Philippe Hernigou

Philippe Hernigou
University of Paris-Est · orthopedic surgery

About

443
Publications
32,159
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
12,469
Citations
Introduction
Skills and Expertise

Publications

Publications (443)
Article
Purpose: Previous studies evaluating hindfoot and knee alignment have suggested compensation between the knee and the hindfoot deformities. However, these studies did not investigate the influence of the orientation of the subtalar axis on the results. Material and methods: Using computed tomography data of patients without osteoarthritis, digit...
Article
Background The Association Research Circulation Osseous (ARCO) developed a novel classification for early-stage (pre-collapse) osteonecrosis of the femoral head (ONFH). We hypothesized that the novel classification is more reliable and valid when compared to previous three classifications: Steinberg, modified Kerboul, and Japanese Investigation Com...
Article
Orthoregeneration is defined as a solution for orthopedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include: drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic sti...
Article
PurposeThe aim of this study was to assess the difference between flexion and extension contact forces—gap balance—after Oxford mobile-bearing medial unicompartmental knee arthroplasty (UKA) performed by surgeons with varying levels of experience.Methods Surgeons in a training programme performed UKAs on fresh frozen cadaveric specimens (n = 60). C...
Article
Purpose: Post-traumatic osteonecrosis of the humeral head has a risk of progression to collapse in absence of treatment. The purpose of this study was to evaluate the results of mesenchymal stem cell grafting of the pre-collapse humeral head (study group) in adult patients with osteonecrosis and to compare the results with a simple core decompress...
Article
PurposeAxial alignment of the talar implant in total ankle arthroplasty remains a major issue, since the real axis of motion of each patient is impossible to determine with usual techniques. Further knowledge regarding individual axis of motion of the ankle is therefore needed.Material and methodsTherefore, digital twins, artificial intelligence, a...
Article
Full-text available
Autologous chondrocyte implantation (ACI) is a cell therapy for the treatment of focal cartilage defects. The ACI product that is currently approved for use in the European Union (EU) consists of spheroids of autologous matrix-associated chondrocytes. These spheroids are spherical aggregates of ex vivo expanded human autologous chondrocytes and the...
Article
Introduction: There are many treatment options for patients who have osteonecrosis of the femoral head (ONFH) and management strategies vary widely both among and within individual countries. Although many researchers have attempted to elucidate the optimal strategies for managing this disease, the lack of large-scale randomized control trials and...
Article
PurposeFrom the eleventh to the thirteenth century, three major events marked surgery in France: the appearance of an epidemic linked to ergotism which led to numerous amputations, the emergence of barber surgeons for civilian practice, and the organization of war surgery for the First Crusade.Material and methodsIf a certain separation between med...
Article
Full-text available
The value of bone marrow aspirate concentrates for treatment of human knee cartilage lesions is unclear. Most of the studies were performed with intra-articular injections. However, subchondral bone plays an important role in the progression of osteoarthritis. We investigated by a literature review whether joint, subchondral bone, or/and scaffolds...
Article
Purpose: Corticoid treatment associated with haematologic treatments can lead to ankle osteonecrosis in children's survivors of acute leukemia (ALL). Based on the efficiency of mesenchymal stem cells (MSCs) in hip osteonecrosis, we performed an evaluation of this treatment in 51 children and adolescents who had symptomatic ankle osteonecrosis afte...
Article
Purpose: Sickle cell disease is often associated with osteonecrosis of the humeral head with a risk of progression to humeral head collapse. The aim of this study was to evaluate the clinical outcome and the effect on the necrosis evolution of humeral head core decompression with autologous bone marrow aspirate injection in these patients. Method...
Article
PurposeHypoxia is a well-known complication in cemented arthroplasty; however, it is not known whether the level of hypoxia is related to the intramedullary pressure or to the age of the patient; therefore, we studied the intramedullary pressure and level of hypoxia in patients undergoing cemented arthroplasty.MethodsA prospective study was perform...
Article
Full-text available
Background: Osteonecrosis (ON) of the femoral head represents a potentially severe disease of the hip where the lack of bone regeneration may lead to femoral head collapse and secondary osteoarthritis, with serious pain and disability. The aim of this European, multicentric clinical trial was to prove safety and early efficacy to heal early femoral...
Chapter
Avascular necrosis of the femoral head is associated with a risk of hip arthroplasty in younger populations when collapse occurs. This chapter describes surgical procedures using percutaneous stem cells and results for patients with pre-collapse osteonecrosis. Stem cells can be obtained by means of bone marrow aspiration usually with concentration...
Article
PurposeDuring the Middle Ages, the Christian church established itself as the dominant force over all aspects of medieval life, including the practice of medicine. As the Church’s influence expanded across Europe, the role of lay practitioners in medicine declined, and clerics gradually assumed the role of healers in surgical practice as the cure o...
Article
PurposeThree hundred seventy million years ago, bone marrow appeared in skeleton of a fish. More than one hundred years ago, the concept of bone marrow transplantation was proposed to treat human diseases. During the last five decades, this concept became a reality first in hematology and later for orthopaedic diseases.Material and methodsThese adv...
Article
Purpose This study compared the clinical and radiological results of bone marrow mesenchymal stem cell implantation with traditional simple core decompression (CD) using a matched pair case-control design for osteonecrosis of the humeral head (ONHH) after fracture of the proximal humerus. Patients We retrospectively reviewed 64 patients who had su...
Article
Introduction Open fractures are at risk of nonunion; surgeons are reluctant to propose early standard bone grafting after open fractures, preferring to wait in order to adequately assess the facture status of infection. Bone marrow contains mesenchymal stem cells (MSCs) and granulocyte and macrophage precursors identified in vitro as colony forming...
Article
Introduction: Total knee arthroplasty (TKA) in patients with established knee osteoarthritis and major varus, mostly due to constitutional proximal deformity, remains a challenging procedure. Orthogonal cuts result in asymmetric bone resection and subsequent bone-related laxity or difficult release. A procedure that combines opening high tibial os...
Article
Purpose To investigate the effects of mesenchymal stem cells injections for treatment of post-traumatic osteonecrosis of the femoral head. Methods A total of 46 patients were eligible and enrolled in the study. Twenty-three patients were treated with cell therapy and 23 patients with hip arthroplasty (control group). During a minimum follow-up dur...
Article
Full-text available
The humeral head is the second most common site for nontraumatic osteonecrosis after the femoral head, yet it has attracted relatively little attention. Osteonecrosis is associated with many conditions, such as traumatism, corticosteroid use, sickle cell disease, alcoholism, dysbarism (or caisson disease), and Gaucher’s disease. The diagnosis is cl...
Article
The prognosis of sickle cell disease (SCD) has greatly improved in recent years, resulting in an increased number of patients reporting musculoskeletal complications such as osteonecrosis of the femoral head. Total hip arthroplasty (THA) can be utilized to alleviate the pain associated with this disease. Although it is well known that hip arthropla...
Article
Introduction Avascular necrosis of the femoral head often progresses to femoral head collapse if not treated. Conservative treatment yields highly variable results and is not standardised, mainly because it is typically evaluated in small patient populations. This led us to conduct a large retrospective comparative study with the goals of 1) analys...
Article
Purpose: The purpose of this study is to discuss the mechanical function of subchondral bone cysts and its relationship with Wolff's law. Methods: One hundred forty symptomatic knees (120 patients) with osteoarthritis were subjected to MRI before high tibial osteotomy (HTO). Subchondral bone cysts (SBCs) were detected on 72 knees of these 140 kn...
Article
Short and long‐term stabilities of cementless implants are strongly determined by the interfacial load transfer between implants and bone tissue. Stress‐shielding effects arise from shear stresses due to the difference of material properties between bone and the implant. It remains difficult to measure the stress field in periprosthetic bone tissue...
Article
Full-text available
Purpose: The long incubation period and asymptomatic spread of COVID-19 present considerable challenges for health care institutions when patients return to elective surgery. Methods: A retrospective review of the first adult elective cases performed between May 18, 2020 and June 14, 2020, after the end of lockdown was analysed in Belgium to ans...
Article
Purpose: There is an increasing number of reports on the treatment of knee osteoarthritis (OA) using mesenchymal stem cells (MSCs). However, it is not known what would better drive osteoarthritis stabilization to postpone total knee arthroplasty (TKA): targeting the synovial fluid by injection or targeting on the subchondral bone with MSCs implant...
Article
Full-text available
Purpose: Based on the recent literature, chest computed tomography (CT) examination could aid for management of patients during COVID-19 pandemic. However, the role of chest CT in management of COVID-19 patients is not exactly the same for medical or surgical specialties. In orthopaedic or trauma emergency, abdomen, pelvis, cervical, dorsal, and l...
Article
Full-text available
Purpose: The current pandemic caused by COVID-19 is the biggest challenge for national health systems for a century. While most medical resources are allocated to treat COVID-19 patients, fractures still need to be treated, as some patients with non-deferrable pathologies. The aim of this paper is to report the early experience of an integrated te...
Article
PurposeRecently, mesenchymal stem cells (MSCs) have been proposed as potential treatment modalities for knee osteoarthritis. However, indications and long-term results have not been frequently reported. The purpose of this study was to determine whether bone marrow lesion on MRI are predictive of risk progression to total knee arthroplasty during t...
Article
Hip osteonecrosis. Hip osteonecrosis of the is a relatively common pathology, responsible for pain and functional disability mainly affecting young people. It corresponds to bone necrosis of the femoral head, secondary to ischemic and/or cytotoxic mechanisms. They can be unilateral, bilateral or multifocal, thus testifying to the systemic nature of...
Article
Full-text available
Background: The use of bone marrow concentrate (BMC) for treatment of musculoskeletal disorders has become increasingly popular over the last several years, as technology has improved along with the need for better solutions for these pathologies. The use of cellular tissue raises a number of issues regarding the US Food and Drug Administration's...
Article
Purpose One of the oldest procedures performed by man is trepanning of the bone and yet it was only in the last 40 years that bone marrow aspiration has been used to treat nonunion disorders. Material and methods These advances were possible due to improvements in instruments and in techniques to make holes in the bone, an history that began with...
Article
Full-text available
Background and study aim Advanced therapy medicinal products (ATMP) frequently lack of clinical data on efficacy to substantiate a future clinical use. This study aims to evaluate the efficacy to heal long bone delayed unions and non-unions, as secondary objective of the EudraCT 2011-005441-13 clinical trial, through clinical and radiological bone...
Article
Full-text available
Osteonecrosis of the femoral head (ONFH) is a common and refractory disease in orthopaedic clinics. The number of patients with ONFH is increasing worldwide every year. There are an estimated 8.12 million patients with nontraumatic osteonecrosis in China alone. Treatment of nontraumatic osteonecrosis has always been a clinical challenge for orthopa...
Article
Background: The knee is the second-most common location for osteonecrosis, although it is affected much less often than the hip. Core decompression by precise drilling into ischemic lesions of the femoral condyle while remaining extra-articular is a challenge, particularly in obese patients. For cell therapy, exact localization of the injection po...
Article
Mesenchymal stem cells (MSCs) comprise a mixture of various stem cells in myeloid tissue with multipotential differentiation capacity. They can differentiate into bone cells under specific conditions and can be used to treat osteonecrosis of the femoral head through cell transplantation. This chapter summarizes research on MSCs in the field of oste...
Preprint
Full-text available
Short and long-term stabilities of cementless implants are strongly determined by the interfacial load transfer between implants and bone tissue. Stress-shielding effects arise from shear stresses due to the difference of material properties between bone and the implant. It remains difficult to measure the stress field in periprosthetic bone tissue...
Article
Background: The Association Research Circulation Osseous (ARCO) presents the 2019 revised staging system of osteonecrosis of the femoral head (ONFH) based on the 1994 ARCO classification. Methods: In October 2018, ARCO established a task force to revise the staging system of ONFH. The task force involved 29 experts who used a web-based survey fo...
Article
Full-text available
Purpose: Surgical treatment of hip osteonecrosis with stem cell therapy is a new procedure in which cells are injected with a trocar under fluoroscopic guidance. Proper surgical technique to obtain appropriate placement of the trocar in the center of the osteonecrosis is sometimes difficult and can require additional radiation exposure until the s...
Article
Purpose With advances in technology and particularly locked screws, patients with high tibial osteotomy (HTO) are frequently allowed full weight bearing for a unilateral procedure. We are aware of no reports comparing the safety of a simultaneous bilateral HTO with staged bilateral HTO. The purpose of this study was to retrospectively compare these...
Article
Résumé Les cellules-souches mésenchymateuses (CSM) comprennent un mélange de différentes cellules-souches dans un tissu myéloïde ayant une capacité de différenciation multipotente. Elles peuvent se différencier en cellules osseuses dans des conditions spécifiques et peuvent être utilisées pour traiter l’ostéonécrose de la tête fémorale par transpla...
Preprint
Full-text available
The primary stability of the femoral stem (FS) implant determines the surgical success of cementless 15 hip arthroplasty. During the insertion, a compromise must be found for the number and energy of 16 impacts that should be sufficiently large to obtain an adapted primary stability of the FS and not too high 17 to decrease fracture risk. The aim o...
Article
Purpose The nutritional basis for rickets was described between 1880 and 1915, at the same period of discovery of other “vital substances” or vitamins. In contrast, rickets could also be prevented or cured by sunshine. But as the capacity to produce vitamin D depends on exposure to ultraviolet B rays (UVB) from sunlight or artificial sources, vitam...
Article
Purpose After Glisson’s description of rickets, it took two centuries to realize that rickets was due to the absence of antirachitic nutrients in the diet or lack exposure of the skin to ultraviolet rays. This bone disease caused by vitamin D deficiency was one of the most common diseases of children 100 years ago. This paper explores how the defin...
Article
Full-text available
Purpose: Osteonecrosis is a rare event during or after pregnancy. Due to the low number of cases, there is no report of long-term results after conservative surgery in this population. Method: From 1992 to 2010, 145 consecutive female patients with unilateral symptomatic (94 stage I and 51 stage II) left hip osteonecrosis (ON) related to pregnan...
Article
Background: Although alcohol is a leading risk factor for osteonecrosis of the femoral head (ONFH) and its prevalence reportedly ranges from 20% to 45%, there are no unified classification criteria for this subpopulation. In 2015, Association Research Circulation Osseous decided to develop classification criteria for alcohol-associated ONFH. Meth...
Article
Background: Glucocorticoid usage, a leading cause of osteonecrosis of the femoral head (ONFH), and its prevalence was reported in 25%-50% of non-traumatic ONFH patients. Nevertheless, there have been no unified criteria to classify glucocorticoid-associated ONFH (GA-ONFH). In 2015, the Association Research Circulation Osseous addressed the issue o...
Article
Full-text available
The primary stability of the femoral stem (FS) implant determines the surgical success of cementless hip arthroplasty. During the insertion, a compromise must be found for the number and energy of impacts that should be sufficiently large to obtain an adapted primary stability of the FS and not too high to decrease fracture risk. The aim of this st...
Article
Approximately 5000 new patients with hip osteonecrosis are diagnosed each year in the France and 10,000 to 20,000 new patients in the USA. Almost two thirds of patients with hip osteonecrosis are between 30 to 60 years of age; as consequence, there are around 500,000 people in Europe and 500,000 others in the USA living with the disease or its cons...
Article
There is an error in the original publication for the photos of the Guest Editors were not included.
Article
Purpose: Despite multiple possible treatments, the risk of collapse remains the main problem of osteonecrosis. Heart failure (HF). In an effort to address the reverse this issue, curative strategies with regenerative medicine are increasingly being considered. The aim of this technology is to halt or reverse progression of the disease to collapse....
Article
Purpose: Symptomatic osteonecrosis related to corticosteroids has a high risk of progression to collapse in absence of treatment. The purposes of this study were to evaluate the results of autologous bone marrow grafting of the symptomatic hip in adult patients with osteonecrosis and to compare the results with core decompression alone in the cont...
Article
RÉSUMÉ Chaque année, environ 140 000 patients subissent une arthroplastie totale de la hanche (THA). Ceci est considéré comme une intervention médicale sûre et efficace pour restaurer la fonctionnalité de la hanche et retrouver une mobilité indolore chez les patients souffrant d’arthrose. Le nombre de personnes opérées ou devant être réopérées devr...
Article
Purpose: Surgical management of osteonecrosis with core decompression with stem cell therapy is a new procedure. The technique is performed with fluoroscopic guidance. This study attempts to determine if computer-navigated technique can improve the procedure. Methods: Thirty consecutive patients with bilateral symptomatic osteonecrosis without c...
Article
Purpose: Total knee arthroplasty (TKA) implanted in patients with secondary osteonecrosis (ON) related to corticosteroids have relatively poor outcome (20% revision rate) at a mean follow-up of only eight years. With the hypothesis that subchondral bone marrow injection might improve knees in these patients, we evaluated 30 patients who had bilate...
Article
The vitamin D history started early in the evolution of life (billion years ago) as a photochemical reaction producing an inert molecule. During the early evolution of vertebrates, this molecule became essential for calcium and bone homeostasis of terrestrial animals and arrived to the status of hormone. Phytoplankton, zooplankton, and most plants...
Article
PurposeIt is unclear whether late THA periprosthetic femoral fractures are related to a mechanical mechanism that decreases strength of the femur (for example, loosening) or to a biological problem as osteolysis. It is also unknown if ceramic on ceramic bearing couples decrease the risk of late periprosthetic fractures as a result of the absence of...
Article
Full-text available
Background: ORTHO-1 is a European, multicentric, first in human clinical trial to prove safety and feasibility after surgical implantation of commercially available biphasic calcium phosphate bioceramic granules associated during surgery with autologous mesenchymal stromal cells expanded from bone marrow (BM-hMSC) under good manufacturing practice...
Article
Full-text available
Background The acetabular cup (AC) implant primary stability is an important determinant for the success of cementless hip surgery but it remains difficult to assess the AC implant fixation in the clinic. A method based on the analysis of the impact produced by an instrumented hammer on the ancillary has been developed by our group (Michel et al.,...
Article
Full-text available
ORTHOUNION is a multicentre, open, comparative, three-arm, randomized clinical trial (EudraCT number 2015-000431-32 ) to compare the efficacy, at one and two years, of autologous human bone marrow-derived expanded mesenchymal stromal cell (hBM-MSC) treatments versus iliac crest autograft (ICA) to enhance bone healing in patients with diaphyseal and...
Article
PurposeAvascular necrosis of the talus is one of the most notable complications associated with talar neck fractures with frequent evolution of the osteonecrosis into a difficult arthrodesis. We tested whether the injection of bone marrow mesenchymal stem cells (MSCs) could improve the repair process of the osteonecrosis. Material and methodsForty-...
Article
Full-text available
The acetabular cup (AC) implant stability is determinant for the success of cementless hip arthroplasty. A method based on the analysis of the impact force applied during the press-fit insertion of the AC implant using a hammer instrumented with a force sensor was developed to assess the AC implant stability. The aim of the present study was to inv...
Article
Purpose: Osteonecrosis has been reported to be associated with pregnancy in the absence of other known risk factors for the disease. Few population-based data exist to support an association since the association is rare. We investigated the association of the femoral head and pregnancy to define if pregnancy was a risk factor and to define the ri...
Article
Résumé Introduction La gonarthrose étant dans la grande majorité des cas monocompartimentale, les ostéotomies de réaxation du membre représentent une solution logique pour limiter la dégradation du compartiment arthrosique et retarder ainsi la mise en place d’une prothèse. Les sujets jeunes ont une demande fonctionnelle importante. L’objectif de c...
Article
Purpose: Infected non-unions present a clinical challenge, especially with risk of recurrent infection. Bone marrow contains granulocyte precursors identified in vitro as colony forming units-granulocyte macrophage (CFU-GM) have a prophylactic action against infection. We therefore tested the hypothesis that bone marrow concentrated granulocytes p...
Article
Introduction Le succès à long terme des prothèses totales de hanche non cimentées dépend de la stabilité primaire de l’implant acétabulaire (IA). Cette stabilité doit être suffisante pour éviter des micromouvements à l’interface os-implant. Toutefois, les contraintes dans le tissu osseux autour de l’IA doivent être suffisamment faibles afin de dimi...
Article
Clubfoot is one of the most common congenital orthopaedic anomalies and was described by Hippocrates in the year 400 BC. From manipulation in antiquity to splint and plaster in the Renaissance the treatment had improved before tenotomy. Many surgical treatments were tested during the nineteenth and twentieth centuries and will be explained in this...