Petra Staubach

Universitätsmedizin der Johannes Gutenberg-Universität Mainz · Department of Dermatology

Zusammenfassung Vitiligo ist eine häufige Erkrankung, die mit einem meist sichtbaren Pigmentverlust der Haut einhergeht. Der wichtigste Vertreter ist die nicht‐segmentale Vitiligo (NSV). Ihr liegt pathogenetisch eine autoimmunvermittelte Zerstörung der Melanozyten zugrunde. Die Erkrankung führt zu Stigmatisierung und signifikanter Einschränkung der...

Zusammenfassung Hintergrund Aktinische Keratosen (AK) zeigen eine steigende Inzidenz und haben als häufigste (prä)kanzeröse Läsionen der hellhäutigen Bevölkerung einen enormen Behandlungsbedarf. Um die Adhärenz zu erhöhen, ist die Erhebung von therapiebezogenen Bewertungen der verschiedenen Behandlungsarten durch die Patienten von großer Bedeutung...

Background Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disorder that affects palms and soles. Patients suffer significant pain, itching, and daily activity impairment. Guselkumab, an interleukin-23 inhibitor, has been approved for PPP treatment in Japan. However, there is no effective therapy licensed for PPP in Europe and the USA....

Background Actinic keratoses (AK) are increasing in incidence and represent the most common (pre‐)cancerous lesion in the fair‐skinned population, with a high unmet medical need. In order to increase treatment adherence, it is very important to assess patients' therapy‐related evaluations of different treatment options. Patients and methods 100 pa...

Vitiligo is a common disorder characterized by the visible loss of skin pigmentation. Non-segmental vitiligo (NSV) is the major subtype. The disease is caused by autoimmune-mediated destruction of melanocytes. Vitiligo leads to stigmatization and a significant reduction in quality of life. Disregarding the psychosocial burden, vitiligo is sometimes...

Ziele Der Erfahrungsbericht zeigt die Bedeutung der Galenik in der medizinischen Ausbildung im Fachbereich Dermatologie. Ziel ist es, die Relevanz galenischer Kenntnisse für die optimale und individualisierte Therapie topischer Arzneimittel zu beleuchten. Wir geben einen Überblick über die Vermittlung dieser Kenntnisse an Medizinstudierende. Metho...

Zusammenfassung Hintergrund und Ziele Hidradenitis suppurativa (HS)/Acne inversa (Ai) ist eine chronische, stark beeinträchtigende Erkrankung mit begrenzten Therapiemöglichkeiten. Die gerätebasierte LAight‐Therapie wurde 2017 in Europa zugelassen. Ziel dieser Studie war es, die Auswirkungen einer Real‐World‐Versorgung mit der LAight‐Therapie auf d...

Pruritus is defined as a symptom that leads to scratching. Clinically, a heterogeneous group of clinical pictures of different etiology must be considered. Pruritus is characterized by varying intensity and duration. Many patients and/or their social environment, which is influenced by this, cite the impact on sleep quality as an accompanying main...

Sexual health, a critical aspect of overall well-being, is often compromised in individuals with chronic disorders. Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that mainly affects intertriginous areas, potentially impacting sexual health as a result of its specific symptoms and psychosocial burden. This cross-sectional st...

Background and objectives Hidradenitis suppurativa (HS)/Acne inversa (Ai) is a chronic debilitating disease with limited therapy options. The device‐based LAight therapy was approved in Europe in 2017. The aim of this study was to evaluate the effect of real‐world care with at least one treatment with LAight therapy on disease activity and burden i...

Zusammenfassung Hintergrund Daten zu den Verlaufsformen der Urtikaria bei Kindern existieren, es mangelt jedoch an fundierten Daten, um eine qualitativ hochwertige Versorgung zu gewährleisten. Methode Es erfolgte eine retrospektive Sekundärdatenanalyse bei Kindern mit Urtikaria in den Routinedaten einer deutschen Krankenversicherung (DAK-Gesundhe...

Background Limited data are available characterizing the impact of the SARS-CoV-2 pandemic on psoriasis care for patients in Germany. Objective To analyze patient perception and impact of the pandemic on well-being and psoriasis management of German patients with moderate-to-severe psoriasis or psoriasis arthritis under systemic therapies. Method...

Background and Study Aim Data from the AWARE study (A Worldwide Antihistamine‐Refractory chronic urticaria patient Evaluation) illustrate a substantial disease burden in German patients with H1‐antihistamine (‐H1‐AH)‐refractory chronic spontaneous urticaria (CSU). Detrimental effects on patients' quality of life, poor disease control and impairment...

Zusammenfassung Einleitung Patienten mit chronisch‐entzündlichen Hauterkrankungen leiden häufig unter Schlafstörungen. Es fehlen jedoch objektive Daten zur Schlafarchitektur, insbesondere zur Beurteilung möglicher Gesamteinflüsse unter Therapie. Patienten und Methodik Pilotstudie zu Veränderungen der Schlafqualität bei Patienten mit Psoriasis und...

Introduction Patients with chronic inflammatory skin diseases often suffer from sleep disturbances. However, objective data on sleep architecture, especially to evaluate potential overall influences under therapy, are lacking. Patients and methods Pilot study on sleep quality changes including psoriasis and atopic dermatitis patients before and 2...

Afamelanotide is a synthetic alpha melanocyte stimulating hormone presenting a higher activity than natural hormones. Its main properties are related to the enhanced production of eumelanin by agonistically binding to the melanocortin-1 receptor. Since 2016 afamelanotide has been especially applied to treat cases of erythropoietic porphyria (EPP),...

Background There is a lack of real-life safety data on treatment options for chronic urticaria in the presence of comedication and comorbidities. Methods We present a single-center UCARE pilot study of 212 outpatients with chronic urticaria. Patients were divided into three groups according to different CU therapies according to international guid...

Background Chronic spontaneous urticaria (CSU) is both physically and emotionally stressful, and guideline recommendations are often not optimally implemented in clinical practice. The objective of this study was to provide an overview on the patient journey in CSU and to develop a mathematical model based on solid data. Methods The journey of CSU...

Introduction: Hidradenitis suppurativa (HS) is a chronic inflammatory disorder of the pilosebaceous unit, often affecting and deforming intimate regions. HS is associated with severe pain, pruritus, and constant, purulent, malodorous discharge expected to impair sexual health of patients. Methods: We performed a cross-sectional, multicentric stu...

What is this summary about? This summarizes an article about the clinical study ‘VANGUARD’ that was published in The Lancet journal in February 2023. Hereditary angioedema (HAE) is a rare genetic disease that causes swellings throughout the body (called HAE attacks). HAE attacks in the upper airways (including the tongue and vocal cords) can be lif...

Background Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting approximately 1% of the population. The patient journey through the German health care system leads to high disease burden and substantial treatment costs. The EsmAiL study showed that an innovative, interprofessional, multimodal care-concept reduces disease a...

Background Hidradenitis suppurativa (HS) is an inflammatory disease of the inverse skin regions with an age peak at around 40 years and an estimated prevalence of 1%. Nodules and abscesses can develop into fistules and scarring, which cause severe pain. HS is a progressive, life‐defining disease that leads to physical limitations, inability to work...

Background Urticarial vasculitis (UV) should be differentiated from chronic spontaneous urticaria (CSU) in patients initially presenting with recurrent wheals, although criteria for differential diagnosis remain ill‐defined. Objectives To set the goals, define criteria and unmet needs in UV diagnosis and differential diagnosis with CSU, and explor...

Introduction The integrated care pathways for atopic dermatitis (AD‐ICPs) aim to bridge the gap between existing AD treatment evidence‐based guidelines and expert opinion based on daily practice by offering a structured multidisciplinary plan for patient management of AD. ICPs have the potential to enhance guideline recommendations by combining int...

Background Monoclonal antibodies to interleukin (IL)-17 have shown strong efficacy in patients with psoriasis. Izokibep is a unique IL-17A inhibitor with a small molecular size and favourable distribution to sites of inflammation. Objectives To evaluate the dose response, efficacy and safety of izokibep in patients with plaque psoriasis. Metho...

Background and objective: Psoriatic arthritis (PsA) is a chronic systemic inflammatory disease affecting the musculoskeletal system, skin and nails. The aim is to characterize sociodemographic and clinical patient profiles documented in dermatologic and rheumatologic care. Patients and methods: Data of 704 patients with PsA from the dermatologic...

Background Non‐sedating H1‐antihistamines (nsAH) are the most commonly used treatment for chronic spontaneous urticaria (CSU). Many patients use them as on‐demand (OD) therapy rather than a maintenance treatment. Here, we compared OD versus daily maintenance treatment with the nsAH rupatadine, assessed the efficacy of rupatadine updosing, and inves...

Background Chronic spontaneous urticaria (CSU), a long‐lasting disease in children, impacts their quality of life. We report the results of a phase 2b dose‐finding trial of ligelizumab (NCT03437278) and a high‐affinity humanized monoclonal anti‐IgE antibody, in adolescents with CSU, supported by modeling and simulation analyses, mitigating challeng...

Chronic urticaria is a disease that can significantly impact a patient's quality of life and ability to function. There are effective treatment options, such as non-sedating antihistamines or biologics, but some patients do not respond to these therapies, or the therapies are not available or affordable to all patients. This review aims to summariz...

Background: Hidradenitis suppurativa is an inflammatory disease of the inverse skin regions that occurs particularly in young women and affects approximately 1% of the population. Outpatient care is often inadequate and usually cannot prevent progression. Objective: The aim of the EsmAiL trial was to evaluate whether an innovative care concept c...

Background: Cold urticaria (ColdU) is characterized by pruritic wheals following exposure of the skin to cold. Many patients show insufficient response to antihistamines, the first line treatment. Based on the high efficacy of interleukin-1(IL-1)-inhibition in cold-induced urticarial autoinflammatory diseases, we assessed the effects of rilonacept...

Background: Chronic recurrent angioedema without wheals (CRA) with normal C1-INH and unresponsive to antihistamines may contain not only patients with recurrent angioedema of unknown cause, i.e., the so-called non-histaminergic idiopathic angioedema, but also patients with hereditary angioedema with normal C1-INH (HAEnCI), in case HAEnCI occurs in...

The present article exemplifies the application of the concept of quality by design (QbD) for the systematic development of a nanoparticulate imiquimod (IMQ) emulsion gel formulation as an investigational medicinal product (IMP) for evaluation in an academic phase-I/II clinical trial for the treatment of actinic keratosis (AK) against the comparato...

Background: Hereditary angioedema is a rare and potentially life-threatening genetic disease that is associated with kallikrein-kinin system dysregulation. Garadacimab (CSL312), a novel, fully-human monoclonal antibody that inhibits activated factor XII (FXIIa), is being studied for the prevention of hereditary angioedema attacks. The aim of this...

Background: Allergen immunotherapy (AIT) is an approved treatment for seasonal respiratory allergic diseases. A depigmented polymerized birch pollen extract for subcutaneous allergen immunotherapy (SCIT) has been demonstrated to be efficacious and safe in patients allergic to birch pollen and its homologous group. Objective: To determine whether...

Zusammenfassung Hintergrund Patienten mit systemischen Autoimmun- und/oder autoinflammatorischen Erkrankungen (AI/AInf) bedürfen in der Regel einer multidisziplinären Zusammenarbeit durch verschiedene Fachrichtungen. Ziel der Arbeit (Fragestellung) Wir evaluierten, ob die Etablierung eines multidisziplinären Boards (sog. Rheumaboard [RB]) zur Opt...

Background: Although chronic urticaria (CU) is a common and primarily affects females, there is little data on how pregnancy interacts with the disease. Objective: To analyse treatment use by CU patients before, during and after pregnancy as well as outcomes of pregnancy. Methods: PREG-CU is an international, multicentre, study of the Urticari...

Background: Hidradenitis suppurativa is a chronic, inflammatory, burdensome skin disease where current first-line treatments are limited to topical and/or systemic antibiotics which cannot be applied for long-term disease management. Period B of the RELIEVE study analyzes whether LAight® therapy can sustain or even increase remission after a first...

Generalized pustular psoriasis (GPP) is a rare, severe, potentially life-threatening, autoinflammatory, neutrophilic skin disease that may be accompanied by fever and leukocytosis. This paper describes the current state of knowledge on GPP in terms of classification, (differential) diagnosis and prevalence. We present a comparison of the genetics a...

Zusammenfassung Die generalisierte pustulöse Psoriasis (GPP) ist eine seltene, schwere, potenziell lebensbedrohliche, autoinflammatorische, neutrophile Hauterkrankung, die von Fieber und Leukozytose begleitet sein kann. Diese Arbeit beschreibt den aktuellen Wissensstand zur GPP bezüglich Klassifizierung, (Differential‐)Diagnostik und Prävalenz. Wir...

Introduction: Chronic urticaria (CU) is a common disease that primarily affects females. Although commonly encountered, there is little data on how pregnancy interact with CU. We analysed treatment use by CU patients before, during and after pregnancy as well as outcomes of pregnancy. Material and Methods: PREG-CU was a prospective and retrospectiv...

Background: Standard treatment options for urticaria are second-generation antihistamines; however, their effect on sleep is uncertain. This study measures the influence of different antihistamines on the biologic sleep pattern of urticaria patients and the relevance of sleep in urticaria patients. Methods: Ten patients with chronic spontaneous...

Background: Chronic spontaneous urticaria (CSU) negatively impacts patients' sleep, thereby reducing health-related quality of life (HRQoL). Half of patients with inadequately controlled CSU report sleep interference often or every night, which can lead to depression, anxiety, social, and work-related problems. Methods: This randomized, double-b...

Introduction Atopic dermatitis (AD) is a chronic inflammatory skin disorder associated with intense itch/pruritus and skin lesions. Several modalities of treatment including topical therapy, systemic agents and biologics are available for the treatment of disease. Despite this, management poses challenge due to chronic nature and recurrent episodes...

Background Chronic urticaria (CU) is a debilitating mast cell-driven disease, often refractory to standard therapy (i.e., antihistamines). Lirentelimab, an anti-Siglec-8 monoclonal antibody, selectively inhibits mast cells and depletes eosinophils. Objective Determine safety and efficacy of lirentelimab in patients with chronic urticaria. Methods...

Background Ligelizumab, a next‐generation, humanized anti‐immunoglobulin E (IgE) monoclonal antibody is in development as a treatment for patients with chronic spontaneous urticaria, whose symptoms are inadequately controlled with standard‐of‐care therapy. Objective To evaluate the long‐term safety and re‐treatment efficacy of ligelizumab 240 mg i...

Bruton’s tyrosine kinase (BTK) is crucial for FcεRI-mediated mast cell activation and essential for autoantibody production by B cells in chronic spontaneous urticaria (CSU). Fenebrutinib, an orally administered, potent, highly selective, reversible BTK inhibitor, may be effective in CSU. This double-blind, placebo-controlled, phase 2 trial (EudraC...

Chronic urticaria (CU) in children as in adults is characterized by the presence of itchy wheals, angioedema, or both daily or almost daily for at least 6 weeks. Most cases of urticaria in the pediatric age group are acute [1–4]. CU is sub-classified as spontaneous (occurring without a known trigger) or inducible. There are also cases of spontaneou...

Background Although well described in adults, there are scarce and heterogeneous data on the diagnosis and management of chronic urticaria (CU) in children (0–18 years) throughout Europe. Our aim was to explore country differences and identify the extent to which the EAACI/GA²LEN/EDF/WAO guideline recommendations for pediatric urticaria are impleme...

Zusammenfassung Hintergrund Eine genitale Beteiligung bei Patienten mit chronisch-entzündlichen Hauterkrankungen ist zwar häufig, wird jedoch nicht ausreichend erkannt. Ziel Die Beurteilung der Prävalenz genitaler Symptome bei Patienten mit Psoriasis und chronischer Urtikaria, der Effekte auf die Lebensqualität, die Arzt-Patienten- Beziehung sowi...

Background: Although well described in adults, there are scarce and heterogeneous data on the diagnosis and management of chronic urticaria (CU) in children (0-18 years) throughout Europe. Our aim was to explore country differences and identify the extent to which the EAACI/GA²LEN/EDF/WAO guideline recommendations for paediatric urticaria are imple...

Background Chronic diseases, like inflammatory skin diseases with pruritus and chronic back pain are associated with reduced quality of life. Psychosocial reasons are also considered to be responsible. So far, it is not known whether chronic pruritus and chronic back pain are related to maladaptive stress coping. Patients and methods In our matche...

Background Genital involvement in patients with chronic inflammatory skin diseases is frequent, yet insufficiently acknowledged. Objective To evaluate the prevalence of genital symptoms in psoriasis and chronic urticaria patients, effects on quality of life, physician-patient relations and disease management. Patients and Methods 100 patients wit...

Purpose: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases. Methods: We analyzed records of CSU patients (n = 1,199) for...

Zusammenfassung Hintergrund: Bisher fehlen robuste epidemiologische Kennzahlen sowie Daten zur Komorbidität bei Kindern mit Urtikaria. Sie bilden die Grundlage zur Gestaltung einer effizienten Gesundheitsversorgung. Methodik: Retrospektive Studie zur Analyse von epidemiologischen Kennzahlen bei Kindern mit Urtikaria. Grundlage der Analyse sind Rout...

Background To date, robust epidemiological metrics as well as data on comorbidity in pediatric urticaria are lacking. They form the basis for the design of efficient healthcare. Methods Retrospective study to analyze epidemiological data in pediatric urticaria. The analysis is based on routine data of a health insurance company operating throughou...

Urticaria and angioedema are experienced by up to 1 in 5 people, usually the result of common allergen or medication triggers and infections. Similarly, the majority of recurrent angioedema has an exogenous trigger, for example, angiotensin converting enzyme inhibitors, or is hereditary (type 1 and 2 hereditary angioedema); chronic spontaneous urti...

Hintergrund: Die chronische Urtikaria (CU) ist eine häufige und für viele Patienten stark belastende Erkrankung. Die aktuelle Urtikaria-Leitlinie beschreibt die evidenzbasierte Diagnostik und Therapie der CU. Darüber hinaus treten jedoch oftmals Fragen im praktischen Alltag auf, die durch die Leitlinie nicht beantwortet werden. Methoden: Im Mai 202...

Background Chronic urticaria (CU) is a common disease which represents a considerable burden for many patients. The current urticaria guideline describes the evidence-based diagnosis and treatment of CU. In addition, however, questions often arise in everyday practice that are not addressed by the guideline. Methods In May 2020, a digital meeting...