Pierre Alexis Geoffroy

Pierre Alexis Geoffroy
Hôpital Bichat - Claude-Bernard (Hôpitaux Universitaires Paris Nord Val de Seine) · Service de Psychiatrie et Addictologie

MD, PhD

About

275
Publications
113,618
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
4,171
Citations
Introduction
Psychiatrist and Sleep physician at the Assistance Publique-Hôpitaux de Paris, Psychiatry and Addiction medicine department, Bichât-Beaujon hospitals. My research activity is at Neurodiderot (Neophen team, French Institute of Health and Medical Research - INSERM) and is focused on sleep, circadian and seasonal biomarkers and treatments. I undertake teaching activity at Paris University, and also have an interest in pedagogy and semiology and collaborate to the AESP. I am a member of the French Sleep Society (SFRMS) and the French biological psychiatry society (AFPBN).
Additional affiliations
September 2012 - October 2012
The University of Newcastle, Australia
Position
  • invited researcher

Publications

Publications (275)
Article
Objectives: To examine (i) the frequency of different sleep complaints (early wake-up, trouble falling asleep, hypersomnia) and their co-occurrence and (ii) the sociodemographic characteristics and psychiatric comorbidity associated with each type of sleep profiles. Methods: Data were drawn from the Wave 2 National Epidemiologic Survey on Alcoho...
Article
The Seasonal Pattern Assessment Questionnaire (SPAQ), by Rosenthal et al. (1984), is by far the most used questionnaire to evaluate seasonal effects on mood and behavior. It includes a general seasonality score (GSS), composed of 6 items, from which cutoffs have been established to screen for seasonal affective disorder (SAD). However, it has never...
Article
Objective: To examine the role of chronobiological dysrhythmicity in suicidal ideation and behaviors and its relation with hopelessness. Methods: One hundred twenty-seven patients (77 females, mean age of 47.4 ± 12.5 years) with a major depressive episode and bipolar disorder (BD) type I or II (according to Structured Clinical Interview for DSM-...
Article
Full-text available
Prior research suggests that sleep disturbances are associated with increased risk of suicide. However, sleep disturbances are associated with a wide range of psychiatric disorders, and it is unknown whether this association is independent of psychopathology. In a large nationally representative prospective survey, the National Epidemiologic Survey...
Article
Full-text available
Purpose: Women with Alcohol Use Disorder (AUD) might be particularly vulnerable to psychiatric comorbidities. However, population surveys have yielded disparate findings. We used data from the French Mental Health in the General Population survey to investigate gender-related risks of psychiatric comorbidities associated with AUD. Methods: A cross-...
Article
Résumé L’utilisation de la technologie connectée en médecine augmente considérablement. L’adoption de ces outils dans la pratique clinique de la psychiatrie semble inévitable. Comment les utiliser de manière efficace ? Pour y répondre, cette courte revue focalise sa réflexion sur trois des apports majeurs de la psychiatrie connectée : 1/l’assistanc...
Article
The use of digital technologies is constantly growing around the world. The wider-spread adoption of digital technologies and solutions in the daily clinical practice in psychiatry seems to be a question of when, not if. We propose a synthesis of the scientific literature on digital technologies in psychiatry and discuss the main aspects of its pos...
Article
Full-text available
Insomnia symptoms are frequent during peripartum and are considered risk factors for peripartum psychopathology. Assessing and treating insomnia and related conditions of sleep loss during peripartum should be a priority in the clinical practice. The aim of this paper was to conduct a systematic review on insomnia evaluation and treatment during pe...
Article
Objective Circadian rhythm disruption is commonly observed in bipolar disorder (BD). Daylight is the most powerful signal to entrain the human circadian clock system. This exploratory study investigated if solar insolation at the onset location was associated with the polarity of the first episode of BD I. Solar insolation is the amount of electrom...
Article
Objective: The study aimed to investigate the possible impact of resilience and emotion dysregulation on the clinical manifestations of bipolar disorders (BDs) focusing on the possible role of circadian rhythm alterations. Method: A sample of 197 inpatients suffering from BD of type I (BDI) or II (BDII) were assessed during a major depressive ep...
Article
Full-text available
Idiopathic hypersomnia (IH), characterized by an excessive day-time sleepiness, a prolonged total sleep time on 24 h and/or a reduced sleep latency, affects 1 in 2000 individuals from the general population. However, IH remains underdiagnosed and inaccurately treated despite colossal social, professional and personal impacts. The pathogenesis of IH...
Article
Full-text available
The objective of this study was to examine the evolution of suicides and suicide attempts over the last 10 years in France. We analyzed the number of deaths by suicide and suicide attempts in metropolitan France (2009–2018) from French national databases, on a daily, weekly or monthly basis. Seasonal variation in suicide rates was modeled using a c...
Article
Objectif La tachypsychie se défini par une accélération et une surproduction subjective des pensées. Elle fait partie des symptômes du trouble bipolaire et est également retrouvée chez le sujet sain. Les mécanismes circadiens, homéostasiques et photiques jouent un rôle important dans les troubles de l’humeur, mais leur impact sur la tachypsychie n’...
Article
Objectif La lumière a un effet éveillant sur l’organisme, notamment grâce à la mélanopsine, un photopigment rétinien sensible à la lumière bleue. Des index de phototransduction ont récemment été identifiés comme marqueurs de pathologies grâce à la pupillométrie. L’objectif de ce travail était d’évaluer la réponse pupillaire mélanopsinergique afin d...
Article
Objectif Le dim light melatonin onset (DLMO) est le marqueur le plus fiable de la phase circadienne chez l’Homme, et son importance est de plus en plus évoquée en clinique. Cependant, les méthodes de calcul utilisées sont diverses dans la littérature, ce qui complique la comparabilité entre les études et souligne le besoin d’identifier la méthode l...
Article
Objectif Depuis le début de la pandémie de COVID-19, les symptômes persistants sont devenus une préoccupation croissante. L’objectif de notre étude est d’évaluer les symptômes psychiatriques et ceux liés au sommeil après une infection à COVID-19, ainsi que sur leur relation avec les autres symptômes résiduels. Notre hypothèse est que les patients a...
Article
Objectif L’interaction entre le tabagisme et le sommeil semble bidirectionnelle, mais peu d’études évaluent l’impact du tabac et de son sevrage sur les paramètres objectifs de sommeil. L’objectif principal de notre étude était d’évaluer l’impact de la nicotine sur les paramètres ventilatoires de sommeil et en particulier sur la présence d’un syndro...
Article
Objectif L’hypersomnolence est associée à des épisodes dépressifs caractérisés (EDC) sévères et compliqués à prendre en charge. Peu d’étude se sont appuyées sur des polysomnographies (PSG) longues pour l’étudier. Notre objectif est d’explorer la plainte d’hypersomnolence de patients souffrant d’un EDC. Méthodes Nous avons réalisé une étude constit...
Article
Objectif Le « seasonal pattern assessment questionnaire » (SPAQ) est le questionnaire le plus utilisé pour évaluer les effets saisonnier de l’humeur et du comportement, et est souvent utilisé comme outil de dépistage de dépression saisonnière syndromale et sous-syndromale. L’objectif de cette étude est de valider la version française du questionnai...
Article
Full-text available
Objectives: To describe 3-6-month neurologic outcomes of survivors of COVID-19-associated acute respiratory distress syndrome, invasively ventilated in the ICU. Design: A bicentric prospective study during the two first waves of the pandemic (March to May and September to December, 2020). Setting: Two academic hospital ICUs, Paris, France. Pa...
Article
Full-text available
In this multicenter retrospective observational study involving 58 562 adult patients hospitalized for COVID-19, melatonin use (N = 272) at a mean daily dose of 2.6 mg was not associated with reduced mortality.
Article
Résumé Les cauchemars chroniques ont un impact majeur sur la santé mentale et le risque suicidaire. Ils présentent une prévalence élevée dans les populations psychiatriques, notamment chez les patients souffrants d’un trouble de stress post-traumatique (TSPT) et également chez les patients atteints de troubles de l’humeur (trouble dépressif unipola...
Article
Full-text available
Light exerts powerful biological effects on mood regulation. Whereas the source of photic information affecting mood is well established at least via intrinsically photosensitive retinal ganglion cells (ipRGCs) secreting the melanopsin photopigment, the precise circuits that mediate the impact of light on depressive behaviors are not well understoo...
Article
Objective To provide a qualitative view and quantitative measure of sleep disturbances across and between early stages – clinical ultra high-risk and first episode – of psychotic and bipolar disorders. Methods Electronic databases (PubMed, Cochrane, Embase, PsychINFO) were searched up to March 2021 for studies comparing sleep measures between indi...
Article
Les effets de la lumière sur l'humeur sont décrits depuis l'Antiquité et dès les premières descriptions médicales. Les neurosciences ont permis, il y a une quarantaine d'années, un regain d'intérêt croissant pour la luminothérapie avec les toutes premières observations : la modification des rythmes bio-logiques pouvait avoir un effet antidépresseur...
Article
Introduction Since insomnia and disturbed sleep may affect neuroplasticity, we aimed at reviewing their potential role as markers of disrupted neuroplasticity involved in mood disorders. Method We performed a systematic review, according to PRIMA, on PubMed, PsycINFO and Embase electronic databases for literature regarding mood disorders, insomnia...
Article
No data exist on the influence of meteorological factors on alcohol use disorders (AUD). The aim of this study was to investigate the relationship between meteorological factors and AUD. All patients who were admitted to an emergency department (ED) in the Paris-region for an alcohol-related condition were included using the Oscour® database over t...
Article
Full-text available
We aimed to examine the association between religious beliefs and observance and the prevalence of psychiatric disorders, psychotic symptoms and history of suicide attempts in the French general population. The cross-sectional survey interviewed 38,694 subjects between 1999 and 2003, using the MINI. Current religious beliefs and observance were ide...
Article
Objective Sleep health is a major public health concern because of its correlation with physical and mental health, and it may be particularly altered in medical students. This study aims: i) to examine the sleep characteristics of French medical students and their knowledge about basic sleep hygiene rules and; ii) to examine the correlations betwe...
Article
Objectif Les troubles bipolaires (TB) sont des troubles psychiatriques sévères qui touchent 1 à 4 % de la population et sont marqués par des altérations des rythmes biologiques au cours de l’ensemble des phases de la maladie. De plus l’ensemble des symptômes des TB (humeur, énergie, activité, appétit, etc) sont régulés par le système circadien. Mé...
Preprint
Full-text available
Introduction: The objective of this study was to examine the evolution of suicides and suicide attempts over the last 10 years in France. Methods: We analyzed the number of deaths by suicide and suicide attempts in metropolitan France (2009-2018) from French national databases, on a daily, weekly or monthly basis. Seasonal variation in suicide rate...
Article
Résumé La pandémie liée à la COVID-19 a altéré de manière significative et importante la qualité du sommeil du personnel soignant. Avec des différences selon le questionnaire utilisé, la spécialité du professionnel, et le pays étudié, environ la moitié des soignants ont développé des troubles du sommeil lors de cette crise sanitaire. Les troubles d...
Article
The full 2-month lockdown to fight the coronavirus disease 2019 (COVID-19) pandemic in 2020 led to substantial disruption of daily life and routines. The present study aimed to comprehensively identify the lockdown’s effects on sleep, daily rhythms and emotions of the French population. A survey was published online during the last week of the 2-mo...
Article
Full-text available
Background: Bipolar disorder is associated with circadian disruption and a high risk of suicidal behavior. In a previous exploratory study of patients with bipolar I disorder, we found that a history of suicide attempts was associated with differences between winter and summer levels of solar insolation. The purpose of this study was to confirm th...
Article
Full-text available
Background: Cognitive arousal is thought to play a key role in insomnia disorder. However, although patients frequently complain about racing thoughts appearing at bedtime, studies have considered 'cognitive arousal' as a synonym of rumination and worry, but not as racing thoughts per se. The latter have been mainly linked to hypomanic/manic episo...
Article
Even though tobacco-induced sleep disturbances (TISDs) have been reported in previous studies, the present article is the first meta-analysis quantitatively assessing the impact of tobacco on sleep parameters. We conducted a systematic review and meta-analysis of the studies comparing objective (i.e. polysomnography and actigraphy) and/or subjectiv...
Article
This article proposes to investigate how Sleep disorders have been conceptualized within the DSM-5 through symptom network analysis of the diagnostic criteria of the “Sleep-Wake Disorders” section in the DSM-5. We hypothesize that the analysis of the most central symptoms will allow us to better analyze the position of Sleep disorders in Mental dis...
Article
Full-text available
The third edition of the International Classification of Sleep Disorders (ICSD-3) is the authoritative clinical text for the diagnosis of sleep disorders. An important issue of sleep nosology is to better understand the relationship between symptoms found in conventional diagnostic manuals and to compare classifications. Nevertheless, to our knowle...
Article
Background: Impulsivity is an important transdiagnostic feature of many psychiatric disorders, as well as a marker of poorer outcome. Topiramate is broadly used for reducing impulsivity in various neuropsychiatric disorders, but no systematic review or meta-analysis has ever explored whether evidence supports this clinical use. Methods: We condu...
Article
Résumé Le cauchemar, défini comme un rêve extrêmement dysphorique, impliquant généralement des menaces vitales sur la sécurité ou l’intégrité physique, représente un phénomène courant. Survenant majoritairement en stade de sommeil paradoxal, il se différencie notamment d’autres parasomnies par l’accès rapide à un état orienté et alerte après l’évei...
Article
Background . Although sleep disturbances are ubiquitous in depression, studies assessing sleep architecture lead to conflicting results, possibly because of the heterogeneity in this disorder. We aimed to focus on Seasonal Affective Disorder (SAD), which is directly associated with circadian and sleep homeostasis impairments. Methods . A systemati...
Article
Full-text available
Transcranial Electrical Stimulation (tES) is a promising non-invasive brain modulation tool. Over the past years, there have been several attempts to modulate sleep with tES-based approaches in both the healthy and pathological brains. However, data about the impact on measurable aspects of sleep remain scattered between studies, which prevent us f...
Article
Full-text available
Introduction: Insomnia and circadian rhythm disorders, such as the delayed sleep phase syndrome, are frequent in psychiatric disorders and their evaluation and management in early stages should be a priority. The aim of this paper was to express recommendations on the use of exogenous melatonin, which exhibits both chronobiotic and sleep-promoting...
Article
Points essentiels La pandémie liée à la COVID-19 a altéré de manière significative et importante la qualité du sommeil du personnel soignant. Avec des différences selon le questionnaire utilisé, la spécialité du professionnel, et le pays étudié, environ la moitié des soignants ont développé des troubles du sommeil lors de cette crise sanitaire. Les...
Article
The study aimed at investigating the potential impact of early stressful events on the clinical manifestations of bipolar disorder (BD). A sample of 162 adult individuals with BD was assessed using the Structural Clinical Interview for DSM-5, the Beck Depression Inventory-II, the Young Mania Rating Scale, the Early Trauma Inventory Self Report-Shor...
Article
Résumé Plusieurs troubles psychiatriques, comme le trouble bipolaire et l’autisme, sont hautement héréditaires. De nombreuses études ont décrit l’existence d’une agrégation familiale dans ces troubles, c’est-à-dire que le risque d’être atteint est supérieur à celui de la population générale si l’un des membres de la famille est atteint. L’héritabil...
Article
Introduction Stressful life events (SLE) may influence the illness course and outcome. Objectives The present study aimed to characterize socio-demographic and clinical characteristics of euthymic major depressive disorder (MDD) outpatients with SLE relative to those without. Methods This sample included 628 (mean age=55.1 ± 16.1) currently euthy...
Article
Objectif Identifier les particularités cliniques associées à la sensibilité subjective aux effets de la lumière et du beau temps. Méthodes Étude observationnelle par auto-questionnaire en ligne évaluant la plainte de sommeil (reseau-morphee.fr). La sensibilité ressentie à la lumière a été évaluée par la question « êtes-vous sensible à la lumière e...
Article
Objectif L’hypersomnolence est un symptôme partagé dans l’hypersomnie idiopathique (HI) et la dépression. La réponse à la lumière étant altérée dans la dépression, notre objectif était d’étudier les relations entre réponse pupillaire, sévérité des symptômes dépressifs et paramètres de sommeil afin d’identifier des biomarqueurs de dépression dans un...
Article
Résumé La tachypsychie est un des symptômes fréquemment retrouvée des troubles de l’humeur. Cet article a pour but de résumer les connaissances actuelles sur le contexte historique, la sémiologie et la fréquence de ce symptôme dans le spectre des troubles de l’humeur. La tachypsychie pourrait se scinder en deux composantes : les « pensées accélérée...
Article
Objective Sadness is a common symptom in the general population. We tested the hypothesis that sadness is an intermediate state on a continuum from well-being to major depressive disorder (MDD). Methods Using data from The National Epidemiologic Study of Alcohol and Related Conditions III (NESARC-III), a large and representative US population samp...
Article
The main objective of this theoretical review is to systematically analyze the type of ICSD-3 diagnostic criteria by labeling each of them in order to propose an overview of the way in which the diagnostic criteria are organized. Labelling of diagnostic criteria using a rigorous iterative process of “aggregation” and “generalization” was conducted...
Article
The present paper aims at reviewing and commenting on the relationships between sleep and circadian phasing alterations and neurodegenerative/neuroprogressive processes in mood disorder. We carried out a systematic review, according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, in PubMed, PsycINFO, and Embase ele...
Article
Full-text available
Chronic nightmares are very common in psychiatric disorders, affecting up to 70% of patients with personality or post-traumatic stress disorders. In other psychiatric disorders, the relationships with nightmares are poorly known. This review aimed to clarify the relationship between nightmares and both mood and psychotic disorders. We performed a s...
Article
Objective There is a growing interest in psychiatry regarding melatonin use both for its soporific and chronobiotic effects. This study aimed to evaluate factors impacting the daily-dose. Methods In a university department of psychiatry in Paris (France), we conducted a posteriori naturalistic observational study from April 03, 2017 to January 31,...
Article
Full-text available
Background The concept of misperception of sleep refers to the estimated discrepancy between subjective and objective measures of sleep. This has been assessed only in a few prior studies in individuals with Bipolar Disorder (BD) as compared to Healthy Controls (HC) and with mixed results. Methods We assessed a sample of 133 euthymic individuals w...
Article
Depressive syndromes are frequent and heterogeneous brain conditions with more than 90% of patients suffering from sleep complaints. Better characterizing this “sleep” domain may allow to both better treat acute episodes with existing chronotherapeutics, but also to prevent the manifestation or recurrences of mood disorders. This work aims to i) re...
Article
Full-text available
Background: Stressful life events (SLE) may influence the illness course and outcome. This study aimed to characterize socio-demographic and clinical features of euthymic major depressive disorder (MDD) outpatients with SLE compared with those without. Methods: The present sample included 628 (mean age=55.1 ± 16.1) currently euthymic MDD outpati...
Article
Bipolar spectrum disorders encompass heterogeneous clinical manifestations and comorbidities. A latent class analysis (LCA) was performed in 1846 subjects who experienced an episode of abnormally elevated or irritable mood to identify homogeneous groups of subjects, based on the distribution of 11 manic and 7 psychotic symptoms. LCA identified five...
Article
Background Interest in biological clock pathways in bipolar disorders (BD) continues to grow, but there has yet to be an audit of circadian measurement tools for use in BD research and practice. Procedure The International Society for Bipolar Disorders Chronobiology Task Force conducted a critical integrative review of circadian methods that have...
Article
What is the most accurate way to capture and organize the tremendous variability in symptoms that occur within and between mood states and over the course of time in bipolar disordersThis question regularly re‐emerges underpinned by an equally fundamental question, which is the best treatment for a given patient. Indeed, the high clinical heterogen...
Article
Full-text available
Transcranial direct current stimulation (tDCS) recently appeared as a novel treatment that could be a potential therapeutic option for patients with bipolar depression. tDCS is an experimental treatment and should not be considered as a treatment that can replace medications or electroconvulsive therapy in bipolar depression tDCS could be a potenti...
Article
Full-text available
Background The worldwide coronavirus outbreak has put hospital workers under extreme stress with possible mental health problems. In this context, we decided to rapidly design and implement a psychological support system for all hospital workers in Paris during the Covid-19 outbreak.Methods We built a hotline in 3 days using the following steps: 1)...
Article
Résumé Objectifs L’évaluation du risque suicidaire est une étape essentielle de l’entretien psychiatrique. Cependant, de nombreux médecins sont en difficultés ou redoutent d’interroger les patients sur leurs idées suicidaires. L’objectif de cette étude est d’évaluer l’intérêt d’un atelier de simulation avec des patients standardisés pour améliorer...
Article
Résumé En plus de l’impact psychologique du confinement et de l’épidémie, il existe des répercussions sur le sommeil qu’il faut prendre en compte par la mise en place de stratégies adaptées afin de maintenir un bon état de santé mental et de santé général. Le confinement peut désorganiser le sommeil en impactant d’une part les rythmes circadiens pa...
Article
Résumé A la fois le confinement lié au virus Covid-19 et le stress induit par la pandémie peuvent entraîner des perturbations importantes des rythmes et du sommeil. Des experts du sommeil de la section Sommeil et rythmes biologiques en Psychiatrie (SoPsy) de l’Association Française de Psychiatrie Biologique et de Neuropsychopharmacologie (AFPBN) et...
Article
Full-text available
Résumé Les effets psychologiques de l’isolement ont déjà été décrits dans la littérature (expéditions polaires, sous-marins, prison). Néanmoins l’échelle du confinement mis en œuvre à l’occasion de la pandémie à COVID-19 est inédite. Il nous faut non seulement relire les études publiées, mais aussi anticiper les problèmes psychologiques qui pourrai...