Pierre Boutouyrie

Pierre Boutouyrie
French Institute of Health and Medical Research | Inserm · Paris-Cardiovascular Research Center PARCC

Professor

About

621
Publications
156,846
Reads
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40,236
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Introduction
Pierre Boutouyrie is MD, Ph.D., specialized in Cardiovascular Medicine and Pharmacology. He currently works at Université de Paris, Assistance Publique Hôpitaux de Paris, and the Paris-Cardiovascular Research Center PARCC, French Institute of Health and Medical Research. Pierre Boutouyrie is head of Pharmacology department at Hôpital Européen Georges Pompidou. He does research in Hypertension, Rare vascular diseases, Spatial Medicine; Diabetology, Internal Medicine (General Medicine) and Cardiology. He leads many project, notably on arterial stiffness, atherosclerosis, cardiovascular adaptaiton to extreme conditions. Pierre Boutouyrie team is composed of PhD and postDoc students from many international origins, from the 5 continents.
Skills and Expertise

Publications

Publications (621)
Poster
Full-text available
Background/Introduction: Most studies on the association between sleep habits and cardiovascular disease (CVD) have focused on one single sleep dimension, essentially sleep duration and sleep apnea. Purpose: To examine the joint effect of several dimensions of sleep habits at baseline and over time with incident CVD (coronary heart disease or stro...
Article
Poor oral health has been linked to coronary heart disease (CHD). Clustering clinical oral conditions routinely recorded in adults may identify their CHD risk profile. Participants from the Paris Prospective Study 3 received, between 2008 and 2012, a baseline routine full-mouth clinical examination and an extensive physical examination and were the...
Article
Introduction Myocardial injury is frequently observed in patients hospitalized with Coronavirus disease 2019 (COVID-19) pneumonia. Different cardiac abnormalities have been reported during the acute COVID-19 phase but there is limited information on late cardiac sequelae in patients who have recovered from acute COVID-19 illness. Objective To docu...
Article
Background Experimental data have shown that some anticancer drugs can affect cardiac repolarization and induce life-threatening cardiac arrhythmias. Objective To identify anti-cancer drugs associated with the occurrence of sudden death (SD) and ventricular arrhythmias using the World Health Organization individual case safety report (ICSR) databa...
Article
Objectives Hearing impairment (HI) is a leading impairment worldwide and identifying modifiable risk factors of HI may have major public health implications. The aim of this study was to investigate the association between obstructive sleep apnea (OSA) and HI. Design Observational longitudinal study (the Paris Prospective Study 3). Setting Popula...
Article
Objectives Assessment of carotid-femoral pulse wave velocity by applanation tonometry independently predicts all-cause and cardiovascular mortality. However, there has been a need for a simpler, user-independent measurement with a validated device, that is applicable even in the primary care setting. Methods and subjects 4146 subjects (49% men) ag...
Article
Introduction Hypertension is one of the major contributors to cardiac diastolic dysfunction as observed in patients with heart failure and preserved ejection fraction. Different therapeutics strategies have been proposed to control blood pressure (BP) but their independent impact on cardiac function remain undetermined. In patients referred to our...
Article
Full-text available
Background/Introduction Increased pulse wave velocity (PWV), is a reliable marker of early vascular aging (EVA). However, the identification of individuals whose arteries are abnormally healthy in comparison to their age and cardiovascular (CV) risk profile might be of interest, to discover novel pathways of cardioprotection and provide preventive...
Article
Objective: Increased carotid stiffness and remodelling is reported in patients with moderate and advanced chronic kidney disease (CKD) and is associated with cardiovascular events. Here, we tested the hypothesis that carotid artery alterations start earlier, during mild CKD. Methods: Within the Paris Prospective Study 3, a large prospective obse...
Article
Objectives: Aortic distensibility estimation of local aortic stiffness is based on local aortic strains and central pulse pressure (cPP) measurements. Most MRI studies used either brachial PP (bPP) despite differences with cPP, or direct cPP estimates obtained after MRI examination, assuming no major pressure variations. We evaluated the feasibili...
Article
CKD frequently leads to chronic cardiac dysfunction. This complex relationship has been termed as cardiorenal syndrome type 4 or cardio-renal link. Despite numerous studies and reviews focused on the pathophysiology and therapy of this syndrome, the role of arterial stiffness has been frequently overlooked. In this regard, several pathogenic factor...
Article
Large artery stiffness is an index of vascular aging associated with cardiovascular mortality. Whereas traditional risk factors for arterial stiffness are known, the contribution of socioeconomic factors is less reported. We sought to determine the relationship between arterial stiffness and socioeconomic deprivation (at the individual and neighbor...
Article
Objective We aimed to investigate the association between cardiovascular health (CVH), as defined by the American Heart Association, and several sleep disturbances. Methods Two community-based cohorts, the Paris Prospective Study 3 (PPS3, France, n=6441) and the CoLaus study (Switzerland, n=2989) were analysed. CVH includes 7 metrics which all can...
Article
Background: Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder secondary to pathogenic variants within the COL3A1 gene, resulting in exceptional arterial and organ fragility and premature death. The only published clinical trial to date demonstrated the benefit of celiprolol on arterial morbimortality. Objectives:...
Article
Shear wave elastography and ultrafast imaging of the carotid artery pulse wave were performed in 27 normotensive participants and 29 age- and sex-matched patients with essential hypertension, and compared with reference techniques: carotid–femoral pulse wave velocity (cfPWV) determined via arterial tonometry and carotid stiffness (carPWV) determine...
Article
Full-text available
Insomnia symptoms are highly prevalent and associated with several adverse medical conditions, but only few determinants, including non-modifiable ones, have been highlighted. We investigated associations between body silhouette trajectories over the lifespan and insomnia symptoms in adulthood. From a community-based study, 7 496 men and women aged...
Article
Full-text available
Background Inflammatory bowel disease (IBD) is characterized by a low prevalence of traditional risk factors, an increased aortic pulse‐wave velocity (aPWV), and an excess of cardiovascular events. We have previously hypothesized that the cardiovascular risk excess reported in these patients could be explained by chronic inflammation. Here, we test...
Article
Arterial fibromuscular dysplasia is a nonatherosclerotic, noninflammatory vascular disease, whose pathophysiology is still unknown. We performed deep image-based vascular phenotyping of nonaffected arteries to look for systemic vascular alterations in fibromuscular dysplasia. This single center cross-sectional study included 50 patients with multif...
Chapter
Two concepts have gained a growing audience these last years: the pressure amplification between central and peripheral arteries in response to arterial stiffening and pressure wave reflection and the left ventricle (LV)-arterial system coupling in heart failure (notably with preserved ejection fraction also referred to as diastolic heart failure)...
Article
Introduction La fièvre méditerranéenne familiale (FMF) est une maladie autosomique récessive responsable d’une inflammation intercritique infraclinique. Une inflammation chronique infraclinique existe également chez les porteurs d’une seule mutation du gène responsable (MEFV). L’inflammation chronique est un facteur de risque d’athérosclérose et d’...
Conference Paper
Full-text available
Objective: PWV measurement devices are technically demanding, expensive and prone to artefacts, thus limiting the measurement of arterial stiffness in primary care. The CARDIS consortium developed a non-contact device based on the detection of skin movements induced by arterial pulses through a laser Doppler vibrometer (CARDIS-LDV). Our objective i...
Article
Full-text available
Background: Late-life depression is related to poor quality of life and increased risk of mortality and cardiovascular disease. Effective interventions for prevention and treatment of late-life depression need to be developed, which requires a better understanding of late-life depression risk factors. Arterial stiffness may contribute to late-life...
Conference Paper
Full-text available
Background: Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory vascular disease involving medium-sized muscular arteries, whose pathophysiology is still unknown. Objectives: We aimed at identifying systemic vascular alterations in usually non-affected arteries of patients with multifocal renal FMD by a deep imaging-based pheno...
Article
Vascular aging is a major contributor to cardiovascular disease and can be quantified by higher carotid stiffness, intima-media thickness and diameter, and hypertension. Weight gain across the lifetime may be an important, modifiable determinant of vascular aging. We therefore aimed to assess lifetime body silhouette trajectories (a marker of weigh...
Article
Full-text available
Increasing evidence points out at vascular stiffness (and in particular aortic stiffness measured by pulse wave velocity) as a reliable biomarker of vascular aging, able to integrate in a single measure the overall burden of cardiovascular (CV) risk factors on the vasculature over time; furthermore, it may be per se a mechanism of disease, by induc...
Article
Background: Arterial stiffness may contribute to late-life depression via cerebral microvascular damage, but evidence is scarce. No longitudinal study has evaluated the association between arterial stiffness and risk of depressive symptoms. Therefore, we investigated the association between carotid artery stiffness and incident depressive symptoms...
Article
Introduction: Late-life depression is related to poor quality of life, functional impairment, and increased risk of mortality and cardiovascular disease. Effective interventions for prevention and treatment of late-life depression need to be developed, which requires a better understanding of late-life depression risk factors. Arterial stiffness, a...
Article
Background: Physical activity (PA) is beneficial for baroreflex sensitivity (BRS), but it is unclear whether the type of PA has similar effects on the neural (nBRS) or vascular (carotid stiffness) components of BRS. We sought to determine this in healthy adults from a community- based study via assessment of occupational (OPA), sport (SPA), leisure...
Poster
Background: Vascular aging, i.e. accumulation of functional and structural changes of vessels throughout life, is a major contributor to cardiovascular disease. It can be quantified by higher carotid stiffness, intima-media thickness and diameter, and hypertension. Weight gain across the lifetime may be an important, modifiable determinant of vascu...
Article
RÉSUMÉ La France a depuis plus de 50 ans, une longue tradition de soins et de recherche dans le domaine de l’hypertension artérielle (HTA) à l’initiative de cliniciens chercheurs qui ont su réunir les centres de soins, des laboratoires expérimentaux et des unités de recherche clinique pour initier, soutenir et développer la recherche en HTA. Ces ac...
Article
Full-text available
Use of intima-media thickness in the assessment of the development of preclinical atherosclerosis R.N.N. Najafov
Article
The aim of this study, enrolling 118 patients, was to clinically evaluate the accuracy of carotid pulse waveform acquisition with a new non-invasive optical fiber probe using invasive and non-invasive pressure readings as references. Pulse waves were acquired simultaneously in the ascending aorta and right common carotid; for the non-invasive study...
Article
Full-text available
In the general population aortic stiffening, assessed by carotid femoral pulse wave velocity (cf‐PWV), is associated with cognitive dysfunction (CO/DY). Data in chronic kidney disease (CKD) are limited. This study tests the hypothesis that large artery stiffness and microvascular damage in CKD patients are related to the damage of brain microcircul...
Article
Objectives: Central pulse pressure (PP) has been suggested a better predictor of cardiovascular risk than brachial PP, and its routine noninvasive assessment can be useful for risk stratification. The present study evaluated the capability of a radiofrequency-based carotid wall tracking to estimate central PP from distension curves, comparing the...
Article
Objective: Arterial ageing is characterized by increasing arterial stiffness as measured by pulse wave velocity (PWV). This process is enhanced in participants with early vascular ageing (EVA), but slowed in participants with healthy vascular ageing (HVA). We aimed to describe characteristics of EVA and HVA in a transcontinental study including 11...
Article
Dear editor, dear referees, please find below the point to point responses to the review of our reply on comments (RE: PMEA-102395) entitled: NUMERICAL ASSESSMENT AND COMPARISON OF PULSE WAVE VELOCITY METHODS AIMING AT MEASURING AORTIC STIFFNESS. We addressed all the questions and tried to modify the text each time it was possible. We hope that our...
Article
Introduction: Arterial stiffness is recognized as an intermediate phenotype and predictor of cardiovascular disease. Arterial stiffness is complex in origin with contributions from lifestyle and genetic factors. However, the association between single nucleotide polymorphisms (SNPs) and arterial stiffness remains unclear. Objective: The aim is t...
Article
Background: We hypothesized that subjects with a high level of perceived stress would be less likely to have ideal cardiovascular health (CVH). Methods: CVH was estimated using the 7-item tool developed by the American Heart Association. Perceived stress was measured using the validated 4-item Perceived Stress Scale at baseline and after 4 years of...
Article
Carotid arterial diameter enlargement is a manifestation of arterial remodeling and may be a risk factor for cardiovascular disease (CVD). We evaluated the association between carotid artery diameter and risk of stroke, coronary heart disease, CVD, and all-cause mortality and explored whether the associations could be explained by processes involve...
Article
Background: Predictive factors associated with normal blood pressure (BP) after unilateral adrenalectomy for primary aldosteronism (PA) are not clearly identified. Aims: To evaluate the predictive value of arterial stiffness before surgery on BP after surgery. Methods: During 2009-2013, 96 patients with PA due to unilateral adrenal adenoma who...
Article
Full-text available
Objectives Excessive daytime sleepiness (EDS) is a common sleep complaint in the population and is increasingly recognised as deleterious for health. Simple and sensitive tools allowing identifying individuals at greater risk of EDS would be of public health importance. Hence, we determined trajectories of body silhouette from early childhood to ad...
Article
Background: Heart failure is a serious event in patients with transposition of the great arteries (D-TGA) after atrial redirection surgery. We aimed to determine the association between myocardial fibrosis and systolic and diastolic systemic right ventricle (sRV) dysfunction. Methods: Diastolic and systolic function of sRV was prospectively asse...
Article
Full-text available
Background: Left ventricular (LV) remodeling and aortic stiffness have independent predictive value for all causes and cardiovascular mortality. Because elastic properties of the arterial wall vary along the aortic pathway, we hypothesized that local and regional aortic stiffness could differently impact on LV remodeling. Methods and results: Re...
Article
Full-text available
Aims Dilated cardiomyopathy (DCM) is an important cause of heart failure with a strong familial component. We performed an exome-wide array-based association study (EWAS) to assess the contribution of missense variants to sporadic DCM. Methods and results Overall, 116,855 single nucleotide variants (SNVs) were analyzed in 2796 DCM patients and 687...
Article
Background Arterial pulse wave velocity and pulse waveform analysis have become an established component of cardiovascular research. As validation and assessment of devices is not always trivial in an in vivo setting, arterial network computer models may be useful for that purpose. It is, however, mandatory that the model includes sufficient detail...
Article
Analysis of the contour of the peripheral pulse to assess arterial properties was first described in the nineteenth century. The reference technique to estimate central blood pressure (CBP), non-invasively, is by analyzing the radial pressure pulse acquired using a tonometer and then to establish a transfer function relating the radial pressure to...
Article
Aims: People with exaggerated exercise blood pressure (BP) have adverse cardiovascular outcomes. Mechanisms are unknown but could be explained through impaired neural baroreflex sensitivity (BRS) and/or large artery stiffness. This study aimed to determine the associations of carotid BRS and carotid stiffness with exaggerated exercise BP. Methods...