Pilar Manuel Manresa

• PhD Student at University of Barcelona

Metastasis is the primary cause of death in cancer patients. Many current chemotherapeutic agents only show cytotoxic, but not antimetastatic properties. This leads to a reduction in tumor size, but allows cancer cells to disseminate, which ultimately causes patient death. Therefore, novel anticancer compounds with both effects need to be developed...

Combining computational modeling, de novo compound synthesis and in vitro and cellular assays, we have performed an inhibition study against the enhancer of zeste homolog 2 (EZH2) histone-lysine N-methyltransferase. This enzyme is an important catalytic component of the PRC2 complex whose alterations have been associated to different cancers. We in...

Lung cancer has become the leading killer cancer worldwide, due to late diagnosis and lack of efficient anticancer drugs. We have recently described novel natural-derived tambjamine analogues that are potent anion transporters capable of disrupting cellular ion balance, inducing acidification of the cytosol and hyperpolarization of cellular plasma...

Introduction: Lung cancer is the most frequent cause of cancer death worldwide, with an increasing incidence and a poor prognosis that depends on tumor stage at presentation. Characterization of molecular abnormalities that play a crucial role on lung cancer will allow the development of targeted therapies for this illness. Our aim is to test novel...

Macroautophagy, herein referred to as autophagy, is a biological process activated under diverse cellular stress conditions, such as starvation or oxidative stress. It involves the internalization of cytoplasmic portions, with or without organelles, within double-membrane vesicles called autophagosomes. These vesicles finally fuse with lysosomes, f...

Current pharmacological treatments for lung cancer show very poor clinical outcomes, therefore, the development of novel anticancer agents with innovative mechanisms of action is urgently needed. Cancer cells have a reversed pH gradient compared to normal cells, which favors cancer progression by promoting proliferation, metabolic adaptation and ev...

Facilitated anion transport potentially represents a powerful tool to modulate various cellular functions. However, research into the biological effects of small molecule anionophores are still at an early stage. Here we have used two potent anionophore molecules inspired in the structure of marine metabolites tambjamines to gain insight into the e...