Pernilla Christina Berg

Astareal AB · R&D Department

Supporting information for "Marine Drugs 21(10):514, DOI: 10.3390/md21100514". Summary of Clinical Trial Results with Topical Use of Astaxanthin

Supporting information for "Marine Drugs 21(10):514, DOI: 10.3390/md21100514". Provides details on the nomenclature of the optical isomers of carotenoids.

Supporting information for "Marine Drugs 21(10):514, DOI: 10.3390/md21100514". We summarized the singlet oxygen scavenging activity of carotenoids and other compounds in a more extended from Table 1.

Supporting information for "Marine Drugs 21(10):514, DOI: 10.3390/md21100514". Information on physical properties of astaxanthin and its metabolism in animals.

Supporting information for "Marine Drugs 21(10):514, DOI: 10.3390/md21100514". Full list of clinical (orally administered) and in vitro therapeutic studies of astaxanthin. This table is chronologically listed in Table 4 without duplication.

Astaxanthin (AX), a lipid-soluble pigment belonging to the xanthophyll carotenoids family, has recently garnered significant attention due to its unique physical properties, biochemical attributes, and physiological effects. Originally recognized primarily for its role in imparting the characteristic red-pink color to various organisms, AX is curre...

Cyclooxygenase enzymes (COX-1 and COX-2) catalyse the production of prostaglandins from arachidonic acid. Prostaglandins are important mediators in the inflammatory process and their production can be reduced by COX-inhibitors. Endocannabinoids, endogenous analogues of the plant derived cannabinoids, occur normally in the human body. The Endocannab...

The cyclooxygenase-2 enzyme (COX-2) is involved in prostaglandin biosynthesis and plays a significant role in the process of inflammation. Several compounds of plant origin affect the COX-2 enzymatic activity [1]. In recent years it has also been suggested that COX-2 is involved in cancer development [2]. Thus, ingested phytochemicals with anti-inf...

A vegetarian diet rich in phytochemicals may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Compounds passing the digestive system reaching the colon could potentially be detected in fecal water. We previously reported that intact fecal water samples from human volunteers significantly decreased prostaglandin...

Many phytochemicals found in the diet may prevent colon carcinogenesis by affecting biochemical processes in the colonic mucosa. Inflammation and subsequent elevation of the enzyme cyclooxygenase-2 (COX-2) are two such factors involved in the development of colon cancer, and inhibition of these processes could be important targets for chemopreventi...

Animal studies suggest that prebiotics and probiotics exert protective effects against tumor development in the colon, but human data supporting this suggestion are weak. The objective was to verify whether the prebiotic concept (selective interaction with colonic flora of nondigested carbohydrates) as induced by a synbiotic preparation-oligofructo...

The assessment of cellular effects by the aqueous phase of human feces (fecal water, FW) is a useful biomarker approach to study cancer risks and protective activities of food. In order to refine and develop the biomarker, different protocols of preparing FW were compared. Fecal waters were prepared by 3 methods: (A) direct centrifugation; (B) extr...

The cyclooxygenase-2 enzyme (COX-2) is involved in prostaglandin biosynthesis and thus plays a significant role in the process of inflammation. Different types of natural compounds can affect the COX-2 enzymatic activity [1]. In recent years it has also been suggested that COX-2 is involved in cancer development [2]. As many natural compounds are p...

The inducible enzyme cyclooxygenase-2 (COX-2) plays a major role in the regulation of inflammation and possibly in the development of colon cancer. The aim of the present study was to screen for COX-2 inhibitors in samples of fecal water (the aqueous phase of feces) and investigate whether phenolic compounds are responsible for any observed effects...

Polyethylene glycol 8000 inhibits the formation of tumors and of aberrant crypt foci (ACF) in carcinogen-initiated rats. We asked: is the inhibition associated with a reduction of colonic inflammation and an increase in colonic cell permeability? Twenty-eight, male F 344 rats were divided into two groups, 10 control animals and 18 animals initiated...

The free water phase of feces (fecal water) may mediate the effects of diet on colon carcinogenesis. We examined the effects of fecal water from adenoma patients and controls on three parameters in colonocytes believed to be relevant to tumorigenesis, i.e. genotoxicity in intact cells and on isolated DNA, proliferative activity and activator protei...