Philippe Codron

Philippe Codron
Centre Hospitalier Universitaire d'Angers | CHU Angers · Département de neurologie

MD - PhD

About

45
Publications
3,513
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389
Citations
Citations since 2017
30 Research Items
378 Citations
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2017201820192020202120222023020406080
2017201820192020202120222023020406080
2017201820192020202120222023020406080

Publications

Publications (45)
Article
Introduction: Therapeutic plasma exchange (TPE) can be proposed in the treatment of chronic dysimmune peripheral neuropathies (CDPN). Actual guidelines are however based on few studies, and indications and protocols still remain to be clarified. We conducted a 10-year retrospective study in order to assess the effectiveness and tolerance of TPE in...
Article
Charcot-Marie-Tooth type 2A disease (CMT2A) is an inherited peripheral neuropathy mainly caused by mutations in the MFN2 gene coding for the mitochondrial fusion protein Mitofusin 2. Although the disease is mainly inherited in a dominant fashion, few cases of early-onset autosomal recessive CMT2A (AR-CMT2A) have been reported in recent years. In th...
Chapter
Neuronal intermediate filaments (NIFs) are the most abundant cytoskeletal element in mature neurons. They are composed of different protein subunits encoded by separate genes such as neurofilament light chain (NFL), neurofilament medium chain (NFM), neurofilament heavy chain (NFH), ɑ‐internexin and peripherin. NIFs are dynamic structures playing im...
Article
Mitochondrial disorders (MIDs) are frequently responsible for neuropathies with variable severity. Mitochondrial diseases causing peripheral neuropathies (PNP) may be due to mutations of mitochondrial DNA (mtDNA), as is the case in MERRF and MELAS syndromes, or to mutations of nuclear genes. Secondary abnormalities of mtDNA (such as multiple deleti...
Article
There have been dramatic changes in neurology over the past decade; these advances require a constant adaptation of residents' theoretical and practical training. The French Association of Neurology Residents and the College of Neurology Teachers conducted a national survey to assess the French neurology residents' satisfaction about their training...
Article
Full-text available
The centrosome, as the main microtubule organizing centre, plays key roles in cell polarity, genome stability and ciliogenesis. The recent identification of ribosomes, RNA-binding proteins and transcripts at the centrosome suggests local protein synthesis. In this context, we hypothesized that TDP-43, a highly conserved RNA binding protein involved...
Article
Full-text available
Glioblastoma is an aggressive brain tumor with a poor prognosis. Glioblastoma Stem Cells (GSC) are involved in glioblastoma resistance and relapse. Effective glioblastoma treatment must include GSC targeting strategy. Robust and well defined in vitroGSC models are required for new therapies evaluation. In this study, we extensively characterized 4...
Article
Amyotrophic lateral sclerosis (ALS) is a rare fatal motor neuron disease. Although many potential mechanisms have been proposed, the pathophysiology of the disease remains unknown. Currently available treatments can only delay the progression of the disease and prolong life expectancy by a few months. There is still no definitive cure for ALS, and...
Article
Full-text available
The diagnosis of neurodegenerative diseases is made complex by the heterogenous phenotype of the patients and the regular occurrence of concomitant pathology. Studying clinicopathological correlations in autopsy series is a central approach to improve pathological prediction in clinical practice. However, such method requires a wealth of informatio...
Article
Introduction Depuis la découverte de la neuropathie optique de Leber en 1870, plusieurs cas d’atteintes neurologiques ont été décrits, en particulier de type sclérose en plaques (SEP). Observation Nous rapportons le cas d’une patiente de 24 ans, sans antécédent personnel ou familial, se plaignant en avril 2018 d’une baisse d’acuité visuelle de l’œ...
Article
The question of a loss or toxic gain of function in FUS-related amyotrophic lateral sclerosis is still debated. Recently, Korobeynikov et al. argued that FUS mutations lead to a gain of function and showed that lowering wild-type and mutant FUS levels could be a promising therapeutic strategy.
Article
Résumé La sclérose latérale amyotrophique (SLA) sporadique est une pathologie neurodégénérative affectant les motoneurones du cortex, des noyaux du tronc cérébral, et de la corne antérieure de la moelle épinière. Cette atteinte est responsable d’une paralysie diffuse d’aggravation rapide aboutissant au décès des patients dans les années suivant le...
Article
Full-text available
Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), 2 incurable neurodegenerative disorders, share the same pathological hallmark named TDP43 (TAR DNA binding protein 43) proteinopathy. This event is characterized by a consistent cytoplasmic mislocalization and aggregation of the protein TDP43, which loses its physiolo...
Article
Introduction Une nouvelle technique d’imagerie optique appelée STORM permet d’obtenir des images dont la résolution est de l’ordre du nanomètre. Toutefois son utilisation est pour le moment principalement restreinte à l’analyse de cellules en culture. Objectifs L’objectif de ce travail était de mettre au point un protocole d’imagerie STORM sur cou...
Article
Full-text available
Aims Histological analysis of brain tissue samples provides valuable information about the pathological processes leading to common neurodegenerative disorders. In this context, the development of novel high‐resolution imaging approaches is a current challenge in neuroscience. Methods To this end, we used a recent super‐resolution imaging techniqu...
Preprint
Full-text available
Background Histological analysis of brain tissue samples provide valuable information about the pathological processes leading to common neurodegenerative disorders such as Alzheimer’s or Parkinson’s diseases. In particular, high resolution and specific analysis of intra-neuronal lesions is crucial to understand the pathogenesis and progression of...
Article
Purpose In developed countries, lead intoxication is decreasing in adults as sources of contamination were considerably reduced. Hence, cases of lead encephalopathy have become scarcer. We report the case of a 50-year-old woman who developed a systemic intoxication due the persistence of lead fragments in her abdomen and back. The patient was shot...
Thesis
La sclérose latérale amyotrophique (SLA) sporadique est une pathologie neurodégénérative affectant les motoneurones, responsable d’une paralysie diffuse d’aggravation rapidement progressive aboutissant au décès des patients dans les 5 années suivant le diagnostic. Il n’existe à ce jour aucun traitement de la maladie. L’étude des lésions neuronales...
Article
Charcot-Marie-Tooth (CMT) disease is a common inherited peripheral neuropathy. The CMT2K axonal form is associated with GDAP1 dominant mutations, which according to the affected domain cause a gradient of severity. Indeed, the p.C240Y mutation, located within GDAP1 glutathione S-transferase (GST) domain and associated to a mitochondrial complex I d...
Article
Full-text available
Amyotrophic lateral sclerosis (ALS) is characterized by a wide metabolic remodeling, as shown by recent metabolomics and lipidomics studies performed in samples from patient cohorts and experimental animal models. Here, we explored the metabolome and lipidome of fibroblasts from sporadic ALS patients (n = 13) comparatively to age- and sex-matched c...
Article
Full-text available
Ubiquilin-2 (UBQLN2) is a member of the ubiquilin family, actively implicated in the degradation of misfolded and redundant proteins through the ubiquitin-proteasome system and macroautophagy. UBQLN2 received much attention after the discovery of gene mutations in amyotrophic lateral sclerosis and frontotemporal dementia (ALS/ FTD). The abnormal pr...
Article
The cytoplasmic aggregation of TAR DNA-binding protein-43 (TDP-43) is a hallmark of degenerating neurons in amyotrophic lateral sclerosis (ALS) and subsets of frontotemporal dementia (FTD). In order to reduce TDP-43 pathology, we generated single-chain (scFv) antibodies against the RNA recognition motif 1 (RRM1) of TDP-43, which is involved in abno...
Article
Full-text available
Introduction Artificial Extracellular Matrices (ECMs) are promising tools for the study of cell behaviors. Methods Here, we report a protocol for the use of a reconfigurable biocompatible azopolymer thin film through a photoinduced reconfigurable structuration of its surface to study nerve growth, differentiation and cell guidance. Results & Disc...
Article
Objective: Sporadic amyotrophic lateral sclerosis (sALS) is a fatal neurodegenerative disorder affecting upper and lower motor neurons. In view of the heterogeneous presentation of the disease, one of the current challenges is to identify diagnostic and prognostic markers in order to diagnose sALS at early stage and to stratify patients in trials....
Article
The ring-substituted derivatives of carbonyl cyanide phenylhydrazone, CCCP and FCCP, are routinely used for the analysis of the mitochondrial function in living cells, tissues, and isolated mitochondrial preparations. CCCP and FCCP are now being increasingly used for investigating the mechanisms of autophagy by inducing mitochondrial degradation th...
Article
Background: Human exposure to insecticides raises serious public health concerns worldwide. Insecticides constitute a wide-ranging heterogeneous group of chemicals, most of which target the nervous system and disrupt neurometabolism and/or neurotransmission. Although the acute effects of insecticide poisoning in humans are well documented, the chr...
Article
Introduction Les échanges plasmatiques (EP) peuvent être proposés comme traitement de certaines Neuropathies Périphériques Dysimmunitaires Chroniques (NPDC). Toutefois, plusieurs points concernant leur utilisation dans ces indications restent encore à préciser. Objectifs Nous avons mené une étude rétrospective de 10 ans au CHU d’Angers afin d’éval...
Article
L’encefalopatia è definita come un danno cerebrale diffuso di comparsa acuta o subacuta. I disturbi psico-comportamentali (agitazione, confusione, allucinazioni) sono, di solito, la prima manifestazione; in una fase più avanzata si verificano disturbi della vigilanza, la cui gravità può variare dalla semplice sonnolenza al coma. Molti segni neurolo...
Article
Résumé L’atteinte du système nerveux périphérique est fréquemment rencontrée dans les cytopathies mitochondriales avec une expression phénotypique très variable et parfois infra-clinique. À cette variabilité phénotypique s’ajoute la complexité génétique puisqu’elles peuvent être dues soit à des mutations de l’ADN mitochondrial, comme par exemple da...
Article
Introduction Dans un contexte d’évolution de l’organisation hospitalière, il semble important de connaître les attentes des internes de neurologie (413 en 2015) concernant leur formation. Objectifs L’Association nationale des assistants et des internes de neurologie de France (ANAINF) a réalisé une enquête auprès des internes et des chefs de clini...
Article
Introduction Le gène MFN2, codant pour la protéine mitofusine 2 responsable de la fusion mitochondriale, est le gène le plus fréquemment impliqué dans les formes axonales de maladie de Charcot-Marie-Tooth (CMT2A). Objectifs Nous avons cherché à caractériser le retentissement sur la bioénergétique et la structure du réseau mitochondrial de deux var...
Chapter
L’encéphalopathie se définit comme une souffrance cérébrale diffuse d’installation aiguë ou subaiguë. Les troubles psychocomportementaux (agitation, confusion, hallucinations) sont le plus souvent au premier plan ; à un stade plus avancé s’installent des troubles de la vigilance, dont la gravité peut aller de la simple somnolence au coma profond. D...
Book
p>Neuronal intermediate filaments (NIFs) are the most abundant cytoskeletal element in mature neurons. They are composed of different protein subunits encoded by separate genes such as neurofilament light chain (NFL), neurofilament medium chain (NFM), neurofilament heavy chain (NFH), ɑ‐internexin and peripherin. NIFs are dynamic structures playing...
Article
Introduction La neuro-tuberculose correspond à la diffusion hématogène de Mycobacterium tuberculosis aux structures du système nerveux central aboutissant à la constitution d’une méningite lymphocytaire, ou d’un ou plusieurs tuberculomes. Observation Nous rapportons le cas d’un patient de 49 ans ayant pour seul antécédent une crise tonico-clonique...
Article
Introduction L’enquête nationale de l’Inter-syndicat national des internes (ISNI) réalisée en 2013 portant sur la qualité de formation des internes de médecine et chirurgie classe la formation neurologique parmi les dernières de France. Objectifs Nous avons réalisé une enquête auprès des internes de neurologie de France afin d’évaluer leur satisfa...

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