Piotr Skrzypczak

Wrocław University of Environmental and Life Sciences · Department of Surgery

Introduction Acute myocardial infarction (MI) is one of the most common causes of death in humans in highly developed countries. Among its most frequent complications affecting the patient’s prognosis are cardiac arrhythmias: ventricular tachycardia (VT) and ventricular fibrillation (VF). Material and Methods The study aimed to characterise arrhyt...

Implantation of composite scaffolds could be potentially associated with the risk of hemostatic disturbances in a recipient. However, there is a lack of information on possible alterations in clotting mechanisms resulting from such a procedure. The aim of the present work was to investigate changes in hemostatic parameters in sheep implanted with a...

Background Despite numerous experimental studies presenting laparoscopic treatment of inguinal hernia in a pig model so far no described technique has been used in clinical patients of this species. Minimal invasiveness and the simplicity of closure of the inguinal canal using the Percutaneous Internal Ring Suturing (PIRS) technique makes it the wo...

Background In the literature, no studies describe the use of laparoscopic techniques for inguinal hernia repair in canine clinical patients. The surgical technique—Percutaneous Internal Ring Suturing (PIRS) presented in this article is the world's first minimally invasive laparoscopic surgical technique for inguinal canal closure in dogs. Aim The...

Prostate cancer is the most common prostate disease diagnosed in castrated dogs. However, prostate cancer is considered to be quite rare in dog population. The presence of prostate tumours can lead to urethral obstruction. Other clinical signs include asymmetric, painful, hard growths on rectal examination, neurological deficit or lameness of the p...

Introduction Pacemaker implantation is the only effective symptomatic treatment for life-threatening bradyarrhythmias. Major complications observed after implantation of cardiac pacemakers include lead dislocation, loss of pulse generator function, and inadequate stimulation. The aim of this retrospective single-centre study was to analyse the indi...

The aim of the study was to compare anaesthesia protocol utilizing combination ketamine/ medetomidine with epidural lidocaine or morphine to orthopaedic surgery in rabbits. All rabbits received intramuscularly medetomidine (0.5 mg/kg) and ketamine (20 mg/kg). In group L (n=13) epidural injection was performed with lidocaine (3 mg/kg) and in group M...

Purpose Clinically available intravenous (IV) nitric oxide (NO) donor drugs such as nitroglycerin (GTN) cause systemic hypotension and/or tolerance development. In a porcine model, novel NO donor compounds – the organic mononitrites of 1,2-propanediol (PDNO) – were compared to GTN with regard to pulmonary selectivity and tolerance development. The...

This study evaluated the effects of inhaled nitric oxide (iNO) therapy combined with intravenous (IV) corticosteroids on hemodynamics, selected cytokines, and kidney messenger RNA toll-like receptor 4 (mRNA TLR4) expression in ischemia–reperfusion injury animal model. The primary endpoint was the evaluation of circulatory, respiratory, and renal fu...

The presence of an accessory atrioventricular conduction pathway may provide the anatomical basis for some tachyarrhythmias. Persistent tachyarrythmias may result in the development of systolic dysfunction or tachycardiomyopathy and eventual progression to heart failure. In this paper we report the successful ablation of an accessory pathway involv...

The paper describes a double symmetrical aortic arch in a dog trapping the oesophagus. Thoracotomy was performed in the fourth inter-costal space under general, isoflurane-maintained, anaesthesia. Cutting of the arterial ligament failed to free the oesophagus. Dissection of further vascular structures revealed the left and right aortic arches to be...

Recurrent airway obstruction (RAO) represents a serious health problem and is traditionally classified as an allergic disease, where contact with an antigen can induce clinical airway inflammation, bronchial hyper-responsiveness and reversible airway obstruction. Previous studies have demonstrated the presence of the Th2 response in the lungs of hu...

The implementation of new methods of osteoporotic therapy requires tests on animal model. The use of sheep as model has numerous advantages over other animals. The aim of this study was to describe the change in parameters in sheep with osteoporosis induced using steroids and ovariorectomy methods as opposed to the parameters in healthy sheep. The...

Platelet-rich plasma (PRP) is an autogenic source of many growth factors that are a part of the healing process and tissue regeneration, which is the cause of its growing popularity in regenerative medicine. In this paper, we present a definition and characteristics of PRP, as well as ways of extracting it. We also present the issue of thrombocyte...

Although sex differences in heart failure (HF) prevalence and severity have been recognized, its molecular mechanisms are poorly understood. We used a tachycardia-induced cardiomyopathy model to determine the sex specific remodeling pattern in male and female adult pigs. We compared the echocardiographic and molecular measures of myocardial remodel...

The implementation of new methods of oseoporotic therapy requires tests on an animal model. One of the best is the sheep, whose numerous advantages over other models are described in the literature. The aim of this study was induction of osteoporosis using steroids and ovariorectomy methods in sheep and description of the change in parameters with...

The aim of the study was the evaluation of post-ovariectomy morphological changes in the ovine uterus and surrounding tissues by diagnostic laparoscopy. After the preparation of ewes and equipment, ports were placed in the abdominal cavity, through which an optic and additional tools were introduced. The exploration and evaluation of the body cavit...

The study describes a case of an 18-month-old Tibetan Mastiff with a diagnosed bone cyst in the area of the right distal humerus. Bone cysts in dogs are a rare occurrence. Most often, they affect animals under 1 year of age. They cause limb lameness, oedema, and soreness during palpation. The examination for a conclusive diagnosis are X-ray images....

The aim of the study was to determine the impact of steroidal medications on the structure and mechanical properties of supporting tissues of sheep under experimentally-induced osteoporosis. A total of 21 sheep were used, divided into three groups: a negative control (KN) (n = 3), a positive control (KP) (n = 3) with ovariectomy, and a steroidal gr...

The aim of the study was to determine the impact of steroidal medications on the structure and mechanical properties of supporting tissues of sheep under experimentally-induced osteoporosis. A total of 21 sheep were used, divided into three groups: a negative control (KN) (n = 3), a positive control (KP) (n = 3) with ovariectomy, and a steroidal gr...

The successful endotracheal intubation of pigs using the standard orotracheal method is challenging and technically difficult, because of the pig’s oral anatomy and the presence of excess tissue in the oropharyngeal region. Hence, the operator, who is usually an anesthetist, requires extensive training in order to successfully perform the procedure...

The aim of this study was to investigate the usefulness of new software Pixel Flux (PXFX) for clinical evaluation of tissue perfusion in the field of reproduction in dogs. The experiment was performed on six adult Beagle dogs. Different organs and tissues of the animals were examined with the MyLab25 Gold ultrasound system. Blood flow in the ovary,...

Ventricular tachycardia may lead to haemodynamic deterioration and, in the case of long term persistence, is associated with the development of tachycardiomyopathy. The effect of ventricular tachycardia on haemodynamics in individuals with tachycardiomyopathy, but being in sinus rhythm has not been studied. Rapid ventricular pacing is a model of ve...

The aim of the study was to assess the atrioventricular conduction in the model of porcine pacing induced tachycardiomyopathy. Fifty-one swine were examined: 27 were paced and 24 served as a control group. Every 4 weeks, the animals were anaesthetised for 1 h and an ECG Holter was performed. Thirty minutes after the onset of anaesthesia, P-R and R-...

Rapid ventricular pacing results in electrophysiological changes in the myocardium. The retrograde conduction can also influence the physiological properties of AV junction. The aim of the study was to assess the electrical remodelling of AV junction and working myocardium during ventricular pacing tachycardiomyopathy. Material and methods: The stu...

The influence of docosahexaenoic (DHA) acid obtained from a new generation of eggs on ventricular electrical function of 24 pigs with experimentally induced tachycardiomyopathy was described. Two groups were formed, 12 pigs had experimentally evoked tachycardiomyopathy and were getting standard feed (control group TIC). Twelve pigs with tachycardio...

Matrix metalloproteinases (MMPs) are involved in the remodeling of extracellular matrix in various tissues. Their functioning could be related to the formation of complexes, containing MMP9, MMP2, tissue inhibitor of metalloproteinases type 1 (TIMP1), and neutrophil gelatinase-associated lipocalin (NGAL). Such complexes have not been investigated i...

Orthopedic surgery and anesthesia procedures Orthopedic procedures are one of the most important departments of small animal surgery. Animals which undergo surgical treatment are either very young or old, and many of the latter are often sick. In young dogs, correction procedures focus on existing genetic or developmental defects of the musculoske...

Dyskopatia to stan zwyrodnienia krążka międzykręgowego, powodujący przemieszczenie się materiału dyskowego do kanału kręgowego z uciskiem rdzenia kręgowego lub korzeni rdzeniowych [1]. Dotyczy ona wszystkich ras psów, a szczególnie ras chondrodystroficznych. Choroba i deficyty neurologiczne dyskopatii ukazują się zwykle po ukończeniu trzeciego roku...

Osteochondrosis is a common and clinically important joint disorder that occurs in human and many species of animals such as pigs, horses and dogs. The aim of this article is to present the results of conservative and surgical treatment of Osteochondrosis dissecans (OCD) and to compare the recovery time in relation to race, age and extent of cartil...

A case of a dog with symptoms of weakness and cough caused by very rapid atrial tachycardia (270 bpm) was presented. Electrocardiography showed P wave preceded, narrow QRS complex incessant tachycardia. Echocardiography showed enlargement of both atria and ventricles. Tachycardia-induced cardiomyopathy resulting from permanent atrial tachycardia wa...

This article aims to compare the treatment of fragmented coronary process in the context of clinical results. Forty-two dogs of both sexes, aged from 5 months to 2 years, all belonging to the predisposed breeds, were tested. Each patient was subjected to radiological and clinical examination on the basis of which was classified into one of four deg...

The issue of the acid-base balance (ABB) parameters and their disorders in pets is rarely raised and analysed, though it affects almost 30% of veterinary clinics patients. Traditionally, ABB is described by the Henderson-Hasselbach equation, where blood pH is the resultant of HCO3- and pCO2 concentrations. Changes in blood pH caused by an original...

Conditions common to foals in the neonatal period that may result in a requirement for blood and plasma transfusion or augmentation of oxygen carrying capacity have been discussed. Methods of recognition and management of massive blood loss, isoerythrolysis in a foal were described. Administering colostrum, plasma or other products because of the f...

Ratajczak K., Golachowski A., Skrzypczak P. Use of blood and derivative products in the immunological disease treatment of foals Summary Conditions common to foals in the neonatal period that may result in a requirement for blood and plasma transfusion or augmentation of oxygen carrying capacity have been discussed. Methods of recognition and manag...

The aim of the study was to assess the usefulness of vascular angiography in the diagnostics of liver vascular system diseases. The study was conducted on 3 dogs: Yorkshire terrier marked C1, German Shepherd - C2 and Airedale Terrier - C3, aged 11 months, 9 and 5 years respectively. The examinations were performed as follows: the history and clinic...

This paper presents the significance and range for the application of blood transfusion in horses. The main objective of total blood transfusion is to help improve oxygen delivery to the tissues during anemia; nonetheless, it is considered a temporary lifesaving procedure that should be only used if necessary. The majority of transfused erythrocyte...

The aim of the study was to elaborate an effective method of triggering iliac artery atherosclerosis in rabbits. The authors applied a diet rich in fat, not based on cholesterol. Investigations were performed on 18 White New Zealand breed rabbits. After 3 weeks of adjustment, morphological and biochemical blood analysis was carried out: ALT activit...

The aim of the research was to determine whether short-time heart muscle ischemia caused by fast ventricular pacing rate (ventricular tachycardia) provokes insulin and glucose blood level alterations and if so, how long those changes last after return to the physiological heart rate and restoration of proper heart muscle perfusion as well. It was s...

To determine changes in physiological parameters of the myocardium in experimentally induced hyperthyreosis in an animal model, the occurrence and type of arrhythmias triggered during programmed electrical stimulation and changes in electrophysiological parameters of ventricular cardiomyocytes with hypertrophy due to hyperthyreosis were investigate...

The aim of the research was to determine whether short-time heart muscle ischemia caused by fast ventricular pacing rate (ventricular tachycardia) provokes insulin and glucose blood level alterations and if so, how long those changes last after return to the physiological heart rate and restoration of proper heart muscle perfusion as well. It was s...

Pulmonic artery stenosis is one of the most common congenital heart abnormalities in dogs. In most publications it is described as the second highest prevalence. Often pulmonic artery stenosis appears as a valvular stenosis. Clinical signs of the disease appear in the first months of life. The reason for this study was evaluating percutaneus valvul...

In this article, the surgical procedure performed on 12 dogs with patent ductus arteriosus (PDA) was described. Diagnostic methods included basic diagnostic procedures along with electrocardiography, x-ray and echocardiography. Moreover, gasometry of blood samples taken from the right atrium, right ventricle and pulmonary artery was conducted for e...

The aim of the study was to determine changes in the clinical image and biochemical and hematological blood parameters in pigs during the course of experimental hyperthyroidism. The research material included 10 pigs of the Wielka Biała Zwisłoucha breed. Experimental hyperthyroidism was produced by administering oral L-thyroxin at a dose of 20 μg/k...

Pulmonic artery stenosis is one of the most common congenital heart abnormalities in dogs. In most publications it is described as the second highest prevalence. Often pulmonic artery stenosis appears as a valvular stenosis. Clinical signs of the disease appear in the first months of life. The reason for this study was evaluating percutaneus valvul...

The aim of the experiment was to evaluate the influence of oral administration of L-thyroxine on the heart. The research material included 8 pigs of the polska biała zwisłoucha breed. The experimental hyperthyroidism was induced by oral administration of L-thyroxine at a dose 20 μg/kg b.w. in 4 pigs. The echocardiography examination was carried out...

Fainting is a symptom of transient, spontaneous blackout. The mechanism underlying fainting is a transient, generalized decrease in brain perfusion. Fainting can be the after-effect of arrhythmias. The aim of the research was to determine the usefulness of the loop recorder Reveal Plus for the diagnosis of fainting in dogs. The loop recorder was im...

Background. Hyperthyroidism is a state predisposing to arrhythmias. Their pathomechanism is not fully understood. The invasive electrophysiological examination in hyperthyroidism in human is not carried out due of the risk of triggering potentially fatal arrhythmias. Objectives. Explanation of the mechanism of arrhythmias in hyperthyroidism and the...

Cor triatriatum dexter is an uncommon cardiac malformation in which the atrium is separated into two parts by a fibrous membrane. The partition of the right atrium can be of varying severity according to the stage of valvular dysplasia. The hemodinamic effect of this malformation is an increased pressure in the vena cava caudalis which leads to asc...

Streszczenie. Cel pracy stanowi analiza tensometryczna obciąŜeń zachodzących w ukła-dzie kość-stabilizator w trakcie 14-tygodniowej obserwacji gojenia się kości piszczelo-wych owiec leczonych metodą ZESPOL. Ocenie poddano wszystkie warianty osteosynte-zy Zespol (kompresyjną, neutralizującą, kontaktową i mostującą) a u jednej owcy zamon-towano stabi...

The paper describes the fundamental indications and procedures for implanting permanent pacemakers via the endocardial method. The surgical permanent pacemaker implantation was performed on four dogs of different breeds, with serious clinical symptoms of bradycardia and restrictions of the dogs' day to day activities. Routine treatment was not succ...

Separate congenital cataract operations on two foals aged six months and five weeks have been described. In the first case, the method of extracapsular extraction of both lenses was applied by means of large incisions near the corneal margin. In the second case, both of the foal's lenses were removed by the aspiration method, using a self construct...

The effects of a modified combination of three agents were assessed in the case of 3 experimental horses and 12 patients of a clinic. After being pre-medicated with a small dose of butorphanol and detomidine, each horse was put under anaesthetic by a rapid I.V. infusion (0.5 ml/kg) of a compound containing 100 mg of glycerol guaiacolate, 2 mg of ke...

Summary This paper presents the significance and range for the application of blood transfusion in horses. The main objective of total blood transfusion is to help improve oxygen delivery to the tissues during anemia; nonetheless, it is considered a temporary lifesaving procedure that should be only used if necessary. The majority of transfused ery...

Noszczyk-Nowak A., Jagielski D., Skrzypczak P., Nowak K., Pas‡awska U., Nicpoæ J. Application of loop recorder Reveal Plus for the diagnosis of fainting Summary Fainting is a symptom of transient, spontaneous blackout. The mechanism underlying fainting is a transient, generalized decrease in brain perfusion. Fainting can be the after-effect of arrh...