Pilli Govindaiah- Doctor of Pharmacy
- Researcher at Wayne State University
Pilli Govindaiah
- Doctor of Pharmacy
- Researcher at Wayne State University
Currently I am working as a Post-Doc in Wayne State University, Detroit, Michigan, USA.
About
14
Publications
3,902
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
207
Citations
Introduction
I am Currently I am working as a Post-Doc in Wayne State University, I does research in Lipid analysis, Medicinal Chemistry and Organic Chemistry.
Current institution
Additional affiliations
January 2011 - May 2013
Publications
Publications (14)
Thiazolidinedione-naphthalene analogues were synthesized and evaluated for antidiabetic activity as Pancreatic α-Amylase (PAA) and intestinal α-glucosidase (IAG) inhibitors. The activity of the compounds (14a–g,17a–k) is compared with acarbose as the standard drug and all the compounds shows good to moderate antidiabetic activity. In-vitro PAA and...
Diabetes mellitus is a serious and complex metabolic disorder characterized by hyperglycemia. In recent years natural products has gained much more interest by researchers as alternative sources for diabetes treatment. Though many potential agents are identified so far but their clinical utility is limited because of their adverse effects. Therefor...
Background
Epidemiological studies have suggested that a regular intake of flavonoids is beneficial for cellular homeostasis and in the prevention of the transformation of normal cells into cancerous cells. Because of their multiple biological targets, flavonoids have been studied and investigated as phytoconstituents with potential anticancer prop...
Many natural products with greater therapeutic efficacy are limited to target several chronic diseases such as cancer, diabetes, and neurodegenerative diseases. Among the natural products from hops, i.e., Xanthohumol (XH), is a prenylated chalcone. The present research work focuses on the enhancement of the poor oral bioavailability and weak pharma...
Objectives:
Xanthohumol (XH) is a prenylated chalcone available naturally and has diverse pharmacological activities. It has some limitations in the physiological environment such as biotransformation and less gastrointestinal tract absorption. To overcome the limitations, we prepared nanoformulations [solid lipid nanoparticles (SLNs)] of XH. Ther...
Investigators were continuously creating novel nanotechnologies to address unmet requirements throughout the administration of therapeutic medicines & imaging agents for cancer treatment & diagnostics, appropriately. LNPs are legitimate particulates (approx 100 nm in size) gathered from various lipid as well as other biochemical compounds which ove...
A series of novel 4‐hydroxycoumarin based acryloylcyanohydrazone derivatives were synthesized and evaluated for in vitro antiproliferative activity against different cancer cell lines (A‐549, HeLa, SK−N‐SH, and MCF‐7) by MTT assay method. All the test compounds (8 a‐m) were exhibited excellent antiproliferative activity (IC50 values ranging between...
Coumarin-based different series of hydrazone derivatives were synthesized and evaluated for anticancer activity against four different human cancer cell lines. The activity of the compounds were compared with doxorubicin as a standard drug and all the compounds exhibited good to moderate cytotoxicity with IC50 values ranging from 6.07 to 60.45 µM a...
A series of novel 4,7-dihydroxycoumarin based acryloylcyanohydrazone derivatives were synthesized and evaluated for antiproliferative activity against four different cancer cell lines (A549, HeLa, SKNSH, and MCF7). Most of the compounds displayed potent cytotoxicity with IC50 values ranging from 3.42 to 31.28 µM against all the tested cancer cell l...
p>Covalent organic Imine polymers with intrinsic meso-porosity were synthesized by condensation reaction between 4,4-diamino diphenyl methane and (para/meta/ortho)-phthaladehyde. Even though these polymers were synthesized from precursors of bis-bis covalent link mode, the bulk materials were micrometer size particles with intrinsic mesoporous enab...
Questions
Questions (6)
Hi, I did enzyme substrate reaction by using oxygraphy instrument. I have the crude enzyme concentration and the rate of the reaction, is it possible to calculate enzyme units and activity of the enzyme?
I have synthesized some compounds and taken 1H NMR as well as 13C NMR and in 1H NMR got two broad peaks at 15ppm and 11ppm respectively. The compounds has both OH and NH groups. I got confused which is OH peak and which is NH peak. It is possible to clarify with HMBC and HSQC NMR? if yes please can anyone help me how to interpret by using these two techniques.
I was synthesized some molecules i would like to determine the molecular properties and drug like properties for that molecules. I find that data warrior software is useful to analyse these properties but i didn't getting how to use that software. Please help me anybody.
Thank you
Please help me in the characterisation of SEM and FESEM pictures. what we should exactly detremines by seeing these pictures
i has BET results for my sample with surface area 500m^2/g. Is this a good surface area or not?
i was synthesised some polymers but they are not soluble in any organic solvent. i need suitable suitable solvent for the solubilisation of polymers. please anyone can help me
