Peter Valkovic

Peter Valkovic
Comenius University Bratislava · 2nd Department of Neurology

Doctor of Medicine, PhD, Professor of Neurology

About

137
Publications
26,247
Reads
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1,476
Citations
Additional affiliations
May 2016 - May 2016
Comenius University Bratislava
Position
  • Professor (Full)
April 2011 - April 2015
Comenius University Bratislava
Position
  • Professor (Associate)

Publications

Publications (137)
Article
Full-text available
Objective There are conflicting data regarding the relationship between Parkinson’s disease (PD) and the atherosclerotic process. This study aimed to compare endothelial function in patients with PD and matched controls. In PD subjects, we searched for factors contributing to endothelial dysfunction as well. Traditional vascular risk factors, PD ch...
Article
Background: Patients with Parkinson disease (PD) treated with levodopa/carbidopa intestinal gel (LCIG) have higher prevalence of hyperhomocysteinemia and peripheral nerves damage. Objective: The aim of our study was to test the effect of catechol-O-methyl transferase inhibitor tolcapone-as an add-on therapy to LCIG in patients with PD-on homocys...
Article
Metabolomics has emerged as a powerful new tool in precision medicine. No studies have yet been published on the metabolomic changes in cerebrospinal fluid (CSF) produced by acute endurance exercise. CSF and plasma were collected from 19 young active adults (13 males and 6 females) before and 60 min after a 90‐min monitored outdoor run. The median...
Article
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Parkinson’s disease (PD) is currently considered progressive neurodegeneration of both the central and peripheral nervous systems. Widespread neuropathological changes lead to a complex clinical presentation with typical motor (hypokinesia, tremor, and rigidity) and various nonmotor symptoms. Orthostatic hypotension is one of the most disabling non...
Article
Objective: Co-morbidities in any disorder can complicate its diagnostic process, they require more complex clinical management and lead to worse health outcomes and increased healthcare costs. There are regional differences in the prevalence of specific co-morbidities in Parkinson's disease (PD), and data from middle Europe are lacking. The projec...
Article
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Improvement of adherence to pharmacotherapy in patients with Parkinson’s disease (PD) is a challenge in routine clinical practice. Our study was aimed at the effect of pillbox organizers with alarms improving adherence to pharmacotherapy and its impact on clinical outcomes. Forty nonadherent patients with PD being treated with ≥ 3 daily doses of le...
Preprint
Full-text available
Objectives: We aimed to disclose the relationship between restless leg syndrome (RLS) and antiparkinsonian treatment, and its effect on quality of life (QoL) in patients with Parkinson's disease (PD). Background: Previous studies documented the prevalence of RLS among patients with PD to be higher than in the general population, but conclusions...
Article
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OBJECTIVES: We aimed to disclose the relationship between restless leg syndrome (RLS) and antiparkinsonian treatment, and its effect on quality of life (QoL) in patients with Parkinson's disease (PD). BACKGROUND: Previous studies documented the prevalence of RLS among patients with PD to be higher than in the general population, but conclusions reg...
Article
Hlboká mozgová stimulácia (deep brain stimulation; DBS) je súčasťou pokročilej liečby vybraných neurologických ochorení, pri ktorých nie je dostatočne efektívna konzervatívna terapia. Etablovanými indikáciami sú Parkinsonova choroba, rôzne formy dystónie a esenciálny tras. V posledných rokoch sa rozšírilo indikačné spektrum DBS v rámci neurológie o...
Article
Hlboká mozgová stimulácia (deep brain stimulation; DBS) je súčasťou pokročilej liečby vybraných neurologických ochorení, pri ktorých nie je dostatočne efektívna konzervatívna terapia. Etablovanými indikáciami sú Parkinsonova choroba, rôzne formy dystónie a esenciálny tras. V posledných rokoch sa rozšírilo indikačné spektrum DBS v rámci neurológie o...
Article
Full-text available
Background Charcot-Marie-Tooth 1C (CMT1C) is a rare form of dominantly inherited CMT1 neuropathy caused by a mutated gene encoding lipopolysaccharide-induced tumour necrosis alpha factor (LITAF). Case presentation We report a 56-year-old patient with an atypical clinical phenotype of CMT1C, which started as progressive weakness of a single upper l...
Chapter
Subtle gait disorders are an integral part of the clinical picture from the early stages of Parkinson’s disease (PD), and these may worsen as the disease progresses. Disorders of gait have a substantial effect on patient quality of life. Despite immense research efforts, gait disorders in PD and related complications remain challenging, especially...
Article
Physical inactivity accelerates ageing‐associated cognitive decline while regular physical exercise improves neurocognitive health, in parallel with improvements of physical fitness and whole‐body metabolism. However, the knowledge on putative bioactive molecules, mediators of exercise benefits in human brain is still very limited. Our aim was to e...
Article
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Repeated injection cycles with abobotulinumtoxinA, a botulinum toxin type A, are recommended in current clinical guidelines as a treatment option for adults with upper limb spastic paresis. However, the magnitude of the maximal therapeutic effect of repeated abobotulinumtoxinA treatment across different efficacy parameters and the number of injecti...
Article
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Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) share a couple of clinical similarities that is often a source of diagnostic pitfalls. We evaluated the discriminatory potential of brain-derived CSF markers [tau, p-tau (181P), Aβ1−42, NSE and S100B] across the spectrum of Lewy body disorders and assessed whether particular mar...
Article
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Wilson's disease is a rare autosomal recessive disease, caused by impaired secretion of copper into bile due to a defective function of the ATPase 7B enzyme. Clinical manifestation is predominantly hepatic and neurological. Wilson's disease is traditionally considered a disease of children and young adults. It rarely manifests after 40 years of age...
Article
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To determine whether systemic medical factors, such as vascular risk factors, metabolic and inflammatory markers contribute to cognitive decline in Parkinson’s disease (PD); if confirmed to determine whether a clinically applicable risk factor model can predict the conversion from normal cognition (NC) to mild cognitive impairment (MCI). 58 patient...
Article
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Background: Gait disorders (GD) are frequent and disabling symptoms in patients with Parkinson's disease, mostly because they significantly limit mobility and often lead to fear of falls or actual falls. Nowadays, rehabilitation is considered to be the most effective nonpharmacological approach to reduce risk of falls. Using paradigms in virtual re...
Article
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Background: Once-daily treatment formulation is associated with better adherence in comparison to more complex medication regimens. The study aimed to detect the extent of adherence to pharmacotherapy in Parkinson disease (PD) patients who take a minimum of three daily doses of drugs, and to identify factors associated with lower levels of adherenc...
Article
Objectives: Theory of Mind (ToM), the ability to understand other people's mental states, is essential in everyday social interactions. The relationship between cognitive domains and ToM impairment in Parkinson disease (PD) has been receiving growing attention with ambiguous findings. The objective of the current study was to ascertain which cogni...
Article
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Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals....
Article
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Introduction: Parkinson‘s disease (PD) is very often accompanied by motor speech disorder – hypokinetic dysathria. This specific speech impairment is characterized by a variety of symptoms in phonation, articulation and resonance, but most strikingly is manifested by gradual worsening of intelligibility which greatly worsens the quality of life in...
Article
Background: Impairments of postural stability occur with increasing age and in neurodegenerative diseases like the Parkinson's disease (PD). While changes in balance have been described in many studies under steady-state conditions, less is known about the dynamic changes in balance following sudden transition to different sensory inputs. Researc...
Article
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Background: Parkinson disease (PD) is the second most common neurodegenerative disease with various motor and nonmotor symptoms. Progressive course of PD requires frequent medication adjustments. Various combinations of drugs and dose regimens could be used to control symptoms. Thus, not surprisingly, adherence to pharmacotherapy is frequently sub...
Article
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Background: Hepatic encephalopathy may manifest by a wide spectrum of neuropsychiatric symptoms, including cognitive impairment, seizures or extrapyramidal symptoms. The liver transplant can lead to improvement of the signs of encephalopathy but subsequent immunosuppressive treatment might possess pronounced neurotoxicity. Case presentation: We...
Article
Background: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. Methods: We collected demographic and disease-related data as well...
Article
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Aim: To map the sentence comprehension in Slovak-speaking patients with Parkinson disease. Method: We assessed the comprehension of reversible sentences (sentences in which the participants of the action can change their roles) with the Test of sentence comprehension and cognitive functions with a standard neuropsychological battery. Subjects: 37 p...
Article
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Regular exercise ameliorates motor symptoms in Parkinson’s disease (PD). Here, we aimed to provide evidence that exercise brings additional benefits to the whole-body metabolism and skeletal muscle molecular and functional characteristics, which might help to explain exercise-induced improvements in the clinical state. 3-months supervised endurance...
Article
This expert working group report proposes an updated approach to subtype definition of vascular parkinsonism (VaP) based on a review of the existing literature. The persistent lack of consensus on clear terminology and inconsistent conceptual definition of VaP formed the impetus for the current expert recommendation report. The updated diagnostic a...
Article
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Background: There are different complications described in deep brain stimulation. They are associated with electrode implantation, stimulation and hardware failure. Vasospasm and ischemic infarction around electrode are less often described complications. Objective: Analysis of group of patients with clinically significant vascular non-hemorrhagic...
Article
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Advanced stages of Parkinson's disease are accompanied by a broad scale of motor and nonmotor complications which negatively impact patients' quality of life. The therapeutic influence of these complications resulting from the neurodegenerative nature of the underlying disease and are additionally caused by long-term use of dopaminergic treatment,...
Article
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Purpose To compare the involuntary head motion, frequency and B0 shim changes, and effects on data quality during real-time-corrected three-dimensional γ-aminobutyric acid-edited magnetic resonance (MR) spectroscopic imaging in subjects with mild cognitive impairment (MCI), patients with Parkinson disease (PD), and young and older healthy volunteer...
Article
Backround: 8-hydroxy-2 deoxyguanosine (8-OHdG) and the 8-hydroxyguanosine (8-OHG) are the most widely used biomarkers of nucleoside oxidation affecting DNA and RNA and are considered reliable markers of oxidative stress. Increased levels of these markers are found in the various biological fluids of patients with neurodegenerative disorders. Obje...
Article
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Background: The Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a newly developed tool to assess Parkinson's disease (PD). Changes in scores on the scale over the course of PD, including increasing disease duration and Hoehn and Yahr (HY) stages, have not been described. The objectives of this study were to analyz...
Article
Background: Autonomic dysfunction is a substantial part of extrapyramidal diseases, including Parkinson's disease (PD). Baroreflex is an important determinant of short-term blood pressure regulation and cardiovascular variability. Impaired baroreflex sensitivity (BRS) in PD has been a subject of investigation in several studies, however the relati...
Article
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V článku prinášame kazuistiky dvoch pacientov s atypickou prezentáciou dvoch rozdielnych neurodegeneratívnych ochorení. U oboch pacientov sa postupne po 60. roku životu vyvinuli znaky kortikobazálneho syndrómu, zahŕňajúce levodopa-rezistentný výrazne asymet-rický akineticko-rigidný parkinsonizmus s dystóniou, myoklonom a fokálnym kortikálnym defici...
Article
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Background: Deep brain stimulation is an effective and safe technique. Displacement of the electrode relative to the optimal stimulation site can lead to insufficient effect and sometimes to the need of operative electrode re-position. Objective: This study was aimed to analyse targeting accuracy of deep brain stimulation electrode implantation...
Article
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The aim of the study was to evaluate the effect of surgical reconstruction of anterior cruciate ligament (ACL) on postural stability and responses to lower limb (LL) muscles vibrations. Centre of pressure (CoP) was measured in 17 subjects during stance on firm/foam surface with eyes open/closed and during unilateral vibrations of LL muscles (m. tri...
Conference Paper
Introduction Balance impairment seen in elderly represents a risk factor for falls and subsequent injuries. Age-related pathologies, e.g. Parkinson’s disease, hinder independent mobility and lead to postural instability. Common method for assessment of the human balance is posturography based on recording of the centre of pressure displacements (C...
Article
Full-text available
Aims: Freezing of gait is a disabling symptom in advanced Parkinson's disease. Positive effects have been suggested with MAO-B inhibitors. We report on an open label clinical study on the efficacy of rasagiline as add-on therapy on freezing of gait and quality of life in patients with Parkinson's disease. Methods: Forty two patients with freezin...
Article
Full-text available
The aim of the study was to identify associations between the symptoms of poststroke apathy and sociodemographic, stroke-related (severity of stroke, degree of disability, and performance in activities of daily living), and radiological correlates. We determined the degree of cortical and subcortical brain atrophy, the severity of white matter and...
Article
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BACKGROUND: Neuropsychiatric symptoms like dysesthesia, sleep disturbances and fatigue could be seen in patients suffering from both multiple sclerosis (MS) and restless leg syndrome (RLS). The aim of study was to investigate the prevalence and characteristics of RLS in MS patients. METHODS: In a cross-sectional study, we used a questionnaire based...
Article
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In 2005, a European expert panel developed and validated an electronic tool to support the appropriate referral of patients with Parkinson's disease (PD) for the consideration of deep brain stimulation (DBS). Since new evidence has become available over the last decade an update of the tool is necessary. A world-wide expert panel (71 neurologists a...
Article
Full-text available
OBJECTIVES: Levodopa is the gold standard of Parkinson’s disease (PD) treatment, but is often associated with disabling motor complications in patients with advanced PD. Levodopa/carbidopa intestinal gel (LCIG) infusion has been proved be beneficial on motor complications in the short-term as well as in long-term follow-up. Therefore is becoming an...