
Péter CsonkaTampere University | UTA · Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology
Péter Csonka
MD, PhD
Research projects: Asthma, allergy, inhalation device testing, health care quality.
About
48
Publications
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Introduction
Research oriented clinician ----> PROJECTS AT https://www.finnatopy.fi
Additional affiliations
December 2007 - present
Publications
Publications (48)
Small children with airway obstruction breathe with very low tidal volumes (VT) and high respiratory rates (RRs). These extreme respiratory patterns affect drug delivery unpredictably through valved holding chambers (VHCs).
We compared in an in vitro study the effectiveness of two VHCs, one small (140 mL, Optichamber Diamond) and one large (350 m...
Background
Valved holding chambers (VHCs) are essential for efficient pulmonary delivery of inhaled medication in preschool children. The numerous devices in the market vary in material, aerodynamic characteristics, volume, valve properties, and mask design. Drug delivery is affected by the VHC characteristics as well as by the age and breathing pa...
Our aim was to construct and test an intervention programme to eradicate cough and cold medicine (CCM) prescriptions for children treated in a nationwide healthcare service company. The study was carried out in the largest private healthcare service company in Finland with a centralised electronic health record system allowing for real-time, doctor...
Upper respiratory tract infection (URTI) is a self-limiting viral infection and should not be treated with antibiotics. The aim was to evaluate antibiotic prescriptions for children with uncomplicated URTI in a large nationwide private clinic network between 2014 and 2020. Special focus was given to macrolide prescriptions and costs. The data were...
Aim:
A lack of stored iron, indicated by low serum ferritin, has been associated with various clinical symptoms. There are no longitudinal data on the frequency of ferritin measurements in children and adolescents.
Methods:
A total of 2834 children aged <18 years with serum ferritin and other anaemia-related blood parameters taken during an outp...
Objective
To obtain priority consensus for outcome measures of oral corticosteroid treatment of preschool wheeze that represent stakeholder groups.
Design
(1) A systematic review to identify a set of outcome measures; (2) an international survey for healthcare professionals (HCPs) and a nominal group meeting with parents; (3) a final consensus nom...
Background
There is a scarcity of high‐quality research on the efficient delivery of inhaled corticosteroids using valved holding chambers (VHCs) in children.
Methods
The delivered dose (DD) of fluticasone from a metered dose inhaler (pMDI) was tested using four VHCs: AeroChamber plus Flow‐Vu (AC), Babyhaler (BH), EasyChamber (EC), and Optichamber...
Aim
To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double‐blind, placebo‐controlled trials in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma.
Methods
PubMed searches were conducted and unpublished data were...
Clinical implications: Inhaled salbutamol's effective delivery is significantly influenced by the breathing patterns of small children and type of VHC used. Regulatory authorities should carefully evaluate and if necessary, restrict the approval and availability of VHCs that exhibit poor drug delivery characteristics.
https://www.jaci-inpractice.o...
Unlabelled:
This study aimed to evaluate antibiotic prescriptions for children with lower respiratory tract infection (LRTI) in public and private primary care clinics and in a hospital's pediatric emergency department (PED) in 2012-2013 (pre-guideline) and in 2014-2015 (post-guideline). Special attention was paid to guideline compliance, especial...
Aim:
We evaluated antibiotic prescriptions issued for Finnish children with acute sinusitis by a nationwide private outpatient clinic network from 2014-2020. Data were compared before and after updated guidelines in 2018.
Methods:
The study comprised data on 45296 children aged 2-17 years with acute sinusitis, namely diagnoses, ages, dates, the...
Aim:
This study aimed to evaluate antibiotic prescriptions for children with otitis media (OM) in a large nationwide network of private clinics between 2014 and 2020. Special focus was paid to amoxicillin and amoxicillin-clavulanic acid prescriptions, which the national guidelines recommend for first-line drugs. We also focused on macrolides, whic...
Clinical Implications:
Industrially processed mango puree may unpredictably contain seed proteins that can cause severe allergic reactions, particularly in patients with cashew nut allergy. However, drupe seed allergens are not included in the mandatory labeling directives for food ingredients.
Aim:
We evaluated main trends in antibiotic prescriptions for children with lower respiratory tract infection (LRTI) by Terveystalo, Finland's largest private healthcare company.
Methods:
The study comprised 89,359 children aged 0-17 years (57.2% boys) who visited Terveystalo primary care clinics from 2014-2020 with LRTI. The data were assessed...
This is a handbook about component resolved allergen diagnosis
Our aim was to synthesize the published literature on factors that potentially affect the delivery of bronchodilators using valved holding chambers (VHC) in preschool children. We also aimed to identify those attributes that are not yet incorporated or clearly stated in the guidelines and those topics that are still lacking sufficient data. There i...
Background
Respiratory syncytial virus (RSV) causes respiratory tract infections, which may require hospitalization especially in early infancy. Transplacental transfer of RSV antibodies could confer protection to infants in their first months of life.
Methods
In this first-in-human, placebo-controlled study, 502 healthy non-pregnant women were ra...
Aim
Our aim was to survey treatment practices used for preschool children with wheezing in emergency rooms (ER) focusing on inhalation device choice and handling, face mask use, salbutamol dosing, and written instructions. We sought to assess weather current protocols are in line with published evidence and guidelines.
Methods
This is a cross‐sect...
Our aim was to evaluate the impact of the 2014 Finnish Current Care Guidelines for paediatric lower respiratory tract infections (LRTIs), particularly on taking of chest radiographs.
Methods: This study used official national data and regional (Pirkanmaa) data on children aged 0‐16 years who underwent chest radiographs in 2011 and 2015. We also co...
Cough is a common symptom in children and a major cause of outpatient visits. As a child´s cough can cause anxiety, interfere sleep and impact quality of life, parents tend to bring children to doctor to relieve their symptoms. Once commonly used, antitussives are no longer recommended due to inefficiency and potential for severe side‐effects (1).
Background
Respiratory syncytial virus (RSV) is a leading cause of bronchiolitis and pneumonia in childhood. Maternal immunization could help to protect infants from RSV-associated infections in their first months of life. We evaluated the safety, reactogenicity and immunogenicity of the RSV maternal (RSVPreF3) vaccine candidate in non-pregnant wom...
Aims:
Our aim was to evaluate whether the number of puffs or antistatic treatment have significant effect on drug delivery of six different valved holding chambers (VHCs).
Methods:
We used simulated paediatric breathing pattern with 25/min frequency and 200 ml tidal volume. When comparing the effect of antistatic treatment, we used 100 μg of salb...
Fractional exhaled nitric oxide (FeNO) reflects eosinophilic airway inflammation and it can be used to diagnose and phenotype asthma and predict treatment responses. However, smoking decreases FeNO and it is not clear if FeNO has clinical value in smoking subjects with asthma. We conducted a systematic review focusing on four basic characteristics...
The diagnosis of food allergy is challenging due to different immunologic mechanisms and diversity of symptoms. An open or double-blinded oral food challenge (OFC) was performed on 391 children (aged 0.2-16.9 years) with suspected cow's milk (n = 266) or wheat allergy (n = 125) to characterize immediate, delayed, and transient symptoms, and to eval...
The clinical value of measuring fractional exhaled nitric oxide ( F eNO ) in asthma is not clear. We aimed to assess whether F eNO can reliably predict clinical outcomes in asthma treated with inhaled corticosteroids (ICS). We also evaluated whether its predictive role is influenced by different inflammatory phenotypes of asthma.
We conducted a sys...
Lähtökohdat Uloshengitysilman typpioksidipitoisuus (FeNO) suurenee etenkin eosinofiilisessa astmatulehduksessa. Tässä järjestelmällisessä katsauksessa arvioidaan FeNO-mittauksen vaikuttavuutta astman glukokortikoidihoidossa. Menetelmät Katsaukseen valittiin kuusi kliinisessä työssä esiin tulevaa kysymystä FeNO-mittauksen käytöstä. Katsauksen aineis...
Treatment guidelines recommend using an inhaled corticosteroid (ICS) plus a long-acting β(2)-agonist (LABA) for childhood asthma when the symptoms are not controlled by ICS alone, but the appropriate use of LABAs in children continues to be debated.
To compare the efficacy of an inhaled salmeterol and fluticasone propionate combination, 50/100 μg t...
To investigate the efficacy of oral prednisolone in virally induced respiratory distress. Study design Randomized, double-blind, placebo-controlled trial involving 230 children age 6 to 35 months in the emergency department. Each patient received either oral prednisolone (2 mg/kg/d) or placebo for 3 days.
The hospitalization rates were similar betw...
Diss. -- Tampereen yliopisto.
To study the frequency of corticosteroid therapy and the use of inpatient care for preschool children with wheezing in two regions in Finland.
The Finnish Social Insurance Institution database on refundable asthma medication indicated that 1.18% of children in Tampere and 2.37% in Turku used inhaled corticosteroids regularly. To clarify the differe...
Early childhood wheezing is associated with asthma later in life. However, the high spontaneous recovery rate and the lack of firm predictors for persistence of wheezing complicates the development of evidence-based guidelines for long-term management of wheezy infants and toddlers. Our aim was to define variables that could be used to identify whe...
To study potential regional variation in asthma diagnostics, we retrospectively analyzed the management of 800 acutely wheezing preschool-age children in two university clinics in Finland. Multivariate modelling indicated that the place of treatment was a strong independent predictor of asthma diagnosis during acute symptoms. Similar regional prefe...
Posteri, Tampereen 20. Lääkäripäivät 24.-26.3.1999.