Philippe Belle Ebanda Kedi

University of Douala | UDLA · Department of Pharmaceutical Sciences

The increasing rate of antimicrobial resistance and pathological consequences associated with long-term use of available anti-inflammatory drugs justifies the urgent need to discover and rationally design new effective antimicrobial and anti-inflammatory drugs. This study reports the antibacterial, anti-inflammatory, and acute toxicity profile of V...

Antimicrobial pollution in Africa is escalating rapidly, threatening ecosystems and human health. Naturally occurring minerals, flora and microbial communities can support cost-effective and environmentally sustainable strategies to address this crisis and help achieve relevant Sustainable Development Goals.

The increasing rate of antimicrobial resistance and pathological consequences associated with long-term use of available anti-inflammatory drugs justifies the urgent need to discover and rationally design new effective antimicrobial and anti-inflammatory drugs. This study reports the antibacterial, anti-inflammatory, and acute toxicity profile of V...

Breast cancer is a major public health concern throughout the world, particularly in Cameroon. Numerous modalities, including surgery, radiotherapy, and chemotherapy, have been used for clinical cancer therapy. Despite advances in anti-cancer therapies, the use of these methods to treat cancer is often associated with deleterious side effects and m...

This study examined the synthesis of silver nanoparticles (SNPs) with aqueous extracts of Cyclosorus dentatus and Nephrolepis biserrata fronds and the evaluation of their biological activities. Mixing of AgNO3 solution and the aqueous extracts resulted in color change, indicating the formation of SNPs. UV‐Vis spectroscopy analysis gave a surface pl...

Magnesium hydroxide nanoneedles derived from Anthocleista schweinfurthii Gilg (Loganiaceae) support mesenchymal stromal cell proliferation and wound healing Abstract Multiple metallic nanoparticles are able to promote cellular and tissue health, but these nanoparticles can be difficult to synthesize and can also cause unintended side-effects. Here,...

In this work, AgCl nanoparticles were synthesized from Microsorum scolo-pendria (MS) aqueous extract and AgNO 3 solution. Preliminary confirmation was a color change from a light brown to a dark-colored solution and a UV-Vis spectra surface plasmon resonance peak at 427 nm. Measured vibra-tional frequencies at 1713 cm −1 and 1030 cm −1 for CO stret...

In this work, AgCl nanoparticles were synthesized from Microsorum scolo-pendria (MS) aqueous extract and AgNO 3 solution. Preliminary confirmation was a color change from a light brown to a dark-colored solution and a UV-Vis spectra surface plasmon resonance peak at 427 nm. Measured vibra-tional frequencies at 1713 cm −1 and 1030 cm −1 for CO stret...

The low therapeutic index of available trypanocidal drugs and the increasing emergence of resistant Trypanosoma parasites indicate the urgent need to develop new strategies for trypanosomiasis control. One such strategy is the screening of medicinal plants as sources of new lead compounds. Trypanosoma brucei brucei is a sub-species only infecting a...

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Ficus elastica Roxb. Ex Hornem, also called Rubber fig tree is a plant of the Moraceae family widely used in traditional medicine for the treatment of various ailments including allergies and skin infections, as well as a diuretic agent. This study points out the acute and sub-acute toxicological profile of the ethanolic extract of Ficus elastica l...

The present study aims to design a cheap and environmentally friendly cotton textile impregnated with green synthesized silver nanoparticles from Cymbopogon citratus leaves. The silver nanoparticles were characterized by umtraviolet spectroscopy and powder X-ray diffraction. Analytical differences between impregnated and non-impregnated cotton text...

Background: Although significant efforts such as insecticide-treated nets distribution campaigns, the introduction of artemisinin-based combination therapies, and more recently first malaria vaccine rolled out have been made by governments to control malaria, this disease remains a devastating human welfare and challenging public health dilemma wor...

Purpose: The recent emergence of Plasmodium falciparum (Pf) parasites resistant to current artemisinin-based combination therapies in Africa justifies the need to develop new strategies for successful malaria control. We synthesized, characterized and evaluated medical applications of optimized silver nanoparticles using Alchornea cordifolia (AC-Ag...

The widespread use of Artabotrys aurantiacus in traditional medicine in the quest for well-being aroused attention to its potential risk to human and animal health. This study points out the acute and sub-chronic toxicological profile of Artabotrys aurantiacus leaves aqueous extract. The extract was prepared following the traditional healer's metho...

Recently, numerous plant-based synthesis techniques have been used to develop metal nanoparticles. The current study uses the medicinal plant extract of couroupita guianensis (CG) petals to create biogenic silver nanoparticles in an environmentally friendly manner. Different techniques, including ultraviolet-visible spectroscopy (UV-vis), Fourier T...

Medicinal plants have shown to have genuine utility especially in developing countries where about 80% of the rural population continuously rely on them for primary health care. They have being explored for many decades as alternative therapeutic to side effects-chemical drugs, exhibiting a wide range of biological activities. However, in addition...

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The discovery of exceptional properties in material with nanometer sized have tremendously improved human well-being all around the globe. Nanoscience/Nanotechnology is yielding far-reaching societal benefits in various aspects of life including biomedical area, manufacturing, environmental protection, energy production and storage, food and feed a...

In this study, Strychnos phaeotricha liana bark extract was used as a metabolite container both on the surface of metallic nanosilver and encapsulated by a chitosan polymer. The plant extract was able to reduce Ag + into Ag 0 efficiently, and the encapsulation rate was determined. The synthesized nanoderivatives were characterized using ultraviolet...

The dsicoveries of exeptional properties in material with nanometer sizes have tremendously improved human wee being all around the globe. Our research group have screened numerous plants for the production of metallic and organic nanoparticles for different applications. This talk presents strategies and opportunities in the ligth of recent findin...

Interest in green nanotechnology is rapidly growing due to simplest, affordable, cost-effective and environmental friendly procedures to generate nanomaterials for biomedical applications. Significant increase in wound contraction rate and reduce period of epithelialisation is observed compared to control groups when silver nanoparticles are consid...

Computational Applications in Secondary metabolite Discovery

Objectives: The current study looks towards reporting the chemical compounds present in the panchagavya (PG), free radicals scavenging and mosquitocidal activity of PG in the laboratory condition. Methods: The existence of chemical compounds in the PG were studied by GC–MS analysis. Free radicals scavenging activity of PG was studied by using vario...

Objectives The current study looks towards reporting the chemical compounds present in the panchagavya (PG), free radicals scavenging and mosquitocidal activity of PG in the laboratory condition. Methods The existence of chemical compounds in the PG were studied by GC-MS analysis. Free radicals scavenging activity of PG was studied by using variou...

The identification of unique properties in material with dimensions in the range 1-100 nm is yielding many far-reaching societal benefits particularly in biomedical area. Among other nanomaterial, metallic nanoparticles (MNPs) have attracted extensive research interest due to their unique tunable features including physicochemical versatility, part...

Studies capturing the high efficiency of green-synthesized metal nanoparticles (NPs) in targeting mosquito vectors of the world's main infectious diseases suggest the NPs’ possible utilization as bio-insecticides. However, it is necessary to confirm that these potential bio-insecticides are not harmful to non-target organisms that are often sympatr...

Objectives Several studies establish the therapeutic properties of various plants which are sometimes a source of minerals, vitamins and phytochemical compounds. However, many studies evoked potential toxic of some. In Cameroon, Crassocephalum crepidioides ( C.c ) is used in folk medicine to treat several diseases, but there are not much informatio...

The progress in the field of nanotechnology has contributed to the development of tools for combating the most critical problems in developing countries. The requirements that such tools should meet are low-cost and resource settings, environmental protection, ease of use, and availability. The use of plant properties for the generation of nanopart...

IJGHC Interest in green nanotechnology is rapidly growing due to simplest, affordable, cost-effective and environmental friendly procedures to generate nanomaterial for biomedical application. Plant-based nanoparticles have been reported to exhibit enhanced biological effects as compare to their medicinal extracts counterpart. The present study hig...

IJGHC 2020 The increasing demand to produce secure and cost-effective healthcare nanodevices is at the forefront of research in nanotechnology. The present work reports a simple and eco-friendly synthetic method for silver nanoparticles using the bark aqueous extract of Mangifera indica (MI-AgNPs) for the management of inflammation. MI-AgNPs were o...

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The present study reports a cost-effective and eco-friendly silver nanoparticles synthesis using Microsorum punctatum frond extract as a new solution in the development of therapeutic strategies against inflammation. Egg albumin denaturation model was used to ascertain the anti-inflammatory potential of the biosynthesized silver nanoparticles. Plas...

Malaria remains a devastating disease, affecting 216 million people annually, with 445.000 deaths occurring primarily in children under 5 years old. It is a major public health issue in Sub-saharan Africa where Anopheles gambiae is the principle vector of malaria. Plant - mediated synthesis of silver nanoparticles is a cost effective and eco-friend...

Background: The recent emergence in Southeast Asia of artemisinin resistance poses major threats to malaria control and elimination globally. Green nanotechnologies can constitute interesting tools for discovering anti-malarial medicines. This systematic review focused on the green synthesis of metal nanoparticles as potential source of new antipla...

Malaria, dengue, chikungunya, Japanese encephalitis, and lymphatic filariasis are amongst parasitic deseases caused by mosquitoes. Anopheles gambiae is the principal vector of malaria in sub-Saharan Africa.[1] An approach for the control of mosquito populations have used silver nanoparticles for their properties and the potential to be used as simp...

The advancement in nanoparticle systems has an impact in scientific areas. Metal nanoparticles such as silver, gold and copper were found to exhibit antibacterial, anti-oxidant and other biological activities. Today, the development of biocompatible, non-toxic and eco-friendly methods for the synthesis of nanoparticles is a topic of concern as biol...

De part leurs propriétés exceptionnelles et leurs utilisations dans des domaines aussi variés que l’électronique, le textile, la cosmétique, la pharmacie, la médecine, l’agroalimentaire, l’automobile, le génie civil, la mécanique; la demande de plus en plus croissante en nanoparticules a poussé les chercheurs à développer des méthodes de synthèses...

This study reports the preparation and characterization of silver nanoparticles synthesized by the mediation of the plant weed Stachytarpheta cayennensis through solution method. Ultraviolet visible spectroscopy (UV-Vis) determines the presence of nanoparticles in the solution. Infrared spectroscopy (IR) proves organic molecules at the particles in...

Plants mediated anti-inflammatory activities are wildly explored as alternative therapeutic to side effects-chemical drugs. This growing interest in plants due to their safeness and worldwide availability arouse attention for their proper exploitation. accordingly, extracts preparation methods based on the collection of fruits (ripe or unripe), lea...

Powder X-ray diffraction and dynamic light scattering (DLS) sizing of silver (Ag) and palladium (Pd) nanoparticles produced within aqueous plant extract and the effect of introducing of an ionic liquid are reported in this paper. The simple and novel synthesis of silver and palladium nanoparticles using the reducing power of Persea americana (Pa) b...

Introduction: There is emerging interest in medicinal plants in the biomedical feld, due to their multitude of chemicals which show anti-inflammatory, antimicrobial, antiviral, or antitumoral potential. Research on medicinal plants has shown that nanotechnology could offer new solutions in the quality control, delivery aspects, or in sustaining herb...

Introduction There is emerging interest in medicinal plants in the biomedical field, due to their multitude of chemicals which show anti-inflammatory, antimicrobial, antiviral, or antitumoral potential. Research on medicinal plants has shown that nanotechnology could offer new solutions in the quality control, delivery aspects, or in sustaining her...

Arthritis is an inflammatory autoimmune disorder of unknown etiology affecting 1-1.5% of the population worldwide. It is a lifelong progressive disease which affects multiple joints and causes cartilage erosion leading to significant morbidity and premature mortality. Hitherto, efforts to identify and develop disease-modifying therapeutics have bee...

These findings shows that Selaginela Myosorus mediated silver nanoparticles are capable of controlling protein denaturation involved in arthritic reaction, thus could be promising for the development of novel plant-based anti-arthritic drugs following an environmental friendly route

This study was designed to investigate the acute and subacute toxicity of the aqueous extract from colocasia esculenta (CE) leaves infected by Phytophthora colocsiae (PC) in rats. Toxicity of the aqueous extract was evaluated in both male and female wistar rats after a single administration (Acute model) and during 21 days (subacute model). Acute a...

Phytochemical investigation of the stem bark of Diospyros longiflora yielded longiflorol ( 1 ), a new bergenin α - d -apioside, together with bergenin ( 2 ) and five known compounds: lupeol ( S1 ), betulin ( S2 ), betulinic acid ( S3 ), stigmasterol ( S4 ) and stigmasterol glucoside ( S5 ). Their structures were determined by one-dimensional (1D) a...

Background: Breast cancer remains a major health dilemma worldwide due to the development of multidrug resistance and high degree of toxicity of surrounding adjacent neoplastic tissues associated to available treatments including surgical resection, chemotherapy, hormonal therapy and radiotherapy. This work report the use of phytosynthesized silver...

Mosquito vectors are solely responsible for parasitic infections such as malaria, dengue, chikungunya, Japanese encephalitis, and lymphatic filariasis. Anopheles gambiae is the major vector of malaria in sub-Saharan Africa.[1] Silver nanoparticles have the potential to be use as simple, inexpensive, biocompatible, eco-friendly approach for the cont...

Mosquito vectors are solely responsible for parasitic infections such as malaria, dengue, chikungunya, Japanese encephalitis, and lymphatic filariasis. Anopheles gambiae is the major vector of malaria in sub saharan Africa. Silver nanoparticles have the potential to be used as simple, inexpensive, biocompatible, eco-friendly approach for the contro...

Interest in medicinal plants with anti-arthritic potential as alternative to side-effect chemical drugs is gaining more attention as they are assume to be safe, cost-effective, affordable and worldwide available. In addition to the fact that extracts preparation methods based on the collection of fruits (ripe or unripe), leaves (fresh or dry), stem...

Development of green nanotechnology is making the interest of researchers towards biosynthesis of nanoparticles. In this work, copper oxides nanoparticles were synthesized from the aqueous leaf extract of Musanga cecropioides. The formation of the nanoparticles was proven by ultraviolet-visible spectroscopy analysis. Infrared spectroscopy in the mi...

Mosquito vectors are solely responsible for parasitic infections such as malaria, dengue, chikungunya, Japanese encephalitis, and lymphatic filariasis. Anopheles gambiae is the major vector of malaria in sub-Saharan Africa.[1] Silver nanoparticles have the potential to be use as simple, inexpensive, biocompatible, eco-friendly approach for the cont...

Nanoparticle, a most popular term nowadays, is a great creation of nanotechnology. Nanotechnology is defined as a research for the design, synthesis and manipulation of structure of particles with dimension smaller than 100 nm. Its applications in drug delivery, target-specific therapy, molecular imaging, biomarker, biosensor, diagnosis, water trea...

The development of drug-resistant strains is rising and the search for new and novel ways of fighting new or reemerging microbes goes on. A hope of treating such multidrug-resistant infections came from plants mediated nanoparticles since nature is a generous source which provides a variety of chemical compounds that can be used for new drug discov...

Plants with medicinal properties are widely explored as alternative therapeutic to side effects-chemical drugs. Though these have potent activities, most of them possess insoluble character leading to lower bioavailability, increased systemic clearance and required high systemic administration. Applying nanotechnology to herbal drugs offer many adv...

Nanobiotechnology is one of the most promising areas in modern nanoscience and technology. Metallic nanoparticles have found uses in many applications in different fields, such as catalysis, photonics, electronics, medicine and agriculture. Synthesized nanoparticles through chemical and physical methods are expensive and have low biocompatibility....

We present in this work the cheap, environmentally friendly green synthesis of silver nanoparticle as antimicrobials mediated by Central African plants extracts from Corchorus olitorus, Ipomoea batatas, Ricinodendron heudelotii, Megaphrynium macrostarchyum and Gnetum bucholzianum. We highlight the nanoparticles’ effectiveness in the conservation of...

Plectranthus glandulosus (Lamiaceae) is used in traditional Cameroon medicine for the treatment of dermatitis, bellyache, venereal diseases, internal inflammation, lower abdominal and nerve ache. In the present study, we have been evaluated analgesic and anti-inflammatory properties of aqueous extract of P. glandulosus in mice (Mus musculus) and Wi...