Peter Korsten

Peter Korsten
Universitätsmedizin Göttingen · Department of Nephrology and Rheumatology

Doctor of Medicine (M.D.)
Focusing on clinical outcome research in Systemic Diseases, such as Systemic Sclerosis, SLE, Myositis, and Sarcoidosis.

About

193
Publications
101,981
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1,699
Citations
Citations since 2017
142 Research Items
1407 Citations
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Introduction
Peter Korsten currently works at the Department of Nephrology and Rheumatology, Universitätsmedizin Göttingen. Peter does research in Emergency Medicine/Critical Care, Nephrology, and Rheumatology. He has a special interest in rare systemic diseases, such as Sarcoidosis, Systemic Lupus erythematosus, and Systemic Sclerosis. Current research projects include 'Circulating CpG DNA in Lupus nephritis' and 'Outcome of immunosuppressive therapy in CTD-ILD'.
Additional affiliations
October 2016 - present
Universitätsmedizin Göttingen
Position
  • Task force member
April 2016 - October 2020
Universitätsmedizin Göttingen
Position
  • Rheumatologist I Intensivist
October 2011 - present
Georg-August-Universität Göttingen
Position
  • Nursing education in Nephrology and Critical Care
Education
February 2009 - April 2016
Universitätsmedizin Göttingen
Field of study
  • Nephrology and Rheumatology, Critical Care, Emergency Medicine
November 2007 - July 2008
Hospital Civil de Guadalajara Juan I. Menchaca
Field of study
  • Internship in Ob/Gyn and Internal Medicine
July 2007 - October 2007
Sana Kliniken Düsseldorf
Field of study
  • Internship Surgery

Publications

Publications (193)
Article
Full-text available
The pillars of scientific progress in rheumatology are experimentation and observation, followed by the publication of reliable and credible results. These data must then be independently verified, validated, and replicated. Peer and journal-specific technical and statistical reviews are paramount to improving rigor and reproducibility. In addition...
Article
Full-text available
Zusammenfassung Unter der Federführung der Deutschen Gesellschaft für Neurologie und Beteiligung vieler weiterer Fachgesellschaften wurde die S2k-Leitlinie zu Myositissyndromen vollständig aktualisiert und überarbeitet. Bei der Klassifikation der Myositiden werden nun die immunmediierte nekrotisierende Myopathie und das Antisynthetasesyndrom als ei...
Article
Objectives: Establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD). Methods: A conceptual framework for subclinical, clinical, and progressive ILD was provided to eighty-three experts, asking them to use the framework and classify actual SSc-ILD patients. Each patient pr...
Article
Full-text available
Objectives: Gastroesophageal reflux disease (GERD) occurs frequently in patients with systemic sclerosis (SSc). We investigated whether the presence of GERD and/or the use of anti-acid therapy, specifically proton-pump inhibitors (PPIs), are associated with long-term outcomes, especially in SSc-associated interstitial lung disease (SSc-ILD). Meth...
Conference Paper
Full-text available
Purpose To evaluate the efficacy and safety of intravenous (IV) belimumab (BEL) in the European subgroup of patients with lupus nephritis (LN) from the previously published BLISS-LN study.1 Methods BLISS-LN was a Phase 3, double-blind, placebo (PBO)-controlled 104-week study (GSK Study BEL114054; NCT01639339). Adult patients with biopsy-proven LN...
Article
A 42-year-old woman with systemic sclerosis presented to our clinic. The diagnosis was based on sclerodactyly, mutilating arthritis, interstitial lung disease and positive antibodies (ANA, Scl70). She reported progressive dyspnoea and debilitating joint pain. Her medical history included surgery for cleft lip/palate (CL/P); a surgically corrected C...
Article
Full-text available
Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease, and organ manifestations, such as lupus nephritis (LN) or skin disease, may be refractory to standard treatment. Therefore, new agents are required to allow for a more personalized therapeutic approach. Recently, several new therapies have been approved internation...
Article
Full-text available
Background Systemic sclerosis (SSc) is characterized by tissue fibrosis and vasculopathy. Raynaud’s phenomenon is present in almost all patients (1). Nailfold video capillaroscopy is an established imaging tool for a morphologic assessment but is not able to quantify blood flow (2). Micro Vascular Imaging (MVI) is a novel ultrasound technique for b...
Preprint
Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease, and organ manifestations, such as lupus nephritis (LN) or skin disease, may be refractory to standard treatment. Therefore, new agents are required to allow for a more personalized therapeutic approach. Recently, several new therapies have been approved internation...
Article
Full-text available
In recent years, advances in the treatment and the management of patients with systemic lupus erythematosus (SLE) have improved their life expectancy and quality of life. However, lupus nephritis (LN) still represents a major life-threatening complication of the disease. Belimumab (BEL), a fully human monoclonal IgG1λ antibody neutralizing soluble...
Article
Full-text available
The discovery of antineutrophil cytoplasmic antibodies (ANCAs) in ANCA-associated vasculitis (AAV) marked a breakthrough in diagnostics. Subsequently, ANCAs were found in distinct small vessel vasculitides, including microscopic polyangiitis (MPA) and eosinophilic GPA (formerly known as Churg-Strauss syndrome). The current recommended diagnostic ap...
Research Proposal
Full-text available
Introduction Raynaud’s phenomenon (RP) and digital ulcers (DU) are frequent manifestations of Systemic Sclerosis (SSc). Despite being very common in SSc patients, both conditions have proven to be notoriously difficult to study. There are very few available approved drugs with varying efficacy. It has been shown that the presence of DU is associate...
Poster
- Patients with SSc without PBC do not have increased liver stiffness compared to healthy controls - Patients with SSc/PBC overlap and PBC have comparable liver stiffness - PBC, if present, is the main driver of increased liver stiffness/fibrosis in SSc/PBC overlap patients
Article
Full-text available
The nephroprotective efficacy of sodium-glucose cotransporter-2 (SGLT-2) inhibitors (SGLT-2i) in patients with chronic kidney disease, with or without type 2 diabetes, has already been described.1 Although patients with autoimmune diseases were excluded from large renal outcome trials, the use of SGLT-2i in antineutrophil cytoplasmic antibody-assoc...
Article
Full-text available
Systemic sclerosis is an autoimmune disease characterized by organ fibrosis and vasculopathy. Almost all patients suffer from Raynaud’s phenomenon. Nailfold video capillaroscopy is the most widely imaging technique available, but flow quantification is impossible. Therefore, novel imaging techniques are of interest. We performed a single-center fea...
Article
Full-text available
Background Lyme disease is a tick-borne multisystem infection. The most common cardiac manifestation is an acute presentation of Lyme carditis, which often manifests as conduction disorder and rarely as myocarditis. Case Summary We report the case of a 37-year-old male with a history of microscopic polyangiitis receiving immunosuppressive therapy....
Article
Full-text available
OBJECTIVES: Anti-hydroxy-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody-associated myopathy was recognised as a new form of immune-mediated necrotising myopathy (IMNM) a decade ago. Due to the rarity of the disease, only limited data on clinical manifestations and therapeutic outcomes are available. METHODS: We retrospectively analysed a mo...
Article
Full-text available
In critically ill patients, liver dysfunction often results in coagulopathy and encephalopathy and is associated with high mortality. Extracorporeal clearance of hepatotoxic metabolites, including bilirubin and ammonia, aims to attenuate further hepatocyte damage and liver injury, resulting in decreased mortality. The efficacy of hemadsorption comb...
Preprint
Full-text available
Systemic sclerosis is an autoimmune disease characterized by organ fibrosis and vasculopathy. Almost all patients suffer from Raynaud's phenomenon. Nailfold video capillaroscopy is the most widely available imaging technique, but flow quantification is impossible. Therefore, novel imaging techniques are of interest. We performed a single-center fea...
Article
Full-text available
Sarcoidosis can present as an acute form or take a chronic course. One of the acute presentations is Löfgren’s syndrome (LS), consisting of the symptom triad of bilateral hilar lymphadenopathy, erythema nodosum, and ankle periarthritis. In addition, there are occasional reports of sarcoid-like reactions following drug exposures. Nevertheless, repor...
Article
Full-text available
Background: Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), potentially leading to chronic kidney disease (CKD), end-stage renal disease (ESRD), or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) and myeloperoxidase (MPO), trigger a deleterious immu...
Article
Full-text available
Previous seminal work has shown that chromogranin A (CgA) can mediate tubular injury, either by intraluminal precipitation with cast formation or excessive tubular CgA uptake. We report an additional case of kidney injury in the context of CgA tubulopathy and explored the efficacy of CgA elimination by therapeutic plasma exchange (PEX). A 69-year-o...
Article
Full-text available
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis affecting multiple organ systems, including the kidney. Besides investigations focusing on renal outcomes, sex differences associated with distinct clinical and histopathological findings in ANCA glomerulonephritis (GN) have not been systematically...
Article
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Purpose: Extrinsic factors and genetic predisposition contribute to the etiology of sarcoidosis, converging in a phenotype of altered immune response associated with multisystemic inflammatory granulomatous tissue infiltration. Immunological reconstitution after hematopoietic stem cell transplantation (HSCT) may represent a unique window for the pa...
Article
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Background: Chronic kidney disease (CKD) is a common medical problem in patients worldwide, with an increasing prevalence of patients with end-stage kidney disease (ESKD) requiring renal replacement therapy (RRT). In patients requiring RRT for more than two weeks or those who develop ESKD, tunneled hemodialysis catheter (HDC) insertion is preferre...
Article
Full-text available
Kidney fibrosis is a common manifestation and hallmark of a wide variety of chronic kidney disease (CKD) that appears in different morphological patterns, suggesting distinct pathogenic causes. Broad macroscopically visible scars are the sequelae of severe focal injury and complete parenchymal destruction, reflecting a wound healing response as a c...
Preprint
Full-text available
Purpose Extrinsic factors and genetic predisposition contribute to the etiology of sarcoidosis, converging in a phenotype of altered immune response associated with multisystemic inflammatory granulomatous tissue infiltration. Immunological reconstitution after hematopoietic stem cell transplantation (HSCT) may represent a unique window for the pat...
Article
Background The impact and consequences of the COVID-19 pandemic on people with rheumatic disease are unclear. We developed the COVID-19 Global Rheumatology Alliance Patient Experience Survey to assess the effects of the COVID-19 pandemic on people with rheumatic disease worldwide. Methods Survey questions were developed by key stakeholder groups a...
Article
Full-text available
Background The coronavirus disease-2019 (COVID-19) pandemic impacted healthcare services for kidney disease patients. Lockdown and social distancing were mandated worldwide, resulting in closure of medical services. The diagnosis of various kidney diseases may have been delayed during the COVID-19 pandemic because non-urgent tests and visits were p...
Article
Full-text available
Acute kidney injury (AKI) is a common and severe complication of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) causing progressive chronic kidney disease (CKD), end-stage renal disease (ESRD) or death. Pathogenic ANCAs, in particular proteinase 3 (PR3) and myeloperoxidase (MPO), trigger a deleterious immune response resul...
Article
Full-text available
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a small vessel vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA). Acute tubular injury with the presence of tubulitis was previously reported to be of prognostic value in ANCA glomerulonephritis (GN)...
Article
Full-text available
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA). Pathogenic ANCAs trigger a deleterious immune response resulting in pauci-immune necrotizing and crescentic glomerulonephritis (GN). Standard therap...
Article
Full-text available
Background: The major reasons to treat sarcoidosis are to lower the morbidity and mortality risk or to improve quality of life (QoL). The indication for treatment varies depending on which manifestation is the cause of symptoms: lungs, heart, brain, skin or other manifestations. While glucocorticoids remain the first choice for initial treatment o...
Article
Full-text available
Background Lupus nephritis (LN) occurs in about 30-60% of patients with systemic lupus erythematosus (SLE). LN is associated with increased mortality. Currently, the diagnosis relies on histopathologic characteristics according to the ISN/RPS classification (1). This classification relies heavily on glomerular changes and may not accurately reflect...
Article
Full-text available
Background Gastroesophageal reflux disease (GERD) occurs frequently in patients with systemic sclerosis (SSc) and SSc-associated interstitial lung disease (SSc-ILD). PPI use has to been shown to improve survival in patients with idiopathic pulmonary fibrosis, whereas to date there are no data on the use of PPI in SSc-ILD. Objectives This study was...
Article
Full-text available
Background ANCA-associated vasculitis (AAV) can present with a wide range of symptoms, including acute kidney injury (AKI) requiring renal replacement therapy or diffuse alveolar hemorrhage (1). These two manifestations often require admission to an intensive care unit (ICU) and are associated with increased mortality. To predict ICU mortality, the...
Article
Full-text available
Background The anti-CD20 antibody rituximab (RTX) is approved for the treatment of rheumatoid arthritis (RA) and ANCA-associated vasculitis (AAV). In addition, RTX is used in a wide range of autoimmune diseases. Belimumab (BEL) is an anti-BAFF antibody approved for the treatment of non-renal systemic lupus erythematosus (SLE) in Europe. These agent...
Article
Background Systemic lupus erythematosus (SLE) can affect almost any organ system. Nevertheless, Lupus nephritis and neuropsychiatric manifestations (NPSLE) are associated with increased mortality (1). Therapeutic options include glucocorticoids, often pulse methylprednisolone (MP), and other immunosuppressive therapies. In refractory cases, therape...
Article
Full-text available
Background Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy and skin as well as organ fibrosis. The lungs, skin, and gastrointestinal care frequently affected. Primary biliary cholangitis (PBC) is an autoimmune disease of the liver associated with potential progression to liver fibrosis. More recently, these two disor...
Article
Full-text available
Sarcoidosis is an immune mediated chronic inflammatory disorder that is best characterized by non-caseating granulomas found in one or more affected organs. The COVID-19 pandemic poses a challenge for clinicians caring for sarcoidosis patients who may be at increased risk of infection compared to the general population. With the recent availability...
Conference Paper
Full-text available
Lupus nephritis (LN) occurs in about 30-60% of patients with SLE. Currently, the diagnosis relies on histopathologic characteristics according to the ISN/RPS classification but is centered on glomerular changes. For the description of transplanted kidneys, the BANFF classification has been established which also incorporates tubulointerstitial find...
Conference Paper
Full-text available
Neuropsychiatric manifestations (NPSLE) are associated with increased mortality and can be particularly difficult to treat. Severe manifestations include movement disorders and transverse myelitis (TM), which can also occur in primary Sjögren’s syndrome (pSS). We retrospectively analyzed clinical data and outcomes in NPSLE and pSS at two academic c...
Conference Paper
Full-text available
Immunosuppressive therapy with Belimumab is employed in SLE patients with active disease (high SLEDAI, glucocorticoid dependency, high serological activity) and has a potential for serious adverse events, including infections or laboratory changes. Here, we report our experience of reported adverse events with Belimumab in a single-center academic...
Article
Full-text available
Objectives: We have recently described the frequency of Bowman's capsule (BC) rupture in a considerable subset of patients with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (GN). Interestingly, recent reports established a better performance of glomerulocentric ANCA scoring systems after adding BC rupture to these classi...
Article
Full-text available
Background: Renal involvement is a common and severe complication of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), potentially resulting in a pauci-immune necrotizing and crescentic ANCA glomerulonephritis (GN) with acute kidney injury (AKI), end-stage renal disease (ESRD) or death. There is recent evidence that the degre...
Article
ZUSAMMENFASSUNG Die Therapie des systemischen Lupus erythematodes (SLE) und des primären Sjögren-Syndroms (pSS) stellt eine Herausforderung dar. Dies liegt nicht nur an der Heterogenität der Ausprägung beider Erkrankungen, sondern auch an den wenigen erprobten und zugelassenen Therapiemöglichkeiten. Für die Behandlung des SLE zugelassen sind Hydrox...
Article
Full-text available
Background: Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic vasculitis, most frequently presenting as microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA). Kidney involvement is a common and severe complication of ANCA AAV which is observed in a considerable subset of patients, mainly affect...
Article
Full-text available
Fatigue is a frequently reported and disabling symptom in patients with systemic lupus erythematosus (SLE). The management of Lupus-associated fatigue (LAF) is complex and requires the exclusion of disease activity and comorbidities as potentially treatable causes. Standard of care recommendations includes psychological counselling and regular phys...
Article
Full-text available
Renal involvement is a common and severe complication of AAV as it can cause ESRD. Histopathological subgrouping and ARRS are helpful to predict long-term ESRD in patients with AAV. Because a subgroup of critically ill patients with severe AAV present with deterioration of kidney function requiring dialysis at admission, we here aimed to evaluate h...
Article
Full-text available
Background Antisynthetase syndrome (ASyS) is a rare autoimmune disease characterized by inflammatory myopathy, arthritis, fever, and interstitial lung disease (ILD). Pulmonary involvement in ASyS significantly increases morbidity and mortality and, therefore, requires prompt and effective immunosuppressive treatment. Owing to the rarity of ASyS, li...
Article
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Context: Due to recent advantages in cancer therapy, immune checkpoint inhibitors (ICIs) are new classes of drugs targeting programmed cell death protein 1 (PD-1) or its ligand programmed cell death protein 1-ligand 1 (PD-L1) used in many cancer therapies. Acute interstitial nephritis (AIN) is a potential and deleterious immune-related adverse even...