Peter Sörös

Peter Sörös
Carl von Ossietzky Universität Oldenburg · Department of Neurology

Priv.-Doz. Dr.

About

89
Publications
11,442
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Introduction
I am a neuroscientist and neurologist working at the University of Oldenburg, Germany. My research focus is on structural and functional brain imaging, pain, stroke, aging, speech & language. For my research, I am using the Siemens Prisma scanner located at the Neuroimaging Unit, School of Medicine and Health Sciences. I analyze my data with FSL, FreeSurfer, CAT12, Ceres, ANTs, MRtrix3, DSI Studio, and fmriprep.

Publications

Publications (89)
Article
Sudden death is an important but widely under-recognised consequence of stroke. Acute stroke can disturb central autonomic control, resulting in myocardial injury, electrocardiographic abnormalities, cardiac arrhythmias, and ultimately sudden death. Experimental and clinical evidence suggests that autonomic imbalance is more frequent after infarcts...
Article
Full-text available
Hypertension is a highly prevalent risk factor for stroke and dementia, and is the greatest risk factor for small-vessel disease-a frequent cause of lacunar infarction and intracerebral haemorrhage. Lacunar and cortical strokes contribute to the development of dementia in patients with, and in those without, Alzheimer disease pathology; this relati...
Article
It is widely believed that most stroke recovery occurs within 6 months, with little benefit of physiotherapy or other modalities beyond a year. We report a remarkable case of stroke recovery beginning 23 years after a severe stroke due to embolization from the innominate artery and subclavian artery, resulting from compression of the right subclavi...
Article
Chronic pain is often associated with changes in brain structure and function, and also cognitive deficits. It has been noted that these chronic pain-related alterations may resemble changes found in healthy aging, and thus may represent accelerated or pre-mature aging of the brain. Here we test the hypothesis that patients with chronic non-cancer...
Article
Full-text available
Background Chronic inflammatory joint diseases (CIJD) have been linked to increased cardiovascular morbidity and mortality. A decisive reason could be a dysregulation of the autonomic nervous system, which is responsible for the control of cardiovascular function. So far, the cause of changes in autonomic nervous system functions remains elusive. I...
Article
Full-text available
Bilingualism and multilingualism are highly prevalent. Non-invasive brain imaging has been used to study the neural correlates of native and non-native speech and language production, mainly on the lexical and syntactic level. Here, we acquired continuous fast event-related FMRI during visually cued overt production of exclusively German and Englis...
Poster
Full-text available
Structural magnetic resonance imaging (MRI) of the brain can be analyzed quantitatively by surface-based morphometry, e.g. with the software package FreeSurfer. FreeSurfer is able to determine the thickness, area, and volume of the cortex, i.e. the superficial layer of the brain containing billions of neurons. ShinySurfer is a software tool for 3D...
Article
Full-text available
To identify robust and reproducible methods of cerebellar morphometry that can be used in future large-scale structural MRI studies, we investigated the replicability, repeatability, and long-term reproducibility of three fully automated software tools: FreeSurfer, CEREbellum Segmentation (CERES), and automatic cerebellum anatomical parcellation us...
Article
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Influenced by Virginia Woolf pain is traditionally believed to be a private object that defies language. However, our analysis of classical and contemporary works of British and American poets, in addition to our own clinical experiences, leads us to challenge this notion. In accordance with Wittgenstein we instead view pain as a concept and object...
Preprint
Full-text available
Bilingualism and multilingualism are highly prevalent. Non-invasive brain imaging has been used to study the neural correlates of native (L1) and non-native (L2) speech and language production, mainly on the lexical and syntactic level. Here, we acquired continuous fast event-related FMRI during visually cued overt production of exclusively German...
Preprint
Full-text available
Chronic inflammatory joint diseases (CIJD) have been linked to increased cardiovascular morbidity and mortality. A decisive reason could be a dysregulation of the autonomic nervous system (ANS), which is responsible for the control of cardiovascular function. So far, the cause of changes in ANS functions remains elusive. In this study, we investiga...
Preprint
Full-text available
To identify robust and reproducible methods of cerebellar morphometry that can be used in future large-scale structural MRI studies, we investigated the replicability, repeatability, and longterm reproducibility of three fully-automated software tools: FreeSurfer, CERES, and ACAPULCO. Replicability was defined as computational replicability, determ...
Preprint
Full-text available
The pathophysiology of many chronic pain disorders is far from evident. MR imaging studies provided initial data indicating chronic pain might lead to changes in brain structure and function. These changes may contribute to cognitive and emotional impairment and maybe even to the chronifica-tion of pain. However, the evidence for pain-related chang...
Preprint
Full-text available
The pathophysiology of many chronic pain disorders is far from evident. MR imaging studies provided initial data indicating chronic pain might lead to changes in brain structure and function. These changes may contribute to cognitive and emotional impairment and maybe even to the chronification of pain. However, the evidence for pain-related change...
Article
Full-text available
The tongue performs movements in all directions to subserve its diverse functions in chewing, swallowing, and speech production. Using task-based functional MRI in a group of 17 healthy young participants, we studied (1) potential differences in the cerebral control of frontal (protrusion), horizontal (side to side), and vertical (elevation) tongue...
Preprint
Full-text available
The tongue performs movements in all directions to subserve its diverse functions in chewing, swallowing, and speech production. The aims of the present study were twofold: using task-based functional MRI in a group of 17 healthy young participants, we studied (1) potential differences in the cerebral control of frontal, horizontal, and vertical to...
Preprint
Full-text available
Chronic pain is often associated with changes in brain structure and function, and also cognitive deficits. It has been noted that these chronic pain-related alterations may resemble changes found in healthy aging, and thus may represent accelerated or pre-mature aging of the brain. Here we test the hypothesis that patients with chronic non-cancer...
Article
Full-text available
Background Adult attention-deficit/hyperactivity disorder (ADHD) is a serious and frequent psychiatric disorder of multifactorial pathogenesis. Several lines of evidence support the idea that ADHD is, in its core, a disorder of dysfunctional brain connectivity within and between several neurofunctional networks. The primary aim of this study was to...
Article
Full-text available
Introduction The Roux-en-Y gastric bypass (RYGB) is one of the most widely used techniques for bariatric surgery. After RYGB, weight loss up to 50%–70% of excess body weight, improvement of insulin-resistance, changes in food preferences and improvements in cognitive performance have been reported. This protocol describes a longitudinal study of th...
Article
Full-text available
Chronic pain (CP) is linked to changes in cognitive function. However, little is known about its influence on number sense, despite the fact that intact numerical-spatial processing is a prerequisite for valid scale-based pain assessments. This study aimed to elucidate whether number sense is changed in CP, to determine if changes have an impact on...
Article
Full-text available
Background Attention-deficit/hyperactivity disorder (ADHD) in adulthood is a serious and frequent psychiatric disorder with the core symptoms inattention, impulsivity, and hyperactivity. The principal aim of this study was to investigate associations between brain morphology, i.e., cortical thickness and volumes of subcortical gray matter, and indi...
Article
Full-text available
Speech impairment is a frequent and often serious symptom of Parkinson’s disease (PD), characterized by a disorder of phonation, articulation and prosody. While research on the pathogenesis of the prominent limb motor symptoms has made considerable progress in recent years, the pathophysiology of PD speech impairment is still incompletely understoo...
Article
Serious arrhythmias often follow stroke, highlighting the important role that the cerebral cortex has in neural regulation of the heart. Neuroimaging studies reveal patterns of activation associated with autonomic cardiovascular responses. Using the Activation Likelihood Estimate, a meta-analysis was performed to identify cortical activation patter...
Article
To assess whether the response decrement of auditory evoked potentials (AEPs) after stimulus repetition is affected by an interplay between sensitization and habituation. AEPs were recorded in 18 healthy participants. Stimulation consisted of trains with eight tones. The 6th stimulus of each train was a frequency deviant. The N100 amplitude to the...
Article
A considerable number of patients with transient ischemic attack suffer from cognitive impairment, even after recovery of focal neurological deficits. In particular, executive functions such as working memory, abstraction, reasoning, verbal fluency and cognitive flexibility are impaired in these patients. The purpose of the present study was to exp...
Article
Full-text available
Functional connectivity between brain regions during swallowing tasks is still not well understood. Understanding these complex interactions is of great interest from both a scientific and a clinical perspective. In this study, functional magnetic resonance imaging (fMRI) was utilized to study brain functional networks during voluntary saliva swall...
Article
Full-text available
We are embarking on a new frontier in human auditory neuroscience, integrating rapidly advancing neurophenotyping approaches to brain research, with genetic and genome-wide studies. A variety of human neuroimaging and electrophysiological techniques allows to analyze brain structure, function, and neurochemistry in the same individual. As human neu...
Article
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Various functional resonance imaging, magnetoencephalographic and lesion studies suggest the involvement of the insular cortex in the control of swallowing. However, the exact location of insular activation during swallowing and its functional significance remain unclear. Invasive electroencephalographic monitoring was performed in a 24-year-old ma...
Article
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A functional magnetic resonance imaging (fMRI)-compatible fiber-optic bend sensor was investigated to assess whether the device could be used effectively to monitor opening and closing of the jaw during an fMRI experiment at 3 T. In contrast to surface electromyography, a bend sensor fixed to the chin of the participant is fast and easy to use and...
Article
Alterations of existing neural networks during healthy aging, resulting in behavioral deficits and changes in brain activity, have been described for cognitive, motor, and sensory functions. To investigate age-related changes in the neural circuitry underlying overt non-lexical speech production, functional MRI was performed in 14 healthy younger (...
Article
A quantitative, voxel-wise meta-analysis was performed to investigate the cortical control of water and saliva swallowing. Studies that were included in the meta-analysis (1) examined water swallowing, saliva swallowing, or both, and (2) reported brain activation as coordinates in standard space. Using these criteria, a systematic literature search...
Article
Full-text available
Impaired speech perception is one of the major sequelae of aging. In addition to peripheral hearing loss, central deficits of auditory processing are supposed to contribute to the deterioration of speech perception in older individuals. To test the hypothesis that auditory temporal processing is compromised in aging, auditory evoked magnetic fields...
Article
Although the posterior oral cavity and oropharynx play a major role in swallowing, their central representation is poorly understood. High-field functional magnetic resonance imaging of the brain was used to study the central processing of brief air-pulses, delivered to the peritonsillar region of the lateral oropharynx, in six healthy adults. Bila...
Article
Hepatic encephalopathy is a frequent complication of cirrhosis. The present retrospective investigation was conducted to characterize metabolic alterations in cirrhotic patients with and without hepatic encephalopathy. We tested the hypothesis that reduced nutritional status or the degree of tissue catabolism are associated with the presence of hep...
Article
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Focal lesions of the frontal, parietal and temporal lobe may interfere with tactile working memory and attention. To characterise the neural correlates of intact vibrotactile working memory and attention, functional MRI was conducted in 12 healthy young adults. Participants performed a forced-choice vibrotactile frequency discrimination task, compa...
Article
We used magnetoencephalography to study contralesional auditory reorganization in three men with chronic unilateral ischemic lesions of the auditory cortex. Although no response was found over the lesioned hemisphere, processing in the unaffected hemisphere was indistinguishable vs healthy controls. In contrast to sensorimotor and language systems,...
Article
To investigate the neural network of overt speech production, event-related fMRI was performed in 9 young healthy adult volunteers. A clustered image acquisition technique was chosen to minimize speech-related movement artifacts. Functional images were acquired during the production of oral movements and of speech of increasing complexity (isolated...
Article
Alterations in brain metabolism as well as in brain function in different brain areas can be observed in severely depressed patients. The present study combined proton magnetic resonance spectroscopy (1H MRS, n=16; healthy controls n=27) and magnetoencephalography (MEG, n=17, controls n=18) of the left auditory cortex in severely depressed inpatien...
Article
Full-text available
A combination of magnetoencephalography and proton magnetic resonance spectroscopy was used to correlate the electrophysiology of rapid auditory processing and the neurochemistry of the auditory cortex in 15 healthy adults. To assess rapid auditory processing in the left auditory cortex, the amplitude and decrement of the N1m peak, the major compon...
Article
Full-text available
The aim of our work was to evaluate digital x-ray radiogrammetry (DXR) for the quantification of disease-related periarticular demineralization and computerized analysis of joint space distances (JSDA) for the measurement of joint space narrowing as a new diagnostic method for the early detection of joint-associated alterations and for monitoring d...
Article
The esophagus plays a major role in the act of swallowing. The aim of the present investigation was to apply whole-head magnetoencephalography in order to study the cortical processing of esophageal sensation in healthy humans in whom the cortical representation of swallowing had been established previously. The proximal esophagus was stimulated in...
Article
Full-text available
Cluster headache (CH) is a neurovascular, primary headache disorder. There are, however, several case reports about patients whose CH started shortly after a structural brain disease or trauma. Motivated by a patient who developed CH 3 weeks after the removal of an eye and by similar case reports, we tested the hypothesis that the removal of an eye...
Article
Activation of the auditory cortex habituates with repeated stimulation. While behaviorally adaptive in most circumstances, decreasing auditory responsiveness could interfere with speech perception. We therefore tested whether auditory habituation differs for speech and non-speech stimuli and for left and right auditory cortex. We examined seven rig...
Article
Full-text available
Conjoined lumbosacral nerve roots (CLNR) are the most common anomalies involving the lumbar nerve structures which can be one of the origins of failed back syndromes. They can cause sciatica even without the presence of a additional compressive impingement (such as disc herniation, spondylolisthesis or lateral recess stenosis), and often congenital...
Article
Full-text available
The aim of this study was to measure and quantify habituation effects to auditory stimulation within the auditory cortex of 11 depressed patients with major depressive disorder compared to 11 healthy subjects. Habituation was visualized by functional magnetic resonance imaging (fMRI) employing a block design (repeated stimulation with sine tones)....
Article
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Background Phantom pain is a well known and extensively documented complication after limb amputation. Nearly all surgical disciplines have to deal with phantom symptoms related to different anatomical regions and organs but limited data is available about phantom eye pain (PEP) after enucleation. Only one pilot study is present in literature. It w...
Article
This study employed whole head magnetoencephalography and synthetic aperture magnetometry to investigate the cortical topography of the preparation and the execution of volitional and reflexive water swallowing and of a simple tongue movement. Concerning movement execution, activation of the mid-lateral primary sensorimotor cortex was strongly late...
Article
Neuropsychological studies have demonstrated that the production of nouns and verbs can be dissociated in aphasia. These reports have been taken as evidence for separate representations of nouns and verbs in the human brain. We used whole-head magnetoencephalography to record cortical dynamics of action and object naming in 10 healthy adults and in...
Article
This study presents data on the clinical characteristics and possible mechanisms of the phantom eye syndrome in 112 patients after removal of one eye. The prevalence of phantom eye pain was 26%, nonpainful phantom sensations 29%, and visual hallucinations 31%. Headaches and preoperative eye pain were associated with the presence of phantom experien...
Article
Previous magnetoencephalography (MEG) studies of sleep spindles have identified a complex and widespread distribution in parietal and frontal cortices by fitting a dipolar model to the data. In this study, we used a whole-head 151-channel MEG system with simultaneous electroencephalography (EEG) recording in eight normal subjects. All subjects fell...
Article
Full-text available
Recently, a new method for placing nasogastric tubes (NGT) in dysphagic patients was proposed, which uses the swallowing reflex and was therefore called 'reflex placement.' The authors describe the use of this method in a patient with a large left sided striatocapsular hemorrhage, in whom decompressive craniotomy had been performed previously. Wher...
Article
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Whereas indirect euthanasia is a common clinical practice, active euthanasia remains forbidden in most countries. The reason for this differentiation is usually seen in the principle of double-effect (PDE). PDE states that there is a morally relevant difference between the intended consequences of an action and merely foreseen, unintended side-effe...
Article
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Mit der Frage, unter welchen Bedingungen die Entscheidung eines Patienten als hinreichend autonom und sein Informed Consent damit als valide betrachtet werden darf, wird ein Kernproblem der Medizinethik an- gesprochen. In der aktuellen Literatur mehren sich in diesem Zusammenhang die Forderungen nach immer differenzierteren Aufklärungsverpflichtung...
Article
Bis zu 50 % aller Schlaganfallpatienten leiden zumindest vorübergehend an einer Störung des Schluckaktes (Dysphagie). Durch die Behinderung der Nahrungsaufnahme beeinträchtigen Schluckstörungen die Lebensqualität der Betroffenen und erhöhen das Risiko für das Auftreten ernster Komplikationen, wie v. a. der Aspirationspneumonie. Der Dysphagiediagnos...
Article
Full-text available
Cluster headache (CH) is a disorder of unilateral attacks of severe periorbital, supraorbital or temporal pain, lasting 15±180 min (1). In general, attacks are accom- panied by autonomic symptoms, i.e. ipsilateral miosis, lacrimation, conjunctival injection, nasal congestion and rhinorrhea. The episodic form of CH, found in about 80% of all CH pati...
Article
Full-text available
Chronic hypoxaemia in chronic obstructive pulmonary disease is a well known risk factor for polyneuropathy but the impact of intermittent hypoxaemia on peripheral nerve function has not been established so far. A case-control study was performed to evaluate the prevalence of polyneuropathy in obstructive sleep apnoea (OSA). Out of 24 patients with...
Article
Full-text available
The somatosensory system is capable of functional reorganization following peripheral denervation or training. Studies on human amputees with phantom limb pain provided evidence that these reorganizational changes are modulated through nociceptive input. In the present study we used magnetoencephalographic recordings of six healthy volunteers to as...
Article
Cluster headache is an idiopathic headache disorder with a characteristic semiology and a typical temporal pattern. However, there are several case reports describing the development of cluster headache after head trauma or in combination with a non-traumatic structural disease of the head. The clinical presentation of these cases is very similar t...
Article
Full-text available
Hemispheric asymmetry is known for higher brain functions like language and attention. We tested whether such an asymmetry also exists in the representation of elementary sensory functions. Magnetic source imaging was used to compare the cortical somatosensory hand representation in seven right- and five left-handed individuals. In all right-hander...
Article
Full-text available
In multiple sclerosis (MS) inflammatory infiltrations cause white matter lesions. Magnetoencephalography (MEG) offers the opportunity to localize abnormal electric activity of neurons with a high spatio-temporal resolution. In this study, we investigated patients with MS in order to find if abnormal cortical activity is associated with (subcortical...