Phanankosi Moyo

Phanankosi Moyo
University of Pretoria | UP · Department of Chemistry

PhD Biochemistry

About

20
Publications
8,934
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134
Citations
Introduction
My research is inspired towards the search of malaria parasites transmission-blocking drugs from plant derived natural compounds. This is currently focused on the gametocyte stages. Further fields of interest include microbial derived natural products (soil bacteria and fungi) and policy development.
Additional affiliations
October 2017 - October 2017
University of Pretoria
Position
  • Fellow
March 2014 - October 2014
University of Pretoria
Position
  • PhD Student
January 2012 - March 2014
Great Zimbabwe University
Position
  • Lecturer
Description
  • Designed Regulations of a new Honours Degree Programme in Biology. Taught Natural Products Chemistry, Physical Chemistry and Environmental Chemistry in Department of Education.
Education
February 2009 - February 2010
University of the Witwatersrand
Field of study
  • MSc Biotechnology

Publications

Publications (20)
Article
Ethnopharmacological relevance: Extracts of plant species, used traditionally to treat malaria, have been extensively investigated for their activity against Plasmodium intraerythrocytic asexual parasites in search of new antimalarial drugs. However, less effort has been directed towards examining their efficacy in blocking transmission. Here, we...
Article
Full-text available
Background Optimal adoption of the malaria transmission-blocking strategy is currently limited by lack of safe and efficacious drugs. This has sparked the exploration of different sources of drugs in search of transmission-blocking agents. While plant species have been extensively investigated in search of malaria chemotherapeutic agents, comparati...
Article
Full-text available
The discovery and development of multistage antimalarial drugs targeting intra-erythrocytic asexual and sexual Plasmodium falciparum parasites is of utmost importance to achieve the ambitious goal of malaria elimination. Here, we report the validation of naphthylisoquinoline (NIQ) alkaloids and their synthetic analogues as multistage active antimal...
Article
Full-text available
The ability to block human-to-mosquito and mosquito-to-human transmission of Plasmodium parasites is fundamental to accomplish the ambitious goal of malaria elimination. The WHO currently recommends only primaquine as a transmission-blocking drug but its use is severely restricted by toxicity in some populations. New, safe and clinically effective...
Article
Full-text available
Chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium . Here, we report the parallel de novo screening of the Medicines for Malaria Venture (MMV) Pandemic Response Box against Plasmodium asexual and liver stage parasites, stage IV/V gametocytes, gametes, oocysts and as endectocides....
Article
Full-text available
Amaryllidaceae is a significant source of bioactive phytochemicals with a strong propensity to develop new drugs. The genera Allium, Tulbaghia, Cyrtanthus and Crinum biosynthesize novel alkaloids and other phytochemicals with traditional and pharmacological uses. Amaryllidaceae biomolecules exhibit multiple pharmacological activities such as antiox...
Article
Ethnopharmacological relevance Aloe marlothii A.Berger (Xanthorrhoeaceae) is indigenous to southern African countries where its aqueous preparations are used in traditional medicine to treat several ailments including hypertension, respiratory infections, venereal diseases, chest pain, sore throat and malaria. Aim of the study The aims of this stu...
Article
Full-text available
Despite the success of combination antiretroviral therapy (cART), HIV persists in low- and middle-income countries (LMIC) due to emerging drug resistance and insufficient drug accessibility. Furthermore, cART does not target latently-infected CD4+ T cells, which represent a major barrier to HIV eradication. The “shock and kill” therapeutic approach...
Chapter
Full-text available
Biofilms, are vastly structured surface-associated communities of microorganisms, enclosed within a self-produced extracellular matrix. Microorganisms, especially bacteria are able to form complex structures known as biofilms. The presence of biofilms especially in health care settings increases resistance to antimicrobial agents which poses a majo...
Article
Full-text available
SARS-CoV-2, the causative agent of COVID-19, continues to cause global morbidity and mortality despite the increasing availability of vaccines. Alongside vaccines, antivirals are urgently needed to combat SARS-CoV-2 infection and spread, particularly in resource-limited regions which lack access to existing therapeutics. Small molecules isolated fr...
Article
Full-text available
Elevated levels of the amylo β-proteins (Aβ), particularly Aβ42, are associated with a high risk of Alzheimer’s disease (AD). The Aβ proteins are produced from cellular processing of the amyloid precursor proteins (APPs). To identify natural products that block the formation of Aβ-proteins from APPs, we previously screened a library of plant extrac...
Article
Full-text available
The continued emergence of resistance to front-line antimalarial treatments is of great concern. Therefore, new compounds that potentially have a novel target in various developmental stages of Plasmodium parasites are needed to treat patients and halt the spread of malaria. Here, several benzimidazole derivatives were screened for activity against...
Preprint
Full-text available
New chemical matter is needed to target the divergent biology associated with the different life cycle stages of Plasmodium . Here, we report the parallel screening of the Medicines for Malaria Venture Pandemic Response Box to identify multistage-active and stage-specific compounds against various life cycle stages of Plasmodium parasites (asexual...
Article
Full-text available
Climate change and the related increasing variability are real phenomena in sub-Saharan Africa. They are exacerbating climatic risks associated with small-scale agriculture in tropical regions. This study seeks to assess smallholder farmers' perceptions of climate change and also their adaptive strategies at the microscale in Mhakwe Communal Area i...
Article
Full-text available
As global warming continues to be a challenge, there is urgency to look into fossil fuel alternatives for sustainable energy supplies which have also been hastened by the volatility of crude oil prices and the fact that fossil fuel depletion is clearly in sight. Zimbabwe has not been spared of the negative effects of climate change which have affec...
Article
Full-text available
Water hyacinth (Eichhornia crassipes) invasion has become a global challenge which has had significant detrimental impacts on ecosystems and economies. A native of the Amazonian region, the free floating water weed has spread to most parts of the world. In Zimbabwe, its invasion of Lake Chivero and Manyame River systems has been well documented alo...

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Projects

Project (1)
Project
The project is on the investigation of anti-gametocyte properties of extracts of plants and natural product compounds in search of new transmission blocking drugs for malaria control.