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Introduction
Peter van der Wel currently works at the R&D, Process & Controls, Hosokawa Micron. Peter does research in Mechanical Engineering, Engineering Physics and Chemical Engineering. Their most recent publication is 'Mechanical strength of microspheres produced by drying of acoustically levitated suspension droplets'.
Publications
Publications (24)
PurposeIn the pharmaceutical industry, there has been a growing interest in continuous manufacturing in recent years. Many efforts have been made to implement new process equipment for various production steps. One step which is not yet covered well is the continuous drying of the active pharmaceutical ingredient (API) after it has been crystallize...
The goal of this investigation was to develop a continuous process for producing as much material on dry basis as possible, at stable operating conditions in an intentionally or unintentionally precipitating environment. The primary goal was to maximize its achievable uninterrupted runtime, despite the challenge of solid formation, its risk of foul...
This work investigates the application of static mixers in precipitating environments as present in certain pharmaceutical processes, in which the undesired side effect of precipitation of the residual dissolved fraction leads to equipment fouling and process stability challenges. The tests were conducted using saturated suspensions mixed with an a...
Spray drying is widely used in pharmaceutical manufacturing to produce microspheres from solutions or suspensions. The mechanical properties of the microspheres are reflected by the morphology formed in the drying process. In suspension drying, solids dissolved in the carrier liquid may form bridges between the suspended primary particles, producin...
Abstract
The mechanics of particle interactions and the prevailing level of compressive stresses and shear
strains are affected by the scale of operation, which in turn affects the granule structure, strength
and functional properties. This may be the main reason why the current scaling relationships are
ineffective from a viewpoint of product engi...
Moving toward continuous manufacturing in the pharmaceutical industry offers new possibilities, such as reducing costs and improving flexibility and product quality. However, this paradigm change requires new small-scale continuous manufacturing technologies. Since drying is one of the crucial elements of pharmaceutical production, we performed an...
The mechanics of particle interactions and the prevailing level of compressive stresses and shear strains are affected by the scale of operation, which in turn affects the granule structure, strength and functional properties. This may be the main reason why the current scaling relationships are ineffective from a viewpoint of product engineering....
Newly developed Stirred Freeze Drying technology is considered as an important development supporting freeze drying and powder technology. Freeze drying under stirred conditions results in a lump-free, free-flowing product. Stirred freeze dryers also exhibit a better heat transfer rate due to the continuous mixing of the product, which shortens the...
Choosing the best mixer for a particular job is a challenge. Before starting the selection process, one needs to decide what the mixing process must achieve. This requires considering not only the characteristics of the materials to be mixed, but the process and production conditions and requirements. An overview is given of the six selection facto...
Mixing operations in the powder processing industries used to be carried out with relatively simple equipment. At present, the trend is the development of more complex mixing requirements. In this report, an overview is given of powder mixers, and the theory of mixing powders. The background of some of the latest developments in powder mixing equip...
This paper reports some tests of dust explosibility made in vessels of two different sizes. Although most powders tested in the 1 m3 vessel and the 20 l sphere give similar results, in some cases the values of KSt measured in the 20-l sphere are somewhat higher than the values found in the 1 m3 vessel. Measurements of the explosion indices of activ...
Particle Size Analysis reviews the development of particle characterization over the past 25 years and also speculates on its future. Interest in the subject has increased enormously over the years and this book highlights the changes and advances made within the field. This book is comprehensive in its coverage of particle size analysis and includ...
Some parameters which affect the explosibility of dusts have been investigated. Important parameters are particle size, dust concentration, pore size and chemical composition. The dust explosion index measurements illustrate the importance of pore size and particle size. The reaction mechanism occurring is also important. Particles which burn at th...
Document uit de collectie Chemische Procestechnologie