: Based on the results of an ethnobotanical survey in Kasaï...
Article
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The purpose of this mini-review was to summarize and update knowledge on the phytochemistry, pharmacology, and toxicity of Cola nitida , with the view of providing baseline data for herbal drug formulation. In January 2021, a non-exhaustive online search of relevant articles was carried out on the phytochemistry, pharmacology, and toxicology of C....
Article
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Diabetes mellitus is a major public health problem in the world. In Africa, more than 80% of patients use plants for their treatment. However, the methods of validation of endogenous knowledge usually used are costly. The alternative method developed in this study aims at creating hyperglycemia in vitro and exploiting the metabolic pathway involvin...
Preprint
Full-text available
This study reports a computational investigation on the antioxidant activity of five plant food benzoic acid derivatives, namely gallic acid (GA), para-hydroxybenzoic acid (PHBA), protocatechuic acid (PCA), syringic acid (SA), and vanillic acid (VA). Based on computed thermodynamics parameters, we discuss their free radical scavenging activity in t...
Article
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The leaves and seeds of Aframomum alboviolaceum and Aframomum angustifolium are specifically used by traditional healers in the Democratic Republic of Congo (DRC) for the treatment of several pathologies. The aim of present study was to determine the microscopic characteristics and phytochemical composition of these species of the genus Aframomum....
Article
Full-text available
L'objectif de la présente étude a été de contribuer à la valorisation de la plante Quassia africana, plante médicinale à multiple usage. Une enquête ethno-botanique a été réalisée à travers un questionnaire soumis aux enquêtés sélectionnés. Les résultats indiquent que Q. africana traite 21 maladies dent le paludisme est le plus crédible. L'indice V...
Article
Full-text available
La Drépanocytose peut être décrite du point de vue biochimique comme la conséquence d'un dysfonctionnement du shunt de pentoses phosphate, la principale voie métabolique impliquée dans la protection des érythrocytes contre les radicaux libres. A cet effet, après la lyse érythrocytaire, l'oxyhémoglobine peut s'auto-oxyder en méthémoglobine en libéra...
Article
Full-text available
La Drépanocytose peut être décrite du point de vue biochimique comme la conséquence d'un dysfonctionnement du shunt de pentoses phosphate, la principale voie métabolique impliquée dans la protection des érythrocytes contre les radicaux libres. A cet effet, après la lyse érythrocytaire, l'oxyhémoglobine peut s'auto-oxyder en méthémoglobine en libéra...
Article
Full-text available
Neonatal infection (NI) remains a public health problem of concern because of its frequency and severity, which is related to the immuno-incompetence of the newborn and the risk of mortality, which is in the order of 10% to 30%. According to the World Health Organization (WHO), 30 to 40% of these newborn deaths are due to neonatal infections of bac...
Article
This study is part of the promotion of local medicinal plants by highlighting their spermicidal activity. An ethnobotanical survey carried out in Kinshasa made it possible to identify the plants used in female intimate hygiene. On the one hand, the aqueous extracts of the organs of ten (10) plants on the inventoried species were subjected to a phyt...
Article
Full-text available
According to the World Health Organization (WHO), more than 80% of the population in Africa in general and in the Democratic Republic of the Congo (DRC) in particular, resorts to Traditional Medicine to solve the problem of primary health care. In this study we had reviewed the relevance of A. angustifoolium in phytochemical composition, traditiona...
Article
Full-text available
The aim of this study was to determine the phytochemical composition and micrographic characteristics of the plants consumed by Okapia johnstoni. The results indicate that each plant species has characteristic microscopic elements for its identification. These plants are rich in phenolic acids, anthocyanins, flavonoids, anthraquinones, coumarins, t...
Article
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Background: Lippia multiflora is a wild/spontaneous food plant with numerous pharmaco-therapeutic activities and rich in terpenic and phenolic bioactive compounds whose valorization as nutaceutical can help a better management of chronic diseases. Mini-review Article Colette et al.; SARJNP, 4(4): 35-48, 2021; Article no.SARJNP.71548 36 Objective: T...
Article
Full-text available
Medicinal plants are suppliers of molecules used in both modern and traditional therapy. One of these plants is Azadirachta Indica (also known as the neem tree).Originally from Asia (India), this plant is currently widespread and cultivated in several countries in the world, including in Africa, because of its extraordinary therapeutic properties....
Article
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Democratic Republic of the Congo is a real reservoir of medicinal plants. These plants play a major role in the treatment of certain common pathologies in tropical regions. The aim of this study was to list the ethnomedical uses of Uvariodendron molundense, a medicinal and aromatic plant from the Ubangi ecoregion. The ethnobotanical survey was carr...
Article
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Background: Ethnopharmacological studies are relevant for sustaining and improving knowledge of traditional medicine within the framework of complementary/alternative therapeutic practices based solely on experience and observation across generations. Hypertension is a common cardiovascular disorder affecting more than 50% of older people in Afric...
Article
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The contamination of freshwater resource by heavy metals is still a major environmental and human health concern globally. The release of these contaminants into the aquatic environment can lead to the pollution of water resources and generate risks for aquatic living organisms and human health. The sediments can act as reservoir for heavy metals,...
Article
Aims: To make an ethnobotanical survey in the province of Kasai Oriental to identify the plant species used in the treatment of bacterial diseases; carry out a floristic analysis and determine their eco-morphological characteristics. Study Design: The surveys were conducted in the villages of all the territories of the Kasai Oriental province in RD...
Article
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Aim: The aim of this study was to compare the texture, mineral element and heavy metal content of the soil under the litter of different selected species in relation to the plan of their pedogenesis. Methods: The granulometric analysis of the various samples based on laser diffraction, measurements of Total Nitrogen and Total Organic Carbon were pe...
Article
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Introduction and objective: Sickle cell disease is an inherited pathology to an abnormality of hemoglobin precisely hemoglobin S for which there is no curative therapy. It mainly affects sub-Saharan African and Caribbean populations. Thus, this study aims to make the phytochemical screening of Cremaspora triflora and Macaranga schweinfurthii as wel...
Article
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Aim: To assess the population's knowledge of COVID-19 in order to guide future scientific research on the alternative management of this pandemic by Traditional Pharmacopoeia. Place and Duration of Study: The study was undertaken in Lisala city (province of Mongala, Democratic Republic of the Congo), from 26 July to 10 August 2020. Methodology: The...
Article
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Curcuma longa is mostly distributed in Asia and is the most common traditional drug of Indian and Chinese medicines used as anti-inflammatory, wound healing, antibacterial, anticancer and antioxidant agents. The present study was designed to characterize Curcuma longa L. from Madagascar by the determination of heavy metals and mineral elements of 3...
Article
Full-text available
Aims: to provide knowledge on the bioactivity and phytochemistry of Jatropha podagrica Hook. Study Design: Advanced multidisciplinary bibliographical research, use of the ChemBioDraw software package and dissemination of the knowledge obtained. Methodology: A literature review was conducted to obtain information on the pharmacognosy and phytochemis...
Article
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Aim: The present study aims at identifying potential inhibitors from a set of ten compounds from Ocimum basilicum against the SARS-CoV-2 main protease, the chymotrypsin-like protease (3CLpro). Materials and Methods: Computational studies by molecular docking (Autodock tool) were used to obtain the scoring function of ten phytochemicals in interacti...
Article
Full-text available
Aim: The aim of this study was to identify bioactive compounds, to determine the mineral content and to evaluate the antibacterial, antioxidant and anti-sickling activities of different parts of Zanthoxylum gilletii. Methods: Phytochemical composition was evaluated by general tests as well as chromatographic technics (TLC and HPLC), the mineral mic...
Article
Full-text available
The aim of this study was to determine the mineral composition of 10 plants especially Alchornea cordifolia, Alternanthera bettzickiana, Annona senegalensis, Cyttaranthus congolensis, Dissotis brazzae, Justicia secunda, Harungana madagascariensis, Hura crepitans, Hypoxis angustifolia and Vigna unguiculata used in the management of sickle cell disea...
Chapter
Ocimum bacilicum L. is an aromatic herb commonly known as sweet basil or sweet tulsi. It is rich in secondary metabolites like phenols, alkaloids, terpenoids, aldehydes, flavonoids, steroids, glycosides, essential oils, saponins, and tannins. The presence of these compounds makes sweet basil one of the most commonly used plants in aromatherapy, per...
Chapter
Ocimum bacilicum L. is an aromatic herb commonly known as sweet basil or sweet tulsi. It is rich in secondary metabolites like phenols, alkaloids, terpenoids, aldehydes, flavonoids, steroids, glycosides, essential oils, saponins, and tannins. The presence of these compounds makes sweet basil one of the most commonly used plants in aromatherapy, per...
Article
Aim: In the most severe case of the COVID-19, there is an excessive production of proinflammatory cytokines, being the main cause of mortality and morbidity. The present study aims at assessing the potential inhibitor effect of six phytochemicals with anti-inflammatory activity derived from Passiflora edulis, against the SARS-CoV-2 main protease. M...
Conference Paper
Full-text available
2% des nouveau-nés en RDC, sont drépanocytaires et environ 40.000 drépanocytaires naissent chaque année. Pour bon nombre de patients drépanocytaires, le traitement est seulement symptomatique d'où le recours à la phytothérapie. Les feuilles (F), les écorces de tige (ET) et les racines (ER) de Oncoba welwitschii (Oliv.) Gilgn constituent les échanti...
Article
Full-text available
The objective of the present study was to evaluate the knowledge of Covid-19 by the population of the city of Gbado-Lite, its prevention and management in order to guide future scientific research on this pandemic. A total of 200 people were interviewed. The majority were men (60% vs. 40%). The majority of respondents were in the age range 18-45 ye...
Article
Full-text available
The aim of the present study was to evaluate the chemical composition and antioxidant activity of Melicope madagascariensis essential oil from Madagascar East Coast Rainforest. Essential oil from the leaves of this plant species was extracted by hydro-distillation and analyzed by TLC and GC-FID. The extraction revealed a yield is of 0.4% for a mass...
Article
Aims: To determine the chemical composition of essential oil of Ageratum conyzoides with antifungal activity on the strain of Lasiodiplodia theobromae in the Kisangani region. Location and Duration of Studies: Faculty of Sciences of University of Kisangani (Democratic Republic of Congo) and Faculty of Biosciences Engineering of University of Ghent...
Poster
Full-text available
L'incidence de la drépanocytose en RDC est de 2% chez les nouveaux-nés, soit environ 40.000 cas par an. Le traitement est seulement symptomatique pour bon nombre de ces patients, d'où le recours à la phytothérapie. Oncoba welwitschii (Oliv.) Gilgn est une des espèces utilisées. Les feuilles (F), écorces de tiges (ET) et racines (ER) ont été analysé...
Article
Full-text available
Background and Aims: Given the importance of finding a new Improved Traditional Medicine (ITM) based on medicinal plants, we reviewed the traditional uses, phytochemical composition, biological properties and toxicity of Aframomum alboviolaceum (Zingiberaceae), a plant species widely used in traditional African medicine as nutraceutical. Review Art...
Article
Full-text available
The concentrations and distribution of naturally occurring radionuclides (238U, 235U, 234U, 230Th, 226Ra, 210Pb, 232Th, 228Ra, and 40K) were determined by alpha and gamma spectrometry in soil and sediments collected from Luilu and Dilala riv-ers located in the mining district of Kolwezi (Lualaba Province) of the Demo-cratic Republic of the Congo. T...
Article
Full-text available
Aims: This study addressed the identification of bioactive compounds, the determination of mineral content and the evaluation of the antibacterial, antioxidant and anti-sickling activities of aqueous extract from stem bark of Harungana madagascariensis. Methodology: Phytochemical screening was evaluated by chromatographic methods (TLC and HPLC), th...
Article
Full-text available
Aims: COVID-19 pandemic affects hundreds of thousands of people worldwide. Since there is no effective treatment, the need of finding alternative methods, which can help to curb this pandemic is urgent. This study aims to collect the information on the virucidal and toxicity properties of Allium species. This genus is known to be source of nutraceu...
Article
Full-text available
Aim: The aim of this work is to evaluate the spermicidal, antimicrobial activity of Oncoba welwitchii Oliv. This will justify its use on reproductive health especially in the occurrence of infertility and the imbalance of vaginal flora. Carried out at the Department of Biology of the Faculty of Sciences of the University of Kinshasa, between Januar...
Preprint
Full-text available
Following our previous investigations relating to the in vitro evaluation of antifungal activity, this study focused on the demonstration of the inhibitory power of extracts of fresh and dry leaves of Ageratum conyzoides, Basella alba and Mitracarpus villosus on the strain of Lasiodiplodia theobromae, fungus responsible for brown rot of cocoa pod i...
Preprint
Full-text available
This study was carried out in order to investigate the safety of Drepanoalpha hard hard capsules, a phytomedicine used for the management of sickle cell disease in the Democratic Republic of Congo by the acute and sub-acute administration in Guinea pigs. The hard capsules were dissolved in saline normal solution (NaCl 0.9 %). The animals were rando...
Article
Full-text available
The aim of this mini-literature review was to describe the traditional use, phytochemistry and biological properties of M. morindoides, a plant used as a conventional African medicine. In this investigation, the literature revealed that M. morindoides extracts were very efficient in the treatment of several diseases including malaria. According to...