Peter Klimek

Medical University of Vienna | MedUni Vienna · Section for Science of Complex Systems

Regular physical activity is essential for the healthy development of children, and sports clubs are one of the main drivers of regular exercise. Previous studies have demonstrated that public subsidies can increase participation rates in sports clubs. The effectiveness of funding in increasing participation rates depends on multiple factors, such...

The Austrian automotive industry is heavily reliant on German carmakers, with 65% of the companies exporting directly to Germany. Recent challenges faced by VW, including plant closures and downsizing, threaten Austrian suppliers, particularly in automotive clusters in Upper Austria and Styria. This study identifies 135 Austrian companies connected...

Global food production and trade networks are highly dynamic, especially in response to shortages when countries adjust their supply strategies. In this study, we examine adjustments across 123 agri-food products from 192 countries resulting in 23616 individual scenarios of food shortage, and calibrate a multi-layer network model to understand the...

Between 14 and 21 September, Storm Boris brought heavy rain and flooding to Central Europe. Such extreme weather events will become more frequent and, above all, more intense as a result of climate change. It is therefore important to develop methods to rapidly assess the economic impact in order to tailor measures to mitigate losses. This Research...

The deployment of diverse data-generating technologies in livestock farming holds the promise of early disease detection and improved animal well-being. In this paper, we combine routinely collected dairy farm and herd data with weather and high frequency sensor data from 6 farms to predict new lameness events in various future periods, spanning fr...

Equal access to health ensures that all citizens, regardless of socio-economic status, can achieve optimal health, leading to a more productive, equitable, and resilient society. Yet, migrant populations were frequently observed to have lower access to health. The reasons for this are not entirely clear and may include language barriers, a lack of...

Our aim is to investigate if sex and gender influence the association of hypertension and their comorbidities. We investigated how gender differences in five socioeconomic factors impact the relation between hypertension and ten comorbidities including diabetes mellitus, renal disease, and chronic pulmonary disease in European countries grouped by...

The rapid advancement of big data technologies has underscored the need for robust and efficient data processing solutions. Traditional Spark-based Platform-as-a-Service (PaaS) solutions, such as Databricks and Amazon Web Services Elastic MapReduce, provide powerful analytics capabilities but often result in high operational costs and vendor lock-i...

Early exposure to food scarcity in Ukraine increases diabetes risk in later life

Objectives This study aimed to assess the guideline recommended diagnostic tools NT-proBNP and NYHA classification, with a focus on sex-specific differences. Background Patients with Type 2 Diabetes (T2D) face a heart failure (HF) risk up to four times higher than those without T2D, particularly affecting women more than twice as much as men. Desp...

The automotive industry is currently in a state of flux, as the green transition means a shift from internal combustion engines to primarily electrically powered vehicles. Austria – and Upper Austria in particular – offers a product portfolio that is embedded in the EU and well diversified across the automotive supply chain. Austrian companies ofte...

Background The effectiveness of non-pharmaceutical interventions to control the spread of SARS-CoV-2 depends on many contextual factors, including adherence. Conventional wisdom holds that the effectiveness of protective behaviours, such as wearing masks, increases with the number of people who adopt them. Here we show in a simulation study that th...

On 12 June, the European Commission announced the first provisional decision under its anti-subsidy inquiry for battery electric vehicles (BEVs) assembled in China. Albeit initially driven by Western foreign direct investment, Chinese car producers have become prominent producers of battery electric vehicles. This note asks if the imposition of imp...

The steel industry is a major contributor to CO2 emissions, accounting for 7% of global emissions. The European steel industry is seeking to reduce its emissions by increasing the use of electric arc furnaces (EAFs), which can produce steel from scrap, marking a major shift towards a circular steel economy. Here, we show by combining trade with bus...

Background The COVID-19 pandemic was largely driven by genetic mutations of SARS-CoV-2, leading in some instances to enhanced infectiousness of the virus or its capacity to evade the host immune system. To closely monitor SARS-CoV-2 evolution and resulting variants at genomic-level, an innovative pipeline termed SARSeq was developed in Austria. Ai...

This report delves into regional roles in the global semiconductor supply chain against the backdrop of significant global initiatives to incentivize the production of semiconductors, to secure availability for applications, to promote innovation and prepare for future chip supply crises. Leveraging a model of the stylized semiconductor value chain...

Evidence on long-term health effects of SARS-CoV-2 infection remains scarce. Using a wearable-derived behavioral and physiological dataset (n = 20,815), we identified 137 individuals characterized by self-reported persistent fatigue and shortness of breath following a SARS-CoV-2 infection. Compared with symptom-free COVID-19 positive and negative c...

Real-world data (RWD) can provide intel (real-world evidence, RWE) for research and development, as well as policy and regulatory decision-making along the full spectrum of health care. Despite calls from global regulators for international collaborations to integrate RWE into regulatory decision-making and to bridge knowledge gaps, some challenges...

We aim to comprehensively identify typical life-spanning trajectories and critical events that impact patients’ hospital utilization and mortality. We use a unique dataset containing 44 million records of almost all inpatient stays from 2003 to 2014 in Austria to investigate disease trajectories. We develop a new, multilayer disease network approac...

Background: Many countries faced health workforce challenges even before the pandemic, such as impending retirements, negative population growth, or sub-optimal allocation of resources across health sectors. Current quantitative models are often of limited use, either because they require extensive individual-level data to be properly calibrated, o...

The EU Directive on Corporate Sustainable Due Diligence has sparked fierce debate about the regulations of supply chains. The Directive's objectives are aligned with European values. Assuming that enforcements of social and environmental rules are absent in certain third countries, it privatises compliance costs in complex supply networks. This pap...

An increasing number of countries are investigating options to stop the spread of the emerging zoonotic infection Salmonella (S.) Dublin, which mainly spreads among bovines and with cattle manure. Detailed surveillance and cattle movement data from an 11-year period in Denmark provided an opportunity to gain new knowledge for mitigation options thr...

ASCII Policy Brief

ASCII Policy Brief

Globalization has had undesirable effects on the labor standards embedded in the products we consume. This paper proposes an ex-ante evaluation of supply chain due diligence regulations, such as the EU Corporate Sustainable Due Diligence Directive (CSDDD). We construct a full-scale network model derived from structural business statistics of 30 mil...

Concerns about the integrity of Turkey’s elections have increased with the recent transition from a parliamentary democracy to an executive presidency under Recep Tayyip Erdoğan. Election forensics tools are used to identify statistical traces of certain types of electoral fraud, providing important information about the integrity and validity of d...

Sharing health data for research purposes across international jurisdictions has been a challenge due to privacy concerns. Two privacy enhancing technologies that can enable such sharing are synthetic data generation (SDG) and federated analysis, but their relative strengths and weaknesses have not been evaluated thus far. In this study we compared...

We aim to comprehensively identify typical life-spanning trajectories and critical events that impact patients' hospital utilization and mortality. We use a unique dataset containing 44 million records of almost all inpatient stays from 2003 to 2014 in Austria to investigate disease trajectories. We develop a new, multilayer disease network approac...

Dependencies in the global food production network can lead to shortages in numerous regions, as demonstrated by the impacts of the Russia–Ukraine conflict on global food supplies. Here we reveal the losses of 125 food products after a localized shock to agricultural production in 192 countries and territories using a multilayer network model of tr...

Undernutrition in early life associates with increased risk for type 2 diabetes in later life. Whether similar associations hold for other diseases remains unclear. We aim to quantify how perinatal exposure to famines relates to the risk of becoming incident with type 2 diabetes in later life. Using population-wide medical claims data for Austrians...

Obesity, a highly prevalent disorder and central diagnosis of the metabolic syndrome, is linked to mental health by clinical observations and biological pathways. Patients with a diagnosis of obesity may show long-lasting increases in risk for receiving psychiatric co-diagnoses. Austrian national registry data of inpatient services from 1997 to 201...

This study aims to quantify whether age and sex groups in Austrian regions are equally affected by the rise of type 2 diabetes. Population-wide medical claims data was obtained for citizens in Austria aged above 50 year, who received antihyperglycemic treatments or underwent HbA1c monitoring between 2012 and 2017. Diabetes incidence was measured us...

Roux-en-Y gastric bypass operations (RYGB-OP) and pregnancy alter glucose homeostasis and the adipokine profile. This study investigates the relationship between adipokines and glucose metabolism during pregnancy post-RYGB-OP. (1) Methods: This is a post hoc analysis of a prospective cohort study during pregnancy in 25 women with an RYGB-OP (RY), 1...

The prevalence of diseases often varies substantially from region to region. Besides basic demographic properties, the factors that drive the variability of each prevalence are to a large extent unknown. Here we show how regional prevalence variations in 115 different diseases relate to demographic, socio-economic, environmental factors and migrato...

Why does the world seem to suddenly be fighting over antibiotics? For one thing, production is increasingly concentrated in two countries - China and India. For another, an entire industry seems surprised by the rapid increase in demand for drugs after the decline during the Covid-19 pandemic. Our results suggest three broad policy recommendations....

Background Common mental disorders (CMDs), multimorbidity, and refugee status are associated with poor labor market outcome. Little is known about how these factors interact in young adults. Objective We aimed to i) investigate whether the association of CMDs and multimorbidity with labor market marginalization (LMM) differs between refugee and Sw...

Despite their importance, federal grant systems often need more clarity regarding cost-effectiveness, lack of transparency, and slow feedback cycles. Sports funding systems aimed at improving child health and contributing to sustainable development goals are incredibly challenging due to their heterogeneity in stakeholders and regional aspects. Her...

Background Combining mouse experiments with big data analysis of the Austrian population, we investigated the association between high-dose statin treatment and bone quality. Methods The bone microarchitecture of the femur and vertebral body L4 was measured in male and ovariectomized female mice on a high-fat diet containing simvastatin (1.2 g/kg)...

Many European countries face rising obesity rates among children, compounded by decreased opportunities for sports activities during the COVID-19 pandemic. Access to sports facilities depends on multiple factors, such as geographic location, proximity to population centers, budgetary constraints, and other socio-economic covariates. Here we show ho...

Background In response to the SARS-CoV-2 pandemic, the Austrian governmental crisis unit commissioned a forecast consortium with regularly projections of case numbers and demand for hospital beds. The goal was to assess how likely Austrian ICUs would become overburdened with COVID-19 patients in the upcoming weeks. Methods We consolidated the outp...

The war in Ukraine highlighted the vulnerability of the global food supply system. Due to dependencies in the global food-production network, the local loss of one crop can lead to shortages in other countries and affect other products made from it. Previous studies treat products in isolation and do not account for product conversion during produc...

The effectiveness of non-pharmaceutical interventions to curb the spread of SARS-CoV-2 is determined by numerous contextual factors, including adherence. Conventional wisdom holds that the effectiveness of protective behaviour such as wearing masks always increases with the number of people adopting it. Here we show in a simulation study that this...

Remarkably little is known about the structure, formation, and dynamics of supply- and production networks that form one foundation of society. Neither the resilience of these networks is known, nor do we have ways to systematically monitor their ongoing change. Systemic risk contributions of individual companies were hitherto not quantifiable sinc...

Patients do not access physicians at random but rather via naturally emerging networks of patient flows between them. As mass quarantines, absences due to sickness, or other shocks thin out these networks, the system might be pushed to a tipping point where it loses its ability to deliver care. Here, we propose a data-driven framework to quantify r...

SARS-CoV-2 surveillance by wastewater-based epidemiology is poised to provide a complementary approach to sequencing individual cases. However, robust quantification of variants and de novo detection of emerging variants remains challenging for existing strategies. We deep sequenced 3,413 wastewater samples representing 94 municipal catchments, cov...

The drivers behind regional differences of SARS-CoV-2 spread on finer spatio-temporal scales are yet to be fully understood. Here we develop a data-driven modelling approach based on an age-structured compartmental model that compares 116 Austrian regions to a suitably chosen control set of regions to explain variations in local transmission rates...

Importance: A male predominance is reported in hospitalised patients with COVID-19 alongside a higher mortality rate in men compared to women. Objective: To assess if the reported sex bias in the COVID-19 pandemic is validated by analysis of a subset of patients with severe disease. Design: A nationwide retrospective cohort study was performed...

Patients do not access physicians at random but rather via naturally emerging networks of patient flows between them. As retirements, mass quarantines and absence due to sickness during pandemics, or other shocks thin out these networks, the system might be pushed closer to a tipping point where it loses its ability to deliver care to the populatio...

Background Due to the circumstances of their early lives, young refugees are at risk of experiencing adverse labour market and health outcomes. The post-settlement environment is thought to play a decisive role in determining how this vulnerability plays out. This study compared trends in labour market marginalisation in young refugees and their ma...

We aim to identify those measures that effectively control the spread of SARS-CoV-2 in Austrian schools. Using cluster tracing data we calibrate an agent-based epidemiological model and consider situations where the B1.617.2 (delta) virus strain is dominant and parts of the population are vaccinated to quantify the impact of non-pharmaceutical inte...

UNSTRUCTURED The Effect of Cardiovascular Comorbidities on Women Compared to Men: Longitudinal Retrospective Analysis

Due to its high lethality among older people, the safety of nursing homes has been of central importance during the COVID-19 pandemic. With test procedures and vaccines becoming available at scale, nursing homes might relax prohibitory measures while controlling the spread of infections. By control we mean that each index case infects less than one...

Background: Young refugees are at increased risk of labor market marginalization (LMM). We sought to examine whether the association of multimorbidity patterns and LMM differs in refugee youth compared to Swedish-born youth and identify the diagnostic groups driving this association. Methodology: We analyzed 249,245 individuals between 20-25 yea...

Livestock farming is currently undergoing a digital revolution and becoming increasingly data-driven. Yet, such data often reside in disconnected silos making them impossible to leverage their full potential to improve animal well-being. Here, we introduce a precision livestock farming approach, bringing together information streams from a variety...

In this study we present systematic framework to analyse the impact of farm profiles as combinations of environmental conditions and management practices on common diseases in dairy cattle. The data used for this secondary data analysis includes observational data from 166 farms with a total of 5828 dairy cows. Each farm is characterised by feature...

Background Although men are more prone to developing cardiovascular disease (CVD) than women, risk factors for CVD, such as nicotine abuse and diabetes mellitus, have been shown to be more detrimental in women than in men. Objective We developed a method to systematically investigate population-wide electronic health records for all possible assoc...

Objective: Patients with type 2 diabetes mellitus (T2DM) are at an increased risk of developing infectious diseases such as pneumonia. Hitherto, there has been uncertainty as to whether there is a relationship between different antidiabetic drug combinations and development of pneumonia in this specific cohort. Research design and methods: In th...

Behavioral gender differences have been found for a wide range of human activities including the way people communicate, move, provision themselves, or organize leisure activities. Using mobile phone data from 1.2 million devices in Austria (15% of the population) across the first phase of the COVID-19 crisis, we quantify gender-specific patterns o...

The drivers behind regional differences of SARS-CoV-2 spread on finer spatio-temporal scales are yet to be fully understood. Here we develop a data-driven modelling approach based on an age-structured compartmental model that compares 116 Austrian regions to a suitably chosen control set of regions to explain variations in local transmission rates...

Disease interaction in multimorbid patients is relevant to treatment and prognosis, yet poorly understood. In the present work, we combine approaches from network science, machine learning and computational phenotyping to assess interactions between two or more diseases in a transparent way across the full diagnostic spectrum. We demonstrate that h...

Background Testosterone plays an important role in the regulation of glucose metabolism. While earlier studies have shown that it has a protective effect in males, unfavorable effects of testosterone on glucose metabolism have been reported in females; however, whether there is a sex-specific relationship between testosterone and glucose metabolism...

Background : The objective of this study was to investigate whether persistence of antidepressant use differs between refugee youth and Swedish-born youth after a diagnosis of a common mental disorder (CMD), and if clinical and sociodemographic factors are associated with antidepressant discontinuation. Methods : Youth aged 16-25 years, with an in...