Petar Eftimov

Petar Eftimov
Sofia University "St. Kliment Ohridski" · Department of Cytology, Histology and Embryology

PhD

About

19
Publications
2,196
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192
Citations

Publications

Publications (19)
Poster
Full-text available
RAMP (Rapid Adhesive Mediated Procedure) is a technique that offers preparation of thin-section histology slides without embedding in paraffin and slicing with a microtome[1]. It could be used as a quick diagnostic method for small animal practices or on-field diagnostics, as well as an educational approach for classroom applications. In this study...
Article
Full-text available
A possible approach for the treatment of meibomian gland disease (MGD) can be the supplementation of meibomian gland secretion (MGS) with nonpolar lipids (NPL) rich plant oils. Sesame oil (SO), approximately equal in monounsaturated fat (oleic acid, 40% of total) and polyunsaturated fat (linoleic acid, 42% of total), has shown multiple health benef...
Article
In a recent study, (Ewurum et al., 2021) wax (WE) and sterol esters (CE) from human meibum secretions (MGS) were separated and reconstituted with controlled WE/CE ratios (0%, 20%, 30%, 40%, 50%, 75% and 100% CE weight fractions). It was found that the alterations in the CE content of WE/CE mixtures modified the hydrocarbon chain conformation and pa...
Article
Full-text available
Recent clinical findings suggest that mucomimetic polymers (MMP) can alter not only the texture of the aqueous tear but also the spreading and structure of the tear film (TF) lipid layer, thereby allowing for their synchronized performance in vivo. Thus, we aimed to evaluate in vitro (i) the capability of pharmaceutically applicable MMP to ensure t...
Article
Full-text available
The tear film at the ocular surface is covered by a thin layer of lipids. This oily phase stabilizes the film by decreasing its surface tension and improving its viscoelastic properties. Clinically, destabilization and rupture of the tear film are related to dry eye disease and are accompanied by changes in the quality and quantity of tear film lip...
Article
Full-text available
Silicone hydrogels (SiHy), represent composite matrices composed of hydrophobic gas permeable silicone (Si) rich core and a surface enriched with hydrophilic polymer moieties. Their utilization in contact lens design requires number of SiHy properties (hydration, wettability, lubricity) to be optimized for the challenging conditions at the ocular s...
Presentation
Full-text available
Description Purpose: Cationic nanoemulsion were demonstrated to enhance tear film (TF) stability in vivo possibly via long term effects on tear film lipid layer (TFLL). Thus the interaction of Catioprost (CPT), an unpreserved Latanoprost 0.005% cationic nanoemulsion, with meibomian and tear films in vitro and in vivo deserves special study. As CPT...
Article
Full-text available
Instability of the tear film (TF) protecting the ocular surface results in dry eye syndrome (DES), the most prevalent public health ophthalmic disease affecting the quality of life of 10 to 30% of the human population worldwide. Although the impact of the tear film lipid layer (TFLL) and of the aqueous tears (AT) to the TF stability is extensively...
Article
Purpose To evaluate (i) the mucomimeticity of pharmaceutically applicable hydrophilic polymers (HP) as well as (ii) their interactions with human meibum films. Methods Four HP were used‐hyaluronic acid (HA), cross‐linked hyaluronic acid (CHA), carboxymethyl cellulose (CMC) and gellan gum (GG)‐ at the concentrations of 0.0001, 0.001,0.01,0.05, 0.1%...
Article
Full-text available
Elevated levels of acyl chain saturation of meibomian lipids are associated with enhanced tear film (TF) stability in infants to shortened TF breakup time with meibomian gland dysfunction. Thus, the effect of saturation on the surface properties of human TF lipids (TFLs) using a Langmuir surface balance and Brewster angle microscopy was studied. Li...
Article
Full-text available
The wettability of silicone hydrogel (SiHy) contact lens (CLs) is crucial for the pre-lens tear film stability throughout the day. Therefore, sessile drop and captive bubble setups were used to study the advancing and receding water contact angles (CA) of four SiHy materials: narafilcon A (TE), senofilcon A (AOD), stenfilcon A (MD), and delefilcon...
Conference Paper
Full-text available
Alumina Toughened Zirconia (ATZ) combining the toughness of alumina with the durability of zirconia are promising implant materials. The topography and wettability, i.e. major bioactivity determinants, of ATZ surfaces were enhanced by femtosecond-laser biomimetic texturing.
Article
Full-text available
Elevated levels of acyl chain saturation of meibomian lipids are associated with vastly different effects: from enhanced tear film (TF) stability in infants to shortened TF breakup time in meibomian gland disease patients. Thus it is important to study the effect of saturation on the surface properties of human meibum (MGS). Therefore, MGS films (1...
Poster
Full-text available
Purpose. Vipera ammodytes transcaucasiana ssp. (VT) (enlisted as nearly threatened by IUCN) shows slight morphological differences, and has neurotoxin composition similar to the European true vipers (V.ammodytes ssp.), but there are some reports on the different pathophysiological effects of its venom. The purpose of this study is to evaluate the p...
Article
Tear film lipid layer (TFLL) stabilizes the air/tear surface of the human eye. Meibomian gland dysfunction (MGD) resulting in quantitative and qualitative modifications of TFLL major (>93%) component, the oily secretion of meibomian lipids (MGS), is the world leading cause of dry eye syndrome (DES) with up to 86% of all DES patients showing signs o...
Article
The surface properties of meibomian secretion (MGS), the major constituent of the tear film (TF) lipid layer, are of key importance for TF stability. The interfacial properties of canine, cMGS, and feline, fMGS, meibum films were studied using a Langmuir surface balance. These species were selected because they have blinking frequency and TF stabil...
Article
Full-text available
The aim of this study was to evaluate the possible implementation of hydrophilic polymers as recovery agents in air-damaged corneal cells. The sessile bubble technique was implemented to measure the wetting properties of four selected polymers: hydroxyethyl cellulose (HEC), sodium chondroitin sulphate (SCS), hydroxypropyl-methylcellulose (HPMC) and...

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