Pierre Cremieux

Pierre Cremieux
Analysis Group

About

91
Publications
6,941
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
2,950
Citations
Citations since 2017
8 Research Items
869 Citations
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150
2017201820192020202120222023050100150

Publications

Publications (91)
Article
Full-text available
In September 2015, the World Health Organization updated their guidelines to recommend antiretroviral therapy (ART) for all people living with HIV. Countries are now in the process of implementing strategies to provide universal HIV treatment. We analyzed the rate of retention and time to ART eligibility (according to 2013 WHO guidelines) among 3,3...
Article
Setting: Haiti has the highest burden of tuberculosis (TB) in the Americas, with an estimated prevalence of 254 per 100 000 population. The Haitian Group for the Study of Kaposi's Sarcoma and Opportunistic Infections (Groupe Haïtien d'Etude du Sarcome de Kaposi et des Infections Opportunistes, GHESKIO) conducted active case finding (ACF) for TB at...
Article
Full-text available
Background: Attrition during the period from HIV testing to antiretroviral therapy (ART) initiation is high worldwide. We assessed whether same-day HIV testing and ART initiation improves retention and virologic suppression. Methods and findings: We conducted an unblinded, randomized trial of standard ART initiation versus same-day HIV testing a...
Data
HIV medication readiness scale. (PDF)
Article
Full-text available
BACKGROUND: In 2011, fee-for-service patients with both Medicare and Medicaid (dual eligible) sustained $319.5 billion in health care costs. OBJECTIVE: To describe the emergency department (ED) use and hospital admissions of adult dual eligible patients aged under 65 years who used an urban safety net hospital. METHODS: This was a retrospective dat...
Article
Full-text available
Purpose: To compare the patient characteristics and the inter-temporal reporting patterns of adverse events (AEs) for atorvastatin (Lipitor(®) ) and sibutramine (Meridia(®) ) in social media (AskaPatient.com) versus the FDA Adverse Event Reporting System (FAERS). Methods: We identified clinically important AEs associated with atorvastatin (muscl...
Article
Full-text available
Objective: We assessed the association between gender and mortality on antiretroviral therapy (ART) using identical models with and without sex-specific categories for weight and hemoglobin. Design: Cohort study of adult patients on ART. Setting: GHESKIO Clinic in Port-au-Prince, Haiti. Participants: 4,717 ART-naïve adult patients consecutiv...
Article
Full-text available
Despite consistently supportive evidence of clinical effectiveness and economic advantages compared with currently available non-surgical obesity treatments, patient access to bariatric and metabolic surgery (BMS) is impeded. To address this gap and better understand the relationship between value and access, the objectives of this study were twofo...
Article
Background: Treatment protocols and prices of antiretroviral therapy (ART) have changed over time. Yet, limited data exist to evaluate the impact of these changes on patient outcomes and treatment costs in resource-poor settings. Methods: We compared patient-level data on outcomes, utilization, and cost for the first 2 years of ART for a cohort...
Article
Diabetes mellitus imposes a large economic burden on individuals and national healthcare systems worldwide. People with type 2 diabetes incur medical costs 2 to 3 times higher than individuals without diabetes. Treatment of type 2 diabetes with conventional lifestyle modification programs and antihyperglycemic medications often fails to achieve lon...
Article
The medical costs for a type 2 diabetes patient are two to four times greater than the costs for a patient without diabetes. Bariatric surgery is the most effective weight-loss therapy and has marked therapeutic effects on diabetes. We estimate the economic effect of the clinical benefits of bariatric surgery for diabetes patients with BMI ≥ 35 kg/...
Article
The risks and benefits of bariatric surgery have rarely been evaluated in large multiyear patient samples. This study identifies the short- and long-term impact of bariatric surgery on comorbidities and medication use among obese patients. A comprehensive analysis of 5,502 obese patients who underwent bariatric surgery was performed. Submissions of...
Article
BACKGROUND: Diabetes mellitus is a chronic disease associated with a significant burden on individuals and society. Type 2 diabetes accounts for 90 to 95% of all diagnosed cases. Weight gain and obesity are major risk factors for type 2 diabetes with studies showing that every 1 kilogram increase in body weight increases the risk of diabetes by app...
Article
To assess effects of antidepressant treatment compliance on health care and workplace costs. By using workplace survey data linked to two employers' health care claims, employees with depression/antidepressant claims were categorized into noncompliant/compliant groups. Annualized costs were compared between compliance groups, for the employees with...
Article
The US Food and Drug Administration (FDA) considers generic and branded drugs to be therapeutically equivalent if they are pharmaceutically equivalent and bioequivalent. The American Academy of Neurology (AAN) disagrees and opposes generic substitution of branded antiepileptic drugs (AEDs) without physician and patient approval due to the risk of l...
Article
The study objective is to compare the annual total medical and indirect costs of newly treated and untreated employees with multiple sclerosis (MS). A retrospective database analysis of employer medical, drug, and disability claims database (Ingenix Employer database, 1999-2005; 17 large US companies) was conducted for employees 18-64 years of age...
Article
In this article, we perform a quantitative analysis of the performance of hospital services in a nonmarket environment based on a very complete data set. Evaluating efficiency in a nonmarket system is important since the absence of market mechanisms could yield large inefficiencies. In fact, we show that hospital performance varies greatly across i...
Article
Full-text available
Recently, meta-analysis has been widely utilized to combine information across comparative clinical studies for evaluating drug efficacy or safety profile. When dealing with rather rare events, a substantial proportion of studies may not have any events of interest. Conventional methods either exclude such studies or add an arbitrary positive value...
Article
Full-text available
To evaluate the private third-party payer return on investment for bariatric surgery the United States. Morbidly obese patients aged 18 years or older were identified in an employer claims database of more than 5 million beneficiaries (1999-2005) using International Classification of Diseases, Ninth Revision, Clinical Modification code 278.01. Each...
Article
Generic substitution of antiepileptic drugs (AEDs) may increase pharmacy utilization, thus counterbalancing per-pill savings. The purpose of our study was to analyze the economic impact of government-mandated switching from branded to generic lamotrigine. Patients in a Canadian public pharmacy claims database using branded lamotrigine (Lamictal Gla...
Article
The purpose of this study was to review and analyze current research to evaluate the dose ratio of epoetin alfa and darbepoetin alfa for the treatment of anemia in chronic kidney disease (CKD) and to identify determinants of the variation in epoetin alfa:darbepoetin alfa dose ratios across studies. A systematic review of the literature for comparat...
Article
17514 Background: Not adhering to treatment (tx) may lead to suboptimal outcomes. This study examined associations between medical costs and IM compliance in CML pts. Methods: CML pts under age 65 were identified with ICD-9 diagnosis code (205.1X) using MarketScan Commercial Claims data between 1/1/02–12/31/05. Pts were required to be continuously...
Article
Full-text available
Using newly collected firm-level data, this paper analyzes the effect of mergers on the earnings and employment of pilots, flight attendants, and mechanics in the US airline industry between 1971 and 1990. The results show that mergers had a significant and largely negative impact on flight attendants’earnings but have a limited impact on mechanics...
Article
Improving Cardiovascular Outcomes in Nova Scotia (ICONS) was a five-year, community partnership-based disease-management project that sought, as a primary goal, to improve the care and outcomes of patients with heart disease in Nova Scotia. This program, based on a broad stakeholder partnership, provided repeated measurement and feedback on practic...
Article
Drug expenditures per capita have drastically increased over the last quarter century in Canada, with a share of overall healthcare costs rising from 8.8% in 1980 to 16.8% in 2002. Pressure to curb expenditure on drugs has increased accordingly, but containing drug expenditure might increase costs elsewhere in the healthcare sector. To measure subs...
Chapter
Introduction In this chapter we review the current state of the literature on the value of pharmaceuticals and provide estimates of the value of pharmaceuticals in Canada following the Murphy and Topel (2005) methodology. Because this literature has become so vast and has morphed in so many different ways, we focus on a subset. Specifically, we rev...
Article
Full-text available
Using national survey data and risk equations from the Framingham Heart Study, we quantify the impact of antihypertensive therapy changes on blood pressures and the number and cost of heart attacks, strokes, and deaths. Antihypertensive therapy has had a major impact on health. Without it, 1999-2000 average blood pressures (at age 40+) would have b...
Article
To evaluate the relationship between hemoglobin (Hb) level and quality of life (QOL) in anemic patients with non-dialysis chronic kidney disease receiving epoetin alfa. A post-hoc analysis using data from a multicenter, open-label, prospective study of epoetin alfa for anemia in patients with chronic kidney disease not on dialysis was conducted. Th...
Article
To determine the dose-conversion ratio (DCR) between epoetin alfa and darb-epoetin alfa in cancer patients and compare the treatment costs of both agents at the estimated DCRs. A comprehensive search of the literature was carried out on clinical trials evaluating patients with chemotherapy-related anemia treated with epoetin alfa or darbepoetin alf...
Article
Full-text available
Estimating the value of medical innovation is a continual challenge. In this research, we quantify the impact of antihypertensive therapy on U.S. blood pressures, risk and number of heart attacks, strokes, and deaths. We also consider the potential for further improvements. We estimate the value of innovation using equations relating blood pressure...
Article
Full-text available
This paper develops flexibility measures in the context of a multi-firm output based on a generalized average cost function. We then apply this methodology to assess and compare the relative flexibility of hospital services in Québec and California based on two very complete data sets. Results indicate that there is no clear distinction between pri...
Article
Full-text available
An Erratum has been published for this article in Health Economics; 14(2): 117 (2005). Canadian per capita drug expenditures increased markedly in recent years and have become center stage in the debate on health care cost containment. To inform public policy, these costs must be compared with the benefits provided by these drugs. This paper measur...
Article
To estimate a dose-conversion ratio (DCR) between epoetin alfa (EPO) and darbepoetin alfa (DARB) and compare the costs of both drugs at the estimated DCRs using average wholesale prices (AWPs). A search of PUBMED, CANCERLIT and references for papers and abstracts reporting on clinical trials of DARB or EPO for chemotherapy-related anaemia (CRA) ide...
Article
Full-text available
For individuals with chemotherapy-related anemia, the clinical effectiveness of epoetin alfa (EPO) dosed once weekly ([QW], 40,000 units per dose) has been demonstrated to be indistinguishable from that observed with thrice-weekly dosing ([TIW], 10,000 units per dose). Whether the advantage of less-frequent administration justifies the higher EPO d...
Article
The purpose is to analyze the incidence and costs of accidents among Attention-Deficit/Hyperactivity Disorder (ADHD) patients. The analysis relied on administrative medical, pharmaceutical, and disability claims for a national manufacturer's employees, spouses, dependents, and retirees (n > 100,000). Accidental injuries were identified using ICD-9...
Article
This study in patients with cancer and anemia, who were receiving chemoradiation and were treated with epoetin alfa, examined the relationship between hemoglobin level and quality of life (QOL), change in hemoglobin and change in QOL, and incremental (1 g/dL) increase in hemoglobin and related incremental improvement in QOL. Data from a multicenter...
Article
This research proposes an approach to measure hospital performance based on a generalization of Banker and Morey (1986) and Frsund (1996). This approach considers quasi-fixed inputs explicitly, calculates their implicit cost, and quantifies returns to scale. The performance measure is decomposed into allocative and technical inefficiencies. Based o...
Article
Hemoglobin increases have been associated with quality of life (QOL) improvements in anemic cancer patients treated with epoetin alfa, but intervention generally has been reserved for symptomatic anemia or hemoglobin < 10 g/dL. Relationships among hemoglobin, functional status, and patient reported QOL have not been well characterized. Data from tw...
Chapter
Approximately 13 million Americans are diagnosed with cancer every year and the various therapies they receive are often as physically trying as the cancer itself [2, 26]. Pain, nausea, infection, and anemia are common and debilitating side effects experienced by many patients undergoing chemotherapy and radiotherapy. As attention has turned toward...
Article
This article presents a quantitative analysis of the production of hospital services in a nonmarket environment based on production theory and a very complete data set on the hospital industry. It provides both insights into the optimality of the hospital industry structure and a useful framework to evaluate the impact of anticipated industry struc...
Article
This article presents a quantitative analysis of the production of hospital services in a nonmarket environment based on production theory and a very complete data set on the hospital industry. It provides both insights into the optimality of the hospital industry structure and a useful framework to evaluate the impact of anticipated industry struc...
Article
Although previous studies have attempted to isolate the effect of pharmaceutical spending on health outcomes, most have been limited by analysis of inherently heterogeneous inter-country data. This study focuses on one particular health outcome — infant mortality at the state level in the U.S. — and shows that its important determinants include: (1...
Article
Full-text available
To examine the actual and anticipated costs of a law regulating workplace smoking and smoking in restaurants, taking into consideration observed and anticipated infrastructure costs, lost productivity, increased absenteeism, and loss of clientele. A survey of 401 Québec restaurants and 600 Québec firms conducted by the Québec Ministry of Health bef...
Article
This research examines the impact of omitted variables on the accuracy of parametric hospital cost function estimations based on Québec hospital level data. We assess the effect of omitted variables resulting from incomplete data on technology and performance measurement and on tests of the cost minimizing behavior of the institution. Our results s...
Article
Full-text available
RÉSUMÉ Dans cet article, nous présentons les résultats d’une analyse de l’efficience des CLSC à l’aide de la méthode DEA. Ces résultats confirment ceux obtenus avec l’approche économétrique publiés dans un précédent article : (1) les CLSC jouissent de forts rendements d’échelle et des économies de diversification pourraient être réalisées en augmen...
Article
Detailed data will be increasingly important in determining the cost of cancer care in the managed care setting. To estimate the full cost of cancer to a major employer in the United States and to determine the nature of the expenditures. Analysis of medical, pharmaceutical, and disability claims data from 1995 to 1997 for a major employer with mor...
Article
To determine the cost of outpatient RBC transfusion from the provider's perspective at a major urban, academic cancer center. We retrospectively studied 517 cancer patients with hematologic or solid tumors who received blood during fiscal year 1995 to 1996. A process-flow diagram was developed, and cost and utilization data for 12 months were colle...
Article
Background and Objective: A growing body of literature on the economics of depression concludes that this illness has an enormous impact on workplace performance. In addition to work cutback and sporadic absenteeism, the symptoms of depression also result in elevated rates of chronic absenteeism that manifest in the form of workplace disability. De...
Article
This paper examines whether a competitive model of the firm appropriately describes the behavior of hospitals in a non-market environment. This test is based on the best database yet available in the hospital sector. We show that properties of the non-market hospitals'cost functions are compatible with short-term, but not long-term, cost-minimizing...
Article
This paper revisits the relationship between health care spending and health outcomes. While previous researchers found it difficult to establish such a relationship based on international comparisons, the results based on rather homogenous province-specific Canadian data show that lower health care spending is associated with a statistically signi...
Article
The use of pharmacoeconomic tools has grown dramatically in the past decade as provision of healthcare throughout the industrialised world has required increased cost consciousness. However, pharmacoeconomic analysis has not yet been fully exploited as a conceptual underpinning for public or private health policy decisions. Pharmacoeconomics is lik...
Article
To measure the cost effectiveness of a supportive care intervention when the no-treatment option is unrealistic in an analysis of recombinant human erythropoietin (epoetin) treatment for anaemic patients with cancer undergoing chemotherapy. Further, to assess whether quality-adjusted life-years (QALYs) can provide the basis for an appropriate measu...
Article
The use of pharmacoeconomic tools has grown dramatically in the past decade as provision of healthcare throughout the industrialised world has required increased cost consciousness. However, pharmacoeconomic analysis has not yet been fully exploited as a conceptual underpinning for public or private health policy decisions. Pharmacoeconomics is lik...
Article
Objective: To measure the cost effectiveness of a supportive care intervention when the no-treatment option is unrealistic in an analysis of recombinant human erythropoietin (epoetin) treatment for anaemic patients with cancer undergoing chemotherapy. Further, to assess whether quality-adjusted life-years (QALYs) can provide the basis for an approp...
Article
Full-text available
Healthcare claims data are a practical complement to data from randomised controlled trials (RCTs) for evaluating health outcomes in non-experimental settings and for generalising results to a broader population. Claims data are a relatively inexpensive way to obtain useful information about patient demographics, as well as healthcare resources use...
Article
In this study, we focus on several potential determinants of provincial social assistance rates: the unemployment rate, the UI wage replacement rate and eligibility rules, the SA benefit level, the minimum wage, and the average industrial wage. Specifically, we try to quantify their respective contributions to observed fluctuations in provincial so...
Article
RÉSUMÉ Depuis quinze ans, on assiste à un effort considérable de mesure de la performance des hôpitaux. Cet effort ne s’est pourtant pas étendu aux autres types d’établissements de santé dont l’importance se trouve pourtant accrue par les transformations du réseau de santé suite aux difficultés budgétaires au Québec comme ailleurs. En particulier,...
Article
Despite a conducive environment, airline strike insurance did not significantly affect flight attendants’ and mechanics’ earnings and depressed pilots’ earnings by a barely statistically significant 3 percent. These results cast doubt on previous assertions that the demise of strike insurance, precipitated by the 1978 Airline Deregulation Act, impr...
Article
Previous studies of the effect of the 1978 Airline Deregulation Act on employee earnings have reported mixed results: some have found no negative long-run effect of deregulation and others have found a negative effect of up to 10%. Most of these studies relied on cross-sectional analysis of a few years' data. This paper, in contrast, examines the l...
Article
Previous studies of the effect of the 1978 Airline Deregulation Act on employee earnings have reported mixed results: some have found no negative long-run effect of deregulation and others have found a negative effect of up to 10%. Most of these studies relied on cross-sectional analysis of a few years' data. This paper, in contrast, examines the l...
Article
The US unemployment insurance system is experience rated. Firms using the system more often have to pay higher UI taxes in order to cover the additional burden imposed on the system. Experience rating introduces a tax on layoffs which is supposed to counterbalance the implicit layoff subsidy resulting from the UI system. In turn, this is expected t...
Article
Previous studies of the effect of the 1978 Airline Deregulation Act on employee earnings have reported mixed results: some have found no negative long-run effect of deregulation and others have found a negative effect of up to 10%. Most of these studies relied on cross-sectional analysis of a few years' data. This paper, in contrast, examines the l...

Network

Cited By