P.F. Zabrodskii

Saratov State Medical University | sgmu · Saratov Military Medical Institute (Toxicology)

In experiments on random-bred albino rats and CBA mice it was found that 2,3,7,8-tetrachlorodibenzo-p-dioxin (TChDBD) induced a dose of 1.0; 4.0 and 8.0 µg/kg when administered single time. The main parameters of nonspecific body resistance (NBR), antibody formation mainly to the T-independent antigen, delayed-type hypersensitivity reactions (DTH)...

Zabrodskii. Since the beginning of the epidemic, vaccine development has been a priority for all developed countries. According to WHO (26 January 2021), more than 60 vaccines worldwide are already in clinical trials. More than 170 are being tested on animals. There are 22 vaccines that have made it through the final phase of testing. The vaccine,...

The damage to the heart can be long-lasting. Even two and a half months after recovery, 78 percent of patients have abnormal heart function. Sixty percent show signs of myocardial inflammation. The extent of the damage does not depend on how severe the illness was. Serious complications have occurred even in those who have had COVID-19 asymptomatic...

Pavel Frantsevich Zabrodsky (on the occasion of his 70th birthday)

Immunotoxicology is the study of the effects of toxic chemicals, pharmacological agents and biological agents on immune homeostasis. Damage to the immune system can result from both direct and indirect effects of xenobiotics and/or their metabolites. In addition, an immune response to xenobiotics (or their metabolites) can develop with the formatio...

As a result of the rapid development of immunology in the last 30 years, a certain system of views on the mechanisms of interaction of a multicellular organism with living bodies and substances carrying signs of genetic foreignness has emerged and developed, based on the idea of the immune system as a multicomponent system responsible for maintaini...

Manuscript Review *** Urticaria, Anaphylaxia and Asthma from Contact with Work Air in Farmers and Agronomists Due to Bruchus Pisorum. ABSTRACT Background: There are few reports of contact urticaria from the inhalation of allergens from legume pests. Objective: To study the origin of an outbreak of contact urticaria, asthma and anaphylaxis in f...

Experiments on random-bred albino mice showed that the administration of α7n-acetylcholine receptors agonist (GTS-21, 15 mg/kg), β2-adrenoreceptor agonist (dexmedetomidine hydrochloride, 25 μg/kg), NF-κB inhibitor (BAY 11-7082, 10 mg/ kg), and STAT3 inhibitor (S3I-201, 15 mg/kg) to mice 2 h before sepsis modeling (i.p, 2.5×109 CFUs diurnal culture...

The gastrointestinal tract, like the respiratory system, is affected by COVID-19. Viral particles replicate in enterocytes. In addition, immune system disorders are important in the pathogenesis of COVID-19. Many commensal microbes are known to have immunomodulatory effects, and changes in the composition of the microbiota can lead to immune system...

Since the inception of the global Human Microbiome Project in 2007, which was aimed at deciphering the genome of bacteria inhabiting the human body, 395 phylogenetic groups of microor-ganisms have been identified and the total number of species is approaching 1500. Among these microorganisms, representatives of the genera Bacteroidetes, Firmicutes...

Data on the impact of xenobiotics on the immune system are of theoretical significance, revealing unknown mechanisms of immunogenesis regulation, as well as practical, making it possible to revise the maximum permissible concentrations of various chemical compounds, to conduct evidence-based prevention and treatment of numerous infectious, allergic...

Acta Scientific MICROBIOLOGY (ISSN: 2581-3226) Volume 4 Issue 3 March 2021 Pavel F Zabrodskii, Vladimir G Lim and Vladimir K Parfenyuk Published: February 10, 2021; Volume 4 Issue 3: 02-05. Chlorinated hydrocarbons (ChH)-1,2-dichloroethane (DchE), tetrachloromethane (TChM), and trichloroethylene (TChE) are widely used in industry as solvents for o...

The monograph is devoted to the consideration of toxic and immunotoxic properties of organophosphorus compounds (OPCs), in particular, chemical warfare agents and insecticides. Author describes the phenomenon discovered by author, which is realized by "cholinergic anti-inflammatory pathway (mechanism)": it is shown that activation of α7n-cholinorec...

ACTA SCIENTIFIC MICROBIOLOGY (ISSN: 2581-3226) Zabrodskii. Obesity rates have increased dramatically in recent decades. Several factors involved in the etiology and pathogenesis of obesity have been identified, including diet, lifestyle, environmental factors and genetics. However, none of them fully explains the development of obesity, and the sea...

There is a close relationship between the intestinal microbiota and the central nervous system, based on the efferent innerva-tion of the gastrointestinal tract and the biochemical signals of neuroactive microbiota molecules. The microbiome-gut-brain axis includes the intestinal microbiota, the central nervous system, the neuroendocrine and neuroim...

Abstract We forecast 1,000,000 COVID-19 cases outside of China by March 31st, 2020 based on a heuristic and WHO situation reports. We do not model the COVID-19 pandemic; we model only the number of cases. The proposed heuristic is based on a simple observation that the plot of the given data is well approximated by an exponential curve. The expone...

Abstract We forecast 1,000,000 COVID-19 cases outside of China by March 31st, 2020 based on a heuristic and WHO situation reports. We do not model the COVID-19 pandemic; we model only the number of cases. The proposed heuristic is based on a simple observation that the plot of the given data is well approximated by an exponential curve. The expone...

We forecast 1,000,000 COVID-19 cases outside of China by March 31st, 2020 based on a heuristic and WHO situation reports. We do not model the COVID-19 pandemic; we model only the number of cases. The proposed heuristic is based on a simple observation that the plot of the given data is well approximated by an exponential curve. The exponential curv...

We forecast 1,000,000 COVID-19 cases outside of China by March 31st, 2020 based on a heuristic and WHO situation reports. We do not model the COVID-19 pandemic; we model only the number of cases. The proposed heuristic is based on a simple observation that the plot of the given data is well approximated by an exponential curve. The exponential curv...

Experiments on random-bred albino mice showed that α7n-acetylcholine receptors (α7nAChRs) agonist (GTS-21) and STAT3 inhibitor (S3I-201) lead to the realization of the cholinergic anti-inflammatory pathway (the reduce the mortality of mice, the blood concentrations of proinflammatory cytokines TNF-α, IL-1β and IL-6 in sepsis (intraperitoneal of 2.5...

Keywords: Cholinergic Anti-Inflammatory Pathway; Proinflammatory Cytokines; Sepsis; Α7n-Acetylcholine Receptors; STAT3 Inhibitor Experiments on random-bred albino mice showed that α7n-acetylcholine receptors (α7nAChRs) agonist (GTS-21) and STAT3 inhibitor (S3I-201) lead to the realization of the cholinergic anti-inflammatory pathway (the reduce th...

Food poisoning is any disease of an infectious or toxic nature caused or suspected to be caused by the consumption of food or water. Food poisoning can be divided into two groups: bacterial (food toxicity and food intoxication) and non-bacterial (chemicals, poisonous fungi and herbs, poisonous fish). Bacterial intoxications (foodborne toxicity) are...

Food poisoning is any disease of an infectious or toxic nature caused or suspected to be caused by the consumption of food or water. Food poisoning can be divided into two groups: bacterial (food toxicity and food intoxication) and non-bacterial (chemicals, poisonous fungi and herbs, poisonous fish). Bacterial intoxications (foodborne toxicity) are...

Experiments on random-bred albino mice showed that the inhibitor of the transcription factor STAT3 (S3I-201) and the NF-Kb inhibitor (BAY 11-7082) significantly reduced the mortality of mice from experimental sepsis (intraperitoneal administration of E. coli) in 4 and 24 h after modeling by reducing blood levels of Proinflammatory cytokines TNFα, I...

Experiments on random-bred albino mice and rats showed that nitrile acrylate acute intoxication (0.25 and 0.75 LD50) dose-dependent reduces the integral state of the organism's anti-infection nonspecific resistance (innate immunity) due to suppression of bactericidal activity of blood serum, serum concentrations of lysozyme, platelet cationic prote...

Experiments on random-bred albino mice showed that the acute intoxication of anticholinesterase compounds (DDVP, 0.75 LD50) is implemented the cholinergic anti-inflammatory pathway (reduced mortality of mice from sepsis and the blood concentration of proinflammatory cytokines TNF-α, IL-1β, IL-6). Sepsis caused by the intraperitoneal administration...

Currently, the actual problems of microbiology are the issues of infectious diseases within the framework of associative sym-biosis (from fundamental research to applied development). The important tasks of medical microbiology of the 21 st century are to decipher the biological role of norm flora in the regulation of homeostasis, the participation...

Experiments on random-bred albino mice showed that the acute intoxication of anticholinesterase compounds (DDVP, 0.75 LD50) is implemented the cholinergic antiinflammatory pathway (reduced mortality of mice from sepsis and the blood concentration of pro-inflammatory cytokines TNF-α, IL-1β, IL-6). Sepsis caused by the intraperitoneal administration...

Literature data, as well as the results of our experimental studies (after the cholinergic anti-inflammatory mechanism we established in 1987) allow us to suppose, that n-cholinomimetic (α7nAChRs agonists, nicotine), acetylcholinesterase reversible inhibitor, adrenomimetics (β2ARs agonists) and M1-cholinomimetics, along with a range of therapeutic...

Literature data, as well as the results of our experimental studies (after the cholinergic anti-inflammatory mechanism - «cholinergic anti-inflammatory pathway» - we established in 1987) allow us to suppose, that n-cholinomimetic (α7nAChRs agonists, nicotine), acetylcholinesterase reversible inhibitor, adrenomimetics (β2ARs agonists) and m-cholinom...

Experiments on random-bred albino mice and rats showed that acute (0.1-0.8 LD50), subacute (1/7 LD50, 6 days) and chronic intoxication (0.01 LD50, 30 days) of sodium meta-arsenite (SMA) causes a dose-dependent reduction of the anti-infection nonspecific resistance (innate immunity), which is manifested by the increase of mortality of mice from expe...

The Combined Effect of α7n-Acetylcholine and β2-Adrenergic Receptors Agonists on the Implementation of the Cholinergic Anti-Inflammatory Pathway in Early Phase of Sepsis Experiments on random-bred albino mice showed that application of β2ARs agonist (hexaprenaline sulfate, 1,5 μg/kg, a single dose) and α7nAChRs agonist (GTS-21, 15 mg/kg, a single...

Editorial In the last 30-40 years, a new scientific direction has been formed, which is studying the effect of xenobiotics on the nonspecific resistance of the organism and the immune system immunotoxicology. The subject of immunotoxicology is the study of the effect on the immune homeostasis of xenobiotics: toxic chemicals (TCh), pharmacological a...

In the last 30-40 years, a new scientific direction has been formed, which is studying the effect of xenobiotics on the nonspecific resistance of the organism and the immune system immunotoxicology. The subject of immunotoxicology is the study of the effect on the immune homeostasis of xenobiotics: toxic chemicals (TCh), pharmacological agents and...

Experiments on random-bred albino rats showed that acetonitrile chronic intoxication (0.05 LD50 daily for 30 days) equally reduces the immune responses associated with the function of Th1, Th2 and B lymphocytes, decreases the activity of natural killer cells, antibody-dependent cellular cytotoxicity, blood concentrations of immunoregulatory, proinf...

Experiments on random-bred albino rats showed that organophosphorus compound (malathion) acute intoxication (0.5 LD50) in the greater degree reduces function of Th1 lymphocytes and bound with them of delayed-type hypersensitivity (DTH) reaction and production IFNγ, in comparison with function of Th2 lymphocytes and synthesis of IL-4 by them; the op...

Experiments on random-bred albino rats showed that organophosphorus compound (malathion) acute intoxication (0.5 LD50) in the greater degree reduces function of Th1 lymphocytes and bound with them of delayed-type hypersensitivity (DTH) reaction and production IFNγ, in comparison with function of Th2 lymphocytes and synthesis of IL-4 by them; the op...

Features of Reduction of Th1, Th2 Lymphocytes Functions after Intoxication of Various Toxic Chemicals Experiments on random-bred albino rats showed that organophosphorus compound (malathion) acute intoxication (0.5 LD50) in the greater degree reduces function of Th1 lymphocytes and bound with them of delayed-type hypersensitivity (DTH) reaction an...

The term “microbial ecology” ( “ecological microbiology”) was first used only in the 1960s although ecologically directed research of microorganisms began to be carried out long before that. Although the of microbial inhabitants of humans resides within clinical microbiology, it was the discovery of environmental pathogenic microorganisms that inva...

As a result of the rapid development of immunology during the last quarter of the last century, a certain system of views on the mechanisms of interaction of a multicellular organism with living bodies and substances bearing signs of genetic foreignness, based on the idea of the immune system as a multicomponent system responsible for maintaining t...

Experiments on random-bred albino rats showed that 1,2-dichloroethane subacute intoxication (0.3 LD50 daily for 3 days) decreases parameters cellular immune response, Th1 cell function is more than humoral immune response and Th2 lymphocyte activity; reduces blood content of immunoregulatory cytokines IFN-γ, IL-2, IL-4 and anti-inflammatory cytokin...

Experiments on random-bred albino rats showed that that ethylene trichloride chronic intoxication (30 days daily subcutaneous 0,05 LD 50) largely decreased Th2 cell activity in comparison with Th1 lymphocytes as well as humoral immune responses compared to the cellular immune response. Ethylene trichloride decreased blood levels of immunoregulatory...

In modern microbiology, there are a large number of fundamental and applied problems that are important both for biology and for solving special problems of science and practice. As a result of scientific and technological progress and an increasing penetration into various microbiological specialties of general microbiology methods, the involvemen...

Experiments on random-bred albino mice showed that the acute Intoxication of organophosphorus compounds (DDVP, 0.75 LD50) is implemented the cholinergic anti-inflammatory pathway (reduced mortality of mice from sepsis and the blood concentration of proinflammatory cytokines TNF-α, IL-1β, IL-6). Sepsis caused by the intraperitoneal administration of...

Influence of Polyoxidonium on the Humoral and Cellular Immune Responses In Mice after Chronic Intoxication with Chlorinated Hydrocarbons *** Experiments on albino outbred mice established that chronic intoxication with carbon tetrachloride and trichlorethylene (45 days, daily subcutaneous injection, 0.03 LD50), reduced the humoral and cell-mediat...

Experiments on albino outbred mice established that chronic intoxication with carbon tetrachloride and trichlorethylene (45 days, daily subcutaneous injection, 0.03 LD50), reduced the humoral and cell-mediated immune responses and the activity of Th1 and Th2 lymphocytes (equally), increased blood levels of proinflammatory cytokines (TNFα, IL-1β, IL...

Background: Using data collected by the Office for Civil Rights, Department of Health and Human Services (HHS), over half of the population in the USA might have been affected by security breaches since Oct 2009. This study provided analysis of the data, presenting the numbers of individuals affected in one breach and the number of breaches. Meth...

Experiments on random-bred albino rats showed that acetonitrile chronic intoxication (0.05 LD50 daily for 30 days) equally reduces the immune responses associated with the function of Th1, Th2 and B lymphocytes, decreases the activity of natural killer cells, antibody-dependent cellular cytotoxicity, blood concentrations of immunoregulatory, proinf...

It was established in experiments on random-bred albino mice that the reduction of mortality of mice from sepsis and decrease the blood concentration of proinflammatory cytokines (TNF-α, IL-1β, IL-6) after acute intoxication of organophosphorus compounds – OPC (DDVP, 0.5 LD50) due to the implementation of the cholinergic anti-inflammatory pathway:...

Experiments on noninbred albino rats showed that chronic intoxication with organophosphorus compounds malathion and parathion methyl (0.01 LD50 daily, for 30 days) significantly reduces the phagocytic-metabolic activity of neutrophils, the activity of natural killer, antibody-dependent cellular cytotoxicity and the production of proinflammatory cyt...

It was established in experiments on random-bred albino mice that the reduction of mortality of mice from sepsis and decrease the blood concentration of proinflammatory cytokines (TNF-α, IL-1β, IL-6) after acute intoxication of organophosphorus compounds – OPC (DDVP, 0.5 LD50) due to the implementation of the cholinergic anti-inflammatory pathway:...

The Effect of Chronic Intoxication by Organophosphate Insecticides on the Parameters of Innate and Adaptive Immunity and Realization of the Cholinergic Anti-inflammatory Pathway Pavel Franzevich Zabrodskii Saratov Medical University "REAVIZ", Saratov, Russia Experiments on noninbred albino rats showed that chronic intoxication with organophospho...

Experiments on random-bred albino mice showed that NF-κB inhibitor (BAY 11-7082) and β2-adrenoreceptor agonist (dexmedetomidine hydrochloride) significantly reduced mouse mortality in 4 and 24 h after sepsis modeling (intraperitoneal administration of E. coli) by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, and IL-6. The combined...

The Influence of Cholinergic and Adrenergic Drugs on Mortality of Mice and the Concentration of Proinflammatory Cytokines in Blood at Sepsis

Военная токсикология, радиология и защита от оружия массового поражения.

Experiments on albino mice showed that administration m-cholinomimetic (aceclydine), n-cholinomimetic (nicotine), reversible inhibitor of acetylcholinesterase (neostigmine methyl sulfate), n-cholinomimetic α7nAChRs agonist (GTS-21), epinephrine hydrochloride, adenomimetic β2ARs agonist (hexaprenaline sulfate) causes decrease in mice mortality in se...

Experiments on random-bred albino mice showed that inhibitor of NF-κB (BAY 11-7082) and -adrenoceptors agonist (dexmedetomidine hydrochloride) significantly reduced mortality of mice from experimental sepsis (intraperitoneal administration of E. coli) in 4 and 24 h after modeling by reducing blood levels of proinflammatory cytokines TNFα, IL-1β, an...

Эксперименты на неинбредных белых мышах показали, что ингибитор NF-κB (BAY 11-7082) и агонист β2-адренорецепторов (дексмедетомидина гидрохлорид) существенно снижают летальность мышей через 4 и 24 ч после моделирования экспериментального сепсиса (внутрибрюшинное введение E. coli) вследствие уменьшения в крови концентрации провоспалительных цитокинов...

Biull Eksp Biol Med. 1993 Aug;116(8):181-3. [The mechanisms of the immunotropic effects of organophosphorus compounds]. [Article in Russian] Zabrodskiĭ PF. Abstract The effects of acute poisoning with anticholinesterase insecticide dimethyldichlorvinylphosphate (DDVP) in doses 0.25; 0.5 and 1.0 LD 50, immobilisation stress (6-hour), hydrocortisone...

Experiments on Wistar rats showed that chronic intoxication of 2-chloroethanol (0.05 DL50 daily for 60 days) causes reduction of parameters humoral and cellular immune responses, decrease of function Th1 and Th2 lymphocytes to the same extent and contents in blood of IFN-γ, interleukins IL-2, IL-4, pro-inflammatory cytokines (TNF-α, IL-6), anti-inf...

Effect of armin on nonspecific resistance factors of the body and on the primary humoral immune response