Pierre-Marie Preux

Pierre-Marie Preux
University of Limoges | UNILIM

MD PhD

About

1,022
Publications
109,291
Reads
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20,534
Citations
Citations since 2017
247 Research Items
11728 Citations
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201720182019202020212022202305001,0001,5002,000
201720182019202020212022202305001,0001,5002,000
Additional affiliations
April 2016 - May 2016
University of Limoges
Position
  • Vice-President for Research
April 2016 - May 2016
University of Limoges
Position
  • Vice-President for Research
January 2012 - present

Publications

Publications (1,022)
Article
Background Peripheral neuropathies (PN) are a group of neurological conditions related to damage to the peripheral nervous system. Due to their wide diversity, few studies in sub-Saharan Africa have explored their epidemiology in general population. Our objective was to study the prevalence and associated factors with PN in general population in Ad...
Article
Introduction: People with epilepsy (PWE) face a variety of psychosocial challenges. A lack of knowledge of epilepsy, a high level of depression and anxiety and a low quality of life (QoL) are among the major problems that affect most PWE. The objective of this study was to examine the association of sociodemographic characteristics, clinical factor...
Article
Introduction: Very little is known about the impact of vision impairment (VI) on physical health in late-life in sub-Saharan Africa populations, whereas many older people experience it. We investigated the association between self-reported VI and frailty in Central African older people with low cognitive performance. Methods: It was cross-sectio...
Article
Introduction Reference values of aortic root diameters (ARD) are proposed to define normal versus diseased aorta. However, reported ranges of normal values are mostly issued from Caucasian cohorts. Data on blacks African subjects are sparse and not issued from community-dwelling cohorts. Purpose Our study aimed to establish reference values for AR...
Article
Objectifs L’espérance de vie des sujets vivant avec le virus de l’immunodéficience humaine (HIV) est aujourd’hui comparable à celle de la population générale. De même, les pathologies chroniques deviennent de plus en plus fréquentes. Des études in vitro, ont montré que l’HIV a un effet délétère direct sur la paroi artérielle, entraînant une inflamm...
Preprint
Objective: To synthesise international findings on the alcohol-dementia relationship and provide a cross-national comparison of the alcohol-dementia relationship with critical evidence for the relationship between alcohol use and dementia in under-studied populations. Design and setting: Individual participant data meta-analysis of 15 prospective e...
Article
Background and aims Although the ageing of the Cameroonian population is a public health issue in the coming years, the nutritional status of the elderly is unknown. The aim of the study was to assess the nutritional status, health status and associated socio-demographic factors among elderly in Cameroon. Methods A cross-sectional study of 599 elde...
Article
Résumé Objectif .- Décrire les représentations sociales des maladies cardiovasculaires (MCV) dans la cohorte TAHES au Bénin. Méthode.- Des entretiens individuels et de groupes ont été réalisés avec des enregistrements audios et des prises de notes. L'analyse des données a permis d'identifier les principales constructions intellectuelles sous-jace...
Article
Full-text available
BACKGROUND Although the World Health Organization has called for mental health services to be integrated into primary care, mental health remains in most countries, and especially in low- and middle-income countries, one of the most neglected topics in the training curriculum of frontline health workers. As a result, primary healthcare professional...
Article
Background: Functional abilities decline with aging as demonstrated by previous studies around the world, but few is known about Cameroonian elderly. Objectives: The aim of this study was to assess factors associated with functional impairments among elderly in Cameroon. Methods: Through a cross-sectional study, a representative sample of 599 elder...
Article
Objective: To assess the availability of health workers and medications for clinical management of amyotrophic lateral sclerosis (ALS) in African hospital centers. Availability and affordability analyses of disease-modifying treatments were performed. Methods: A multicenter observational study involving African hospitals was conducted. A standard q...
Conference Paper
Full-text available
Introduction: The burden of depression and anxiety is poorly documented in Central African populations. Objectives: To present the epidemiology of depressive and anxiety disorders among older people in two Central African countries. Methods: A cross-sectional population-based study was carried out in Republic of Congo (ROC) and Central African Re...
Article
Full-text available
BackgroundA noticeable change of the male-to-female sex ratio (SR) has been observed in Amyotrophic Lateral Sclerosis (ALS) leading to an apparent regression of SR with time (SR close to 1:1). Objective To provide a global SR estimate and investigate its relation with respect to population age.MethodsA systematic review and meta-analysis was conduc...
Article
Introduction Epilepsy is a chronic disease of the brain that affects approximately 50 million people globally, with over 80 % of them living in low- and middle-income countries (LMICs). In Madagascar, as in most LMICs, one of the main obstacles to treatment is the stigma and discrimination experienced by patients. Beliefs and prejudices regarding t...
Article
Background according to the hygiene hypothesis, infections by agents such as parasites have a protective role on the risk of developing Multiple Sclerosis (MS). Among parasites, Toxoplasma gondii, an intracellular parasite, showed evidence of a protective effect. Objective to summarize the available evidence on the association between Toxoplasma g...
Article
Introduction: In sub-Saharan Africa, many older people experience vision impairment (VI) and its adverse health outcomes. In this study, we examined separately the association between VI and each adverse health conditions (cognitive disorders, vision-related quality of life [VRQoL], and daily functioning interference [DFI]) among Congolese older p...
Article
Introduction: Epilepsy affects >50 million people worldwide, with 80% of them living in low- and middle-income countries (LMICs). Studies with a standardized methodology are required to obtain comparable data on epilepsy and implement health policies in order to reduce the treatment gap and improve the diagnosis and management of epilepsy. In 2000...
Article
Full-text available
Background The term Nodding Syndrome (NS) refers to an atypical and severe form of childhood epilepsy characterized by a repetitive head nodding (HN). The disease has been for a long time limited to East Africa, and the cause is still unknown. The objective of this study was to confirm the existence of NS cases in Central African Republic (CAR). M...
Article
Full-text available
Objective Epilepsy is a major neurological disorder that requires long-term medical treatment. Once epilepsy is diagnosed, people with epilepsy face many difficulties in accessing treatment (treatment gap). Our objective was to assess the situation regarding the availability, price, affordability, and quality of anti-seizure medication (ASM), which...
Article
Background Meningiomas are the most common primary brain tumors, followed by glioblastomas. Nevertheless, no previous studies have been conducted to evaluate the epidemiology of meningiomas and glioblastomas in the southern region of Italy. Thus, the aim of our study was to evaluate incidence, temporal trend and survival rate of meningiomas and gli...
Article
Introduction Essential Tremor (ET) is increasingly recognized as a complex disorder with additional clinical signs other than tremor. It is still unknown whether a unique pathophysiologic or neurodegenerative process underlies progression and prognosis of the disease. The aim of the study was to identify ET phenotypes through a clinical-instrumenta...
Article
Full-text available
Introduction: despite the high prevalence and significant burden of mental disorders, they remain grossly under-diagnosed and undertreated. In low-income countries, such as Mali, integrating mental health services into primary care is the most viable way of closing the treatment gap. This program aimed to provide a mental health training intervent...
Article
Introduction: Heterogeneity of amyotrophic lateral sclerosis (ALS) has been suggested in terms of epidemiology, phenotypes and genetics between geographic areas and populations. However, there is limited information in Latin America. We conducted a systematic review that aimed to describe the epidemiology, frequency of genetic mutations, clinical c...
Article
Background: Assessing clinical progression in amyotrophic lateral sclerosis (ALS) remains a challenge. We evaluated the validity and predictive capabilities of the King’s and Milano-Torino Staging (MiToS) systems in a cohort of patients with ALS to demonstrate their benefit in clinical practice. Methodology: A cohort study was performed by includin...
Article
La sclérose latérale amyotrophique (SLA) est une maladie neurodégénérative fatale. Les travaux scientifiques suggèrent que l’ethnicité et l’origine ancestrale influencent le risque de développer la maladie. L’ethnicité peut prendre en compte les caractéristiques sociales, culturelles ainsi que les générations antérieures. L’origine ancestrale se ré...
Article
Introduction Les données épidémiologiques sur les troubles psychiques, les troubles neurocognitifs et l’épilepsie mettent en évidence des maladies ubiquitaires, présentes dans toutes cultures et latitudes, avec des prévalences élevées, notamment dans les pays en développement. Objectifs L’objectif principal était d’évaluer les connaissances, attit...
Article
Introduction et but de l’étude Environ 50 à 60 % des patients avec une sclérose latérale amyotrophique (SLA) présente une augmentation de leur niveau métabolique ou hypermétabolisme. L’augmentation du niveau métabolique dans la SLA est définie par une variation de la dépense énergétique au repos (DER) entre DER mesurée (DERm) et DER calculée (DERc)...
Article
Introduction et but de l’étude Dans la sclérose latérale amyotrophique (SLA), le bénéfice de la gastrostomie sur la survie dans la SLA n’est pas clair et sa mise en place est probablement trop tardive. Les objectifs de notre travail étaient chez des patients SLA avec indication de gastrostomie et qui acceptaient ou refusaient la gastrostomie d’étud...
Article
Introduction et but de l’étude L’augmentation de la variation de la dépense énergétique au repos (DER) dans la SLA est un facteur pronostique pour la survie principalement chez les patients avec une variation de DER > + 20 %. La mesure de DER par calorimétrie indirecte (CI) par rapport à DER prédit avec la formule (Harris et Benedict [HB] 1919, HB...
Article
Introduction et but de l’étude Environ 5 % à 10 % des patients atteints de SLA souffrent de SLA/DFT. Dans la SLA, l’augmentation de la dépense énergétique au repos (DER) est un facteur pronostique de survie. Aucune étude n’a étudié l’état nutritionnel et métabolique dans la SLA/DFT et son impact sur la survie. Les objectifs de cette étude étaient:...
Article
Introduction et but de l’étude Le vieillissement de la population camerounaise sera un problème de santé publique dans les prochaines années. L’état socio-économique et nutritionnel des personnes âgées est mal connu. Une seule publication a montré une prévalence de dénutrition de 5,5 %, d’obésité de 19,0 % chez des personnes âgées de plus de 55 ans...
Article
Introduction et but de l’étude Dans la SLA, l’état nutritionnel est un facteur prédictif de survie. En Limousin, un réseau de santé spécialisé en nutrition (LINUT) évalue les patients SLA à domicile afin d’optimiser leur prise en charge nutritionnelle. Les objectifs de notre étude étaient : – de comparer l’évolution nutritionnelle, neurologique et...
Article
Like much of the developing world, sub-Saharan Africa (SSA) is facing a major challenge. This challenge is due to noncommunicable diseases (NCDs) whose rates are rising dramatically in SSA. Two conditions that frequently coexist head the list of NCDs as either established disease entities or risk factors for NCDs. These are hypertension and diabete...
Conference Paper
Objectives: Older people are vulnerable to mental and cognitive health issues. Studies reported that depressive or anxious older people are more likely to present or to develop dementia over time. The relations between these psychiatric disorders and dementia are poorly explored in sub-Saharan Africa. Therefore, we investigated the association betw...
Conference Paper
Full-text available
Objective: To review studies conducted on the costs of dementia in low- and middle-income countries (LMICs), describe their methodology and summarize costs estimates.
Article
Objectives To evaluate the association between neuropsychiatric symptoms and apolipoprotein E (APOE) ϵ4 allele among older people in Central African Republic (CAR) and the Republic of Congo (ROC). Design Multicenter population-based study following a two-phase design. Setting From 2011 to 2012, rural and urban areas of CAR and ROC. Participants...
Article
Full-text available
Background: The burden of stroke is high in sub-Saharan Africa (SSA), but few data are available on its long-term mortality. Objective: To estimate over one-month stroke case-fatality in sub-Saharan Africa Methods: Systematic review and meta-analysis was performed according to Meta-analysis of Observational Studies in Epidemiology and Preferred Rep...
Article
Background: The burden of stroke is high in sub-Saharan Africa; however, few data are available on long-term mortality. Objective: To estimate over one-month stroke case fatality in sub-Saharan Africa. Methods: A systematic review and meta-analysis were performed according to meta-analysis of observational studies in epidemiology and Preferred Repo...
Article
Full-text available
Stroke frequently causes deglutition disorders, leading to a decline in nutritional status and complications, and increasing mortality. Sub-Saharan data are scarce. The objectives of this study were to assess complications and mortality among hospitalized patients in Burkina Faso during the first two weeks after stroke, and to investigate associate...
Article
Rationale Hypermetabolism (HM) in Amyotrophic lateral sclerosis (ALS) is the reflection of a high energy metabolic level, but this alteration seems controversial. The main objective of the study was to confirm the existence of HM during ALS compared to healthy subjects. Methods A cohort of ALS patients was compared to a control group without metab...
Article
Background Onchocerciasis is a serious problem in tropical areas. The role of the parasite as a factor associated with neurological diseases needs to be addressed because it might involve a reduction of the risk via elimination strategies. We performed a systematic scoping review to identify available studies on this association and put into perspe...
Article
Full-text available
Background The possibility that onchocerciasis may cause epilepsy has been suggested for a long time, but thus far, an etiological link has not been universally accepted. The objective of this review is to critically appraise the relationship between Onchocerca volvulus and epilepsy and subsequently apply the Bradford Hill criteria to further evalu...
Article
Study Objectives To provide an overall estimate of the prevalence of idiopathic REM Sleep Behavior Disorder (iRBD). Methods Two investigators have independently searched the PubMed and Scopus databases for population-based studies assessing the prevalence of iRBD. Data about type of diagnosis (polysomnographic diagnosis, defined iRBD [dRBD]; clini...
Article
Although psychiatric and neurological disorders are among the first contributors to the global burden of disease, they remain among the most neglected topics of Global Health. There is a real need to raise their profile, to improve advocacy so that the impact of these diseases is better understood, and greater political efforts are made to improve...
Article
Full-text available
Background Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer’s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Methods We combined individual participant data for 16 cohorts from 15 countries (member...
Article
Introduction: The prevalence of neurocognitive disorders (NCDs) increases with age and is associated with cognitive impairment. Older patients with NCD admitted to the emergency department (ED) are readmitted after discharge to home more often than those without NCD. Comprehensive geriatric assessment (CGA) is effective for improving clinical outc...
Article
Background Visual impairment (VI) and determinants of poor cardiovascular health are very common in sub-Saharan Africa. However, we do not know whether these determinants are associated to VI among older adults in this region. This study aimed at investigating the association between the determinants of poor cardiovascular health and near VI among...
Conference Paper
Background With global ageing, multimorbidity becomes a priority for global health research. Multimorbidity prevalence increases with age and is associated with poorer health outcomes. As people live longer, chronic conditions, including dementia, are rising in low‐ and middle‐income countries (LMIC) but the relationship between multimorbidity and...
Conference Paper
Full-text available
Introduction: Depression and anxiety are two very common psychiatric disorders in late-life. They are markers of poor quality of life and are strongly associated with death among older people. Yet, few studies on these comorbidities have been conducted in the African population. This study aims to present the epidemiology of depression and anxiety...
Article
Full-text available
Background: Epilepsy affects more than 50 million people worldwide, 80% of whom live in low- and middle-income countries (LMICs). In Southeast Asia, the prevalence is moderate (6‰), and the main public health challenge is reducing the treatment gap, which reaches more than 90% in rural areas. Methods: This 12-month comparative study (intervention v...
Article
Objectifs L’espérance de vie des sujets vivant avec le virus de l’immunodéficience humaine (HIV) est aujourd’hui comparable à celle de la population générale. De même, les pathologies chroniques deviennent de plus en plus fréquentes. Des études in vitro, ont montré que l’HIV a un effet délétère direct sur la paroi artérielle, entraînant une inflamm...
Chapter
This chapter is dedicated to the epidemiology of common non-bacterial central nervous system infections: parasitic, fungal, and viral infections. Non-bacterial central nervous system infections are public health challenges in developing and developed countries. Clinical manifestations and severity depend on pathogenic characteristics of the agents...
Conference Paper
Le fardeau des accidents vasculaires cérébraux (AVC) est assez lourd pour les pays en développement et plus particulièrement en Afrique subsaharienne. La mortalité des AVC est assez élevée dans cette région et pouvait s’expliquer par le système de santé, des facteurs culturels et même des spécificités des AVC dans cette population. Les données sur...
Conference Paper
Introduction Les déficiences visuelles (DV) seraient impliquées dans la survenue des troubles cognitifs (TC) chez les personnes âgées. Cependant, aucune étude n’a exploré cette relation en population Africaine. Objectif Investiguer la relation entre les DV et les TC chez les personnes âgées du Congo. Méthodes Les données exploitées sont celles co...
Article
Objectives: Visual impairment and cognitive disorders are common among older people in Lowand Middle-Income Countries (LMIC). Several recent studies performed in High-Income Countries suggested that visual impairment is associated with cognitive disorders. However, no synthesis of current knowledge exists for LMIC. Methods: We have conducted an ex...
Article
Full-text available
Objective Epilepsy is a chronic condition treatable by cost‐effective antiepileptic drugs (AEDs), but limited access to treatment was documented. The availability and affordability of good quality of AEDs play a significant role in access to good health care. This study aimed to assess the availability, affordability, and quality of long‐term AEDs...
Article
Introduction Malgré les progrès spectaculaires de la recherche, le cancer du sein reste un problème majeur de santé publique et une priorité de la recherche biomédicale. L’incidence du cancer du sein est plus élevée dans les pays occidentaux mais sa mortalité est relativement plus élevée dans les pays d’Afrique subsaharienne comme la République du...
Article
Introduction: The number of people living with dementia is growing worldwide and most rapidly in low- and middle-income countries. Little is known about dementia in Benin. We estimated the prevalence of dementia among retired people in Parakou, a northern city in Benin, and then assessed associated factors. Methods: A cross-sectional study was p...
Article
Full-text available
Background: Dementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied. Methods: We harmonized and pooled baseline data from 11 population-based cohorts from 11 countries ove...
Article
Background Epilepsy is among the more stigmatising diseases, leading to a negative impact on the quality of life (QoL) of people with epilepsy (PWE). Assessment of the QoL and stigma in PWE reflects the outcome of their disease, and the findings can be used to improve the management of epilepsy. To fill a gap in the literature, our primary aim is t...
Article
Introduction Few studies have investigated the effect of electromagnetic waves on the human fetus whereas nowadays mobile phone use is ubiquitous. The aim of this study was to evaluate the association between mobile phone use by pregnant women and fetal development during pregnancy in the general population. Material and methods Data came from the...
Article
Full-text available
Introduction Stroke is one of the most common causes of high mortality rates in Africa with many unknown aspects around its prognosis. In this study we aim to describe stroke characteristics and in-hospital mortality of stroke in Parakou. Methods This is a retrospective cohort study including all stroke patients admitted to the Department of Neuro...
Article
Full-text available
Epilepsy is a major public health concern in low and middle-income countries (LMICs) and comorbidities aggravate the burden associated with the disease. The epidemiology of these comorbidities has not been well described, although, identifying the main comorbidities of epilepsy, and their relative importance, is crucial for improving the quality of...
Article
Background: Peripheral artery disease (PAD) is one of the most common manifestations of atherosclerosis affecting more than 200 million people globally but little is known about its epidemiology in Middle East populations, particularly in Arab countries. The present study was undertaken to assess the prevalence of PAD in the general population aged...
Preprint
Full-text available
Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer`s disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. Therefore, we combined individual participant data for 16 cohorts from 15 countries (members of the...
Article
Full-text available
Recently, there were anecdotal reports of a high number of persons with epilepsy, including children with nodding seizures in the Landja Mboko area located about 9 km from the capital city Bangui, Central African Republic. We suspected the area to be endemic for onchocerciasis, and that the alleged increase in the number of epilepsy cases was due t...
Article
Objectives: Mortality data have been used as a proxy for amyotrophic lateral sclerosis (ALS) incidence. However, the accuracy of death certificates (DCs) needs to be validated. This study aims to assess the accuracy of DCs in the identification of ALS cases. Methods: This is a retrospective population-based validation study. DC information, provide...
Article
Introduction Stroke is a major public health problem with a high burden in Sub-Saharan Africa. We aimed to determine the prevalence of stroke in Titirou in Parakou. Methods It was a cross-sectional study using a door-to-door survey in Titirou (Parakou) from 15 march to 15 October 2016 and included 4671 adults. We did a two stages survey. In the fi...
Article
Introduction et but de l’étude La sclérose latérale amyotrophique (SLA) est une maladie neurologique d’évolution sévère très souvent accompagnée de dénutrition. L’état nutritionnel et la composition corporelle sont des facteurs associés à la survie. L’impédance bioélectrique corporelle totale (BIA) avec une équation validée permet d’évaluer la comp...
Article
Introduction et but de l’étude La sclérose latérale amyotrophique (SLA) est une pathologie rare mais de pronostic sombre. La composition corporelle est un facteur pronostic de survie. Au cours de la SLA, la composition corporelle peut être évaluée par impédancemétrie biolélectrique corporelle totale (BIA) à l’aide d’une formule de référence validée...
Article
Background & Aims: Epilepsy affects nearly 70 million people worldwide. Vitamin D deficiency may influence the balance of certain epilepsies. The purpose of this study was to determine the vitamin D status and anthropometric measurements of people with epilepsy (PWE), according to their pharmacosensitivity. Methods: Forty-six PWE, with or without d...