Pi-Hua Chen

Taipei Medical University | TMU · Department of Obstetrics and Gynecology

To determine whether genetic predisposition to endometriosis varies depending on ethnicity and in association with expression quantitative trait loci (eQTL) in a Taiwanese population. We conducted a genome-wide association study (GWAS) and replicated it in 259 individuals with laparoscopy-confirmed stage III or IV endometriosis (cases) and 171 wome...

Endometriosis shares similarities with several autoimmune diseases. The human leukocyte antigen (HLA)-C genotype is associated with several human autoimmune diseases. HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity, which is associated with endometriosis progression. Pol...

Vanishing fetuses are frequently encountered in pregnancies results from in vitro fertilization. Ultrasound scans taken at the 4-5th weeks showed multiple gestation has occurred, it frequently happens that more than one amniotic sac can be seen in early pregnancy, whereas a few weeks later there is only one to be seen and the other has disappeared....

This study investigated the occurrence of peritoneal fluid in women undergoing intrauterine insemination (IUI) and its correlation with the stage of pelvic endometriosis and its influence on pregnancy outcomes. A retrospective case-control design was used to recruit 272 infertile women with pelvic endometriosis. The treatment protocol consisted of...

The antenatal diagnosis of aortic dissection carries a grave prognosis. Although cases of pregnant women with Marfan syndrome have been encountered, resulting in either sudden death or emergency surgery at diagnosis, of the patients that survive to delivery, cesarean section is associated with the risk of anesthesia and manipulation of the abdomen....

The American Journal of Gastroenterology is published by Nature Publishing Group (NPG) on behalf of the American College of Gastroenterology (ACG). Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastr...

Objective Bladder endometriosis is a rare disease with variable symptoms. No definite treatment for this disease has been documented due to its rarity. We present a case of bladder endometriosis mimicking a lower segment uterine adenomyoma. Case Report A 25-year-old woman presented with the complaint of severe dysmenorrhea and suprapubic tendernes...

The physiological changes in endometriosis involving multiple steps of matrix remodeling include abnormal tissue growth, invasion, and adhesion formation. Endometriosis-associated abnormal matrix remodeling is affected by several molecular factors including proteolytic enzymes and their inhibitors, which mediate tissue turnover throughout the repro...