Pierre Denise

Pierre Denise
Université de Caen Normandie | UNICAEN · COMETE Inserm

M.D., Ph.D.

About

225
Publications
26,333
Reads
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3,809
Citations
Citations since 2017
38 Research Items
1536 Citations
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2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Additional affiliations
November 2013 - February 2014
January 2009 - present
French Institute of Health and Medical Research
Position
  • Professor
May 2005 - July 2005
Imperial College London
Position
  • Visitor Scientist

Publications

Publications (225)
Article
Full-text available
While the influence of the vestibular and extra-vestibular gravity signals on the cardiovascular system has been demonstrated, there is little evidence that visual stimuli can trigger cardiovascular responses. Furthermore, there is no evidence of interaction between visual and vestibular signals in autonomic control, as would be expected since they...
Article
Full-text available
We perceive the environment through an elaborate mental representation based on a constant integration of sensory inputs, knowledge, and expectations. Previous studies of astronauts on board the International Space Station have shown that the mental representation of space, such as the perception of object size, distance, and depth, is altered in o...
Preprint
Full-text available
While the influence of the vestibular and extra-vestibular gravity signals on the cardiovascular system has been demonstrated, there is little evidence that visual stimuli can trigger cardiovascular responses. Furthermore, there is no evidence of interaction between visual and vestibular signals in autonomic control, as would be expected since they...
Article
New findings: What is the central question of this study? What is the effect of exercise countermeasure on microgravity-induced change in cerebral blood flow? What is the main finding and its importance? Jump exercise training as a countermeasure did not modify this heterogeneous cerebral blood flow response to the HDBR, suggesting that this metho...
Article
Animal and human studies demonstrate anatomical and functional links between the vestibular nuclei and the circadian timing system. This promotes the hypothesis of a circadian rhythm of vestibular function. The objective of this study was to evaluate the vestibular function through the vestibulo-ocular reflex using a rotatory chair at different tim...
Article
Full-text available
The vestibular system is responsible for sensing every angular and linear head acceleration, mainly during periods of motor activity. Previous animal and human experiments have shown biological rhythm disruptions in small rodents exposed to a hypergravity environment, but also in patients with bilateral vestibular loss compared to a control populat...
Article
Full-text available
Input from the light/dark (LD) cycle constitutes the primary synchronizing stimulus for the suprachiasmatic nucleus (SCN) circadian clock. However, the SCN can also be synchronized by non-photic inputs. Here, we hypothesized that the vestibular system, which detects head motion and orientation relative to gravity, may provide sensory inputs to sync...
Article
Full-text available
As we move through an environment the positions of surrounding objects relative to our body constantly change. Maintaining orientation requires spatial updating, the continuous monitoring of self-motion cues to update external locations. This ability critically depends on the integration of visual, proprioceptive, kinesthetic, and vestibular inform...
Article
Aerobatic flight is a challenge for the vestibular system, which is likely to lead to adaptive changes in the vestibular responses of pilots. We investigated whether aerobatic pilots, as individuals who experience intense vestibular stimulation, present modifications of the vestibular-ocular reflex, motion sickness susceptibility and intensity, vis...
Article
New findings: • What is the central question of this study? It has been demonstrated that there was a heterogeneous cerebral blood flow (CBF) response in the cerebral arteries during several physiological conditions and it may be owing to differing physiological properties. However, a whole cerebral hemodynamic response to weightlessness remains u...
Poster
Full-text available
This study assessed cardiovascular control during Head Down Neck Flexion (HDNF) in a group of patients suffering from total bilateral idiopathic vestibular loss (BVL) for 7 ± 4 years. Nine adult patients (age 53.6 ± 11.5 years) with BVL were recruited. Calf blood flow (CBF), mean arterial pressure (MAP), heart rate (HR) were measured with eyes clos...
Article
Full-text available
Galvanic vestibular stimulation (GVS) is a non-invasive method used to stimulate the vestibular system. The vestibular system includes the sensors, neural pathways, vestibular nuclei and the cortical areas receiving integrated vestibular inputs. In addition to its role in postural control or gaze stabilization, the vestibular system is involved in...
Article
Full-text available
[This corrects the article DOI: 10.3389/fnsys.2019.00014.].
Data
Anxiety score and Graybiel score for time and session factors for all participants.
Article
Among possible causes of visual impairment or headache experienced by astronauts in microgravity or post-flight and that hamper their performance, elevated intracranial pressure (ICP) has been invoked, but never measured for lack of non-invasive methods. The goal of this work was to test two noninvasive methods of ICP monitoring using in-ear detect...
Article
Full-text available
New findings: What is the central question of this study? It is known that respiration is affected by graviceptors, but it remains unclear to what extent labyrinthine and non-labyrinthine graviceptors are involved in this process. What is the main finding and its importance? Our results suggest that the respiration modulation is not a result of a...
Article
Background: Sleep deprivation has been associated with an increased incidence of medical errors and can jeopardise patients' safety during medical crisis management. The aim of the study was to assess the effect of sleep deprivation on the management of simulated anaesthesia crisis by residents in anaesthesiology. Methods: A randomised, comparat...
Article
To understand the impact of physical deconditioning with head-down tilt bed rest (HDBR) on the malleability of sympathetic discharge patterns, we studied a) baseline integrated muscle sympathetic nerve activity (MSNA; microneurography) from 13 females participating in the WISE-2005 60-day HDBR study (Female, retrospective analysis), b) integrated M...
Article
We have recently demonstrated that heterogeneous cerebral blood flow (CBF) response in each cerebral artery may contribute to the maintenance of circulatory homeostasis in the brain. However, to what extent weightlessness associated with fluid shift from peripheral to central circulations influences distribution of CBF in each cerebral artery remai...
Article
Full-text available
Elhers-Danlos syndrome (EDS) is the clinical manifestation of connective tissue disorders, and comprises several clinical forms with no specific symptoms and selective medical examinations which result in a delay in diagnosis of about 10 years. The EDS hypermobility type (hEDS) is characterized by generalized joint hypermobility, variable skin hype...
Article
Both parabolic flight, i.e. a condition of altered gravity, and loss of vestibular function, have been suggested to affect spatial learning and memory, which is known to be influenced by neurogenesis in the hippocampus. In this study we investigated whether short alternated micro- and hyper-gravity stimulations during parabolic flight and/or loss o...
Article
BACKGROUND: The objective was to determine if short term exposure to dry immersion (DI) results in a cephalic fluid shift similar to what has been observed with spaceflight. METHODS: Data were collected from 10 individuals at rest and during the first 2 h of dry immersion. Jugular vein (JV), portal vein (PV), and thyroid volume were measured using...
Article
Full-text available
Constant velocity Off-Vertical Axis Rotation (OVAR) imposes a continuously varying orientation of the head and body relative to gravity, which generates a modulation of horizontal (conjugate and vergence), vertical, and torsional eye movements. We introduced the head-turn-on-trunk paradigm during OVAR to examine the extent to whether the modulation...
Article
Introduction: Zero-G parabolic flight reproduces the weightlessness of space for short periods. However, motion sickness may affect some fliers. The aim was to assess the extent of this problem and to find possible predictors and modifying factors. Methods: Airbus zero-G flights consist of 31 parabolas performed in blocks. Each parabola consiste...
Article
Full-text available
Three electrophysiological endophenotypes are routinely studied in schizophrenia: smooth pursuit eye movement (SPEM) dysfunction, deficits in P50 auditory-evoked potential inhibition, and saccadic inhibition deficits. The current study aimed to investigate the relationship between the COMT val158met polymorphism and these three endophenotypes. One...
Article
Permanent vestibular loss has detrimental effects on the hippocampus, resulting in a disruption to spatial learning and memory, hippocampal theta rhythm and place cell field spatial coherence. Little is known about the vestibular system-related hippocampal cholinergic transmission. Since the pharmacological blockade of muscarinic acetylcholine rece...
Article
Full-text available
Background: New insights have expanded the influence of the vestibular system to the regulation of circadian rhythmicity. Indeed, hypergravity or bilateral vestibular loss (BVL) in rodents causes a disruption in their daily rhythmicity for several days. The vestibular system thus influences hypothalamic regulation of circadian rhythms on Earth, wh...
Data
The individual data points of participants. As explained in the journal instruction, this file provides the individual data points of participants for circadian rhythms, sleep and actigraphy. (XLSX)
Poster
Full-text available
ID: 236 / Poster session 06/06: 9 Poster Presentation Topics: Neuroscience research (including neurovestibular and neuroendocrine systems) Does the vestibular system influences circadian rhythmicity ? Tristan Martin1,2,3, Stéphane Besnard1,2,3, Damien Davenne1,2,3, Benoit Mauvieux1,2,3, Sébastien Moussay1,2,3, Jan Bulla4, Antoine Gauthier1,2,3, Pie...
Chapter
Les technologies d’assistance facilitent la communication et favorisent la mobilité. Le système développé Head-Pilot permet le pilotage d’un ordinateur par mouvement de tête grâce à une webcam. Il présente comme avantages (i) de pouvoir être utilisé avec des outils informatiques déjà utilisés par les personnes en situation de handicap et (ii) il s’...
Article
Full-text available
In the nineteenth century Pierre–Jean–Marie Flourens (1825) and Ernst Mach described the vestibular system and its peripheral organs while Robert Barany, rewarded by the Nobel prize in 1914, was the first to investigate vestibular disorders with caloric tests making surgical treatments of the vestibular organ possible. Recently, Graf and Klam (2006...
Article
Full-text available
Introduction Le syndrome d’Ehlers-Danlos (SED) est l’expression clinique d’atteintes du tissu conjonctif. Sa forme hypermobile (SEDh) s’exprime principalement à travers l’hyperlaxité articulaire, source de troubles proprioceptifs. Cette étude visait à évaluer : – les conséquences de ces troubles sur l’intégration sensori-motrice dans le contrôle po...
Chapter
L'utilisation d'un véhicule associé à la consommation de psychotropes relève de pratiques relativement courantes (21% des causes d'accident en 2013 selon l'Observatoire National Interministériel de Sécurité Routière). Les données épidémiologiques et les pourcentages de consommation de médicaments ne permettent pas de faire un lien de causalité dire...
Article
Systemic blood distribution is an important factor involved in regulating cerebral blood flow (CBF). However, the effect of an acute change in central blood volume (CBV) on CBF regulation remains unclear. To address our question, we sought to examine the CBF and systemic hemodynamic responses to microgravity during parabolic flight. Twelve healthy...
Article
Full-text available
Introduction: Despite its high incidence and severe morbidity, the physiopathogenesis of adolescent idiopathic scoliosis (AIS) is still unknown. Here, we looked for early anomalies in AIS which are likely to be the cause of spinal deformity and could also be targeted by early treatments. We focused on the vestibular system, which is suspected of a...
Research
Full-text available
Flow cytometry allows single cell analysis through specific fluorescent markers covering numerous fields of research and clinical application mainly in hematology, immunology and cancer. Additionally, flow cytometry extracts stem cells from healthy or tumoral cerebral tissue for pharmacological studies but remains poorly used in receptors and neuro...
Research
Full-text available
Vestibular system is the sense organ of equilibrium involved in postural control and occulomotricity and additionally in spatial navigation in our environment. Indeed, it has been recently shown that vestibular loss decreased spatial memory performances in human and rodent with a structural impact on hippocampus in human. However, neurotransmitters...
Article
The vestibular system is a small bilateral structure located in the inner ear, known as the organ of balance and spatial orientation. It senses head orientation and motion, as well as body motion in the three dimensions of our environment. It is also involved in non-motor functions such as postural control of blood pressure. These regulations are m...
Article
Full-text available
Objective: To assess the specific prefrontal activity in comparison to those in the other main cortical areas in primary insomnia patients and in good sleepers. Methods: Fourteen primary insomnia patients and 11 good sleepers were included in the analysis. Participants completed one night of polysomnography in the sleep lab. Power spectra were c...
Book
L'utilisation d'un Îhicule associé à la consommation de psychotropes relève de pratiques relativement courantes (21% des causes d'accident en 2013 selon l'Observatoire National Interministériel de Sécurité Routière). Les données épidémiologiques et les pourcentages de consommation de médicaments ne permettent pas de faire un lien de causalité direc...
Article
Full-text available
Hypergravity disrupts the circadian regulation of temperature (Temp) and locomotor activity (Act) mediated through the vestibular otolithic system in mice. In contrast, we do not know if the anatomical structures associated with vestibular input are crucial for circadian rhythm regulation at 1G on Earth. In the present study we observed the effects...
Conference Paper
Full-text available
Décrit classiquement comme l’organe de l’équilibre, le système vestibulaire (SV) aurait un rôle dans la régulation de la rythmicité biologique. C’est pour confirmer ce rôle que notre équipe a étudié l’impact de la suppression du SV chez le rat et chez l’homme et ensuite l’impact d’une stimulation vestibulaire sur les rythmes. Chez le rat, une lésio...
Article
Introduction L’intérêt fonctionnel des techniques de rééducation de la négligence spatiale unilatérale (NSU) est discuté. Quelques études rapportent un effet de la stimulation galvanique vestibulaire (SGV) pour traiter la NSU. Nous cherchons à déterminer si l’effet de la SGV persiste à l’arrêt des stimulations. Patients et méthode Cette étude incl...
Poster
Full-text available
The vestibular system encoding head rotation velocity, linear acceleration and gravity level has recently been highlighted as a potential non-photic time cue for the circadian system when stimulated by centrifugation or after vestibular loss in rodent. However, it is still unknown in what extend it might interact with circadian rhythms in humans. T...
Article
Declarative memory refers to a spatial strategy using numerous sources of sensory input information in which visual and vestibular inputs which are assimilated in the hippocampus. In contrast, procedural memory refers to a response strategy based on motor skills and familiar gestures and involves the striatum. Even if vestibular loss impairs hippoc...
Article
Spatial disorientation is defined as an erroneous body orientation perceived by pilots during flights. Limits of the vestibular system provoke frequent spatial disorientation mishaps. Although vestibular spatial disorientation is experienced frequently in aviation, there is no intuitive countermeasure against spatial disorientation mishaps to date....
Article
The aim of this study was to evaluate the relationship between olfaction and motion sickness. A sample of 18 participants was recruited and submitted to 3 sessions of nauseogenic stimulations, Off Vertical Axis Rotation (OVAR), performed under conditions of olfactory stimulation with limonene (pleasant odor), petrol (unpleasant odor) or distilled w...
Article
Full-text available
Study objectives: To evaluate driving performance and psychomotor vigilance in patients with primary insomnia. Design: After 1 night of polysomnography, participants performed a 1-h simulated monotonous driving task and a psychomotor vigilance task (PVT). Self-ratings of sleepiness, mood, and driving performance were completed. Setting: This s...
Article
The aim of the present study was to investigate (1) the relative contribution of the egocentric reference as well as body orientation perception to visual horizon percept during tilt or during increased gravito-inertial acceleration (GiA, hypergravity environment) conditions and (2) the role of vestibular signals in the inter-individual differences...
Article
The aim of the present study was to investigate (1) the relative contribution of the egocentric reference as well as body orientation perception to visual horizon per- cept during tilt or during increased gravito-inertial accel- eration (Gia, hypergravity environment) conditions and (2) the role of vestibular signals in the inter-individual differ-...
Article
Full-text available
Several studies have suggested that anxiety may play a role in motion sickness susceptibility (MSS) variability. This study aimed to assess motion sickness susceptibility in healthy subjects and chronic vestibular patients and to investigate its relationship to gender, age and trait-anxiety. Healthy subjects (n = 167) and chronic dizzy patients wit...
Article
Full-text available
The vestibular system undergoes considerable modification during spaceflight [5]. This is paralleled by microgravity-induced muscle atrophy [6]. However, the possibility of vestibulo-autonomic regulatory mechanisms affecting skeletal muscle structure and function have not yet been addressed. We hypothesise that the vestibular system affects anti-gr...
Poster
Full-text available
All living organisms have endogenous biological timing mechanisms that regulate behavior and physiology. These biological rhythms such as body temperature (Tb) are controlled both by endogenous master clock and synchronized by external factors such as light/dark cycle (LD cycle), physical and social activities. Others parameters such as gravity has...
Article
Bone remodeling allows the conservation of normal bone mass despite constant changes in internal and external environments. The adaptation of the skeleton to these various stimuli led credence to the notion that bone remodeling is a true homeostatic function, and as such is under the control of specific centers in the central nervous system (CNS)....