Petra Klose

Petra Klose
Kliniken Essen-Mitte Knappschafts-Krankenhaus · Department of Integrative Medicine

PhD

About

138
Publications
51,321
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3,861
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Additional affiliations
March 2025 - present
University of Duisburg-Essen
Position
  • Researcher

Publications

Publications (138)
Article
Full-text available
Background and objective: This systematic review evaluated the effectiveness, tolerability and safety of cannabis-based medicines (CbMs) for chronic non-cancer pain (CNCP) in long-term observational studies. Databases and data treatment: CENTRAL, EMBASE and MEDLINE were searched to December 2021. We included prospective observational studies wit...
Article
ZUSAMMENFASSUNG Von dem zu den Efeugewächsen gehörigen Ginseng sind vor allem zwei Arten bekannt: Der Asiatische oder Koreanische Ginseng Panax ginseng und der Amerikanische Ginseng Panax quinquefolius. Anwendung finden Verarbeitungen der Ginsengwurzel (Ginseng Radix), welche etliche gesundheitsförderliche Inhaltsstoffe enthält. Die wichtigsten pha...
Article
Zusammenfassung Frauen mit Brustkrebs leben oft mit erheblichen Nebenwirkungen einschließlich der Einleitung einer frühen Menopause, die u. a. zu vasomotorischen Symptomen, Stimmungsschwankungen und muskuloskelettalen Schmerzen führt. Präparate aus der Traubensilberkerze (Cimicifuga racemosa) können hier eine Therapieoption darstellen, da in zahlre...
Article
Background: A large part of the population in Germany makes use of naturopathic, complementary and integrative medical treatments. There are now numerous scientific studies that provide evidence of efficacy for certain indications. At German medical faculties, selected procedures and their application are taught within the cross-sectoral unit calle...
Article
Unter der Federführung der Deutschen Krebsgesellschaft, der Deutschen Gesellschaft für Hämatologie und Medizinische Onkologie, der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe und der Deutschen Gesellschaft für Radioonkologie haben 72 ehrenamtliche Fachvertreter aus 46 Fachgesellschaften in einem dreijährigen Kraftakt die weltweit erste...
Article
Zusammenfassung Ingwer ist eine tropische Pflanze, welche im Wurzelstock 1,5–3% ätherisches Öl enthält. Ingwer fördert die Magenentleerung und den Magen-Darm-Transit und kann einen kurzfristigen Effekt bei der Behandlung und Prävention von Übelkeit und Erbrechen hervorrufen. Als in Pulverform anerkannte Arznei findet sie auch in der Onkologie Verwe...
Article
Zusammenfassung Bestimmte Extrakte des Johanniskrautes sind in Deutschland als Arzneimittel zugelassen und können auf Patientenwunsch zur Therapie der leichten bis mittelschweren Depression sowie zur kurzzeitigen symptomatischen Therapie bei leichter depressiver Verstimmung angewandt werden. Eine Überlegenheit oder Gleichwertigkeit von Johanniskrau...
Article
ZUSAMMENFASSUNG Von dem zu den Efeugewächsen gehörigen Ginseng sind vor allem zwei Arten bekannt: Der Asiatische oder Koreanische Ginseng Panax ginseng und der Amerikanische Ginseng Panax quinquefolius. Anwendung finden Verarbeitungen der Ginsengwurzel (Ginseng Radix), welche etliche gesundheitsförderliche Inhaltsstoffe enthält. Die wichtigsten pha...
Article
ZUSAMMENFASSUNG Ingwer ist eine tropische Pflanze, welche im Wurzelstock 1,5–3% ätherisches Öl enthält. Ingwer fördert die Magenentleerung und den Magen-Darm-Transit und kann einen kurzfristigen Effekt bei der Behandlung und Prävention von Übelkeit und Erbrechen hervorrufen. Als in Pulverform anerkannte Arznei findet sie auch in der Onkologie Verwe...
Article
ZUSAMMENFASSUNG Onkologisch tätige Ärzte und Ärztinnen vermeiden es häufig, mit ihren Patienten das Thema komplementäre Therapien anzuschneiden, da sie sich selbst nicht ausreichend informiert fühlen. Das kann sich ungünstig auf die langfristige Interaktion zwischen Arzt und onkologisch Erkranktem auswirken, der – so besagen es die Zahlen – höchstw...
Article
Zusammenfassung Im Jahr 2018 wurde die „Leitlinie zur Hormontherapie in der Peri- und Postmenopause“ von 2010 erneuert, neu ausgerichtet und umbenannt. Der Schwerpunkt liegt nach wie vor auf der wissenschaftlichen Aufarbeitung der Möglichkeiten und Risiken der Hormontherapie zur Linderung von menopausalen Beschwerden. Aber im ersten Kapitel zu Diag...
Article
Zusammenfassung Hintergrund: Der Einsatz von Phytotherapeutika hat in den letzten Jahren auch in der Behandlung psychiatrischer Erkrankungen erheblich an Bedeutung gewonnen. Methodik: Dieser narrative Überblick fasst die bisherige Evidenzlage zu Wirkungen und Nebenwirkungen pflanzlicher Arzneimittel bei der Behandlung von depressiven Störungen, Ang...
Article
Background Diagnosis, treatment and survival of cancer are associated with a complex set of stress factors. To promote emotional and physical well-being and also reduce psychological stress, mind–body therapies are often used in integrative cancer treatment.ObjectivesA survey of the state of evidence and fields of application of mind–body medicine...
Article
Background Therapies from traditional Chinese medicine (TCM) are increasingly being integrated into western treatment concepts within the framework of integrative oncology. The focus is on reducing side effects caused by oncological treatment, improving the quality of life and promoting a healthy lifestyle. The aim is not to achieve a cure but to s...
Article
Full-text available
Introduction Chronic non-specific low back pain is a major public health problem. Evidence supports the effectiveness of exercise as an intervention. Due to a paucity of direct comparisons of different exercise categories, medical guidelines were unable to make specific recommendations regarding the type of exercise working best in improving chroni...
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2016 erhielt der Japaner Yoshinori Ohsumi den Nobelpreis für die Entdeckung der Mechanismen der Autophagie, des Selbstverdauungs- und Wiederverwertungsprozesses der Zellen. Dieser Mechanismus trägt dazu bei, das Gleichgewicht zwischen dem Abbau alter und der Produktion neuer Zellkomponenten herzustellen. Auch krankhafte oder krankmachende Strukture...
Article
Full-text available
Background The update of the German S3 guidelines on long-term opioid therapy of chronic noncancer pain (CNCP), the LONTS (AWMF registration number 145/003), was scheduled for February 2020 due to the expiry of the validity period.Methods The guidelines were updated by 28 scientific societies and 2 patient self-help organizations under the coordina...
Article
There is a growing interest in non-pharmacological pain treatment options such as cupping. This meta-analysis aimed to assess the effectiveness and safety of cupping in chronic pain. PubMed, Cochrane Library, and Scopus were searched through November 2018 for randomized controlled trials on effects of cupping on pain intensity and disability in pat...
Article
Full-text available
Background and objective: This updated systematic review evaluated the efficacy, tolerability and safety of opioids compared to placebo in non-malignant chronic low back pain. Databases and data treatment: Clinicaltrials.gov, CENTRAL, MEDLINE and PsycINFO were searched from October 2013 to May 2019. Randomized controlled trials comparing opioids...
Article
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Background and objective: This updated systematic review evaluated the efficacy and safety of opioids compared to placebo for chronic osteoarthritis pain. Databases and data treatment: Clinicaltrials.gov, CENTRAL, MEDLINE and PsycINFO were searched from October 2013 to July 2019. Randomized controlled trials comparing opioids with placebo and at...
Article
Full-text available
Background and objective: This updated systematic review evaluated the efficacy, tolerability and safety of opioids compared to placebo in chronic non-cancer neuropathic pain. Databases and data treatment: Clinicaltrials.gov, CENTRAL, PubMed, and PsychInfo were searched from October 2013 to June 2019. Randomized controlled trials comparing opioi...
Article
Background Headache disorders are currently the sixth leading cause of disability across the globe and therefore carry a significant disease burden. This systematic review and meta-analysis aims to investigate the effects of yoga on headache disorders. Methods MEDLINE/PubMed, Scopus, the Cochrane Library, and PsycINFO were screened through May 201...
Article
Full-text available
Background and objective: This updated systematic review evaluated the efficacy, acceptability and safety of long-term opioid therapy (LTOT) for chronic non-cancer pain (CNCP). Databases and data treatment: Clinicaltrials.gov, CENTRAL and MEDLINE were searched to June 2019. We included open-label extension trials with a study duration ≥ 26 weeks...
Article
Objectives To determine the effectiveness and safety of yoga interventions on disease symptoms, quality of life and function in patients diagnosed with chronic obstructive pulmonary disease (COPD). Data sources Medline/PubMed, Scopus, and CENTRAL (Cochrane Central Register of Controlled Trials) were searched through 6 June 2019. Review methods Ra...
Article
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Background The importance of medical cannabis and cannabis-based medicines for cancer pain management needs to be determined. Methods A systematic literature search until December 2018 included CENTRAL, PubMed, SCOPUS and trial registers. Randomised controlled trials (RCTs) investigating medical cannabis and/or pharmaceutical cannabinoids for pain...
Article
This is a protocol for a Cochrane Review (Overview). The objectives are as follows: To provide an overview of the therapeutic efficacy of pharmacological therapies for fibromyalgia, and to report on adverse events associated with their use. The major comparison of interest will be with placebo.
Article
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Background and Objective This systematic review aimed at evaluating the efficacy, acceptability and safety of internet‐based psychological therapies (IPTs) in fibromyalgia syndrome (FMS). Databases and Data Treatment Cochrane Library, MEDLINE, PsycINFO and SCOPUS were searched from inception to January 2018. Randomized controlled trials (RCTs) com...
Article
Background Mindfulness-based stress reduction/cognitive therapy are frequently used for pain-related conditions, but their effects on headache remain uncertain. This review aimed to assess the efficacy and safety of mindfulness-based stress reduction/cognitive therapy in reducing the symptoms of chronic headache. Data sources and study selection...
Article
BACKGROUND: In Germany herbal medicines are traditionally frequently used. They represent an important therapeutic option, especially in self-medication. METHODS: Current systematic review articles and meta-analyses were evaluated and summarized with respect to the evidence of phytotherapeutic drugs for selected psychiatric indications. RESULTS:...
Article
BACKGROUND: In Germany herbal medicines are traditionally frequently used. They represent an important therapeutic option, especially in self-medication. METHODS: Current systematic review articles and meta-analyses were evaluated and summarized with respect to the evidence of phytotherapeutic drugs for selected psychiatric indications. RESULTS:...
Article
Objective: Despite the recent re-emergence of the process of cupping by athletes, supporting evidence for its efficacy and safety remains scarce. This systematic review aims to summarize the evidence of clinical trials on cupping for athletes. Methods: SCOPUS, Cochrane Library, PubMed, AMED, and CNKI databases were searched from their inception...
Article
Full-text available
Background: Fibromyalgia is a clinically defined chronic condition of unknown etiology characterized by chronic widespread pain that often co-exists with sleep disturbances, cognitive dysfunction and fatigue. People with fibromyalgia often report high disability levels and poor quality of life. Drug therapy, for example, with serotonin and noradre...
Article
Objectives: The aim of this review was to systematically assess and meta-analyze the effects of a low fermentable, oligo-, di-, mono-saccharides and polyol (FODMAP) diet (LFD) on the severity of symptoms, quality of life, and safety in patients with irritable bowel syndrome (IBS). Methods: The MEDLINE/PubMed, Scopus, and Cochrane Library databas...
Conference Paper
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Background: High expectations about acupuncture might contribute to larger treatment effects (Prady et al., 2015). However, problems in the assessment are well known: 1) floor or ceiling effects lower variance; 2) expectation measures include general beliefs about complementary medicine; 3) construct validity of expectation measures remains unclear...
Article
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Significance: This updated systematic review with meta-analysis on cognitive behavioural therapies (CBTs) including acceptance-based CBTs endorse the efficacy and tolerability of CBTs in reducing key symptoms and disability in FMS in the short- and long-term if compared to waiting list, treatment as usual, attention controls and active non-pharmac...
Article
Background: The aim of this meta-analysis was to systematically update the evidence for mindfulness-based stress reduction (MBSR) and mindfulness-based cognitive therapy (MBCT) in women with breast cancer. Material and methods: In October 2016, PubMed, Scopus, and Central were searched for randomized controlled trials on MBSR/MBCT in breast cancer...
Article
Objective: The aim of this review was to systematically assess and meta-analyze the effectiveness of yoga in relieving chronic neck pain. Methods: PubMed/MEDLINE, the Cochrane Library, Scopus, and IndMED were screened through January 2017 for randomized controlled trials assessing neck pain intensity and/or neck pain-related disability in chroni...
Article
Unter der Einbindung der Task Force „Naturheilkunde und Komplementärmedizin in Medizinischen Leitlinien“ wurde anhand einer systematischen Literaturrecherche die Evidenzlage für komplementäre Methoden in der aktualisierten Version der Leitlinie „Nicht spezifischer Kreuzschmerz“ neu bewertet, in die Leitlinienkonferenz eingebracht und in den Leitlin...
Article
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Introduction: After the reform of the German Medical Licensure Act of 2003, Rehabilitation, Naturopathy and Physical Medicine were integrated into one discipline to be taught in Medical University. The aim of this survey is to determine the outcome of this change by evaluating the current status of education of these three disciplines based on the...
Article
Phytotherapie bei Arthrose: Evidenz zweier Cochrane-Reviews Hintergrund: Um aktuelle Erkenntnisse über Wirksamkeit und Sicherheit von phytotherapeutischen Präparaten bei der Behandlung von Osteoarthritis (OA) zu erlangen, wurden die beiden neuesten Cochrane-Reviews (Cameron & Chrubasik, 2013; ­Cameron & Chrubasik, 2014) zusammengefasst. Ein Review...
Article
Background: Breast cancer is the cancer most frequently diagnosed in women worldwide. Even though survival rates are continually increasing, breast cancer is often associated with long-term psychological distress, chronic pain, fatigue and impaired quality of life. Yoga comprises advice for an ethical lifestyle, spiritual practice, physical activi...
Chapter
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Background: This review is one of a series on drugs used to treat fibromyalgia. Fibromyalgia is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue affecting approximately 2% of the general population. People often report high disability leve...
Article
Introduction Fasting during the month of Ramadan is considered one of the five pillars of the Islamic religion, and Muslims must abstain from food and drink between dusk and dawn. Research has found that fasting during Ramadan may affect the health of Muslims. Results of those studies however are often contradictory, with quantity and composition o...
Article
Pflanzliche Arzneimittel haben in der medizinischen Versorgung im deutschsprachigen Raum eine lange Tradition, werden aber bei der Erstellung medizinischer Leitlinien selten berücksichtigt. In einer Vorstudie wurde von unserer Arbeitsgruppe aufgearbeitet, in welchem Ausmaß sie in den aktuellen interdisziplinär, evidenz- und konsensusbasiert erstell...
Article
Herbal medicine is a promising alternative in the treatment of acute rhinosinusitis (ARS). We performed a systematic review for phytopharmaceutical treatments of ARS. A computerized search of databases (Cochrane Library, PubMed, and Scopus) up to 16 September 2015 was performed. Randomized controlled trials (RCTs) and controlled trials (CTs) were i...
Article
Background: This review is one of a series on drugs used to treat fibromyalgia. Fibromyalgia is a clinically well-defined chronic condition of unknown aetiology characterised by chronic widespread pain that often co-exists with sleep problems and fatigue. It affects approximately 2% of the general population. Up to 70% of patients with fibromyalgi...
Article
Full-text available
Several studies reported that Tai Chi showed potential effects for chronic pain, but its role remains controversial. This review assessed the evidence regarding the effects of Tai Chi for chronic pain conditions. 18 randomized controlled trials were included in our review. The aggregated results have indicated that Tai Chi showed positive evidence...
Article
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Background: The aim of this review was to systematically assess the literature on herbal medicine for cough as a symptom of upper respiratory tract infections and common cold. Methods: The Cochrane Library, Scopus, MEDLINE/PubMed, and Embase were searched through March 2012 for RCTs testing the effects of herbal medicine for cough. Risk of bias...
Chapter
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the analgesic efficacy of antipsychotics for fibromyalgia in adults, and to assess the associated adverse events.
Article
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In the sentence "For dichotomous variables, the threshold for 'appreciable benefit' or 'appreciable harm' was set at a relative risk reduction (RRR) or relative risk increase (RRI) ≥ 10 % [5]" the relative risk increase (RRI) is not ≥10 %, but ≥ 25 %.
Chapter
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the analgesic efficacy of cannabinoids for fibromyalgia in adults and to assess the associated adverse events.
Article
Objective: We performed a systematic review for Complementary and Alternative Medicine [CAM] as defined by the National Institute of Health in Inflammatory Bowel Disease [IBD], ie Crohn’s disease [CD] and ulcerative colitis [UC], with the exception of dietary and nutritional supplements, and manipulative therapies. Methods: A computerized search of...
Article
Full-text available
The update of the German S3 guidelines on long-term opioid therapy of chronic noncancer pain (CNCP), the"LONTS" (AWMF registration number 145/003) was scheduled for May 2014. The guidelines were developed by 25 scientific societies and two patient self-help organizations under the coordination of the German Pain Society and the Association of the S...
Article
Full-text available
Phytotherapy in the German Medical AWMF S3 Guidelines - a Systematic OverviewIn Deutschland werden an die interdisziplinär, evidenz- und konsensbasiert erstellten S3-Leitlinien der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) höchste wissenschaftliche Ansprüche gestellt; sie prägen die Gestaltung der Patientenv...
Article
Full-text available
Background. The efficacy and safety of opioid therapy in chronic low back pain (CLBP) is under debate. We updated a recent systematic review on the efficacy and safety of opioids in CLBP. Methods. We screened MEDLINE, Scopus and the Cochrane Central Register of Controlled Trials (CENTRAL) up until October 2013, as well as reference sections of orig...
Article
Full-text available
Hintergrund Die Wirksamkeit und Sicherheit der Opioidtherapie bei chronischen neuropathischen Schmerzen (CNS) ist umstritten. In der vorliegenden Publikation wird ein kürzlich erschienenes systematisches Cochrane-Review zur Wirksamkeit, Verträglichkeit und Sicherheit von Opioiden bei CNS aktualisiert. Methoden Bis Oktober 2013 wurden MEDLINE, Sc...