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Introduction
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October 2005 - December 2015
Publications
Publications (307)
Background
Headache disorders are among the most prevalent neurological disorders worldwide. However, whether groups differing in socioeconomic position (SEP) are disproportionately affected by headache disorders has not yet been adequately clarified. Our aim was to analyse (1) the headache prevalence by socioeconomic position (SEP) and (2) the att...
Background
Avoidant/restrictive food intake disorder (ARFID), an eating disorder not associated with weight and shape concerns, results in nutrient or energy deficiencies related with further health consequences and a pronounced need for specialized treatment. These interventions need to be tailored to individual health behavior. However, research...
Background
Abnormalities in electrocortical parameters and persistence of afterimage after visual stimulation are known to occur in migraine patients. The results of studies on Contingent Negative Variation (CNV) and afterimage persistence in migraine patients suggest a link between these two phenomena and a connection to the pathomechanism of migr...
ZUSAMMENFASSUNG
Ein Zusammenhang zwischen Sport und Kopfschmerz ergibt sich im Wesentlichen auf 2 Ebenen: Kann Sport zu Kopfschmerzen führen? Kann Sport in der Therapie von Kopfschmerzen eingesetzt werden? Der Artikel beleuchtet diesen Zusammenhang am Anfang aus historischer und systematischer Sicht. Die Frage der Kopfschmerzauslösung beim Sport un...
GMS Journal for Medical Education 2024; 41 (1): Doc7
Background
The Burning mouth syndrome (BMS) is a chronic pain syndrome characterized by a burning sensation in the oral mucous membranes. The etiology and pathophysiology of BMS is largely unexplained. To date, there is no evidence-based treatment strategy for BMS. Cranial electrical stimulation (CES) represents a non-invasive treatment option with...
The medial portrayal of migraine is often stereotypical and inaccurate but reflects how society perceives migraine. The discrepancy between others’ views and the reality of affected individuals may negatively affect access to treatment and the disease course of patients with migraine. This study aimed to investigate whether images presented in the...
Background: It is known from studies that migraine patients show a higher amplitude of the early component of the contingent negative variation (iCNV) 1 , a habit deficit 1 and a prolonged afterimage duration 2 compared to healthy subjects. The aim of the present study is to examine whether there is a relationship between these phenomena.
Methods:...
Primary headaches are among the most common pain disorders. They include migraines (prevalence 15%), tension headaches (up to 80%), and others, including trigeminal autonomic headaches (about 0.2%). Migraine, in particular, leads to significant impairment of personal life and high societal costs. Therefore, the need for effective and sustainable th...
Einleitung: Bisher ist wenig über das Gesundheitsverhalten von Personen mit einer vermeidend/restriktiven Essstörung (ARFID) bekannt. Forschung in der Allgemeinbevölkerung zeigt, dass allgemeine Psychopathologie mit einem höherem prevention focus (d.h. Fokus den Gesundheitszustand zu halten und eine Verschlechterung zu vermeiden) beim Gesundheitsve...
Backgound
Headache disorders are not only among the most prevalent, they are also among the most disabling disorders worldwide. This paper investigates the association between headache impact on daily life and the socioeconomic status (SES) of headache sufferers.
Methods
Data stem from a random general population sample in Germany. Respondents who...
To examine factors for adherent and non-adherent behavior in patients with cluster headache and migraine. Adults with cluster headache or migraine were included in this anonymous online survey using a questionnaire accessed via homepages of headache support groups. Medication adherence in preventive treatment was measured with the Medication Adhere...
Patients with adrenal insufficiency (AI) are treated with conventional or modified-release glucocorticoid (GC) replacement therapy (GRT). Although current GRT regimens aim to mimic the physiological circadian pattern of cortisol secretion, temporary phases of hypo- and hypercortisolism are common. There is good evidence that prolonged phases of hyp...
Background
The rational use of antibiotics is of great importance in health care. In primary care, acute respiratory infections are the most common cause of inappropriate antibiotic prescribing. Since existing studies aiming to optimize antibiotic use are usually based on the voluntary participation of physicians, general practitioners (GPs) with i...
Introduction
Chronic headache due to the overuse of medication for the treatment of migraine attacks has a prevalence of 0.5–2.0%. This guideline provides guidance for the management of medication overuse (MO) and medication overuse headache (MOH).
Recommendations
Treatment of headache due to overuse of analgesics or specific migraine medications...
This citizen science project CLUE compared the attack frequency between school and vacation periods among adolescents. The data collection process adopted in citizen science projects opens up the possibility of conducting analyses by including a large number of participants over a long period and across different regions. The data on 684 migraine a...
Headaches are a frequent reason for presentation to the emergency department (ED) and can pose a great challenge for the attending physicians. First and foremost, the distinction between a primary and secondary headache with potentially life-threatening implications can be difficult. Moreover, it often occurs that no specific headache diagnosis is...
Introduction:
The aim of this analysis is to determine whether regular physical activity is associated with less analgesic use in men and women suffering from headache disorders based on population-based cross-sectional data.
Methods:
We used data from a random general population sample in Germany that comprised 2477 participants aged ≥ 14 years...
ZUSAMMENFASSUNG
Die Suche nach einer Migränepersönlichkeit ist in der Medizingeschichte nicht neu. Es gab verschiedene Ansätze, alle Menschen mit Migräne einem bestimmten Persönlichkeitstypus zuzuordnen. Dies ist aus heutiger Sicht gescheitert, obwohl es Verhaltensmerkmale und kognitive Besonderheiten gibt, die bei der Mehrzahl der Menschen mit Mig...
Background
The aim of this work is to analyze reports of migraine attacks collected online in the citizen science project CLUE with respect to gender- and migraine type-specific differences in drug effectiveness and pain perception. Citizen science project data collection opens the possibility to examine these differences based on a large number of...
2.8.2.1. Einführung Stellen Sie sich vor, Sie bekommen beim Zahnarzt wegen einer Karies eine Füllung. Der Zahnarzt muss dabei bohren und den kariösen Zahnanteil entfernen. An was denken Sie dabei? Richtig-Sie empfinden möglicherweise Unbehagen und denken an schmerzvolle Situationen auf dem Behandlungsstuhl. So intensiv wir Schmerzen wahrnehmen, so...
For decades, headache was not considered a typical symptom of multiple sclerosis (MS) and was construed as a "red flag" for important differential diagnoses such as cerebral vasculitis. Meanwhile, several studies have demonstrated an increased prevalence of headache in MS compared to the general population. This is due to the heterogeneity of heada...
Background: The care of patients with headache in the emergency department (ED) represents a diagnostic and clinical challenge. Data on the prevalence and characteristics of headache patients in purely neurological EDs are sparse. The aim of the present study is to examine patient profiles with the cardinal symptom of headache in an academic neurol...
Background
Patients with adrenal insufficiency (AI) are treated with glucocorticoid replacement therapy (GRT). Although current glucocorticoid regimens aim to mimic the physiological circadian rhythm of cortisol secretion, temporary phases of hypo- and hypercortisolism are common undesired effects which lead to a variety of consequences like increa...
Background
Several psychological cofactors of migraine have been identified, but relationships to different headache parameters (e.g., headache frequency vs. headache-related disability) are only incompletely understood.
Methods
We cross-sectionally assessed 279 migraine patients at their first presentation at our tertiary headache center. We obta...
Background
The use of new concepts in patient care, such as video-consultations, reminder systems, and online evaluation portals, is becoming increasingly important in the physician–patient relationship and outpatient care. This study examines the acceptance of these approaches in a neurological setting and determines the patients’ preferences.
Me...
Background
To (a) describe the pattern of leisure time physical activities (LTPA) in community-dwelling persons who have been screened positive for dementia and (b) determine the health-related and sociodemographic factors associated with LTPA.
Methods
Data of the general practitioner-based, randomized, controlled intervention trial, DelpHi-MV (De...
Background
The aim of this work is to analyze the reports on cluster headache attacks collected online in the citizen science project CLUE with respect to the effectiveness of drugs taken during the attacks. The collection of data within the framework of citizen science projects opens up the possibility of investigating the effectiveness of acute m...
Biofeedback is an instrument-based treatment procedure that is derived from behavioral therapy and aims to actively and consciously regulate the normally autonomic physiological processes (“bio”). These are acquired via a measuring device and transformed so that they can be acoustically, visually or tactually perceived. As soon as such a perception...
PurposePatients with adrenal insufficiency are usually treated with conventional hydrocortisone replacement therapy which fails to mimic the circadian rhythm of cortisol secretion. Dual-release hydrocortisone (DR-HC) resembles the daily normal cortisol profile improving metabolic parameters and quality of life. However, currently little is known ab...
Background
The use of new concepts in patient care, such as video-consultation, reminder systems and online-evaluation portals is becoming increasingly important in the physician-patient relation and in the care of outpatients. This study examines the acceptance of these approaches in a neurological setting and characterizes the patients’ preferenc...
End‐stage renal disease is associated with chronic stress that in turn may result in endocrine changes, affect cognitive and physical capacities and increase the risk for cardiovascular events. Objective of this study was to evaluate and characterize possible stress parameters and compare cognitive function in those patients. Physiological and bioc...
Patients with adrenal insufficiency (AI) are treated with glucocorticoid (GC) replacement therapy. Although current GC regimens aim to mimic the physiological circadian rhythm of cortisol secretion, temporary phases of hypo- and hypercortisolism are common undesired effects. Both conditions may lead to impairment in cognitive functioning. At presen...
Objectives
The future state treaty on the admission of students to German medical schools calls for a variety of selection criteria among which at least two are required to be independent of school leaving grades. Against this background, the present study investigated achievement motivation and executive functions as predictors of academic success...
Background:
The coronavirus disease 2019 (COVID-19) pandemic has substantially changed life worldwide in 2020. This also influences the psychological treatment options of patients with headache.
Aim:
The present article intends to illustrate the different psychological forms of treatment for headache patients and their implementation during the...
Background:
Migraine is a frequently underdiagnosed disease that is associated with a high burden on affected patients. There are a variety of prophylactic treatment options available, that have been expanded with the introduction of the CGRP-(receptor-)antibodies.
Objectives:
Status of pharmacologic and nonpharmacologic preventive treatment in...
The relationship between headache and multiple sclerosis (MS) has been a matter of controversy for over 60 years. Headaches are still rated as a “red flag”, indicating alternative diagnoses to MS, although in the last few years numerous studies have shown a frequent association between headache and MS. In recent studies on MS patients, a link was f...
Background:
Headache sufferers in need of professional health care often do not utilize the care available, and factors influencing headache-specific physician consultation are not yet understood. Objectives of this study are (1) to assess self-reported headache-specific physician consultations and (2) to identify headache-related and sociodemogra...
In diesem Kapitel werden alle gängigen Methoden der Schmerztherapie beschrieben, angefangen mit der medikamentösen Therapie. Es werden nicht nur spezielle Einsatzgebiete von Wirkstoffen vorgestellt sondern auch auf die damit verbundenen Gefahren hingewiesen. Ausführlich kommt hier der Einsatz von Medikamente in der Schwangerschaft, im Sport, auf Au...
Objectives The aim of this Delphi survey was to
establish an international consensus on the most useful outcome measures for research on the effectiveness of non-pharmacological interventions for migraine. This is important, since guidelines for pharmacological trials recommend measuring the frequency of headaches with 50% reduction considered a cl...
Zusammenfassung
Ziel der Studie Durch den Masterplan Medizinstudium 2020 und die Entwicklung des Nationalen Kompetenzbasierten Lernzielkatalogs Medizin (NKLM) wurden bedeutsame Veränderungen in der universitären Medizin angestoßen. Ziel der Studie war eine systematische Erfassung des Standes und der Perspektiven der Fächer Medizinische Psychologie...
Background: Reliable population-based data on the prevalence and characteristics of primary headache across the lifespan are essential. However, robust data are lacking.
Methods: We utilized questionnaire data from a random general population sample in Germany, that comprised 2,478 participants aged ≥14 years. A standardized questionnaire addressin...
ZUSAMMENFASSUNG
In diesem Beitrag wird beschrieben, welche psychologischen Behandlungsverfahren in der Therapie von Kopfschmerzerkrankungen eingesetzt werden können. Technologische Entwicklungen in den letzten Jahrzehnten habe neue Möglichkeiten eröffnet, deren Potenzial es allerdings noch genauer auszuloten gilt. Die Idee moderner Kopfschmerzthera...
Objective: While there is solid evidence for a bilateral correlation between psychiatric comorbidities and migraine, loneliness has been only been examined sparsely in migraine. Increased rates of loneliness have been reported in elderly patients with migraine. Importantly, loneliness correlates also with depression, physical activity and sleep. Th...
Introduction Patients with primary and secondary adrenal insufficiency (PAI/ SAI) are usually treated with glucocorticoid replacement therapy which fails to mimic the circadian rhythm of cortisol secretion thereby resulting in temporary hypo- and hypercortisolism. The unphysiological replacement is associated with impairment in cognitive function....
Seit Anfang der 1970er-Jahre wird die progressive Muskelrelaxation (PMR) nach Jacobson in der Migräneprophylaxe eingesetzt. Hintergrund ist die Annahme, dass Migränepatienten eine erhöhte autonome Aktivierung aufweisen, der man mit systematischer Entspannung entgegensteuern kann. Entspannungsverfahren reduzieren neben dem Aktivierungsniveau auch di...
Zur Behandlung von Kopfschmerzen sind medikamentöse Therapien nicht immer ausreichend wirksam oder können aus medizinischen Gründen nicht eingesetzt werden. Die psychologische Kopfschmerztherapie ist besonders bei chronischen Kopfschmerzen, einer hohen Beeinträchtigung der Patienten sowie als Ergänzung oder Alternative zur medikamentösen Behandlung...
Multiple sclerosis (MS) is the most common immune-mediated inflammatory disease of the central nervous system (CNS). Early diagnosis and treatment is important to prevent progression of disability in the course of the chronic disease. Therefore, correct and fast identification of early symptoms is vital. Headache is generally not recognized as an e...
In collaboration with some of the leading headache centres in Germany, Switzerland and Austria, we have established new guidelines for the treatment of migraine attacks and the prevention of migraine. A thorough literature research of the last 10 years has been the basis of the current recommendations. At the beginning, we present therapeutic novel...
Zur Behandlung von Kopfschmerzen sind medikamentöse Therapien nicht immer ausreichend wirksam oder können aus medizinischen Gründen nicht eingesetzt werden. Die psychologische Kopfschmerztherapie ist besonders bei chronischen Kopfschmerzen, einer hohen Beeinträchtigung der Patienten sowie als Ergänzung oder Alternative zur medikamentösen Behandlung...
Objective
To determine if migraine patients with high achievement motivation have an increased use of acute headache medication.
Background
It has been hypothesized that high achievement‐motivated migraine patients have an increased use of acute headache medication to be able to perform at work and during daily life, putting them at risk for medic...
Aims:
Headaches have not been considered a typical symptom of multiple sclerosis (MS), although since 2000, almost every study showed high prevalence. We screened 50 MS patients at the time of first occurrence of neurological symptoms and found the highest prevalence of headache in MS that was ever recorded (78%). Postmortem histological analyses...
Seit Anfang der 1970er-Jahre wird die progressive Muskelrelaxation (PMR) nach Jacobson in der Migräneprophylaxe eingesetzt. Hintergrund ist die Annahme, dass Migränepatienten eine erhöhte autonome Aktivierung aufweisen, der man mit systematischer Entspannung entgegensteuern kann. Entspannungsverfahren reduzieren neben dem Aktivierungsniveau auch di...
The positive effects of physical and sports therapy for strain dependent physical practice and improved quality of life (QoL) are well known. Nevertheless, the available capacities and problem-oriented therapies in the setting of hematopoietic stem cell transplantation (HSCT) are limited. We conducted a prospective, randomized study among 42 HSCT r...
Patients with primary and secondary adrenal insufficiency (PAI/ SAI) are treated with glucocorticoid replacement therapy (GRT). However, current GRT regimens do not mimic the circadian rhythm of cortisol secretion sufficiently, resulting in temporary hypo- and hypercortisolism. Both conditions may lead to impairment in cognitive function. At presen...
In this paper we introduce the design and technical implementation of the citizen science project Migraine Radar. The goal of the project is to establish a large collection of migraine attack data in order to explore the trigger factors of migraine attacks. A main focus is the investigation of the influence of environmental factors like weather or...
Gesundheits-Apps für Smartphone oder Tablet spielen im Alltag vieler Menschen eine immer größere Rolle. Auch bei Kopfschmerzpatienten steigt das Interesse, sie in die Behandlung zu integrieren.
Objectives
Multiple sclerosis (MS) is the most frequent immune‐mediated inflammation of the central nervous system that can lead to early disability. Headaches have not been considered as MS‐related symptoms initially, whereas higher prevalence rates were reported since 2000. Postmortem histological analyses of MS patients’ brains revealed lymphoid...
Glucosylceramide and glucosylsphingosine are the two major storage products in Gaucher disease (GD), an inherited metabolic disorder caused by a deficiency of the lysosomal enzyme glucocerebrosidase. The build-up of glucosylceramide in the endoplasmic reticulum and prominent accumulation in cell lysosomes of tissue macrophages results in decreased...
Introduction:
Besides pharmacological and interventional treatments a variety of non-medical therapeutic options exist for migraine, which has largely been derived from behavioral therapy. Areas covered: For our update we collected available studies via PubMed searches. This review highlights that already consulting of the patient is able to reduc...
Wenn Patienten mit Migräne in Ihrer Praxis Rat suchen, sollten Sie nicht nur Ihren Rezeptblock zücken. Mittlerweile gibt es auch für die Wirksamkeit verschiedener nicht-medikamentöser Verfahren gute Evidenz.
Neben medikamentösen und interventionellen Verfahren bestehen zur Behandlung der Migräne nichtmedikamentöse Möglichkeiten, die großenteils der Verhaltenstherapie entstammen. In der Zusammenschau kann dabei aufgezeigt werden, das bereits eine ausführliche Beratung des Patienten zu positiven Effekten in der Migränehäufigkeit führen kann. Entspannung...
