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Publications (29)
Dokument po připomínkovém kole MZ ČR a po jednání se zástupci Reformy psychiatrické péče, pojišťoven a MZ dne 6. 8. 2019 (redakčně uzavřeno 13. září 2019). Dokument úzce navazuje a vychází z verze 6.0 chvále-né výborem SNN ČLS JEP dne 3. dubna 2019 a následně výborem ČAA dne 8. dubna 2019 a doporučené pro další diskusi jak uvnitř obou odborných spo...
Kniha popisuje okolnosti vzniku nejstaršího léčebného programu na území České republiky existujícícho bez přerušení od roku 1948. Snaží se zachytit klíčové etapy vývoje této instituce až do roku 2012, kdy byla tranformována do dnešní podoby Kliniky adiktologie 1. LF UK a VFN. Ve druhé části knihy jsou pak popsány všechny klíčové provozy a programy...
Objective:
The objective of this research was to determine the prevalence of problematic and risky sexual behaviour after alcohol consumption and the correlation between this prevalence and sex, behavioural factors, problematic drinking, and alcohol consumption characteristics.
Methods:
A survey of students was carried out at four faculties. Dat...
Abstract Opioid agonist therapy (OAT) has been available in a standard regime in the Czech Republic since 2000. Buprenorphine is the leading medication, while methadone is available only in a few specialised centres. There is an important leakage of buprenorphine onto the illicit market, and the majority of Czech opioid users are characterised by t...
The aim of this paper is to present a specific patient population who were treated for alcohol addiction in the Department of Addictology of the General University Hospital in Prague (DoA) between 10/2016 and 02/2017, and discuss the psychopathologies, quality of life, levels of alcohol consumption and depression found in this group. After applying...
BACKGROUND: Social work students deal with the topic of alcohol both as part of their studies and later in practice as helping professionals. OBJECTIVES: The article focuses on experience with alcohol use and on experience with alcohol- related problems in bachelor’s students of social work. METHODS: The research was designed as a sample survey usi...
CHILD AND ADOLESCENT ADDICTOLOGY ON THE THRESHOLD OF EMANCIPATION?
BACKGROUND: The development of a comprehensive
system of a specialised network of addiction treatment services
and the relevant needs analysis gave rise to the idea of
creating a model of an outpatient addiction treatment clinic
for children and adolescents. Subsequently, a need arose to
pilot test this concept as a specific type of multithreshold...
SUMMARY: In view of the development of the epidemiological situation in substance use
among children and adolescents and the results of needs assessment studies, the management
of the Department of Addictology, First Faculty of Medicine, Charles University, and General University
Hospital in Prague, resolved to propose a design of an outpatient add...
Aims: The International Survey Informing Greater Insights in Opioid Dependence Treatment (INSIGHT) study evaluated the implementation of opioid dependence treatment across different countries to assess treatment delivery, quality of care and outcomes. Methods: A questionnaire-based survey was used to gather data in nine countries across Central and...
Background:
To map systems of care for persons with acute intoxications with alcohol and other drugs in European countries, to identify various models of this care and to contribute to discussion on the reform of sobering-up stations in the Czech Republic.
Methods:
In 2012, a questionnaire survey was performed among national institutions which a...
Introduction: Since 1950s, sobering-up stations (SUS) represent traditional type of health care of persons with acute intoxication with addictive substances, especially alcohol. Their number reduced after 1989 and information about their functioning is scarce. Goal: To describe and to analyse current state of SUS in the Czech Republic and to identi...
Záchytné stanice se v ČR od 50. let minulého století staly tradičním typem zdravotní služby o akutně intoxikované návyykovými látkami, především alkoholem. Po roce 1989 se ale jejich počet snížil a informace o způsobu fungování stávajících zařízení jsou kusé.
Long-term alcohol consumption results in menstrual irregularities due to the inhibition of progesterone secretion. Some progesterone metabolites, including three pregnanolone isomers (PI), abate, while pregnenolone sulfate (PregS) and dehydroepiandrosterone sulfate (DHEAS) increase, alcohol tolerance. The rationale of this study was to evaluate how...
170. M. Hill, P. Popov, H. Havlíková, L. Kancheva, J. Vrbková, M. Meloun, R. Kancheva, D. Cibula, V. Pouzar, I. Černý, L. Stárka: Reinstatement of Serum Pregnenolone Isomers and Progesterone Dutiny Alkohol Detoxification Therapy in Premenopausal Women, Alcoholism: Clinical and Experimental Research, 29 (2005) 1010-1017, DOI: 10.1097/01. alc.0000167...
General practitioners (GPs) in their surgeries and substitution treatment centres are the major providers of opioid maintenance treatment in a number of European countries. Although in the Czech Republic any GP has been allowed to prescribe buprenorphine (Subutex) since 2001, the opioid substitution treatment provided by primary care professionals...
The aim of our study was to determine serum levels of advanced glycation end-products (AGE) in patients with chronic alcohol misuse and to examine their relationship to markers of nutrition and inflammation.
The study group consisted of 23 heavy alcohol drinkers treated for chronic alcohol misuse and 22 healthy controls. Studied parameters included...
Objectives of the study: Formation of advanced glycation end products (AGEs) is influenced by actual metabolic situation and by nutritional effects. Acetaldehyde formed in the metabolism of ethanol should prevent formation of AGEs, while oxidative stress accompanying alcohol administration might enhance it. The aim of our investigation was to study...
This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was Albert Y. Sun. The presentations were (1) Ethanol-inducible cytochrome P-4502E1 in alcoholic liver disease, by Magnus Ingelman-Sundberg and Etienne Neve; (2) Regulation of NF-kappaB by ethanol, by H. Matsumoto, Y. Nishitani, Y. Minowa,...
This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was Albert Y. Sun. The presentations were (1) Ethanol-inducible cytochrome P-4502E1 in alcoholic liver disease, by Magnus Ingelman-Sundberg and Etienne Neve; (2) Regulation of NF-κB by ethanol, by H. Matsumoto, Y. Nishitani, Y. Minowa, and...
Alcohol-induced oxidative stress is linked to the metabolism of ethanol. Three metabolic pathways of ethanol have been described in the human body so far. They involve the following enzymes: alcohol dehydrogenase, microsomal ethanol oxidation system (MEOS) and catalase. Each of these pathways could produce free radicals which affect the antioxidant...
Antiphospholipid antibodies (APA) are a generic term describing antibodies that recognize various phospholipids. Hepatocyte damage is a cardinal event in the course of alcoholic liver injury and autoantibodies against phospholipids could play an important role in this process. APA in alcoholic patients seem to reflect membrane lesions, impairment o...
