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Phonepadith Xangsayarath

Phonepadith Xangsayarath
National institute of public health, Lao PDR

MD, MTM, PhD

About

20
Publications
1,240
Reads
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49
Citations
Citations since 2017
14 Research Items
26 Citations
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2017201820192020202120222023024681012
2017201820192020202120222023024681012

Publications

Publications (20)
Article
Full-text available
Plasmodium vivax is the leading cause of malaria outside Africa and represents a significant health and economic burden on affected countries. A major obstacle for P. vivax eradication is the dormant hypnozoite liver stage that causes relapse infections and the limited antimalarial drugs that clear this stage. Advances in studying the hypnozoite an...
Data
List of genes contained within the mathematically defined confidence intervals (725,528–813,866 bp) of the locus under selection on chromosome 7. (PDF)
Data
List of genes contained within the mathematically defined confidence intervals (1,229,582–1,363,920 bp) of the locus under selection on chromosome 8. (PDF)
Data
Supplementary mathematical methods. (PDF)
Data
Intracellular localization of EBL in parasite strains CU, 17XL, 17X1.1pp and in transfected parasites CU(CY) and 17X1.1pp(YC). (PDF)
Data
Parasitaemias after immune challenges. (PDF)
Data
Bayesian Information Criterion (BIC) values for varying models for candidate regions of the genome, within each replica, calculated under different models. (PDF)
Data
Inferred recombination rates from driver models. (PDF)
Data
Expression of Pyebl alleles in both wild type (WT) and transfected strains. (PDF)
Data
Selected alleles identified by the SDR model. (PDF)
Data
List of genes contained within the mathematically defined confidence intervals (1,436,717–1,528,275 bp) of the locus under selection on chromosome 13. (PDF)
Data
PCR primers used to generate constructs for transfection experiments. (PDF)
Article
Full-text available
Identifying the genetic determinants of phenotypes that impact disease severity is of fundamental importance for the design of new interventions against malaria. Here we present a rapid genome-wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gen...
Preprint
Full-text available
Identifying the genetic determinants of phenotypes that impact on disease severity is of fundamental importance for the design of new interventions against malaria. Traditionally, such discovery has relied on labor-intensive approaches that require significant investments of time and resources. By combining Linkage Group Selection (LGS), quantitati...
Article
Full-text available
The recent detection of clinical Artemisinin (ART) resistance manifested as delayed parasite clearance in the Cambodia-Thailand border area raises a serious concern. The mechanism of ART resistance is not clear; but the P. falciparum sarco/endoplasmic reticulum Ca(2+)-ATPase (PfSERCA or PfATP6) has been speculated to be the target of ARTs and thus...
Article
Full-text available
Plasmodium falciparum Clag protein is a candidate component of the plasmodial surface anion channel located on the parasite-infected erythrocyte. This protein is encoded by 5 separated clag genes and forms a RhopH complex with the other components. Previously, a signature of positive diversifying selection was detected on the hypervariable region o...
Article
Full-text available
Plasmodium falciparum SURFIN(4.1) is a type I transmembrane protein thought to locate on the merozoite surface and to be responsible for a reversible adherence to the erythrocyte before invasion. In this study, we evaluated surf(4.1) gene segment encoding extracellular region for polymorphism, the signature of positive selection, the degree of link...
Article
Full-text available
Plasmodium falciparum SURFIN₄.₂ (PFD1160w) is a polymorphic protein expressed on the surface of parasite-infected erythrocytes. Such molecules are expected to be under strong host immune pressure, thus we analyzed the nucleotide diversity of the N-terminal extracellular region of SURFIN₄.₂ using P. falciparum isolates obtained from a malaria hypoen...

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