Peter Weyrich

Peter Weyrich
Ludwig-Maximilians-University of Munich | LMU · Faculty of Medicine

Prof. Dr. med.

About

110
Publications
37,703
Reads
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1,976
Citations
Citations since 2016
14 Research Items
1179 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
Introduction
Peter Weyrich currently works at the Faculty of Medicine, Ludwig-Maximilians-University of Munich. Peter does research in Nephrology, Diabetology and Medical Education. Their current project is 'Clinical Nephrology and Medical Education.'
Additional affiliations
October 2013 - present
KfH Dialysezentrum Unterhaching
Position
  • Ärztlicher Leiter
August 2000 - August 2013
Universitätsklinikum Tübingen
Position
  • Consultant
June 1997 - November 1998
Ludwig-Maximilians-University of Munich
Position
  • Research Assistant

Publications

Publications (110)
Article
ZUSAMMENFASSUNG GLP-1-Rezeptoragonisten beeinflussen den Stoffwechsel über zahlreiche Mechanismen und haben einen festen therapeutischen Stellenwert bei der Blutzuckerkontrolle diabetischer Patienten. Der unbestrittene Nutzen der GLP-1-Rezeptoragonisten für kardiovaskuläre Endpunkte lässt vermuten, dass auch die sehr gefäßreiche Niere bei Diabetes...
Article
Der Diabetes mellitus ist trotz besserer Blutzucker- und Blutdruckeinstellung nach wie vor die häufigste Grunderkrankung beim Auftreten einer terminalen Niereninsuffizienz. Sofern eine Nierentransplantation nicht möglich ist, sind Hämodialyse und Peritonealdialyse bei der diabetischen Dialysepopulation als gleichwertige Verfahren anzusehen. Dieser...
Article
Zusammenfassung Der Diabetes mellitus ist trotz besserer Blutzucker- und Blutdruckeinstellung nach wie vor die häufigste Grunderkrankung beim Auftreten einer terminalen Niereninsuffizienz. Sofern eine Nierentransplantation nicht möglich ist, sind Hämodialyse und Peritonealdialyse bei der diabetischen Dialysepopulation als gleichwertige Verfahren an...
Article
Das Fehlen akuter Niederschäden sollte nicht zu einem entspannten Einsatz von Protonenpumpeninhibitoren (PPI) verleiten: Sie können womöglich direkt und unabhängig zu Niereninsuffizienz führen.
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The high salt intake in Western countries causes hypertension and an increase in cardiovascular mortality beside other lifestyle factors. The aim of this article is a fact-check of the current salt consumption in Germany as well as the salinity of typical foods and convenience products. The basic principles of salt sensitivity and salt mortality in...
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Redundant training and feedback are crucial for successful acquisition of skills in simulation trainings. It is still unclear how or how much feedback should best be delivered to maximize its effect, and how learners' activity and feedback are optimally blended. To determine the influence of high- versus low-frequency expert feedback on the learnin...
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Background: Nephropathia epidemica (NE) is a mild form of hemorrhagic fever with renal syndrome (HFRS) that is caused by the Puumala virus. Periodic outbreaks have been described in endemic areas, with a substantial number of previously healthy individuals developing acute kidney injury (AKI). There is a considerable diversity in the clinical cour...
Article
To evaluate heart rate deceleration capacity, an electrocardiogram-based marker of autonomic nervous system activity, as risk predictor in a medical emergency department and to test its incremental predictive value to the modified early warning score. Prospective cohort study. Medical emergency department of a large university hospital. Five thousa...
Article
Die rasch progrediente Glomerulonephritis (RPGN) ist durch einen Verlust der Nierenfunktion innerhalb von Wochen charakterisiert. Histologisch sind sog. Halbmonde – extrakapillare Proliferate – kennzeichnend. Unter einem pulmorenalen Syndrom im engeren Sinne versteht man das gleichzeitige Auftreten von alveolarer Hamorrhagie und RPGN. Wir berichten...
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Skills lab training has become a widespread tool in medical education, and nowadays, skills labs are ubiquitous among medical faculties across the world. An increasingly prevalent didactic approach in skills lab teaching is peer-assisted learning (PAL), which has been shown to be not only effective, but can be considered to be on a par with faculty...
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History and admission findings: A 67-year-old male patient developed progressive renal failure following successful treatment of a soft tissue sarcoma that comprised surgical resection after neoadjuvant radiochemotherapy with the application of doxorubicin (cumulative dose 180 mg/m²) and ifosfamide (cumulative dose 33 g/m²). Investigations: Plas...
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Patient chart review is the gold standard for detection of potential patient hazards (i.e. medication errors or failure to follow up actionable results) in both routine clinical care and patient safety research. However, advanced medical students' ability to read patient charts and to identify patient hazards is rather poor. We therefore investigat...
Article
History and admission findings: We report on a 53-year-old female patient who was admitted to hospital with fever, dyspnoea and arthralgias that was followed by diarrhoea and anuria. Upon respiratory deterioration she was referred to our hospital. Investigations: Urine analysis revealed an active urine sediment and kidney ultrasound showed hyper...
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Background: Benefits of skills lab training are widely accepted, but there is sparse research on its long-term effectiveness. We therefore conducted a prospective, randomised controlled-trial to investigate whether in a simulated setting students trained according to a "best practice" model (BPSL) perform two skills of different complexity (nasoga...
Article
History and admission findings: We report on a patient presenting with renal failure who developed mutliple episodes of flash pulmonary edema. Investigations: Volume retention due to ischemic nephropathy was found to be the cause. Diagnosis, treatment and course: She was diagnosed to have a high grade renal artery stenosis in a functional soli...
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Background Central line catheter insertion is a complex procedure with a high cognitive load for novices. Providing a prepackaged all-inclusive kit is a simple measure that may reduce the cognitive load. We assessed whether the use of prepackaged all-inclusive central line insertion kits reduces procedural mistakes during central line catheter inse...
Article
History and admission findings: We report on a 58-year-old patient with weight loss, weakness and polyarthralgia. She reported of recurrent drops, painful joints and muscle weakness. Investigations: The patient had swollen joints, clubbing and cachexia. The radiogram of the hands and feet showed a hypertrophic oseoarthropathy. In further investi...
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Background Informed consent talks are mandatory before invasive interventions. However, the patients’ information recall has been shown to be rather poor. We investigated, whether medical laypersons recalled more information items from a simulated informed consent talk after advanced medical students participated in a communication training aiming...
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Purpose: The acquisition of clinical-technical skills is of particular importance for the doctors of tomorrow. Procedural skills are often trained for the first time in skills laboratories, which provide a sheltered learning environment. However, costs to implement and maintain skills laboratories are considerably high. Therefore, the purpose of t...
Article
History and admission findings: We report on a 78-year-old female patient, who presented to the emergency department with nausea and vomiting. Investigations: Endoscopy of the upper gastrointestinal tract revealed gastric erosions and duodenal ulcers. The patient had iron deficiency anemia. Diagnosis, treatment and course: Following treatment...
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Background Focused emergency echocardiography performed by non-cardiologists has been shown to be feasible and effective in emergency situations. During resuscitation a short focused emergency echocardiography has been shown to narrow down potential differential diagnoses and to improve patient survival. Quite a large proportion of physicians are e...
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In hemodialysis patients, elevated plasma troponin concentrations are a common finding that has even increased with the advent of newly developed sensitive assays. However, the interpretation and relevance of this is still under debate. In this cross-sectional study, we analyzed plasma concentrations of sensitive troponin I (TnI) and troponin T (Tn...
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During internships most medical students engage in history taking and physical examination during evaluation of hospitalized patients. However, the students' ability for pattern recognition is not as developed as in medical experts and complete history taking is often not repeated by an expert, so important clues may be missed. On the other hand, s...
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Peer-assisted learning is widely used in medical education. However, little is known about an appropriate didactic preparation for peer tutors. We herein describe the development of a focused didactic training for skills lab tutors in Internal Medicine and report on a retrospective survey about the student tutors' acceptance and the perceived trans...
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Hospital doctors face constantly increasing workloads. Besides caring for patients, their duties also comprise the education of future colleagues. The aim of this study was to objectively investigate whether the workload arising from increased patient care interferes with student supervision and is associated with more non-medical activities of fin...
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Microalbuminuria represents an established surrogate marker of early diabetic nephropathy and glomerular microangiopathy. Increasing evidence is emerging of a role of perivascular adipose tissue (PVAT) as an important link between obesity, insulin resistance and both macro- and microangiopathy. It is not known whether perivascular renal sinus fat (...
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Background: The effectiveness of skills laboratory training is widely recognized. Yet, the transfer of procedural skills acquired in skills laboratories into clinical practice has rarely been investigated. We conducted a prospective, randomised, double-blind, controlled trial to evaluate, if students having trained intravenous (IV) cannulation in...
Data
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CONSORT 2010 checklist. (PDF)
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Emergency department (ED) triage systems facilitate the categorization of emergency patients according to their disease severity and determine both treatment priority and treatment location. Four different five-level triage systems are internationally accepted. The Australasian Triage Scale (ATS, Australasia) allows categorization based on symptoms...
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Triagesysteme in der Notaufnahme ermöglichen die Kategorisierung der dort vorstellig werdenden Patienten anhand ihrer Erkrankungsschwere und legen Behandlungspriorität und -ort fest. International setzten sich 4 Triagesysteme durch, die jeweils 5 Kategorien definieren: Die australische Triageskala (ATS, Australien/Neuseeland) kategorisiert symptomb...
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Densely arranged pericytes engird the endothelial tube of all coronary microvessels. Since the experimental access to these abundant cells in situ is difficult, a prerequisite for broader investigation is the availability of sufficient numbers of fully differentiated pericytes in homogenous culture. To reach this goal, we applied strictly standardi...
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Kidney International aims to inform the renal researcher and practicing nephrologists on all aspects of renal research. Clinical and basic renal research, commentaries, The Renal Consult, Nephrology sans Frontieres, minireviews, reviews, Nephrology Images, Journal Club. Published weekly online and twice a month in print.
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Although skills-lab training is widely used for training undergraduates in technical procedures, the way in which clinical skills are to be used and instructed remains a matter of debate. We conducted a randomized controlled trial to evaluate the learning outcome of two different instructional approaches in the context of acquiring procedural-techn...
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Obwohl die Visiten zu den wichtigsten täglichen Aktivitäten auf einer Intensivstation gehören, gibt es in Bezug auf Form und Inhalt der Visiten keine etablierten Konzepte oder Standards. Dieser Artikel geht auf verschiedene organisatorische Aspekte wie den Zeitpunkt und den Ort der Visite ein. Er beschreibt die Zusammensetzung eines Visitenteams un...
Article
We report on two patients with cardiorenal and renocardiac syndrome, respectively, who were treated with peritoneal dialysis. Patient 1 suffered from dilated cardiomyopathy with an ejection fraction of 20%. There was no hint for an intrinsic renal disease, urinalysis showed microalbuminuria at the most. Due to progressive cardiac forward failure ki...
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Toll-like-receptor 4 (TLR) is discussed to provide a molecular link between obesity, inflammation and insulin resistance. Genetic studies with replications in non-diabetic individuals in regard to their fat distribution or insulin resistance according to their carrier status of a common toll-like receptor 4 (TLR4) variant (TLR4(D299G/T399I)) are st...
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Ultrasound is a widely used diagnostic tool. In medical education, it can be used to teach sonographic anatomy as well as the basics of ultrasound diagnostics. Some medical schools have begun implementing student tutor-led teaching sessions in sonographic abdominal anatomy in order to meet the growing demand in ultrasound teaching. However, while t...
Article
A 79-year-old female patient was referred with acute renal failure requiring haemodialysis and haemoptysis. Kidney biopsy showed extracapillary proliferative glomerulonephritis with crescents in 7 from 15 glomeruli and sclerosis in the remaining. A computed tomography scan of the chest showed evidence of alveolar haemorrhage. Serologic testing reve...
Article
student tutors in the dissection course are expected to meet high demands on their job. We developed a combined technical and didactical training on the basis of literature review and needs assessment. The three-week training program comprised dissection as well as presentation techniques, group dynamics and activating teaching methods. A randomize...
Article
student tutors have a long tradition in gross anatomy instruction. However, the full potential of the tutors is generally not tapped, since little attention is paid to their technical and didactical training. The aim of this paper is to report a systematic approach to the development, didactic reasoning and implementation of a curriculum for traini...
Article
Prescribing correctly represents one of the most essential skills of a doctor when it comes to patient safety. Unfortunately, prescribing errors still account for a large proportion of avoidable drug-related problems (DRP). Despite this shortcoming, many medical schools do not provide specific prescribing training and assume that students acquire s...
Article
We report on a female patient with rheumatoid arthritis and end-stage renal-disease following AA-amyloidosis who presented with chest pain to the emergency department. ECG showed no signs of ischemia, echocardiography revealed a concentric left ventricular hypertrophy with increased texture. Serum concentration of troponin I was mildly elevated whe...
Article
Background The amended German license to practice medicine (ÄAppO) focuses on practically oriented, patient-centred medical education. After the cancellation of the former medical doctor traineeship „Arzt im Praktikum“ (AiP) qualification period in October 2004, the final year of medical education, the so-called “practical year” (PJ), has become a...
Article
A 35-year old patient (male, headaches, visual impairment, 170/100 mmHg, case 1) and a 61-year old patient (female, headaches, epistaxis, 230/110 mmHg, case 2) were investigated in our hospital. Laboratory findings in case 1 verified acute renal failure (serum creatinine 23 mg/dl, urea 146 mg/dl, pH 7.19). Bilateral obstructive uropathy was seen in...
Article
Avoidable drug-related problems (DRPs) cause substantial morbidity, mortality and costs. As most prescription errors are committed by recently graduated doctors, undergraduate training should specifically address DRPs. This study set out to investigate whether a DRP teaching module can reduce prescription errors made by advanced medical students in...
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Neuron-derived orphan receptor (Nor) 1, nuclear receptor (Nur) 77, and nuclear receptor-related protein (Nurr) 1 constitute the NR4A family of orphan nuclear receptors which were recently found to modulate hepatic glucose production, insulin signalling in adipocytes, and oxidative metabolism in skeletal muscle. In this study, we assessed whether co...
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The final year of medical education is considered crucial in making students 'fit for purpose'. Studies have shown that many students leave medical school without having experienced sufficient preparation for their upcoming professional life. The aim of this study was to examine the effectiveness of a supplementary internal medicine final year curr...
Data
Logistic regression analysis for differences of NR4A3 SNP's minor allele prevalences in individuals with normal glucose tolerance (NGT) and overt diabetes mellitus (DM) in the METSIM Study. The [95%] confidence interval of the data provided is indicated for all different statistical models (additive, dominant, recessive) for all investigated SNPs.
Data
Distribution of NR4A3 SNP minor allele frequencies according to glucose tolerance status in the TÜF/TULIP (N = 1495) and the METSIM (N = 6147) cohort. Minor allele frequencies for each investigated NR4A3 SNP are presented for study participants (TUEF-TULIP/METSIM trial) with normal glucose tolerance (NGT), impaired fasting glucose and/or impaired g...
Data
Associations of NR4A3 SNPs rs7047636 and rs2416879 with anthropometric and metabolic data (TÜF/TULIP cohort, N = 1495). Data are given as means ± SD. For statistical analysis, data were log-transformed. p1 – non-adjusted additive model; p2 – adjusted additive model: age was adjusted for gender; BMI and body fat were adjusted for gender and age; glu...
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Following the changes made to the medical licensing regulations of 2002, medical education in Germany has been subject to radical modification, especially at undergraduate level. The implementation of the Bologna Process is still a matter of intense political debate, whilst positive movement has occurred in developing the professionalisation of tea...
Article
Apoptosis is involved in the development and progression of atherosclerotic lesions. Protein kinase C (PKC) signalling is of importance in atherosclerosis as well as apoptosis. Therefore, we tested the involvement of PKC in lipid-induced apoptosis of human coronary artery endothelial cells (HCAEC).Protein expression of PKC isoforms α, βI, δ, ɛ, and...
Article
Due to the new licensing regulations for physicians, social and communicative aspects have attained a central position within medical education. In developing self-reflexive, empathetic and communicative skills, medical students are influenced on the one hand by encounters with real physicians in the role of supervisor or colleague, and on the othe...
Article
Although peer-assisted learning (PAL) is widely employed throughout medical education, its effectiveness for training in technical procedures in skills laboratories has been subject to little systematic investigation. We conducted a prospective, randomised trial to evaluate the hypotheses that PAL is effective in technical skills training in a skil...
Article
The amended German license to practice medicine (AAppO) focuses on practically oriented, patient-centred medical education. After the cancellation of the former medical doctor traineeship "Arzt im Praktikum" (AiP) qualification period in October 2004, the final year of medical education, the so-called "practical year" (PJ), has become a key teachin...
Article
Nicht zuletzt durch die Anforderungen im Rahmen der neuen Approbationsordnung kommt derzeit der Qualitätssicherung von Prüfungen in der medizinischen Ausbildung ein hoher Stellenwert zu. Der OSCE (Objective Structured Clinical Examination) als Prüfungsformat für klinisch-praktische Fertigkeiten wird in der Literatur hinsichtlich seiner Reliabilität...
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Sirtuin1 (SIRT1) regulates gene expression in distinct metabolic pathways and mediates beneficial effects of caloric restriction in animal models. In humans, SIRT1 genetic variants associate with fasting energy expenditure. To investigate the relevance of SIRT1 for human metabolism and caloric restriction, we analyzed SIRT1 genetic variants in resp...
Article
A 29-year-old woman in the early stage of pregnancy ( approximately 6 (th) week) presented in our hospital with influenza-like symptoms of fever, headache, aching limbs and tenderness over the costovertebral angle. Acute oliguric renal failure occurred within a few days. Ultrasonography revealed symmetrically enlarged kidneys with a small amount of...
Article
Procolipase (CLPS) is secreted from the exocrine pancreas into the gastrointestinal tract and becomes proteolytically cleaved into colipase and the pentapeptide enterostatin. While colipase is an indispensable cofactor for pancreatic lipase, enterostatin acts as a hormone that inhibits insulin secretion and confers satiety signals to the brain, the...