Philippe Nubukpo

Philippe Nubukpo
French Institute of Health and Medical Research | Inserm · Unit of Tropical Neuroepidemiology

MD-PhD, HDR, Psychiatrist

About

107
Publications
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Publications

Publications (107)
Article
Smoking cessation is a global public health issue. Nicotine dependence is a dynamic process that is not limited to physical dependence. Hypnosis can be helpful in the global management of smoking cessation. We explored this effect by comparing the effects of hypnosis and nicotine-replacement therapies (NRT) on tobacco withdrawal. Thirty participant...
Article
Full-text available
Purpose: Extended-release buprenorphine (XR-BUP) covers a range of formulations of buprenorphine-based treatments for opioid use disorder (OUD) that release the medication over a period of one week, one month, or six months. OUD is particularly prevalent among incarcerated populations, and previous findings have shown that incarcerated subjects we...
Article
Objectives To evaluate the association between neuropsychiatric symptoms and apolipoprotein E (APOE) ϵ4 allele among older people in Central African Republic (CAR) and the Republic of Congo (ROC). Design Multicenter population-based study following a two-phase design. Setting From 2011 to 2012, rural and urban areas of CAR and ROC. Participants...
Article
Objectives: Relapse rates in subjects with an alcohol use disorder who have undergone alcohol detoxification are high, and risk factors vary according to the studied population and the context in which withdrawal occurred. Subjects being treated in psychiatric settings require increased monitoring at the moment of detoxification and during follow-...
Article
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Aim: To explore the factors determining the interest in extended-release buprenorphine (XR-BUP) injections among patients receiving opioid agonist treatment (OAT) in France. Methods: 366 patients receiving OAT for opioid use disorder, recruited in 66 French centers, were interviewed from 12/2018 to 05/2019. A structured questionnaire assessed thei...
Article
Background: Brain-derived neurotrophic factor (BDNF) plays a key role in the processes of withdrawal and addiction in alcohol use disorder (AUD), and is also involved in liver homeostasis. The role of BDNF in liver damage and its link with liver stiffness are not known. We hypothesize that serum BDNF levels are linked to changes in hepatic elastici...
Article
The measurement of liver stiffness (LS) show promise as a follow-up tool after alcohol withdrawal but has mainly been studied in the early phase or in patients with severe liver disease. A six-month ancillary study of a specific psychiatric cohort of alcoholic patients without known liver disease followed after withdrawal was conducted (Clinical Tr...
Article
Objectives: Brain Derived Neurotrophic Factor (BDNF) has been associated to alcohol dependence and appear to vary after withdrawal, although the link with the withdrawal outcome on the long term is unknown. We aimed to assess the evolution of BDNF levels during the six months following withdrawal, and determine the association with the status of al...
Article
Objectives: Neuropsychiatric symptoms are common in dementia. Limited data are available concerning their association with dementia in developing countries. Our aim was to describe the severity of neuropsychiatric symptoms among older people, evaluate the distress experienced by caregivers, and assess which neuropsychiatric symptoms were specifica...
Presentation
Full-text available
In France, the use of alcohol is very frequent, and is placed in a context of a cultural habit. This psychoactive substance is traditionally associated with the notion of pleasure and conviviality in all environments. However, social representations of "alcoholics" have always been paradoxical and ambivalent. One of the most "popular" stigmas today...
Article
Objectives: Our study aimed at estimating the prevalence of neuropsychiatric symptoms and investigating associated factors among older adults living in two countries in Central Africa (Central African Republic (CAR) and Republic of Congo (ROC)). Methods: The EPIDEMCA multicentre population‐based study was carried out in rural and urban areas of CAR...
Conference Paper
Introduction Les déterminants génétiques des troubles du comportement ont été proposés à partir d’études familiales. Aucune étude n’a examiné le lien apolipoprotéine E (APOE) et troubles du comportement en Afrique centrale. Objectifs L’objectif de notre étude était d’évaluer l’association entre l’allèle ɛ4 de l’APOE et les troubles du comportement...
Conference Paper
Introduction Il existe peu d’études sur les facteurs associés aux troubles du comportement chez les sujets âgés en Afrique. Objectifs L’objectif de notre étude était de décrire les facteurs associés aux troubles du comportement chez les sujets âgés dépistés avec un trouble cognitif en République centrafricaine et au Congo. Méthodes Une étude tran...
Article
Objectives: Our aim is to describe changes in serum concentration for the proinflammatory factors TNF-α, IFN-gamma, IL-1beta, IL-8, IL-6, IL-10, IL-12, and MCP-1, for the satiety factor leptin and for factors associated with neuronal changes, neuron-specific enolase (NSE) and glial activation S100-beta protein (S100-β), and explore their associatio...
Article
Full-text available
Background: Blood Brain Derived Neurotrophic Factor (BDNF) levels are influenced by both addiction and mood disorders, as well as somatic conditions, gender, and genetic polymorphisms, leading to widely varying results. Depressive symptoms and episodes are frequently observed in patients with alcohol-use disorder, and vary widely over time, making...
Conference Paper
Full-text available
Introduction L’association des troubles du comportement avec les troubles cognitifs est frequente. Peu d’etudes sont disponibles sur les troubles du comportement chez les sujets âges en Afrique. Objectifs L’objectif de notre etude etait de decrire les troubles du comportement chez les sujets âges depistes avec un trouble cognitif en Republique Cent...
Article
Full-text available
Patients with psychiatric disorders are usually more exposed to multiple somatic illnesses, including liver diseases. Specific links are established between psychiatric disorders and alcohol hepatitis, hepatitis B, and hepatitis C in the population as a whole, and specifically in drug abusers. Metabolic syndrome criteria, and associated steatosis o...
Article
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Background The objective of this study was to describe the profile and alcoholic status of a population with alcohol use disorders (AUD) requesting help from a psychiatric hospital to stop drinking, as well as their clinical outcome and care consumption over the 2 years following the request. Methods The visits were conducted at baseline (M0) and a...
Article
Background: The role of information and communications technology is becoming increasingly prevalent in daily life and in the organization of medical care: are some people being left out? Aims: To evaluate access to and the uses of communication resources by psychiatric patients, focusing on the means of communication (e.g. mobile phones and com...
Article
Full-text available
Introduction According to the World Health Organization, dementia poses a public health problem in sub-Saharan Africa because of the growing number of elderly. But the perception of this condition is poorly documented in low-income countries. Objectives To Identify and analyze the perceptions of dementia in different population groups more or less...
Article
Les troubles de l’usage de l’alcool représentent un problème de santé publique majeur, et sont souvent associés à des co-morbidités psychiatriques [1]. La recherche clinique est indispensable pour mieux connaître la physiopathologie, et ses mécanismes, pour optimiser le diagnostic, et identifier des marqueurs de suivi et rechutes. Nous pensons que...
Article
Il apparaît évident aujourd’hui de la nécessité, dans une perspective de santé publique, d’aider à réduire les dommages liés à l’alcool. Les leviers d’action sont nombreux et doivent tenir compte de l’environnement. Nous souhaitons l’illustrer par quelques exemples. Le premier concerne l’âge. L’enjeu du trouble de l’usage d’alcool chez la personne...
Article
La recherche d’indices biologiques de dépendance à l’alcool est nécessaire pour le développement de nouvelles thérapeutiques et de marqueurs de suivi. Elle implique d’explorer les mécanismes physiopathologiques qui peuvent être modifiés, de préférence au niveau périphérique, afin d’en faciliter la mesure. Les phénomènes inflammatoires, la possible...
Article
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Introduction: Alcohol use is responsible for a high level of mortality and morbidity throughout the world. The WHO global strategy recommends that the detrimental effects of alcohol use be reduced. Aims: The objective of this paper was to investigate, using data from the 2010 Togo STEPS survey, alcohol use and other health-related factors in the ge...
Article
While the DSM 5 has formalized the terminology "Alcohol Use Disorders" (AUD) or "disorders of the use of alcohol" (UAW French translation in progress), the term "alcohol dependence" still used in ICD-10, apriority in the future ICD-11 and above in clinical practice. Addiction to alcohol is the cause of mortality and major morbidity. In terms of the...
Article
Alors que le DSM 5 a officialisé la terminologie « Alcohol Use Disorders » (AUD) ou « troubles de l’usage d’alcool » (TUA, traduction française en cours), le terme de « dépendance à l’alcool » reste d’actualité dans la CIM-10, a priori dans la future CIM-11 et surtout dans la pratique clinique. La dépendance à l’alcool est à l’origine d’une mortali...
Article
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L 'épilepsie, depuis des temps anciens, a été une maladie d é c o n c e rtante entraînant l'ex clusion. A i n s i , il est stipulé dans le code d'Hammurabi des règles touchant à une mala-die qui fait évoquer l'épilepsie. « Maldina » ou encore « mal démoniaque », c'était la maladie sacrée des Grecs que H i p p o c rate nommera le premier par le mot...
Article
Résumé Pratiqué depuis les années 1950, le training autogène de Schultz (TAS) est la technique de relaxation la plus utilisée dans le monde, mais pas en France, à côté des techniques dérivées de la méthode de Jacobson. Ces deux méthodes ont une filiation importante… De nombreuses autres techniques de relaxation sont apparues et la pratique de la re...
Article
En addictologie, l’approche motivationnelle se veut centrée sur le patient pour l’encourager à changer de comportement en l’aidant à explorer et à résoudre son ambivalence. L’ambivalence (avantages et inconvénients du statu quo ou du changement) est nommée et résolue par la personne, aidée par le thérapeute. En effet, Entre le produit et le patient...
Article
les techniques de relaxation psychothérapique inspirées de méthodes orientales pour la plupart, et réaménagées par les différentes écoles (physiologie, psychanalyse, cognitivo-comportementalisme) opèrent des transformations chez le sujet qui le pratique grâce aux bénéfices d’un État Modifié de Conscience (État Autogène, État hypnoïde, etc.). Schult...
Article
Background: Alzheimer's disease (AD) causes progressive loss of memory and disability, especially in older people. As worldwide population grows older, AD is responsible for an important social and economical burden in many nations. People suffering from AD may experience health-related stigma that influences their attitudes towards seeking assist...
Article
Drug addiction is often underestimated among the aged. Opiate drugs (mostly pain killers) are the most frequently implicated in drug addiction after benzodiazepines (BZD) in the aged. The subjects aged of 65 years or more are the most represented among the BZD users in France. Frequency of BZD use varies according to various studies from 39 to 55%...
Article
Une étude transversale, de type porte-à-porte dans le troisième arrondissement de Bangui, menée en population générale, a été réalisée, entre octobre 2008 et mars 2009, afin d’aider à une meilleure connaissance des démences chez les personnes âgées de plus de 65 ans vivant dans la capitale centrafricaine. Sur 496 personnes âgées interrogées, 188 su...
Article
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This review is devoted to alcoholism but also to other substance-dependences (tobacco, medication, illicit drugs) and behavioral addictions (gambling) in the aged. Compared to younger subjects, addictions in older people are marked by the high frequency of somatic comorbidities, physiological changes related to age, increased severity due to atypic...
Article
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Given the gradual improvement of living conditions and aging, dementia and related syndromes are becoming serious problems in the developing countries. A cross-sectional door to door type study in neighbourhood, was conducted from October 2008 to January 2009, in the general population in Bangui, order to help get a better understanding of the prev...
Article
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Dementia will concern more and more people in the developing countries, but the perception people have of dementia in these areas has not yet been studied. During a general population survey (EDAC) carried out in Brazzaville (Republic of Congo), 27 elderly persons suspected of having dementia and 31 of their relatives, 90 cognitively impaired elder...
Article
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Risk factors for dementia in American and European countries have been well investigated. However, little research has been carried out in sub-Saharan Africa, where life events as well as environmental, socio-economic, and modifiable risk factors (i.e., cardiovascular risk factors) may differ. Two cross-sectional surveys were conducted in represent...
Article
Depression is often overlooked in elderly nursing home residents because symptoms may be masked or dismissed as an inevitable consequence of ageing. Current tools for the detection of depression in institutionalised older people are not always specific. To construct and verify an instrument with which to detect depression in elderly nursing home re...
Article
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Background/aims: The population of Benin is, like those of most developing countries, aging; dementia is therefore a major concern. Our goal was to estimate the prevalence of dementia in an elderly population living in urban Benin. Methods: In a cross-sectional community-based study, people aged 65 years and above were screened using the Communi...
Article
To investigate the association between a low ankle-brachial index (ABI) and several grades of cognitive disorders: cognitive impairment, dementia and Alzheimer's disease (AD), in the general population. We performed a systematic review of the literature, including all prospective, longitudinal or cross-sectional studies assessing both peripheral ar...
Article
All studies conducted among the general population on the representations of "madness" and the "mad" reflect pejorative images. The few investigations directly questioning the mentally ill show that they feel stigmatized because of their illness. This clinical study examines 40 patients with schizophrenia regarding their knowledge of the disease an...
Article
Full-text available
Behavioral and psychological symptoms in dementia (BPSD) are very common, with 90% of patients experiencing at least one during the course of the disease. One-third of persons with dementia have depressive symptoms, and concomitant BPSD are very likely. This study aimed to characterize the psychological and behavioral manifestations of depression i...
Article
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Data on dementia from low- and middle-income countries are still necessary to quantify the burden of this condition. This multicenter cross-sectional study aimed at estimating the prevalence of dementia in 2 large cities of Central Africa. General population door-to-door surveys were conducted in the districts of Bangui (Republic of Central Africa)...
Article
Stigma is a major burden of epilepsy. In sub-Saharan Africa the few studies that addressed epilepsy stigma emphasize enacted, rather than perceived, stigma. This inattention may compromise clinical management and delay help seeking, thereby contributing to the treatment gap. We assessed perceived stigma and identified sociocultural and psychologica...
Article
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Background: Epilepsy is often associated with discrediting representations even in the developed countries. The prevalence of disease is 3-5 in thousand. Purpose: Our purpose was to assess social and cultural representation of epilepsy in the elderly in two French departments (Haute-Vienne and Creuse). Methods: An analysis of the answers given...
Poster
L’épilepsie est un problème de santé majeur par ses conséquences médicosociales et économiques. Cela est particulièrement vrai dans de nombreux pays du Sud, où elle reste une maladie négligée et sous-traitée. Le stigma associé à l’épilepsie a été identifié comme un fardeau supplémentaire. Peu d’études portent sur la perception de stigma chez les pe...
Article
Full-text available
Our aim was to validate the use of historical events as tools for estimating the age of people > or = 65 years in Cotonou (Benin). The survey was conducted in Cotonou, the economic capital of Benin. We included people aged > or = 65 years, with at least a primary education level and an administrative document certifying their date of birth. The his...
Article
Stigma of schizophrenia: a survey of forty patients with stabilized schizophrenia All studies conducted among the general population on the representations of “madness” and the “mad” reflect pejorative images. The few investigations directly questioning the mentally ill show that they feel stigmatized because of their illness. This clinical study e...
Article
Hospitalization in psychogeriatrics and role of other structures The psychopathology of aging confers a particular tendency as regards the expression of mental suffering in the elderly. The fragility of common social perspectives at this age requires a broader approach than at other ages, with a multidisciplinary team, a specific assessment and rel...
Article
The psychopathology of aging confers a particular tendency as regards the expression of mental suffering in the elderly. The fragility of common social perspectives at this age requires a broader approach than at other ages, with a multidisciplinary team, a specific assessment and relevant answers which are longer to build. The psychogeriatric in-p...
Article
The objective of this study was to assess the knowledge and attitudes of people living in two French counties. The data were collected from 1777 adults in the general population who were interviewed. Knowledge of and attitudes toward epilepsy in these French samples proved largely favorable: 90.6% identified epilepsy as different from a mental diso...
Article
Contexte La dépression du sujet âgé en institution est mal repérée du fait de différentes présentations masquées et parce que souvent imputée à tord à la vieillesse. Les instruments actuels de dépistage ou de diagnostic de la dépression de la personne âgée institutionnalisée ne sont pas toujours spécifiques. Objectif Construire et valider un instr...
Conference Paper
Introduction Avec le vieillissement de la population mondiale, les demences et syndromes apparentes sont en passe de devenir des problemes prioritaires de sante publique dans les pays en developpement. A ce jour, peu de recherches ont ete menees dans les pays en developpement, notamment en Afrique ou les donnees sont rares en comparaison avec les p...
Article
Full-text available
Ethnopsychiatry is defined as an approach aimed to understand the ethnic and cultural dimensions of mental illnesses. The triple interest of cross-cultural approach in psychiatry in the elderly is highlighted by a review of the literature and five clinical vignettes. The first interest is to help the diagnosis of mental disorders in aged immigrants...
Article
Full-text available
Dementia is increasing as a priority public health problem because of the ageing of the world population. Our goal was to estimate dementia and cognitive impairment prevalence in an elderly population of rural Benin. In a door-to-door survey, elderly people aged 65 years and above were screened using the Community Screening Interview for Dementia a...
Article
Les troubles psychiatriques survenant chez le patient avec une maladie d’Alzheimer sont très fréquents, hétérogènes et souvent associés. Ils sont regroupés sous l’intitulé de « signes et symptômes psychologiques et comportementaux des démences » (SSPCD). Ils doivent être soigneusement évalués et traités car ils aggravent le pronostic (accélération...
Article
We carried out an analytic study on anxiety and depression in people with epilepsy (PWE) in Lao PDR. The study confirmed a Goldberg's anxiety and depression score threefold in PWE than in villagers (matched by age group, sex and village). A probable psychological disorder was also threefold in patients than in controls (94.8 % versus 33.1 % ; p < 0...