Peter Mariën

Peter Mariën
Ziekenhuis Netwerk Antwerpen | ZNA · Department of Neurology

Professor of Neurolinguistics

About

257
Publications
55,678
Reads
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8,457
Citations
Additional affiliations
January 2014 - present
City, University of London
Position
  • Professor
May 2002 - present
Vrije Universiteit Brussel
Position
  • Professor of Neurolinguistics and Research Methodology

Publications

Publications (257)
Article
Full-text available
Brain tumour patients with mild language disturbances are typically underdiagnosed due to lack of sensitive tests leading to negative effects in daily communicative and social life. We aim to develop a Dutch standardised test-battery, the Diagnostic Instrument for Mild Aphasia (DIMA) to detect characteristics of mild aphasia at the main linguistic...
Article
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Repetitive thought about oneself, including one’s emotions, can lead to both adaptive and maladaptive effects. Construal level of repetitive self-referential thought might moderate this. During interoception , which engages areas such as the insula, the anterior and/or posterior cingulate cortex (PCC) and the somatosensory cortex, concrete low leve...
Article
Full-text available
Background and objectives We provide a case analysis for a 28-year-old, native Dutch-speaking lady who developed Foreign Accent Syndrome (FAS), a few weeks after falling down the staircase. In addition to FAS, which gave the impression she spoke with a German accent, German(-like) words and structures occurred. Speech symptoms were aggravated by in...
Article
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Magnetoencephalographic imaging (MEGI) offers a non-invasive alternative for defining preoperative language lateralization in neurosurgery patients. MEGI indeed can be used for accurate estimation of language lateralization with a complex language task – auditory verb generation. However, since language function may vary considerably in patients wi...
Chapter
Cerebellar mutism can be considered the hallmark feature of the cerebellar mutism syndrome (CMS), previously also frequently termed the posterior fossa syndrome (PFS). The syndrome consists of specific linguistic, cognitive, behavioral, and affective symptoms following acute posterior fossa damage in children and adults. Although the symptoms have...
Article
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Structural changes in the brain take place throughout one’s life. Changes related to cognitive decline may delay the stages of the speech production process in the aging brain. For example, semantic memory decline and poor inhibition may delay the retrieval of a concept from the mental lexicon. Electroencephalography (EEG) is a valuable method for...
Article
Semantic processing is a fundamental aspect in human communication. The cortical organization of semantic processing has been exhaustively described, in contrast to inconsistent results on the function of subcortical grey matter structures. Hence, this manuscript reports a systematic review and meta-analysis on the subcortical involvement in verbal...
Article
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Recent research has revealed that the cerebellum plays a critical role in social reasoning and in particular in understanding false beliefs and making trait attributions. One hypothesis is that the cerebellum is responsible for the understanding of sequences of motions and actions, which may be a prerequisite for social understanding. To investigat...
Article
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vestigations of neurodegenerative disorders may reveal functional relationships in the cognitive system. C.S. was a 63-year-old right-handed man with Pick's disease with a range of progressive impairments including nonfluent aphasia, limb, oculomotor, bucco-facial and speech apraxia but mostly intact intelligence, perception, orientation, memory, s...
Article
Foreign Accent Syndrome (FAS) is an intriguing motor speech disorder which has captured the interest of the scientific community and media for decades. At the moment, there is no comprehensive model which can account for the pathophysiology of this disorder. This paper presents a review of 112 FAS cases published between 1907 and October 2016: thes...
Article
Full-text available
Background Although language deficits after awake brain surgery are usually milder than post-stroke, postoperative language assessments are needed to identify these. Follow-up of brain tumor patients in certain geographical regions can be difficult when most patients are not local and come from afar. We developed a short telephone-based test for pr...
Article
During the past 3 decades numerous neurophysiological, neuroimaging, experimental and clinical studies have evidenced a crucial role for the cerebellum in cognitive, affective and behavioral functions. As a result of the acknowledged modulatory role of the cerebellum upon remote structures such as the cerebral cortex, cerebellar injury may give ris...
Article
Full-text available
Titel/ Title Foreign accent syndrome als planningsstoornis. Een gevalstudie. Foreign accent syndrome as a planning disorder. A case study. Abstract Foreign accent syndrome (FAS) is een zeldzame motorische spraakstoornis waarbij de uitspraak van de patiënt door luisteraars wordt opgevat als een buitenlands accent. Meestal is de aandoening het gevolg...
Article
Background & objective: During the past 3 decades, numerous neurophysiological, neuroimaging, experimental and clinical studies have evidenced a crucial role for the cerebellum in cognitive, affective and behavioral functions. As a result of the acknowledged modulatory role of the cerebellum upon remote structures such as the cerebral cortex, cere...
Article
In this analysis we explored the effective connectivity of the cerebellum with the cerebrum in social mentalizing, across five studies (n = 91) involving abstract and complex forms of mentalizing, such as (a) person and group impression formation, based on behavioral descriptions, and (b) constructing personal counterfactual events. Connectivity wa...
Article
Research has shown that linguistic functions in the bilingual brain are subserved by similar neural circuits as in monolinguals, but with extra-activity associated with cognitive and attentional control. Although a role for the right cerebellum in multilingual language processing has recently been acknowledged, a potential role of the left cerebell...
Article
Objectives: To understand the subjective pain experience of patients, healthcare providers rely heavily on self-reporting. However, to quantify this unique pain experience, objective parameters are not yet available in daily clinical practice. With regard to patients with failed back surgery syndrome (FBSS) treated with spinal cord stimulation (SC...
Chapter
At the beginning of the twentieth century, several authors defined the role of the cerebellum as a modulator of motor functions including diadochokinesia, tonus, coordination, and motor speech production (Babinski 1902; Luciani 1891; Holmes 1922). Although from time to time clinical case descriptions and experimental evidence from animal studies da...
Article
- Aim: To explore the differences between the oral and written description of a picture in individuals with chronic aphasia (IWA) and healthy controls. Descriptions were controllled for productivity, efficiency, grammatical organization, substitution behavior and discourse organization. - Method: 50 IWA and 50 healthy controls matched for age, gen...
Article
Full-text available
Foreign accent syndrome (FAS) is een zeldzame motorische spraakstoornis waarbij de uitspraak van de patiënt door luisteraars wordt opgevat als een buitenlands accent. Meestal is de aandoening het gevolg van een CVA in de taaldominante hemisfeer, maar in enkele gevallen werd FAS als een spraakontwikkelingsstoornis beschreven. In dit artikel wordt ee...
Article
Research has shown that linguistic functions in the bilingual brain are subserved by similar neural circuits as in monolinguals, but with extra-activity associated with cognitive and attentional control. Although a role for the right cerebellum in multilingual language processing has recently been acknowledged, a potential role of the left cerebell...
Article
Full-text available
Background: Evidence suggests that the concordance between amyloid-PET and cerebrospinal fluid (CSF) amyloid-β (Aβ) increases when the CSF Aβ1-42/Aβ1-40 ratio is used as compared to CSF Aβ1-42 levels alone. Objective: In order to test this hypothesis, we set up a prospective longitudinal study comparing the concordance between different amyloid...
Article
Full-text available
Patients with Parkinson’s disease (PD) display a variety of impairments in motor and non-motor language processes; speech is decreased on motor aspects such as amplitude, prosody and speed and on linguistic aspects including grammar and fluency. Here we investigated whether verbal monitoring is impaired and what the relative contributions of the in...
Data
Table A. Number of observations per percentile. Table B. Performance per participant on the Standard Progressive Matrices (SPM). Table C. Performance on the COWAT task. Participant data are compared to normative data from Miatton et al. (2004), calculated for the age distribution within the respective groups. On the left are the data for an educati...
Data
Transcript perception network task. (PDF)
Article
Full-text available
Foreign accent syndrome is a rare motor speech disorder that causes patients to speak their language with a non-native accent. In the neurogenic condition, the disorder develops after lesions (often stroke or trauma) in the language dominant hemisphere, often affecting Broca's area, the insula, the supplementary motor area and the primary motor cor...
Article
Background. The diagnostic work-up of Alzheimer Disease (AD) is complex, time-consuming, expensive, and quite demanding for the patients. Therefore, there is a growing need for simple non-invasive tools that add to the diagnostic work-up of patients. Objectives. This paper investigates a new method for monitoring motor functions in AD using everyda...
Article
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Awake surgery with electrocorticosubcortical stimulation is the golden standard treatment for gliomas in eloquent areas. Preoperatively, mostly mild cognitive disturbances are observed with postoperative deterioration. We describe pre- and postoperative profiles of 4 patients (P1–P4) with gliomas in “critical” language areas (“Broca,” “Wernicke,” a...
Article
Full-text available
Transcranial magnetic and electric stimulation of the brain are novel and highly promising techniques currently employed in both research and clinical practice. Improving or rehabilitating brain functions by modulating excitability with these noninvasive tools is an exciting new area in neuroscience. Since the cerebellum is closely connected with t...
Article
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Background: The thumb plays a critical role for manual tasks during the activities of daily life and the incidence of neurological or musculoskeletal disorders affecting the voluntary movements of the thumb is high in the elderly. There is currently no tool to assess repetitive motor sequencing of the thumb during ageing. Objectives: To report a...
Article
Full-text available
Over the past three decades, insights into the role of the cerebellum in emotional processing have substantially increased. Indeed, methodological refinements in cerebellar lesion studies and major technological advancements in the field of neuroscience are in particular responsible to an exponential growth of knowledge on the topic. It is timely t...
Article
Full-text available
BACKGROUND: Cerebellar mutism syndrome (CMS) or posterior fossa syndrome (PFS) consists of a constellation of neuropsychiatric, neuropsychological and neurogenic speech and language deficits. It is most commonly observed in children after posterior fossa tumor surgery. The most prominent feature of CMS is mutism, which generally starts after a few...
Article
Background Until today, there is no satisfying explanation for why one language may recover worse than another in differential bilingual aphasia. One potential explanation that has been largely unexplored is that differential aphasia is the consequence of a loss of language control rather than a loss of linguistic representations. Language control...
Chapter
Several studies have implicated the cerebellum in cognitive and behavioral-affective functions, including language. Clinical evidence and imaging studies point to a cerebellar involvement in motor speech production; verbal fluency and lexical/semantic retrieval; grammatical/syntactical processing; reading, writing, and metalinguistic skills; and ve...
Chapter
The deep cerebellar nuclei (DCN) are the sole output channel of the cerebellum and form part of the cerebellar system of closed loops connected to the sensorimotor region, the associative cortices, and the limbic system. Besides a motor function, it has been suggested that the cerebellum, and therefore also the deep cerebellar nuclei, are involved...
Chapter
Traditional models of writing and spelling do not include the cerebellum as a writing-specific area in the written language network. In functional neuroimaging studies, cerebellar activation during writing was commonly ascribed to pure motor execution of the movements necessary to produce written language output, without any involvement of the cogn...
Chapter
The traditional view of the cerebellum as the sole coordinator of sensorimotor function has been substantially redefi ned during the past decades. Neuroanatomical, neuroimaging and clinical studies have extended the role of the cerebellum to the modulation of cognitive, affective and social processing. Neuroanatomical studies have demonstrated cere...
Chapter
The functional neuroanatomy of cerebellar systems has been extensively studied during the past decades by means of experimental animal studies, anatomoclinical studies, as well as structural and functional neuroimaging studies in patients and healthy subjects. Within a system of closed-loop circuits, this wealth of studies identified reciprocal pro...
Presentation
Full-text available
Presentation during the course Psycholinguistics at the Free University of Brussels.
Article
Full-text available
Awake surgery is the gold standard for eloquent area low-grade gliomas (LGG) to preserve cognition and Quality of Life (QoL). LGG patients often report mild language disturbances which cannot always be captured with “classical” language tests (e.g. Boston Naming Test). Therefore a sensitive protocol was designed: Dutch Linguistic Intraoperative Pro...
Article
Full-text available
Objective To investigate the molecular basis of a Belgian family with autosomal recessive adult-onset neuronal ceroid lipofuscinosis (ANCL or Kufs disease [KD]) with pronounced frontal lobe involvement and to expand the findings to a cohort of unrelated Belgian patients with frontotemporal dementia (FTD). Methods Genetic screening in the ANCL fami...
Article
Objective: The occurrence of Twiddler's syndrome in subjects with neurostimulator devices is poorly understood and might be influenced by age, sex, BMI, use of medication or psychologic disorders. Methods: Two hundred thiry-five patients who received a neuromodulator were included in this retrospective study in a period between 2008 and 2015. Th...
Article
Dear Editor, Severe kyphoscoliosis is a deformity with fixed spinal vertebrae that does not allow traction, suspension, or side bending of the spine [1]. Treatment of rigid scoliosis in adults involves correction of complex three-dimensional deformities and restoring balance to the spine but is challenging due to a high rate of associated neurolog...
Article
This multi-study analysis (6 fMRI studies; 142 participants) explores the functional activation and connectivity of the cerebellum with the cerebrum during repeated behavioral information uptake informing about personality traits of different persons. The results suggest that trait repetition recruits activity in areas belonging to the mentalizing...
Article
Neurochirurgie bij patiënten met hersentumoren in eloquente zones beoogt een maximale resectie van de tumor met een minimaal risico op postoperatieve functionele uitval, zoals taalstoornissen (afasie). Inzicht in de functie en de exacte lokalisatie van corticosubcorticale gebieden en hun verbindingen is daarbij van cruciaal belang. Momenteel geldt...
Article
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Transcranial Direct Current Stimulation (tDCS) is an up-and-coming electrical neurostimulation technique increasingly used both in healthy subjects and in selected groups of patients. Due to the high density of neurons in the cerebellum, its peculiar anatomical organization with the cortex lying superficially below the skull and its diffuse connect...
Article
Full-text available
In the majority of cases published between 1907 and 2014, FAS is due to a neurogenic etiology. Only a few reports about FAS with an assumed psychogenic origin have been published. The present article discusses the findings of a careful database search on psychogenic FAS. This review may be particularly relevant as it is the first to analyze the sal...
Article
This paper presents the case of a 33-year-old, right-handed, French-speaking Belgian lady who was involved in a car accident as a pedestrian. Six months after the incident she developed a German/Flemish-like accent. The patient's medical history, the onset of the FAS and the possible psychological causes of the accent change are analyzed. Relevant...
Article
Full-text available
This paper presents the case of a 33-year-old, right-handed, French-speaking Belgian lady who was involved in a car accident as a pedestrian. Six months after the incident she developed a German/Flemish-like accent. The patient’s medical history, the onset of the FAS and the possible psychological causes of the accent change are analyzed. Relevant...
Article
Full-text available
This paper presents the case of a 17-year-old right-handed Belgian boy with developmental FAS and comorbid developmental apraxia of speech (DAS). Extensive neuropsychological and neurolinguistic investigations demonstrated a normal IQ but impaired planning (visuo-constructional dyspraxia). A Tc-99m-ECD SPECT revealed a significant hypoperfusion in...
Article
Full-text available
A 40-year-old, non-aphasic, right-handed, and polyglot (L1: French, L2: Dutch, and L3: English) woman with a 12-year history of addiction to opiates and psychoactive substances, and clear psychiatric problems, presented with a foreign accent of sudden onset in L1. Speech evolved toward a mostly fluent output, despite a stutter-like behavior and a m...
Article
Background: During the past three decades neuroanatomical, neuroimaging, and clinical studies have substantially altered the view on the role of the cerebellum as a sole coordinator of sensorimotor function. Currently, the cerebellum is believed to be also crucially involved in cognitive, affective, and behavioural functioning.Aims: This paper aims...
Article
In terms of cerebellar research and ataxiology, a most fascinating period is currently going on. Numerous academic groups are now focusing their innovative research on the so-called little brain, hidden at the bottom of our brain. Indeed, its unique anatomical features make the cerebellum a wonderful window to address major questions about the cent...
Chapter
During the past few decades, the role of the cerebellum in behavioral, cognitive, and affective processes has evolved from a mere afterthought to an exciting area of innovative research across disciplines. Advances in the understanding of the neuroanatomy of the cerebellum and its reciprocal connections with the supratentorial brain regions subserv...
Article
Associative learning denotes a specific kind of learning process, in which a change in the behavior of an organism results from adaptation to a particular relation between events occurring in an environment. Current insights in the neurobiological mechanisms subserving associative learning are primarily based on experimental and clinical research w...
Article
Full-text available
In the majority of right-handed subjects, language processing is subserved by a close interplay between the left cerebral hemisphere and right cerebellum. Within this network, the dominant fronto-insular region and the contralateral posterior cerebellum are crucially implicated in oral language production. Case Presentation We report atypical anato...
Article
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Schmahmann’s syndrome represents a novel clinical condition consisting of a constellation of cognitive and affective deficits following cerebellar disease. The complex was first described in 1998 as cerebellar cognitive affective syndrome (CCAS) on the basis of a careful neurological examination, detailed bedside mental state tests, neuropsychologi...