Peter van Dam

Peter van Dam
University of Amsterdam | UVA · Department of Molecular Plant Pathology

PhD

About

32
Publications
5,543
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613
Citations
Citations since 2017
28 Research Items
598 Citations
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2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140

Publications

Publications (32)
Article
Formae speciales (ff.spp.) of the fungus Fusarium oxysporum are often polyphyletic within the species complex, making it impossible to identify them on the basis of conserved genes. However, sequences that determine host-specific pathogenicity may be expected to be similar between strains within the same forma specialis. Whole genome sequencing was...
Article
Full-text available
The mimp family of miniature inverted-repeat transposable elements was previously found only in genomes of Fusarium oxysporum and is contextually associated with virulence genes in this species. Through extensive comparative analysis of 83 F. oxysporum and 52 other Fusarium genomes, we uncovered the distribution of different mimp families throughou...
Article
Full-text available
The genome of Fusarium oxysporum (Fo) consists of a set of eleven 'core' chromosomes, shared by most strains and responsible for housekeeping, and one or several accessory chromosomes. We sequenced a strain of Fo f.sp. radicis-cucumerinum (Forc) using PacBio SMRT sequencing. All but one of the core chromosomes were assembled into single contigs, an...
Article
Full-text available
The polyphyletic nature of many formae speciales of Fusarium oxysporum prevents molecular identification of newly encountered strains based on conserved, vertically inherited genes. Alternative molecular detection methods that could replace labor- and time-intensive disease assays are therefore highly desired. Effectors are functional elements in t...
Article
Full-text available
Two isolates of Fusarium oxysporum , ISS-F3 and ISS-F4, were cultured from the dining table on the International Space Station (ISS). Genomic analyses using EF-1α sequences, presence/absence of effector proteins, k-mer comparisons, and single nucleotide polymorphisms indicate that these two strains are genomically different from 65 known sequenced...
Article
Full-text available
The fungus Fusarium oxysporum is infamous for its devastating effects on economically important crops worldwide. F. oxysporum isolates are grouped into formae speciales based on their ability to cause disease on different hosts. Assigning F. oxysporum strains to formae speciales using non-experimental procedures has proven to be challenging due to...
Preprint
The fungus Fusarium oxysporum is infamous for its devastating effects on economically important crops worldwide. F. oxysporum isolates are grouped into formae speciales based on their ability to cause disease on different hosts. Assigning F. oxysporum strains to formae speciales using non-experimental procedures has proven to be challenging due to...
Article
Full-text available
Fusarium oxysporum f. sp. radicis‐cucumerinum (Forc) causes severe root rot and wilt in several cucurbit species, including cucumber, melon, and watermelon. Previously, a pathogenicity chromosome, chrRC, was identified in Forc. Strains that were previously nonpathogenic could infect multiple cucurbit species after obtaining this chromosome via hori...
Article
Full-text available
The fungus Fusarium oxysporum f.sp. cubense (Focub) causes Fusarium wilt of banana. Focub strains are divided into races according to their host specificity, but which virulence factors underlie these interactions is currently unknown. In the F. oxysporum f.sp. lycopersici (Fol)-tomato system, small secreted fungal proteins, called Six proteins, we...
Data
List of primers being used in this study. (DOCX)
Data
PCR control of FocubΔSIX1a and FocubΔSIX1a::SIX1a. In the FocubΔSIX1a strain (KO), the SIX1a ORF has been replaced by a hygromycin resistance cassette. The FocubΔSIX1a::SIX1a strains (C1-7) have regained the gene by transformation. The upper panel shows the presence of the hygromycin resistance cassette both in the knock-out mutant and in the ectop...
Data
Disease scoring system for external and internal symptoms in banana bioassay. (PDF)
Data
Phenotypic visualization of internal symptoms in the FocubΔSIX1a and SIX1a transformants of FocubΔSIX1a. (PDF)
Data
Sequences used in this study. (XLSX)
Article
Full-text available
The fungus Fusarium oxysporum f.sp. cubense (Focub) causes Fusarium wilt of banana. Focub strains are divided into races according to their host specificity, but which virulence factors underlie these interactions is currently unknown. In the F. oxysporum f.sp. lycoper-sici (Fol)-tomato system, small secreted fungal proteins, called Six proteins, w...
Thesis
Full-text available
Fusarium oxysporum is a fungus hat occurs frequently in soils worldwide and can cause wilt disease and root rot in various plant species. An interesting aspect of the biology of this fungus is the fact that every individual strain is restricted to causing disease in only one or a few plant species. I studied this aspect of host specificity, asking...
Article
Full-text available
Background The Fusarium oxysporum species complex (FOSC) contains several phylogenetic lineages. Phylogenetic studies identified two to three major clades within the FOSC. The mitochondrial sequences are highly informative phylogenetic markers, but have been mostly neglected due to technical difficulties. Results A total of 61 complete mitogenom...
Poster
Full-text available
The genome of Fusarium oxysporum (Fo) is typically divided into a set of eleven ‘core’ chromosomes, shared by most strains and responsible for housekeeping, and one or several accessory chromosomes. In Fo f.sp. lycopersici, one of these chromosomes was shown to be horizontally transferrable and responsible for pathogenicity towards tomato. In de no...
Poster
Full-text available
In the 1990s, the barcoding of life project was started, aiming to use a single sequence to identify animals, fungi and plants to the species level. The first marker that was proposed was a mitochondrial marker: the mitochondrially encoded cytochrome oxidase I (cox1 in filamentous fungi). However, amplifying the cox1 sequence proved problematic in...
Article
Full-text available
Background Helitrons are eukaryotic rolling circle transposable elements that can have a large impact on host genomes due to their copy-number and their ability to capture and copy genes and regulatory elements. They occur widely in plants and animals, and have thus far been relatively little investigated in fungi. ResultsHere, we comprehensively s...
Article
Chromosomal inversions can provide windows onto the cytogenetic, molecular, evolutionary and demographic histories of a species. Here we investigate a paracentric 1.17 Mb inversion on chromosome 4 of Arabidopsis thaliana with nucleotide precision of its borders. The inversion is created by Vandal transposon activity, splitting an F-box and relocati...
Article
Full-text available
Development of resistant crops is the most effective way to control plant diseases to safeguard food and feed production. Disease resistance is commonly based on resistance genes, which generally mediate the recognition of small proteins secreted by invading pathogens. These proteins secreted by pathogens are called 'avirulence' proteins. Their ide...

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