Peter Stanko

Peter Stanko
Comenius University Bratislava · Institute of Pathological Physiology (Faculty of Medicine)

MD

About

9
Publications
580
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
19
Citations

Publications

Publications (9)
Article
Full-text available
Lactacystin is a specific proteasome inhibitor that blocks the hydrolysis of intracellular proteins by ubiquitin/proteasome system inhibition. The administration of lactacystin to rats induced hypertension and remodeling of the left ventricle and aorta. This study tested whether lactacystin induces structural and fibrotic rebuilding of the kidneys...
Article
Full-text available
This study investigated whether sacubitril/valsartan and ivabradine are able to prevent left ventricular (LV) fibrotic remodelling and dysfunction in a rat experimental model of spontaneous hypertension (spontaneously hypertensive rats, SHRs) and whether this potential protection is associated with RAAS alterations. Five groups of three-month-old m...
Article
Obesity with its negative health impacts results in the decreased quality of life and shortened life expectancy, mainly via induction of cardiovascular alterations, type 2 diabetes mellitus, oncologic diseases and osteoarthritis. However, obesity and concomitant comorbidities can be manifested at different qualitative and quantitative levels. Recen...
Article
Experimental and clinical studies from recent decades provided evidence supporting the hypothesis that the heart’s endocrine function is part of the neurohumoral network. The natriuretic peptide system consists of hormones generated by the myocardium having similar cardioprotective effects involved in cardiovascular homeostasis. During hemodynamic...
Article
Full-text available
Arterial blood pressure (BP) undergoes variable changes over 24 hours conforming to physiological daily rhythms. Disruption of the natural BP circadian rhythm is associated with worsened cardiovascular disease (CVD) prognosis. Increased nocturnal BP or at least insufficient BP decline at night, i.e. non-dipping, may be associated with morphological...
Article
Full-text available
Despite advances in heart failure (HF) pharmacotherapy over the last three decades, the residual mortality with HF remains high. The antipode to the drug-induced inhibition of vasoconstrictive and proliferative substances could be an increase of vasodilative and antiproliferative humoral substances, including the natriuretic peptides (NPs). NPs are...
Article
Full-text available
Hypertension-induced renal injury is characterized by structural kidney alterations and function deterioration. Therapeutics for kidney protection are limited, thus novel renoprotectives in hypertension are being continuously sought out. Ivabradine, an inhibitor of the I f current in the sinoatrial node reducing heart rate (HR), was shown to be of...
Article
Full-text available
This study investigated the effect of lisinopril (angiotensin-converting enzyme inhibi-tor) on potential behavioural alterations in spontaneously hypertensive rats (SHR). Three groups of 15-17-week-old rats were investigated for 2 weeks: Wistar control group, SHR group and SHR+lisinopril group. Systolic blood pressure (SBP) was normal in Wistar rat...
Article
Full-text available
There is a great urgency of detecting and monitoring myocardial fibrosis in clinical practice with the aim to improve and personalize therapy against cardiac remodelling. Hence, the aim of this study was to describe alterations in and show potential correlations between the structural characteristics and the molecular and biochemical markers of car...

Network

Cited By