Petr Marusic

Petr Marusic
Charles University in Prague | CUNI · Department of Neurology (2. LF)

About

120
Publications
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1,371
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Publications

Publications (120)
Article
Full-text available
Identifying factors whose fluctuations are associated with choice inconsistency is a major issue for rational decision theory. Here, we investigated the neuro-computational mechanisms through which mood fluctuations may bias human choice behavior. Intracerebral EEG data were collected in a large group of subjects (n = 30), while they were performin...
Article
Full-text available
Background The possibility to better predict the severity of the disease in a patient newly diagnosed with multiple sclerosis would allow the treatment strategy to be personalized and lead to better clinical outcomes. Prognostic biomarkers are highly needed. Objective To assess the prognostic value of intrathecal IgM synthesis, cerebrospinal fluid...
Article
Full-text available
Objective: Functional specialization is fundamental to neural information processing. Here, we study whether and how functional specialization emerges in artificial deep convolutional neural networks (CNNs) during a brain-computer interfacing (BCI) task. Approach: We trained CNNs to predict hand movement speed from intracranial EEG (iEEG) and de...
Article
Objectives: High counts of averaged interictal epileptiform discharges (IEDs) are key components of accurate interictal electric source imaging (ESI) in patients with focal epilepsy. Automated detections may be time-efficient, but they need to identify the correct IED types. Thus, we compared semiautomated and automated detection of IED types in l...
Article
MRI is a cornerstone in presurgical evaluation of epilepsy. Despite guidelines, clinical practice varies. In light of the E-PILEPSY pilot reference network, we conducted a systematic review and meta-analysis on the diagnostic value of MRI in the presurgical evaluation of epilepsy patients. We included original research articles on diagnostic value...
Preprint
Full-text available
Identifying factors whose fluctuations are associated with choice inconsistency is a major issue for rational decision theory. Here, we investigated the neuro-computational mechanisms through which mood fluctuations may bias human choice behavior. Intracerebral EEG data were collected in a large group of participants (n = 30), while they were perfo...
Article
Full-text available
Objective Epilepsy surgery fails in >30% of patients with focal cortical dysplasia (FCD). The seizure persistence after surgery can be attributed to the inability to precisely localize the tissue with an endogenous potential to generate seizures. In this study, we aimed to identify the critical components of the epileptic network that were actively...
Article
Full-text available
Objective: Diagnosing autoimmune encephalitis (AIE) is difficult in patients with less fulminant diseases, like epilepsy. However, recognition is important, as patients require immunotherapy. This study aims to identify antibodies in patients with focal epilepsy of unknown etiology, and to create a score to preselect patient requiring testing. Me...
Article
Full-text available
Objective Clinical care of rare and complex epilepsies is challenging, because evidence‐based treatment guidelines are scarce, the experience of many physicians is limited and interdisciplinary treatment of comorbidities is required. The pathomechanisms of rare epilepsies are, however, increasingly understood, which potentially fosters novel target...
Article
Full-text available
Human perception and cognition are based predominantly on visual information processing. Much of the information regarding neuronal correlates of visual processing has been derived from functional imaging studies, which have identified a variety of brain areas contributing to visual analysis, recognition, and processing of objects and scenes. Howev...
Article
Background Surgery is a widely accepted treatment option for drug-resistant focal epilepsy. A detailed analysis of longitudinal postoperative seizure outcomes and use of antiepileptic drugs for different brain lesions causing epilepsy is not available. We aimed to analyse the association between histopathology and seizure outcome and drug freedom u...
Poster
Full-text available
Using intracranial EEG (iEEG) recording, we revealed distinct brain networks underlying egocentric and allocentric spatial coding in the human brain with specific processing time.
Article
Full-text available
Purpose Epilepsy patients consider driving issues to be one of their most serious concerns. Ideally, decisions regarding fitness to drive should be based upon thorough evaluations by specialists in epilepsy care. In 2009, an EU directive was published aiming to harmonize evaluation practices within European countries, but, despite these recommendat...
Article
Alemtuzumab as a treatment of highly active multiple sclerosis causes a rapid decrease in inflammatory activity due the lysis of immune cells. Subsequent cytokine release determines the infusion-associated reaction that is a frequent adverse event of alemtuzumab treatment. Recently, serious cardiovascular and thrombotic adverse reactions following...
Article
Full-text available
Background: We hypothesized that right and left temporal lobe epilepsy (RTLE and LTLE, respectively) have distinctive spatial patterns of white matter (WM) changes that can be differentiated and interpreted with the use of multiple diffusion parameters. We compared the global microstructure of fiber bundles with regard to WM alterations in both RTL...
Article
Full-text available
Abstract Aim: An overview of MRI in patients with implanted vagal nerve stimulator (VNS) and the method of surgical explantation of VNS, reflect ing the MRI protocol al low ing the subsequent MRI examination without signifi cant limitations. Patients and methods: MRI can also be safely performed in patients with the implanted VNS device. Head exam...
Article
Purpose Epileptic seizures are a common manifestation of autoimmune encephalitis, but the role of neural antibodies in long-term epilepsy remains unclear. The aim of this study was to assess the prevalence of neural-surface antibodies (NSAbs) and antibodies against glutamic acid decarboxylase (GAD) in patients with chronic temporal lobe epilepsy (T...
Article
Multiple sclerosis is a chronic, autoimmune and neurodegenerative disorder of the CNS. The course of the disease is highly variable among different patients. Even though there has been great progress in the diagnostics of MS in recent decades, we still lack a reliable diagnostic tool that would distinguish between a relatively benign course and a h...
Article
Objective: Resective surgery is effective in treating drug-resistant focal epilepsy, but it remains unclear whether improved diagnostics influence postsurgical outcomes. Here, we compared practice and outcomes over 2 periods 15 years apart. Methods: Sixteen European centers retrospectively identified 2 cohorts of children and adults who underwen...
Article
Full-text available
Zusammenfassung Eine 2013 von der „International Federation of Clinical Neurophysiology“ gegründete Taskforce hat eine international konsensfähige EEG-Terminologie entwickelt. Im Folgenden soll das Resultat – die 2. Version des Standardized Computer-based Organized Reporting of EEG (SCORE) - vorgestellt werden. Die Terminologie wurde im Rahmen eine...
Preprint
Full-text available
Deep learning techniques have revolutionized the field of machine learning and were recently successfully applied to various classification problems in noninvasive electroencephalography (EEG). However, these methods were so far only rarely evaluated for use in intracranial EEG. We employed convolutional neural networks (CNNs) to classify and chara...
Article
Full-text available
Between seizures irritative network generates frequent brief synchronous activity, which manifests on the EEG as interictal epileptiform discharges (IEDs). Recent insights into the mechanism of IEDs at the microscopic level have demonstrated a high variance in the recruitment of neuronal populations generating IEDs and a high variability in the tra...
Article
Full-text available
Error detection in motor behavior is a fundamental cognitive function heavily relying on cortical information processing. Neural activity in the high-gamma frequency band (HGB) closely reflects such local cortical processing, but little is known about its role in error processing, particularly in the healthy human brain. Here we characterize the er...
Preprint
Full-text available
Error detection in motor behavior is a fundamental cognitive function heavily relying on cortical information processing. Neuronal activity in the high-gamma frequency band (HGB) closely reflects such local cortical processing, but little is known about its role in error processing, particularly in the healthy human brain. Here we characterize the...
Article
The nature of human error processing and the underlying cerebral mechanisms are of great interest in neuroscience, and error-related brain responses may provide information useful to improve the accuracy of brain-machine interfaces (BMIs). So far, many studies focused on error-related responses below 30 Hz. We were interested in error-related effec...
Poster
Full-text available
Using intracranial electroencephalography, we aim to distinguish temporal dynamic of egocentric and allocentric navigation and its impact on low frequency oscillations in medial temporal lobe and hippocampal regions. We expect low theta (1-4 Hz) power in hippocampal channels to increase during movement and also to manifest earlier onset of activity...
Article
Epilepsy is chronic neurological disease characterized by occurrence of spontaneous recurrent seizures affecting approximately 1% of people. One of the most common causes of epilepsy in adults is a stroke. The precise mechanism of development of vascular epilepsy is not known, and thus no reliable biomarker of postischemic epileptogenesis currently...
Article
Introduction: Interferon-β (IFNβ) is the first-line treatment for relapsing-remitting multiple sclerosis. Myxovirus resistance protein A (MxA) is considered to be an IFNβ bioactivity marker. Responsiveness to the IFNβ treatment may be reduced by neutralizing antibodies (NAbs). Material and methods: We investigated the presence of NAbs and mRNA MxA...
Article
Full-text available
The aim of the article is to review the evidence for the mediating role of pain-related fear, and its immediate and long-Term consequences in the initiation and maintenance of chronic low back pain disability. Low back pain is one of the most frequent reasons why patients ask for consultation and are on sick leave. In these patients, pain-related f...
Article
Purpose: Focal cortical dysplasia (FCD) represents a common cause of refractory epilepsy. It is considered a sporadic disorder, but its occasional familial occurrence suggests the involvement of genetic mechanisms. Methods: Siblings with intractable epilepsy were referred for epilepsy surgery evaluation. Both patients were examined using video-E...
Article
Epilepsy is both a disease of the brain and the mind. Here, we present the first of two papers with extended summaries of selected presentations of the Third International Congress on Epilepsy, Brain and Mind (April 3-5, 2014; Brno, Czech Republic). Epilepsy in history and the arts and its relationships with religion were discussed, as were overvie...
Article
Background: Neuronal surface antibodies are associated with numerous neurological symptoms. Better knowledge of these symptoms may improve identification of potential candidates for immunotherapy. Aim: Characterize clinical signs in patients with neuronal surface antibodies positivity. Methods: We detected neuronal surface antibodies in 11/2011-12/...
Article
Following a first seizure, it is important to establish whether this was an epileptic or non-epileptic seizure, and to ascertain possible cause of an epileptic seizure. With respect to further management, diagnostic or therapeutic, it is crucial to differentiate non-epileptic from epileptic seizures and to identify provoked epileptic seizures (acut...
Article
Novel and quantitative methods EEG signal analysis are being developed by close multidisciplinary collaborations between epilepsy specialists, biomedical engineers and mathematicians. Quantitative analysis of the long-term monitoring from intracranial electrodes is expected to provide precise and objective results. High performance computational al...
Article
Rationale The irritative zone is an area of the brain generating interictal epileptiform discharges (IEDs) that is used together with other results when planning epilepsy surgery. This zone possesses relatively low diagnostic value due to lack of a specific marker that would identify IEDs generated within the epileptogenic tissue. To increase diagn...
Article
Objective To assess whether available algorithms of quantitative EEG (qEEG) could practically help in localizing epileptogenic zone (EZ) and modify surgical planning in patients with focal intractable epilepsy. Methods We will present a case report of a 7-year-old boy with catastrophic epilepsy caused by focal cortical dysplasia located in the ope...
Article
Full-text available
Objective Interictal epileptiform discharges (IEDs) are electrographic hallmark of epilepsy. Information about the spatiotemporal distribution of IEDs in intracranial EEG is utilized to localize epileptogenic zone during the presurgical evaluation and plan the resection. Visual evaluation of long-term multi-channel intracranial recordings is extrem...
Article
Background High frequency oscillations (HFOs) represent new electrographic marker of epileptogenic tissue and they are considered as a surrogate marker of seizure onset and epileptogenic zones. HFOs are recorded mainly in intracranial recordings. Visual analysis of HFOs in long-term recordings is extremely difficult due to the low signal-to-noise r...
Article
We introduce a new MR method based on a pixel-by-pixel image processing to examine relationships between metabolic and structural processes in the pathologic hippocampus. The method was tested for lateralization of the epileptogenic zone in patients with temporal lobe epilepsy (TLE). Twenty patients with drug-resistant TLE and fifteen healthy contr...
Article
Bilateral temporal lobe epilepsy is characterized by evidence of seizure onset independently in both temporal lobes. The main aim of the present study was to determine whether patients with evidence of independent bilateral temporal lobe epilepsy (biTLE) can be identified noninvasively on the basis of seizure semiology analysis. Thirteen patients w...
Article
A clear concept of epileptic zones remains of high clinical relevance in presurgical evaluation of refractory epilepsy patients and in resection planning. Recent advances in understanding how each of the epileptic zones is functionally organized strengthened the importance of the network concept. It has been shown that neuronal networks underlying...
Article
Full-text available
Interictal epileptiform discharges (spikes, IEDs) are electrographic markers of epileptic tissue and their quantification is utilized in planning of surgical resection. Visual analysis of long-term multi-channel intracranial recordings is extremely laborious and prone to bias. Development of new and reliable techniques of automatic spike detection...
Conference Paper
High frequency oscillations (HFOs) are novel biomarkers of epileptogenic tissue. Visual identification of HFO in long-term EEG recordings is time consuming due to low HFOs rate, low signal-to-noise ratio and presence of biological and technical artifacts. In this study, we have examined several algorithms of HFOs detection to facilitate analysis of...
Article
The abilities to identify facial expression from another person's face and to attribute mental states to others refer to preserved function of the temporal lobes. In the present study, we set out to evaluate emotion recognition and social cognition in presurgical and postsurgical patients with unilateral refractory temporal lobe epilepsy (TLE). The...
Article
Purpose Patients with hippocampal sclerosis associated with focal cortical dysplasia can have a higher risk of seizure recurrence if both of these pathologies are not removed. The aim of our study was to determine the role of intraoperative electrocorticography in detection of this dual pathology. Methods Intraoperative electrocorticography record...
Conference Paper
Interictal epileptiform discharges (spikes) represent electrographic marker of epileptogenic brain tissue. Besides ictal onsets, localization of interictal epileptiform discharges provides additional information to plan resective epilepsy surgery. The main goals of this study were: 1) to develop a reliable automatic algorithm to detect high and low...
Conference Paper
High-frequency oscillations (HFOs) represent relatively new electrographic marker of epileptogenic tissue. It is starting to be used in presurgical examination to better plan surgical resection and to improve outcome of epilepsy surgery. Development of new techniques of unsupervised HFOs detection is required to further investigate the role of HFO...
Article
Full-text available
Aims: To assess the practical localising value of subtraction ictal single-photon emission computed tomography (SISCOM) coregistered with MRI and (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in patients with extratemporal epilepsy and normal MRI. Methods: We retrospectively studied a group of 14 patients who received surgery d...
Article
Purpose: The aim of this survey was to review and compare the current approaches to epilepsy management in central and eastern EU (CEEU) countries. Method: The questionnaire was sent to ten invited experts from Bulgaria, Czech Republic, Estonia, Hungary, Latvia, Lithuania, Poland, Romania, Slovakia, and Slovenia. It focused on the treatment of a...
Article
Full-text available
The electroencephalography (EEG) signal has a high complexity, and the process of extracting clinically relevant features is achieved by visual analysis of the recordings. The interobserver agreement in EEG interpretation is only moderate. This is partly due to the method of reporting the findings in free-text format. The purpose of our endeavor wa...