Philippe E. Mounmbegna

Madonna University · Department of Biological and Health Sciences

Ocimum gratissimum belongs to the group of plants known as spices. The plant is an erect small plumb with many branches usually not more than 1m high. It is of the familylabiatae, genus Ocimum and species gratissimum. It is commonly known as scent leaf. This project is focused on the pharmacognostic and coagulant activities of the ethanol extract o...

Introduction: Parkia biglobosa belong to the family mimosaceae and Acanthus montanus belong to the family acanthaceae. The plants both have a multipurpose use as herbal medicine. Aim: This work investigate the pharmacognostic standard and anti-dysentery activity of the mixed ethanol extract of both plants on E. histolytical induced dysentery. Metho...

Cola nitida and Garcinia kola are found and widely consumed in West Africa. The seeds of these plants have various traditional uses and are reported to exhibit several bioactivities. Their phytochemical, antioxidant and antibacterial properties of methanol, ethanol and aqueous extracts were investigated in the present study. Phytochemical screening...

Objective: This study investigated the effects of Tartrazine and Erythrosine (T+E) on the reproductive hormones and expression of some pro-inflammatory cytokines and testicular genes in testis of male Wistar rats. Methods: 25 male Wistar rats (150-180g) were divided into 5 groups (n=5). Group 1 received distilled water while groups 2, 3, 4 and 5...

Lead is a naturally occurring toxic metal with widespread use which has resulted in extensive environmental contamination, human exposure and significant public health problems in many parts of the world. This study assessed the renal function status in persons occupationally exposed to lead in lead acid battery manufacturing factory in Nnewi. A...

Today, industrialization has been implicated in the generation of certain compounds which are potentially hazardous to human life. This is a cross sectional study designed to evaluate some heavy metal levels in blood of lead acid battery manufacturing factory workers in Nnewi, Nigeria. A total of 39 apparently healthy individuals in lead acid batte...

Background of Study: Heavy metals are toxic and have adverse effects on human health depending on the intensity and duration of exposure. Materials and Methods: This is a cross sectional study designed to assess the heavy metal levels in blood of cable manufacturing factory workers in Nnewi, Nigeria. A total of forty (40) apparently healthy individ...

Background: Heavy metal toxicity has proved to be a major threat to human health as several health risks are associated with it. Materials and Methods: This is a cross sectional study designed to assess the heavy metal levels in blood of metal forging factory workers in Nnewi, Anambra State, Nigeria. A total of eighteen (18) apparently healthy subj...

Introduction of Study: Heavy metal contamination or toxicity poses serious deleterious effects to human health. Materials and Methods: This is a cross sectional study designed to assess the heavy metal levels in blood of metal fabricating factory workers in Nnewi. A total of 39 apparently healthy individuals in the exposed group (metal fabricating...

Recently, progressive use of synthetic food additives has paid more attention on their benefit and less attention on their toxic effect. Tartrazine and erythrosine are synthetic food colorants widely used in food, cosmetics and pharmaceuticals industries. This study is aimed at evaluating the possible hepatotoxic effect of these synthetic food colo...

To further understand the increased frequency in the use of spices such as Xylopia aethiopica as herbal treatment in Africa, this research was carried out to evaluate the possible effect of X. aethiopica on male albino wistar rats. A total of 50 adult rats (125g-150g) were randomly divided into 5 groups of 10 rats per group using normal saline as c...

Moringa oleifera is known for its therapeutic effects as it has been long used in treatment of many diseases. The haematinic effect of this plant was investigated in this work. The work was carried in Madonna University Elele Campus Rivers State. A total of 15 rats were procured and grouped into three groups and allowed to acclimatize for one week....

The use clozapine as antipsychotic agent poses high risk of developing agranulocytosis and hyperglycemia. We investigated the ameliorative effects of annona muricata seed on blood glucose, total and differential white cell count after repeated exposure of rats to 20mg/kg of clozapine. Twenty male albino wistar rats were divided into group A (contro...

The effect of methanol extract of annona muricata seed on packed cell volume, hemoglobin concentration, red cell count, alanine and aspartate aminotransferases, and alkaline phosphatases was investigated using albino wistar rats. Acute hemolytic anemia was induced with phenylhydrazine. The rats packed cell volume was used to determine anemia. Only...

The anti-inflammatory activity of methanol extract of hibiscus sabdariffa in comparison with most widely used nonsteroidal anti-inflammatory drug was studied in 25 adult albino rats. Acute inflammation was induced using 0.1 ml of egg albumin and was treated with 100, 200 and 400 mg/kg of the extract and aspirin (200 mg/kg). The sizes of the right h...

Background: Reproductive functions are impaired in diabetes mellitus. Polyherbal extracts from ocimum gratissimum and gongronema latifolium extracts on reproductive hormones and sperm parameters were studied in alloxan induced diabetic rats. Materials and Methods: Twenty five adult male albino rats were used in the study. Twenty rats were made dia...

This manual is designed to provide advanced biochemistry students a better understanding of biochemical methods such chromatography, electrophoresis, dialysis etc., which are discussed during lectures. These techniques are part of modern biochemistry and the rapidly growing field of cell and molecular biology and biotechnology. The selected experim...

Triclisia dictyophylla have been used traditionally for the treatment of different ailments. The root was therefore subjected to phytochemical analysis and antimicrobial/antifungal activity against some hospital-strain disease causing microorganisms. Standard methods were used for the phytochemical screening. The extract was subjected to antimicrob...

This book provides the reader with a comprehensive and authoritative insight of the whole field of modern immunology and immunochemistry and its ramifications into such areas as genetics, transplantation, cancer and infectious diseases. It differ from other textbooks in that there is emphasis on principles of immunochemical techniques. An attempt h...

This study investigated the combined effects of Vernonia amygdalina and Ocimum gratissimum on some liver enzymes; aspartate aminotransferase (ALT) and alanine aminotransferase (AST), serum albumin, bilirubin and total protein in streptozotocininduced diabetic rats. Experiments were performed in 36 adult male Wistar rats weighing 150-270 g. Thirty r...

Total body irradiation (TBI) is a choice therapy for the management of some malignancies; it is also a major cause of oxidative stress. The aim of this research is to sequentially document the effect of total body radiation on body function utilizing the sequential changes in liver function enzymes and proteins in rats. Serum protein and liver enzy...

Phytochemical screening of stem bark and leaves of Gmelina arborea; and effect of aqueous and ethanolic extracts of Gmelina arborea stembark on hepatic and renal insufficiency in rats was assessed in this study. Phytochemical screening was carried out on the air-dried leaf, oven-dried leaf, air-dried stembark and oven-dried stembark samples. Sixty...

Serum lipid and electrolyte imbalances are common in critically ill patients undergoing radiation therapy. Although multiple disease states and medication may be responsible for the development of these disorders, the aim of this research is to sequentially document the effect of total body radiation on body function utilizing the sequential change...

We examined time-dependent changes in plasma lipids of rats given total body irradiation (TBI) with X-rays at 3 Gy. for consecutive periods. Animals were exposed to x ray radiations consecutively for 20 days at 5 day interval thereafter five animals were picked at random and sacrificed (5, 10, 15 and 20 days after beginning the exposure). The triac...

Foundation to Membrane Biochemistry provides the reader with and integrated and up-to-date covering of basic membrane biochemistry. It give a details account of both basic knowledge on the composition of membrane as well as providing the reader with insight to the basis of the different type of molecular transaction they are involved in. The struct...

Male reproductive dysfunctions have been widely reported in individuals with diabetes mellitus. This study investigated the synergistic effect of methanolic extract of Vernonia amygdalina Del . (V.A) and Ocimum gratissimum (O.G) on reproductive functions in diabetic rats in comparison with insulin on follicle stimulating hormone (FSH) , luteinizing...

Male reproductive dysfunctions have been widely reported in individuals with diabetes mellitus. This study investigated the synergistic effect of methanolic extract of Vernonia amygdalina Del . (V.A) and Ocimum gratissimum (O.G) on reproductive functions in diabetic rats in comparison with insulin on follicle stimulating hormone (FSH) , luteinizing...

Today plant foods and beverages are receiving more scientific attention because of their potential to curb the effect of free radicals in the human system. The present study reports on the antioxidant potentials of some plants foods and beverages consumed in the Eastern Region of Nigeria. The study made use of the ferric reducing antioxidant power,...

In this study, the changes in rats fed with Erythrophleum suaveolens were analyzed using Haematological parameters. The parameters investigated include: packed cell volume (PCV), haemoglobin concentration (Hb), platelet count (PC) and white blood cell count (WBC). Rats were fed with different concentrations of the leaf and bark extract of the plant...

In the course of fighting malaria, insecticide-treated mosquito nets were introduced in African countries. This approach as described in this chapter did not entirely solved malaria problem in Africa. 95% of people sleeping under mosquito nets in selected African countries had malaria before and were still complaining of the disease and were actual...

In this chapter, a review of anti-malaria drugs combinations manufacturers and slogans used in Nigeria is smartly presented. Despite this myriad of drugs in their various combinations and permutations it has remained a challenge to completely overcome or eradicate the disease in Africa. A painstaking elucidation of the various drugs and their limit...

This research is aimed at investigating the hepatotoxic effect of mercury chloride and effects of zingiber officinale on this hepatotoxicity. These were carried out via estimation of liver function tests. Fifteen adult wistar rats were used for the experimental investigations. They were grouped into three: groups 1, 2 and 3 respectively. Animals in...

The book provide a concise but comprehensive coverage of the materials studied in undergraduate courses on taxonomy of living organisms. The organization of the book into separate chapter each for a kingdom of life make learning more interesting and easy. Also in order to enhance the learning of biological sciences and their applications a chapter...