Piaopiao Li

• Master of Science
• University of Florida

OBJECTIVE The Diabetes in Children, Adolescents, and Young Adults (DiCAYA) network seeks to create a nationwide electronic health record (EHR)-based diabetes surveillance system. This study aimed to develop a DiCAYA-wide EHR-based computable phenotype (CP) to identify prevalent cases of diabetes. RESEARCH DESIGN AND METHODS We conducted network-wi...

Objective Time in range (TIR) is an important metric to measure variability of blood glucose levels. The aim is to quantify the long‐term health benefits and economic return associated with improved TIR for individuals with type 2 diabetes (T2D). Method A Markov model with three states (T2D, T2D with cardiovascular disease (CVD) and death) estimat...

This pooled cross-sectional study explores prescribing rates for glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter 2 inhibitors among US patients with type 1 diabetes.

Aim To develop an automated computable phenotype (CP) algorithm for identifying diabetes cases in children and adolescents using electronic health records (EHRs) from the UF Health System. Materials and Methods The CP algorithm was iteratively derived based on structured data from EHRs (UF Health System 2012–2020). We randomly selected 536 presume...

Aim Dysglycaemia accelerates cognitive decline. Intensive glucose control may help delay or prevent cognitive function decline (CFD). We aimed to determine how patient characteristics influence the effect of intensive glucose control [glycated haemoglobin (HbA1c) <6.0%] on delaying CFD in people with type 2 diabetes. Research design and methods In...

Aim To examine the associations between low cognitive performance (LCP) and diabetes‐related health indicators (including body mass index [BMI], HbA1c, systolic blood pressure [SBP], low‐density lipoprotein [LDL] and self‐reported poor physical health) and whether these associations vary across racial/ethnic subgroups. Methods We identified adults...

Introduction: Hypoglycemia is a potential side effect of Intensive Glycemic Control (IGC) in diabetes management. We aimed to investigate whether individuals with certain GLP1R gene variations were at greater hypoglycemia risk with IGC. Methods: A dynamic cohort design with time-varying exposures was employed using electronic health records linked...

New evidence highlights GLP-1 RAs' significant benefits in blood glucose and weight control for those with T2D and/or obesity, yet their real-world use and related disparities are unexplored. We conducted a pooled cross-sectional study using electronic health records from the Epic Cosmos database (2010-2023), an integrated database covering 176 mil...

Aim The action to control cardiovascular risk in diabetes (ACCORD) trial showed a neutral average treatment effect of intensive blood glucose and blood pressure (BP) controls in preventing major adverse cardiovascular events (MACE) in individuals with type 2 diabetes. Yet, treatment effects across patient subgroups have not been well understood. We...

Objective Having sufficient population coverage from the electronic health records (EHRs)-connected health system is essential for building a comprehensive EHR-based diabetes surveillance system. This study aimed to establish an EHR-based type 1 diabetes (T1D) surveillance system for children and adolescents across racial and ethnic groups by ident...

Depression, commonly treated with antidepressants, is associated with an increased risk of dementia, especially in older adults. However, the association between antidepressant use and dementia risk is unclear. We searched for randomized controlled trials and observational studies from PubMed, Embase, and Cochrane on 1 February 2022, restricting to...

Aims To quantify the incremental health and economic burden associated with cognitive impairment (CI) among non‐institutionalized people with diabetes ≥65 years in the United States. Materials and Methods Using 2016‐2019 Medical Expenditure Panel Surveys data, we identified participants ≥65 years with diabetes. We used propensity score weighting t...

The DiCAYA Network, which is funded by the CDC and NIDDK, is working to create a nationwide electronic health record-based diabetes surveillance system. The feasibility and performance of existing diabetes computable phenotypes in this system were unknown, as they had only been tested in individual health systems. This study aimed to develop a DiCA...

Objective: To examine changes in racial and ethnic disparities in glucose-lowering drugs (GLD) use and HbA1c in US adults with diabetes from 2005 to 2018. Methods: We conducted pooled cross-sectional analysis using data from the 2005-2018 Medical Expenditure Panel Surveys, and the 2005-2018 National Health and Nutrition Examination Survey. Indiv...

The Assessing the Burden of Diabetes by Type in Children, Adolescents, and Young Adults (DiCAYA) Network, a CDC/NIDDK-funded collaborative, aims to create a multi-site electronic health record (EHR) -based diabetes surveillance system. Foundational to the network's efforts is the development of a computable phenotype (CP) algorithm that can identif...

This study aimed to develop a novel method that can accurately estimate the prevalence of T1D in children and adolescents using EHR data. T1D cases among individuals <= 18 years old were identified from the OneFlorida EHR (2018-2020) using a computable phenotype algorithm we have developed. The T1D prevalence was estimated at the zip code level, wi...

Cognitive impairment (CI) is associated with adverse health outcomes, but little is known about whether this varies across different racial and ethnic subgroups. We compared health outcomes associated with CI across racial and ethnic groups among adults aged ≥ 60 years old with diabetes in the US. Adults with diabetes were identified from the 2011-...

Objective This study simulated the 5-year risk of diabetes complications associated with the use of iGlarLixi, a fixed-ratio combination of insulin glargine 100 U/ml and lixisenatide, in type 2 diabetes (T2D) using the BRAVO diabetes model. Methods The six-month efficacy data of iGlarLixi and Standard of Care (SOC) were extracted from the LixiLan-...

Background The difference between the costs of the newer and older glucose-lowering drugs (GLMs) has been steadily increasing since 2010. In 2018, newer drugs cost 8-12 times more than older drugs (except for insulin). This study aimed to understand how the cost change influenced the cost-effectiveness of the newer GLMs. Methods Based on our previ...

Background Left ventricular assist device (LVAD) implantation improves outcomes in advanced heart failure, however, the optimal frequency of outpatient assessments to improve cost-effectiveness and potentially avert readmissions is unclear. Methods To test if varying the frequency of follow-up after LVAD implantation reduces readmissions and impro...

Fast escalating price of insulin and introductions of high-cost new GLMs in the last decade could affect racial/ethnic groups differently. This study examined trends in GLM uses, OOP payments for GLMs, and HbA1c control by racial/ethnic group among US adults with diabetes from 2005 to 2018. Data were from the Medical Expenditure Panel Survey and th...

Background: The difference between the costs of the newer and older glucose-lowering drugs has been steadily increasing since 2010. In 2018, newer drugs cost 8-12 times more than older drugs (except for insulin). This study aimed to understand how this change in drug cost influenced the cost-effectiveness (CE) of newer drugs compared with older dru...

Purpose Left ventricular assist device (LVAD) implantation has improved mortality and quality of life in end-stage HF. However, the optimal frequency of outpatient assessments to improve cost-effectiveness and potentially avert readmissions is unclear. Methods The readmission rate, cost of readmission, and follow-up visits were obtained via claims...

Lanthanum can reduce absorption of phosphate by forming lanthanum phosphate complexes after oral administration of lanthanum carbonate tablets (FOSRENOL®) in patients. Based on the pH-responsive interaction of phosphate and lanthanum ions, the chitosan coated siRNA-loaded lanthanum phosphate nanoparticles (CS/LaP/siRNA NPs) were prepared for improv...

In the present study, a chitosan-coated calcium phosphate nanoparticle (CS/CaP/siRNA NP) was developed to deliver siRNA for treatment of cervical cancer. The CS/CaP/siRNA NPs were prepared by the nano-precipitation method. The resulted NPs had a uniform spherical morphology with a size of ~194 nm and a zeta potential of ~+27 mV. In vitro experiment...

To achieve a higher transfection efficiency and lower toxicity, a novel herringbone-like cationic lipid (2ssHLL) composed of hydrophilic aspartic acid linked with two reduction-responsive cleavable hydrophobic oleic acid tails was synthesized and assessed in this study. In our results, the cationic nanoplexes with a uniform spherical shape and a pa...

OBJECTIVE: To prepare amphiphilic polycaprolactone-poly (arginine polymer) (PCL-R15)/siRNA Nanopexes, and two kinds of nanoparticles with different particle size were prepared by different process. After encapsulated siRNA with electrostatic interaction, both of two nanoplexes (NR60/siRNA and NR160/siRNA) were used to compare the effects in vitro c...