Peter Karlskov-Mortensen

Peter Karlskov-Mortensen
University of Copenhagen · Department of Veterinary and Animal Sciences

DVM, PhD

About

51
Publications
11,671
Reads
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716
Citations
Citations since 2016
18 Research Items
396 Citations
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
2016201720182019202020212022020406080
Additional affiliations
January 2010 - December 2016
University of Copenhagen
Position
  • Professor

Publications

Publications (51)
Preprint
Full-text available
The Farm animal Genotype-Tissue Expression (FarmGTEx, https://www.farmgtex.org/) project has been established to develop a comprehensive public resource of genetic regulatory variants in domestic animal species, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biology discovery and exploitation in...
Preprint
Full-text available
The Farm animal Genotype-Tissue Expression (FarmGTEx, https://www.farmgtex.org/) project has been established to develop a comprehensive public resource of genetic regulatory variants in domestic animal species, which is essential for linking genetic polymorphisms to variation in phenotypes, helping fundamental biology discovery and exploitation in...
Preprint
Improvement of feed efficiency (FE) in pigs is an important milestone in order to reduce the economic and environmental impact of pig production. The goal of finding biomarkers for FE has been persisting for decades. However, due to the complexity of the FE trait, these goals have still not been met. Here, we search for quantitative trait loci (QTL...
Article
Full-text available
The functional annotation of livestock genomes is crucial for understanding the molecular mechanisms that underpin complex traits of economic importance, adaptive evolution and comparative genomics. Here, we provide the most comprehensive catalogue to date of regulatory elements in the pig (Sus scrofa) by integrating 223 epigenomic and transcriptom...
Article
The dog breed Petit Basset Griffon Vendeen has a relatively high prevalence of idiopathic epilepsy compared to other dog breeds and previous studies have suggested a genetic cause of the disease in this breed. Based on these observations, a genome‐wide association study was performed to identify possible epilepsy‐causing loci. The study included 30...
Preprint
Full-text available
The functional annotation of livestock genomes is crucial for understanding the molecular mechanisms that underpin complex traits of economic importance, adaptive evolution and comparative genomics. Here, we provide the most comprehensive catalogue to date of regulatory elements in the pig (Sus scrofa) by integrating 223 epigenomic and transcriptom...
Article
Full-text available
Abstract Dyslipidemia is the primary cause of cardiovascular disease, which is a serious human health problem in large parts of the world. Therefore, it is important to understand the genetic and molecular mechanisms that regulate blood levels of cholesterol and other lipids. Discovery of genetic elements in the regulatory machinery is often based...
Article
Whole genome sequencing of 217 animals from three Danish commercial pig breeds (Duroc, Landrace, and Yorkshire) was performed. Twenty-six million single nucleotide polymorphisms (SNPs) and 8 million insertions or deletions (indels) were uncovered. Among the SNPs, 493,099 variants were located in coding sequences, and 29,430 were predicted to have a...
Article
Full-text available
This study aimed to estimate genetic parameters of the linear trait genetic residual feed intake (RFI) and the ratio traits feed conversion ratio (FCR) and feed conversion efficiency (FCE) along with dry matter intake (DMI) and energy sink traits such as energy-corrected milk (ECM), body weight (BW), body condition score (BCS), and BW change (BWC)...
Article
Full-text available
Reprogramming of adipocyte function in obesity is implicated in metabolic disorders like type 2 diabetes. Here, we used the pig, an animal model sharing many physiological and pathophysiological similarities with humans, to perform in-depth epigenomic and transcriptomic characterization of pure adipocyte fractions. Using a combined DNA methylation...
Article
Progressive retinal atrophy (PRA) is a common cause of blindness in many dog breeds. It is most often inherited as a simple Mendelian trait, but great genetic heterogeneity has been demonstrated both within and between breeds. In many breeds the genetic cause of the disease is not known, and until now, the Old Danish Pointing Dog (ODP) has been one...
Article
Taste receptors (TASRs) and appetite and reward (AR) mechanisms influence eating behaviour, which in turn affects food intake and risk of obesity. In a previous study, we used next generation sequencing to identify potentially functional mutations in TASR and AR genes and found indications for genetic associations between identified variants and gr...
Article
Full-text available
Disinfection of hatching eggs is essential to ensure high quality production of broilers. Different protocols are followed in different hatcheries; however, only limited scientific evidence on how the disinfection procedures impact the microbiome is available. The aim of the present study was to characterize the microbiome and aerobic bacterial loa...
Article
Full-text available
We have established a pig resource population specifically designed to elucidate the genetics involved in development of obesity and obesity related co-morbidities by crossing the obesity prone Göttingen Minipig breed with two lean production pig breeds. In this study we have performed genome wide association (GWA) to identify loci with effect on b...
Conference Paper
Cholesterol is a ubiquitous steroid and a vital component of cellular membranes in vertebrates. At the same time, subendothelial deposition of cholesterol and other lipoproteins is the culprit of atherosclerotic lesions leading to a range of cardiovascular diseases which together represent the most frequent causes of death in the industrialized wor...
Article
Full-text available
The pig is a well-known animal model used to investigate genetic and mechanistic aspects of human disease biology. They are particularly useful in the context of obesity and metabolic diseases because other widely used models (e.g. mice) do not completely recapitulate key pathophysiological features associated with these diseases in humans. Therefo...
Article
Full-text available
Obesity is a complex condition that increases the risk of life threatening diseases such as cardiovascular disease and diabetes. Studying the gene regulation of obesity is important for understanding the molecular mechanisms behind the obesity derived diseases and may lead to better intervention and treatment plans. MicroRNAs (miRNAs) are short non...
Article
Full-text available
Background Peripheral nerve sheath tumors (PNSTs) are frequently found in Danish cattle at slaughter. Bovine PNSTs share several gross and histopathological characteristics with the PNSTs in humans with heritable neurofibromatosis syndromes. The aim of the present study was to investigate a possible hereditary disposition to PNSTs in dairy cattle b...
Article
Obesity has reached epidemic proportions globally and has become the cause of several major health risks worldwide. Presently, more than 100 loci have been related to obesity and metabolic traits in humans by genome-wide association studies. The complex genetic architecture behind obesity has triggered a need for the development of better animal mo...
Article
Full-text available
Obesity is a rising worldwide public health problem. Difficulties to precisely measure various obesity traits and the genetic heterogeneity in human have been major impediments to completely disentangle genetic factors causing obesity. The pig is a relevant model for studying human obesity and obesity-related (OOR) traits. Using founder breeds dive...
Data
Phenotypic and genetic correlations of all analyzed variables. Excel file including all phenotypic and genetic correlations, with their standard errors.
Article
Full-text available
Herniation of the intervertebral disk is a common cause of neurological dysfunction in the dog, particularly in the Dachshund. Using the Illumina CanineHD BeadChip, we have previously identified a major locus on canine chromosome 12 nucleotide positions 36,750,205-38,524,449 that strongly associates with intervertebral disk calcification in Danish...
Article
Inflammatory diseases in mouse models are under strong impact from the gut microbiota. Therefore increased interindividual gut microbiota similarity may be seen as a way to reduce group sizes in mouse experiments. The composition of the gut microbiota is to a high extent defined by genetics, and it is known that selecting siblings as mothers even i...
Article
Our previously published second generation genetic map for the American mink (Neovison vison) has been used and redesigned in its best for genome-wide studies with maximum of efficiency. A number of 114 selected markers, including 33 newly developed microsatellite markers from the CHORI-231 mink Bacterial Artificial Chromosome (BAC) library, have b...
Article
Full-text available
Fertility is one of the most important traits in dairy cattle, and has been steadily declining over the last decades. We herein use state-of-the-art genomic tools, including high-throughput SNP genotyping and next-generation sequencing, to identify a 3.3 Kb deletion in the FANCI gene causing the brachyspina syndrome (BS), a rare recessive genetic d...
Data
Full-text available
Effects on fertility of the FANCI deletion. Pregnancy failure rate detected as 100% minus non return into oestrus (NR) at 56, 90 and 270 days post-insemination in the four possible matings. The genotype probabilities of the dams are estimated from the knowledge of the genotype of their sire combined with the known frequency of the BS mutation in th...
Data
Full-text available
Primer pairs to validate the deletion in the FANCI gene. (PDF)
Data
Full-text available
Targeted and genome-wide resequencing of BS cases and controls. (A) Distribution of the genomic distance separating random mate-pairs and mate-pairs flanking the BS deletion. (B) IGV screen captures of mate-pair reads mapping to the BTA21 20,536,086–20,541,232 chromosome interval for three unaffected controls (lanes 1–3) and a BS calve (lane 4), as...
Article
Immunity induced by DNA vaccines containing the hemagglutinin (H) and nucleoprotein (N) genes of wild-type and attenuated canine distemper virus (CDV) was investigated in mink (Mustela vison), a highly susceptible natural host of CDV. All DNA-immunized mink seroconverted, and significant levels of virus-neutralizing (VN) antibodies were present on...
Conference Paper
Full-text available
Background / Purpose: An F2 pig population was established to study the genetic background of obesity and obesity-related traits. Genetic parameters are estimated and presented to show the genetic background of obesity in this research population. Main conclusion: Heritabilities and genetic correlations are moderate to high and show a strong g...
Article
Helminths almost invariably have an over-dispersed distribution in the host population. Human and animal studies have provided evidence suggesting that a large part of this variation is due to host genetic factors. Recently, the heritability for roundworm (Ascaris suum) infection levels in pigs was estimated to be 0.45. We used single nucleotide po...
Article
Full-text available
Epilepsy is the most common neurological disorder in dogs, with an incidence ranging from 0.5% to up to 20% in particular breeds. Canine epilepsy can be etiologically defined as idiopathic or symptomatic. Epileptic seizures may be classified as focal with or without secondary generalization, or as primary generalized. Nine genes have been identifie...
Data
Summary of the clinical features of 94 epileptic Belgian Shepherds collected through the owner-filled epilepsy questionnaires. (XLS)
Article
A case of X-linked hypohidrotic ectodermal dysplasia (XHED) was identified in a family of Danish Red Holstein cattle. The ectodysplasin-signalling protein (EDA) is known to be central in the normal development of ectodermal structures, and mutations in the ectodysplasin A (EDA) gene have been reported to cause XHED. In this study, we analysed diffe...
Article
Full-text available
Myxomatous mitral valve disease (MMVD) is the most common heart disease in dogs. It is characterized by chronic progressive degenerative lesions of the mitral valve. The valve leaflets become thickened and prolapse into the left atrium resulting in mitral regurgitation (MR). MMVD is most prevalent in small to medium sized dog breeds, Cavalier King...
Article
Full-text available
Intervertebral disc calcification and herniation commonly affects Dachshund where the predisposition is caused by an early onset degenerative process resulting in disc calcification. A continuous spectrum of disc degeneration is seen within and among dog breeds, suggesting a multifactorial etiology. The number of calcified discs at 2 years of age d...
Article
In this report we present an extended linkage map of the American mink (Neovison vison) consisting of 157 microsatellite markers and comprising at least one linkage group for each of the autosomes. Each linkage group has been assigned to a chromosome and oriented by fluorescence in situ hybridization (FISH) and/or by means of human/dog/mink compara...
Article
The aim of the study was to investigate the different phases of the immune response after DNA immunization with the hemagglutinin and nucleoprotein genes from canine distemper virus (CDV). Although attenuated live CDV vaccines have effectively reduced the incidence of disease, canine distemper is still a problem worldwide. The broad host range of C...
Article
Diarrhoea in newborn and weaned pigs caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbriae leads to considerable losses in pig production. In this study, we refined the mapping of the receptor locus for ETEC F4ab/F4ac adhesion (F4bcR) by joint analysis of Nordic and Swiss data. A total of 236 pigs from a Nordic experimental herd,...
Article
Full-text available
Meat quality traits are important in pig breeding programs, but they are difficult to include in a traditional selection program. Marker assisted selection (MAS) of meat quality traits is therefore of interest in breeding programs and a Quantitative Trait Locus (QTL) analysis is the key to identifying markers that can be used in MAS. In this study,...
Article
A total of 10 882 porcine microsatellite repeats were identified in genomic shotgun sequences from the Sino-Danish Pig Genome Sequencing Consortium (http://www.piggenome.dk). Of these, 4528 microsatellites were placed on a pig-human comparative map by blast analysis of porcine sequences against the human genome (blast cut-off threshold =1 x 10(-5))...
Article
We report the identification of quantitative trait loci (QTL) affecting carcass composition, carcass length, fat deposition and lean meat content using a genome scan across 462 animals from a combined intercross and backcross between Hampshire and Landrace pigs. Data were analysed using multiple linear regression fitting additive and dominance effe...
Article
We report on the construction of a high-resolution comparative map of porcine chromosome 17 (SSC17) focusing on evolutionary breakpoints with human chromosomes. The comparative map shows high homology with human chromosome 20 but suggests more limited homologies with other human chromosomes. SSC17 is of particular interest in studies of chromosomal...
Article
We have investigated the protective effect of immunization of a highly susceptible natural host of canine distemper virus (CDV) with DNA plasmids encoding the viral nucleoprotein (N) and hemagglutinin (H). The combined intradermal and intramuscular routes of immunization elicited high virus-neutralizing serum antibody titres in mink (Mustela vison)...
Conference Paper
Animal models of high comparative value are essential for unraveling the complex genetic architecture behind obesity. We have established a 3-generation intercross pedigree by crossing Göttingen minipigs (prone to obesity) with production pigs (selected for leanness) to produce 454 F2’s. A total of 36 obesity related traits have been recorded for a...

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Projects (7)
Project
Genome and Epigenome eNabled breedIng in MOnogastrics To face human population growth, increasing environmental constraints and changes in socio-cultural values, animal breeding must evolve toward a more sustainable model that guarantees production while promoting efficient resource use, animal health and welfare, and preserving genetic diversity. Thanks to recent developments in omics technologies, it is now possible to rethink breeding, taking advantage of improved knowledge on genome-to-phenome relationships that accounts for both genetic and non-genetic mechanisms controlling traits. GEroNIMO will work on chicken and pig, the most used sources of animal protein worldwide, to provide breeders with new knowledge and tools to promote innovative genome- and epigenome enabled selection methods for traits related to production (quantity and quality), efficiency, productive longevity, fertility, resilience and welfare. A large number of animals from cosmopolitan and local breeds will be characterized phenotypically, genetically and epigenetically under different environments to i) identify underlying biological mechanisms affecting trait variation, ii) develop methods to improve selection strategies integrating genetic- and non-genetic factors, and iii) propose strategies to optimize the conservation of genetic and epigenetic diversity. GEroNIMO proposes demand-driven innovation employing a multiactor approach through the involvement of breeders, professional associations of animal production, and scientists, engaged from the planning phase to the dissemination of results over Europe. GEroNIMO will build on existing academic and commercial knowledge and will analyze large populations to quantify the contribution of genetic and epigenetic variation in gene expression, trait variation and trade-offs between traits. GEroNIMO will also propose a comprehensive and enhanced characterization of diversity by integrating epigenetic diversity into conservation purposes, corresponding to a new integrated conservation strategy.
Archived project