Philippine Fassier

• Université Sorbonne Paris Nord

The French National Cancer Institute conducted a collective expertise study with researchers and clinical experts from the French Network for Nutrition And Cancer Research (NACRe Network). The objective was to update the state of knowledge on the impacts of nutritional factors on clinical endpoints during or after cancer. Data from 150 meta-analyse...

Résumé Les facteurs nutritionnels (alimentation, poids, alcool, activité physique) sont identifiés comme des facteurs ayant un impact sur l’apparition de cancers pour plusieurs localisations. Des données scientifiques, quoique moins abondantes, soulignent leur impact également sur l’évolution de la maladie. Un état des lieux des connaissances a été...

Introduction et but de l’étude Les innovations technologiques ont contribué à l’évolution rapide de la recherche translationnelle, permettant le partage de plus grandes quantités de données. Toutefois, les méthodes permettant d’impliquer les patients dans la recherche n’ont pas suivi l’évolution des capacités de recherche. Des outils modernes offra...

Background Technological innovations have contributed to rapid changes in translational research, allowing greater amounts of shared data on an unprecedented scale. However, methods for involving patients in research have not kept pace with changes in research capacity. Modern tools offering more flexibility in the management of patient consent are...

Introduction Dietary supplements (DS) containing nutrients found mainly in animal products might be useful for individuals following specific type of vegetarian diet. However, the nutritional quality of the overall diet has been reported better in vegetarians compared to meat eaters, nuancing this potential interest. Little information is available...

Background Dietary supplements (DS) are largely consumed in Western countries without demonstrating their nutritional benefits and safety in the general population. The aims, in a large population-based study of French adults, were: (1) to compare the prevalence of nutrient intake inadequacy and the proportion of individuals exceeding tolerable upp...

Lipid intakes such as saturated (SFA), monounsaturated (MUFA) and polyunsaturated (PUFA) fatty acids have been widely studied regarding cardiovascular health, but their relevance to cancer is unclear. Inconsistent epidemiological results may be explained by varied mechanisms involving PUFAs and redox balance, inflammatory status and cell signalling...

Introduction et but de l’étude Les objectifs de cette étude étaient 1) d’investiguer les opinions des survivants du cancer de l’étude NutriNet-Santé concernant certains facteurs nutritionnels spécifiques, 2) de mettre en relation ces opinions avec d’une part, les pratiques nutritionnelles, et d’autre part, avec les sources d’informations nutritionn...

Several national and international authorities have proposed nutritional and lifestyle recommendations with the aim of improving health of the general population. Scores of adherence to these recommendations can be calculated at the individual level. Here, we investigated the associations between four nutritional scores and overall, breast, prostat...

Nutrition is often used by cancer survivors as a lever to take charge of their own health. However, some dietary behaviors are not currently recommended for patients without medical supervision. This study aimed at evaluating weight‐loss restrictive diets and fasting practices among cancer survivors of the NutriNet‐Santé cohort, as well as related...

Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadian behaviours and cancer is not...

Diverse plant products (e.g. fruits, vegetables, legumes) are associated with decreased cancer risk at several locations while red and processed meat were found to increase cancer risk. A pro plant‐based dietary score reflecting the relative contribution of consumed plant vs animal products was developed, and was associated with lower overall morta...

Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few of them included quantitative assessment of supplemental intake. This prospective study aimed at investigating the a...

Objective To assess the prospective associations between consumption of ultra-processed food and risk of cancer. Design Population based cohort study. Setting and participants 104 980 participants aged at least 18 years (median age 42.8 years) from the French NutriNet-Santé cohort (2009-17). Dietary intakes were collected using repeated 24 hour d...

Background: Dietary guidelines in France give quantitative recommendations for intake of meat, fish and dairy products whereas consumers are increasingly concerned by the environmental impacts associated with the production of these foods. This potentially leads to consumer dilemmas when purchasing food products. The present study aimed at investi...

Background and objectives: Cancer survivors need to get more actively involved in their disease, notably through their nutritional behavior. For instance restrictive diets may be considered, including fasting practice or restrictive diets to lose weight. For the moment, no previous study has investigated theses both types of restrictive diets among...

Background and objectives: While many cancer patients are affected by weight loss, others tend to gain weight, which may impact prognosis and risk of recurrence and of second cancer. The aim of this prospective study was to investigate weight variation between before and after cancer diagnosis and socio-demographic, economic, lifestyle and clinical...

Background and objectives: Circadian disruption, resulting from shiftwork, has been classified as probably carcinogenic to humans by the International Agency for Research on Cancer. The biological circadian clock is subject to environmental effects, particularly light exposure and rhythmic food intake. However, the association between circadian nut...

This project has been conducted in the framework of the French network for Nutrition And Cancer Research (NACRe network). This project was funded by the Canceropole Ile de France/Region Ile de France (PhD grants of Melanie Deschasaux and Philippine Fassier and QUANTICA Emergence project). The NutriNet-Sante study was supported by the following publ...

The International Agency for Research on Cancer (WHO-IARC) classified red meat and processed meat as probably carcinogenic and carcinogenic for humans, respectively. These conclusions were mainly based on studies concerning colorectal cancer, but scientific evidence is still limited for other cancer locations. In this study, we investigated the pro...

Introduction et but de l’étude Les compléments alimentaires sont largement consommés dans les pays occidentaux, mais les études disposant de données quantitatives sont rares. Les objectifs de cette étude étaient : (1) d’évaluer la contribution des compléments alimentaires vitaminiques et minéraux aux apports nutritionnels usuels et l’impact de la c...

Introduction et but de l’étude Le Centre international de recherche sur le cancer (WHO-IARC) a récemment conclu à un niveau de preuve élevé concernant le caractère procarcinogène des charcuteries et viandes rouges. Ces conclusions étaient principalement basées sur le cancer colorectal, alors que la littérature scientifique est encore limitée concer...

Introduction et but de l’étude Des études expérimentales ont suggéré un effet protecteur des vitamines B vis-à-vis du cancer du sein, potentiellement modulé par l’apport en alcool. Cependant, les études épidémiologiques sont limitées, en particulier concernant les vitamines du groupe B hors folates. En outre, relativement peu d’études disposent des...

Introduction et but de l’étude Le grand public a récemment été exposé à une quantité importante d’information concernant la vitamine D provenant de différentes sources. Un rôle bénéfique de la vitamine D vis-à-vis de différentes pathologies a en effet été suggéré et la prévalence élevée d’une insuffisance en vitamine D dans la population a soulevé...

Introduction et but de l’étude En France (et en Europe), les autorités de santé considèrent la possibilité d’implémenter un système d’étiquetage simplifié à apposer en face avant des emballages des produits alimentaires afin d’aider les consommateurs à effectuer des choix alimentaires plus sains. Une des propositions actuellement à l’étude serait u...

Introduction et but de l’étude De nombreuses études expérimentales ont montré un effet bénéfique des antioxydants dans la prévention des cancers digestifs. Toutefois, les études épidémiologiques restent contrastées. En outre, relativement peu disposent des doses d’apport incluant une mesure quantitative de la consommation via les compléments alimen...

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Objectives French authorities are considering the implementation of a simplified nutrition labelling system on food products to help consumers make healthier food choices. One of the most documented candidates (Five-Colour Nutrition Label/Nutri-score) is based on the British Food Standards Agency Nutrient Profiling System (FSA-NPS), a score calcula...

Experimental studies suggest a protective effect of B-vitamins on breast cancer risk, potentially modulated by alcohol intake. However, epidemiological studies are limited, especially regarding non-folate B-vitamins. Furthermore, few studies included quantitative assessment of supplemental intake. This prospective study aimed to investigate the ass...

Purpose: While many cancer patients are affected by weight loss, others tend to gain weight, which may impact prognosis and risk of recurrence and of second cancer. The aim of this prospective study was to investigate weight variation between before and after cancer diagnosis and socio-demographic, economic, lifestyle and clinical factors associat...

A number of motives such as constraints or pleasure have been suggested to influence dish choices during home-meal preparation. However, no study has evaluated how the importance conferred to these motives potentially influence diet quality. The present study aims at investigating the difference in diet quality according to the importance attached...

Post-diagnosis diet and alcohol consumption may be associated with cancer prognosis, recurrence and mortality. Our aim was to investigate food, nutrient and alcohol intake variations between before and after cancer diagnosis and their determinants in a prospective cohort. Subjects (n=696) were incident cancer cases diagnosed in the NutriNet-Santé c...

Background: Metabolic activity in lesions, measured by FDG-PET, is often used for assessing tumor aggressiveness and response to therapy. Patients may be scanned on different machines, so quantitative measurements should be reproducible. Reducing SUV variability in PET machines throughout a local network can aid in monitoring patient response to th...

Introduction Over the last 2 decades, an increasing number of primary breast cancer (PBC) patients opted for a risk reducing contralateral mastectomy, to minimize risk of subsequent contralateral breast cancer (CBC). Therefore, accurate risk estimates of CBC are important for patient tailored counseling and decision making regarding treatment. Curr...

Introduction et but de l’étude Malgré l’évolution des pratiques culinaires ces dernières décennies, un nombre limité d’études a évalué l’impact potentiel de ces pratiques sur la qualité de l’alimentation et le statut pondéral. Ces études ont suggéré un bénéfice potentiel des repas préparés à la maison comparés aux plats préparés hors foyer, du fait...

Introduction et but de l’etude Internet est aujourd’hui devenu une source majeure d’informations dans le domaine de la sante et de la nutrition. Peu de connaissances ont ete publiees sur le type de sites Internet consultes (sites institutionnels/officiels vs non institutionnels). En outre, les connaissances sont egalement limitees sur la propension...

People have been exposed to a lot of information regarding vitamin D, with evidence suggesting that vitamin D may be involved in numerous health conditions, subsequently creating concerns about vitamin D insufficiency. As a result, what do people really know or believe about this topic? In this cross-sectional study, we assessed vitamin D-related k...

Experimental results suggested that iron-induced lipid peroxidation may explain the direct associations observed between red/processed meat intakes and colorectal and breast cancer risk. However, epidemiological evidence is lacking. Thus, we investigated the association between dietary iron intake and breast cancer risk, and its potential modulatio...

Physical activity (PA) but also reduced sedentary behavior may be associated with better prognosis and lower risk of recurrence in cancer patients. Our aim was to quantify the variations in PA and time spent sedentary between before and after diagnosis, relying on prospective data in French adults. We also investigated sociodemographic and lifestyl...

Introduction Internet est aujourd’hui une source majeure d’informations en santé/nutrition. Peu de connaissances ont été publiées sur le type de sites consultés (institutionnels/non institutionnels) et sur la propension des internautes à discuter avec un professionnel de santé des informations trouvées sur internet. L’objectif était d’étudier l’uti...

Introduction Alors que certains patients atteints de cancer ont tendance à perdre du poids, d’autres au contraire subissent une prise de poids, qui peut avoir un impact sur le pronostic, le risque de récidive ou de second cancer. L’objectif de cette étude prospective était d’étudier la variation de poids avant/après diagnostic de cancer et les fact...

Although home cooking has been associated with a lower body mass index in a few studies, no data exists on the motives behind food dish choices during home meal preparation and on their association with overweight. This study aimed to evaluate this association in 50,003 participants from the NutriNet-Santé cohort. Dimensions underlying the importan...

The Internet has become a major source of health and nutrition information. Little is known about the type of consulted websites (institutional v . non-institutional) and the tendency to discuss with a healthcare professional (HCP) the information found on the Internet. The aim of this cross-sectional study was to investigate health- and nutrition-...

Plusieurs milliers de compléments alimentaires sont commercialisés en vente libre. Leur succès s’accroît depuis plusieurs décennies en France et leur contribution à l’apport nutritionnel est importante. Or, leurs conséquences à long terme sont très mal connues. Il est primordial de mieux cerner les potentiels effets bénéfiques ou délétères de leur...

Introduction et but de l’étude Suite au diagnostic d’un cancer, alors que certains patients ont des difficultés à s’alimenter et souffrent de dénutrition, d’autres au contraire, prennent du poids. Dans les deux cas, ces évolutions peuvent avoir un impact sur le pronostic de la maladie et le risque de récidives ou de second cancer. L’objectif de cet...

Although culinary practices have strongly evolved over time, few data are available on contemporary dish choices during meal preparation. We therefore sought to determine individual motives when choosing dishes to be prepared during weekdays and on weekends. The importance of 27 criteria related to dish choices was assessed in 53,025 participants i...

The objective of the present study was to conduct the first systematic review and meta-analysis of prospective studies investigating the associations between total cholesterol (TC), HDL-cholesterol (HDL-C) and LDL-cholesterol (LDL-C) levels and the risk of breast cancer. Relevant studies were identified in PubMed (up to January 2014). Inclusion cri...

Alcohol intake is associated with increased circulating concentrations of sex hormones, which in turn may increase hormone-dependent cancer risk. This association may be modulated by dietary fiber intake, which has been shown to decrease steroid hormone bioavailability (decreased blood concentration and increased sex hormone-binding globulin concen...

Dietary supplements (DS) may influence cancer prognosis. Their use in cancer patients has been described in the United States, but data are largely lacking in Europe and notably in France. The present study's objectives were (1) to assess DS use and its sociodemographic, lifestyle, and dietary correlates in a large sample of French cancer survivors...

In spite of the growing literature in the field of e-epidemiology, clear evidence about computer literacy or attitudes toward respondent burden among e-cohort participants is largely lacking. We assessed the computer and Internet skills of participants in the NutriNet-Santé Web-based cohort. We then explored attitudes toward the study demands/respo...

Dietary supplements (DS) may influence cancer prognosis. Their use in cancer patients has been described in the United States, but data are largely lacking in Europe and notably in France. The present study's objectives were (1) to assess DS use and its sociodemographic, lifestyle, and dietary correlates in a large sample of French cancer survivors...

Introduction et but de l’etude Depuis les annees 80 et jusqu’a tres recemment, plusieurs etudes epidemiologiques ont investigue les relations entre les taux de cholesterol total plasmatique ou serique (C-T), d’HDL, de LDL et le risque de cancer du sein. Ces etudes, aux resultats contrastes, necessitent d’etre mises en perspective, or aucune revue s...