Philip Wagstaff

Philip Wagstaff
Amsterdam University Medical Center | VUmc · Department of Clinical Genetics

Master of Research

About

6
Publications
4,495
Reads
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45
Citations
Citations since 2017
6 Research Items
45 Citations
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Introduction
Philip Wagstaff currently works at the Department of Clinical Genetics, Academisch Medisch Centrum Universiteit van Amsterdam. Philip does research in Neuroscience, Molecular Biology and Genetics. Their current project is 'Genetics of Glaucoma'.

Publications

Publications (6)
Article
Purpose: Albinism refers to a group of genetic disorders typically characterized by a loss/reduction of melanin in the hair, skin and eyes of affected patients. Apart from pigment changes, all albinism patients present with foveal hypoplasia and optic nerve misrouting, and have blurred vision. The molecular mechanisms that link this lack of pigment...
Article
Full-text available
Albinism is a pigment disorder affecting eye, skin and/or hair. Patients usually have decreased melanin in affected tissues and suffer from severe visual abnormalities, including foveal hypoplasia and chiasmal misrouting. Combining our data with those of the literature, we propose a single functional genetic retinal signalling pathway that includes...
Article
Full-text available
Early in vivo embryonic retinal development is a well-documented and evolutionary conserved process. The specification towards eye development is temporally controlled by consecutive activation or inhibition of multiple key signaling pathways, such as the Wnt and hedgehog signaling pathways. Recently, with the use of retinal organoids, researchers...
Article
Full-text available
Genetically complex ocular neuropathies, such as glaucoma, are a major cause of visual impairment worldwide. There is a growing need to generate suitable human representative in vitro and in vivo models, as there is no effective treatment available once damage has occured. Retinal organoids are increasingly being used for experimental gene therapy,...
Article
Full-text available
The retinal pigment epithelium (RPE) and the adjacent light-sensitive photoreceptors form a single functional unit lining the back of the eye. Both cell layers are essential for normal vision. RPE degeneration is usually followed by photoreceptor degeneration and vice versa. There are currently almost no effective therapies available for RPE disord...

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Projects

Projects (3)
Project
EGRET is the training environment for 15 highly talented Early Stage Researchers. The individual and collaborative outputs of their work contribute to the following aims: a) acquiring new, quantitative knowledge on glaucoma and the ageing visual system; and b) applying this new knowledge to boost innovation in glaucoma care in both the public and private sectors.
Project
EGRET-plus is the training environment for 15 highly talented Early Stage Researchers. The individual and collaborative outputs of their work contribute to the following aims: a) acquiring new, quantitative knowledge on glaucoma and the ageing visual system; and b) applying this new knowledge to boost innovation in glaucoma care in both the public and private sectors. For more information about EGRET+ and its fellows, please visit www.egret-plus.eu