Philippe Domenech

Philippe Domenech
L'Institut du Cerveau et de la Moelle Épinière

MD, PhD

About

49
Publications
13,428
Reads
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1,016
Citations
Additional affiliations
November 2016 - September 2022
Hôpital Henri Mondor (Hôpitaux Universitaires Henri Mondor)
Position
  • Professor (Associate)
November 2014 - November 2016
Hôpital Henri Mondor (Hôpitaux Universitaires Henri Mondor)
Position
  • Professor (Assistant)
November 2014 - present

Publications

Publications (49)
Article
Deep brain stimulation is an effective treatment for obsessive–compulsive disorder but is rarely used. Action is needed by psychologists, psychiatrists and insurers so that patients with otherwise intractable cases can receive this therapy to improve their mental health.
Article
Full-text available
Making accurate decisions based on unreliable sensory evidence requires cognitive inference. Dysfunction of n-methyl-d-aspartate (NMDA) receptors impairs the integration of noisy input in theoretical models of neural circuits, but whether and how this synaptic alteration impairs human inference and confidence during uncertain decisions remains unkn...
Article
Full-text available
BACKGROUND Functional magnetic resonance imaging (fMRI) capture aims at detecting auditory-verbal hallucinations (AVHs) from continuously recorded brain activity. Establishing efficient capture methods with low computational cost that easily generalize between patients remains a key objective in precision psychiatry. To address this issue, we devel...
Article
Full-text available
Introduction Deep brain stimulation (DBS) of bilateral anteromedial subthalamic nucleus (amSTN) has been found to be helpful in a subset of patients with severe, chronic and treatment-refractory obsessive–compulsive disorder (OCD). Biomarkers may aid in patient selection and optimisation of this invasive treatment. In this trial, we intend to evalu...
Preprint
Full-text available
BACKGROUND Functional magnetic resonance imaging (fMRI) capture aims at detecting auditory-verbal hallucinations (AVHs) from continuously recorded brain activity. Establishing efficient capture methods with low computational cost that easily generalize between patients remains a key objective in precision psychiatry. To address this issue, we devel...
Article
Full-text available
For over 10 years, electrical stimulation within the limbic cor-ticosubcortical network has been evaluated for treating patients with severe obsessive-compulsive disorder (OCD) (1). High-frequency deep brain stimulation (DBS) of various targets has been tested, including the anteromedial part of the subthalamic nucleus (amSTN), nucleus accumbens (N...
Article
Full-text available
To continue or to switch strategy? Successful behavior in an uncertain, changing, and open-ended environment critically relies on the ability to decide between continuing with the ongoing strategy or exploring new options. Neuroimaging studies have shown that the human medial prefrontal cortex (mPFC) is the part of the brain that primarily deals wi...
Article
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Standard neuroeconomic decision theory assumes that choice is based on a value comparison process, independent from how information about alternative options is collected. Here, we investigate the opposite intuition that preferences are dynamically shaped as options are sampled, through iterative covert pairwise comparisons. Our model builds on two...
Article
La psychiatrie computationnelle est une approche théorique utilisant des modèles mathématiques pour éclairer les liens entre symptômes et anomalies neurobiologiques observées dans les troubles mentaux. Cette introduction passe en revue trois champs d'application principaux : les modèles issus de l'apprentissage par renforcement, les modèles issus d...
Preprint
Full-text available
In uncertain environments, accurate decision-making requires integrating ambiguous or conflicting signals - a cognitive inference process thought to require n-methyl-d-aspartate (NMDA) synaptic receptors. Here we characterized the causal impact of human NMDA receptor hypofunction on cognitive inference using placebo-controlled infusions of ketamine...
Article
Full-text available
Estimating the value of alternative options is a key process in decision-making. Human functional magnetic resonance imaging and monkey electrophysiology studies have identified brain regions, such as the ventromedial prefrontal cortex (vmPFC) and lateral orbitofrontal cortex (lOFC), composing a value system. In the present study, in an effort to b...
Article
Full-text available
Obsessive-Compulsive Disorder (OCD) is a neuropsychiatric disorder comprises repetitive intrusive thoughts and behaviours leading to significant handicap. 20% of patients are refractory to medication and cognitive behavioural therapy. Refractory OCD is associated with suicidal behaviour and significant degradation of social and professional functio...
Article
Vagus nerve stimulation (VNS) is an old, yet new, option for treatment-resistant depression. Despite several clinical trials over the last 15 years showing a consistent benefit-risk balance of the technic, VNS still struggles to find its place in our therapeutic algorithms. This is especially true in France, where only a few surgeries have been per...
Article
Full-text available
by Suhan SENOVA, Corentin RABU, Sami Beaumont, Valériane MICHEL, Stéphane PALFI, Luc MALLET, Philippe DOMENECH
Article
La dépression est une pathologie fréquente, touchant 5-18 % de la population générale, qui évolue vers la rechute puis la récurrence, voire la chronicité dans au moins 50 % des cas. De plus, 20 à 40 % des dépressions ne répondent pas aux antidépresseurs. L’OMS estime de plus qu’en 2020, la dépression sera la seconde cause de dépense de santé dans l...
Article
La stimulation cérébrale profonde est une technique qui consiste à poser par voie neurochirurgicale des électrodes dans une zone cérébrale précise sous contrôle stéréotaxique. Ces électrodes sont reliées à un stimulateur posé au niveau thoracique et délivrent un courant. La stimulation par des courants de haute fréquence du noyau sous-thalamique es...
Conference Paper
Les hallucinations fascinent depuis les débuts de l’humanité, mais ce n’est que depuis quelques décennies seulement que leur exploration par les outils des neurosciences a été possible et a permis de mieux comprendre les bases neurales de ces expériences. Cette présentation est l’occasion de reprendre l’état de l’art en matière d’imagerie cérébrale...
Article
La dépression caractérisée figure parmi les affections psychiatriques les plus fréquentes avec une prévalence sur la vie entière de 16-17 % en population générale [1]. Elle se montre d’évolution récidivante, voire chronique dans 50 à 80 % des cas, avec un impact important sur le fonctionnement au quotidien, ainsi que sur la qualité de vie. Elle est...
Article
Le trouble lié à l’usage de cocaïne est à l’origine de nombreuses complications médicales, psychiatriques et sociales. De plus, ce trouble est associé à une multiplication par 4 du risque de mortalité standardisé. Les patients qui présentent une dépendance constituée à la cocaïne sont souvent difficiles à capter dans les soins. Enfin, il n’existe p...
Article
Full-text available
Parkinson's disease is typically treated with oral dopamine replacement therapies, however long term use is complicated by motor fluctuations from intermittent stimulation of dopamine receptors and off-target effects. ProSavin, a lentiviral vector based gene therapy that delivers local and continuous dopamine, was previously shown to be well tolera...
Article
Full-text available
Background Major depression is characterized by (i) a high lifetime prevalence of 16–17% in the general population; (ii) a high frequency of treatment resistance in around 20–30% of cases; (iii) a recurrent or chronic course; (iv) a negative impact on the general functioning and quality of life; and (v) a high level of comorbidity with various psyc...
Article
Full-text available
The ability to infer other people’s intentions is crucial for successful human social interactions. Such inference relies on an adaptive interplay of sensory evidence and prior expectations. Crucially, this interplay would also depend on the type of intention inferred, i.e., on how abstract the intention is. However, what neural mechanisms adjust t...
Article
Full-text available
Current neural models of value-based decision-making consider choices as a 2-stage process, proceeding from the " valuation " of each option under consideration to the " selection " of the best option on the basis of their subjective values. However, little is known about the computational mechanisms at play at the selection stage and its implement...
Article
Full-text available
Understanding how option values are compared when making a choice is a key objective for decision neuroscience. In natural situations, agents may have a priori on their preferences that create default policies and shape the neural comparison process. We asked participants to make choices between items belonging to different categories (e.g., jazz v...
Article
Full-text available
The aim of this study was to estimate the prevalence of psychostimulant use in the French medical community and their motives. A population-based cross-sectional study using a self-administered online survey was done. A total of 1718 French students and physicians (mean age, 26.84±7.19 years, 37.1% men) were included. Self-reported lifetime use, mo...
Article
Aims To estimate the prevalence of psychostimulant use in French medical undergraduate and postgraduate students, associated consumption behaviors and motives. Design A population-based cross-sectional study using a self-administered online survey. Participants A total of 1718 French students and physicians (mean age 26.84 ± 7.19 years, 37.1% mal...
Article
Full-text available
The prefrontal cortex (PFC) subserves decision-making and executive control. Here we review recent empirical and modeling works with a focus on neuroimaging studies, which start unifying these two conceptual approaches of PFC function. We propose that the PFC comprises two arbitration systems: (1) a peripheral system comprising premotor/caudal PFC...
Article
Full-text available
Pathological gambling is an addictive disorder characterized by a persistent and compulsive desire to engage in gambling activities. This maladaptive behaviour has been suggested to result from a decreased sensitivity to experienced rewards, regardless of reward type. Alternatively, pathological gambling might reflect an imbalance in the sensitivit...
Article
Full-text available
Sir, In a recent study (Chambon et al., 2011), we investigated the ability of patients with schizophrenia to make accurate predictions about other people's intentions. This ability has long been shown to be impaired in schizophrenia, and this impairment may be ac-counted for by an abnormal integration of two different sources of information: the se...
Article
Full-text available
Background: Pathological gambling (PG) is an impulse control disorder characterized by excessive monetary risk seeking in the face of negative consequences. We used tools from the field of behavioral economics to refine our description of risk-taking behavior in pathological gamblers. This theoretical framework allowed us to confront two hypothese...
Thesis
Full-text available
Decision-making is the selection of an alternative according to our inner goals. Perceptual decisions, the selection of an action based on our perceptions, are made when sensory evidence accumulated over time reaches a decision threshold. This cognitive process is well accounted for by sequential sampling models of decision-making. Moreover, the mo...
Data
Basic experiment: psychometric curve fit to the cumulative distribution of participant's correct responses (red dots). Responses for the different actions were pooled across. The blue dot refers to the inflexion point of the sigmoid curve. In each experiment, the inflexion point occurs at the following duration: A. Basic: 1576 ms. B. Superord.: 155...
Data
Pre-tests: intra- and inter-sequence comparisons; selection of low, moderate and high amounts of information. (DOC)
Data
Distribution of participant's reaction times (blue dots) across the 12 movie segments. Reaction times for the different actions were pooled across subjects. Red squares: mean reaction times across participants for each of the 12 duration ranges. (TIF)
Article
Full-text available
Explaining or predicting the behaviour of our conspecifics requires the ability to infer the intentions that motivate it. Such inferences are assumed to rely on two types of information: (1) the sensory information conveyed by movement kinematics and (2) the observer's prior expectations--acquired from past experience or derived from prior knowledg...
Article
Full-text available
Perceptual decisions are made when sensory evidence accumulated over time reaches a decision threshold. Because decisions are also guided by prior information, one important factor that is likely to shape how a decision is adaptively tuned to its context is the predictability of forthcoming events. However, little is known about the mechanisms unde...
Article
Full-text available
Objective: Risk-taking behaviors represent the main cause of morbi-mortality in adolescence. Here, we analyze their neural correlates, based on a neuroeconomics approach. This approach postulates that risk-taking behaviors result from multiple decision-making biases that impair the selection of the most appropriate action among alternatives based...
Article
Full-text available
Schizophrenia, the most disabling of psychiatric diseases, is frequently associated with sleep disorders which nature and severity depend on the active/chronic phase and subtype of the disease. Experimentally schizophrenic patient's sleep is characterized by an increased latency and fragmentation leading to decrease of total sleep time and sleep ef...

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