Perikles Simon

Perikles Simon
  • Dr.med., Dr. rer.nat.
  • Professor at Johannes Gutenberg University Mainz

About

441
Publications
95,506
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9,952
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Introduction
Perikles Simon is Professor of Sports Medicine, Rehabilitation and Disease Prevention at Johannes Gutenberg-University Mainz. He studied Medicine and Neural and Behavioral Science in Tübingen (Germany) and Philadelphia (USA). His research is focusing on performance diagnostics, web-based life-style interventions, as well as liquid biopsy for diagnostics and disease prevention. Recently, he filed a patent for isothermal amplification and quantification of DNA directly in whole blood samples.
Current institution
Johannes Gutenberg University Mainz
Current position
  • Professor

Publications

Publications (441)
Article
Full-text available
Infrared thermography (IRT) is a non-invasive tool to measure the body surface radiation temperature (Tsr). IRT is an upcoming technology as a result of recent advancements in camera lenses, detector technique and data processing capabilities. The purpose of this review is to determine the potential and applicability of IRT in the context of dynami...
Article
Full-text available
Circulating cell-free DNA (cfDNA) has been investigated as a screening tool for many diseases. To avoid expensive and time-consuming DNA isolation, direct quantification PCR assays can be established. However, rigorous validation is required to provide reliable data in the clinical and non-clinical context. Considering the International Organizatio...
Preprint
Full-text available
Cell-free DNA (cfDNA) methylation-based diagnostics is a promising approach in oncology and hematooncology. Exercise impacts immune homeostasis and leads to a rapid and marked increase of cfDNA levels in blood. Since the origin of cfDNA during exercise remains elusive, the implications for liquid biopsy are unknown. In this study, we identified the...
Article
Infrared thermography is increasingly applied in sports science due to promising observations regarding changes in skin’s surface radiation temperature ( $T_{sr}$ ) before, during, and after exercise. The common manual thermogram analysis limits an objective and reproducible measurement of $T_{sr}$ . Previous analysis approaches depend on expert...
Article
Full-text available
Background: It has been observed that severe muscle damage induced by drop jumps has a significant effect on cell-free DNA (cfDNA) concentration. We hypothesized that a reduced volume of drop jumps would indicate a dose-dependent release of cfDNA. Methods: Seven participants (aged 21 ± 1.5 years) performed 25, and 4 participants (aged 22 ± 1.8 year...
Article
Full-text available
Circulating cell‐free DNA (cfDNA), circulating tumour DNA (ctDNA) and inflammatory cytokines have prognostic and predictive value in oncology. However, the effects of acute exercise on cfDNA levels are unknown. Here, we explore the kinetics of cfDNA, ctDNA and cytokines upon an incremental exercise test in a pilot cohort of cancer patients compared...
Article
Full-text available
Background Mitochondria are versatile eukaryotic organelles that play a crucial role in the body’s stress response. Prolonged stress exposure can cause structural and functional alterations, leading to mitochondrial DNA (mtDNA) damage and subsequent release of mtDNA into the circulation. Cell-free circulating mtDNA (ccf-mtDNA) is a potential biomar...
Article
Full-text available
Circulating cell‐free DNA (cfDNA) is a promising biomarker for physiological stress, including exercise‐induced responses. However, the lack of standardization in blood collection tubes (BCTs) for quantification of cfDNA hampers inter‐study comparisons. In this study, we assessed the impact of different BCTs on exercise‐induced cfDNA dynamics. Elev...
Article
Aims Patients suffering from heart failure with preserved ejection fraction (HFpEF) often exhibit a sedentary lifestyle, contributing to the worsening of their condition. Although there is an inverse relationship between physical activity (PA) and adverse cardiovascular outcomes, the implementation of Class Ia PA guidelines is hindered by low parti...
Article
ZUSAMMENFASSUNG Depressive Störungen gehören zu den häufigsten psychischen Erkrankungen in Deutschland. Trotz umfassender Versorgungsstrukturen gelingt es im deutschen Gesundheitssystem häufig nicht, eine an den Empfehlungen der Nationalen VersorgungsLeitlinie Depression orientierte Behandlung umzusetzen. Auch ist es für Patienten herausfordernd, s...
Article
Full-text available
Infrared thermography is an emerging technique in biomedical research, potentially providing diagnostic insights into psychological stress, physical strain, muscle fatigue, inflammation, tissue damage, and diseases with thermogenic effects. However, manual analysis strategies are frequently applied causing incomparable, non-reproducible results and...
Article
Background: Societal measures to contain the spread of COVID-19 (eg, lockdown and contact restrictions) have been associated with decreased health and well-being. A multitude of prepandemic studies identified the beneficial effects of physical exercise on both physical and mental health. Objective: We report on the feasibility of a remote physic...
Preprint
BACKGROUND Patients affected by post COVID-19 condition have long-term and health-related consequences of severe acute respiratory syndrome coronavirus-2, manifesting as persistent fatigue, dyspnea/hyperventilation, limitations in daily activities, cognitive impairment and mental disorders. Consequences exceed individual health, impacting social sy...
Article
Full-text available
Background The transition from school to university is often accompanied by a change in students’ lifestyles. So far little is known whether convenience behavior is an essential factor affecting students’ health and social interaction. In a heterogeneous population regard to sociodemographic and anthropometric characteristics the Convenience Behavi...
Article
Full-text available
In sports science, thermal imaging is applied to investigate various questions related to exercise-induced stress response, muscle fatigue, anomalies, and diseases. Infrared thermography monitors thermal radiation from the skin’s surface over time. For further analysis, regions of interest are extracted and statistically analyzed. Although computer...
Article
Full-text available
A significant increase in circulating cell‐free DNA (cfDNA) occurs with physical exercise, which depends on the type of exertion and the duration. The aims of this study were as follows: (1) to investigate the time course of cfDNA and conventional markers of muscle damage from immediately after to 96 h after muscle‐damaging exercise; and (2) to inv...
Article
Full-text available
This study examined the acute effects of exercise testing on immunology markers, established blood-based biomarkers, and questionnaires in endurance athletes, with a focus on biological sex differences. Twenty-four healthy endurance-trained participants (16 men, age: 29.2± 7.6 years, maximal oxygen uptake ( V ˙ O 2 max ): 59.4 ± 7.5 ml · min-1 · kg...
Article
Full-text available
1) Background: Cigarette smoking, risky alcohol consumption, and marijuana smoking are the most common behaviors related to legal and illicit drug use worldwide, including among university students. To plan effective evidence-based programs to prevent the risky consumption of these substances among university students, the present study aimed to id...
Article
Full-text available
Purpose This study aimed to investigate the impact of sprint interval training (SIT) on both the acute and 3-week modulations of cell-free DNA (cfDNA), as well as its association with neuromuscular fatigue and physical performance in healthy young and old men. Methods Ten young (20–25 year old) and nine elderly (63–72 year old) healthy men perform...
Article
Full-text available
In 2011, a group of researchers investigated the 12-month prevalence of doping at the 13th International Association of Athletics Federations World Championships in Athletics (WCA) in Daegu, South Korea, and also at the 12th Pan-Arab Games (PAG) in Doha, Qatar. The prevalence of doping at each event was estimated using an established randomized res...
Article
Full-text available
Background Extracellular vesicles (EVs) originating from the central nervous system (CNS) can enter the blood stream and carry molecules characteristic of disease states. Therefore, circulating CNS-derived EVs have the potential to serve as liquid-biopsy markers for early diagnosis and follow-up of neurodegenerative diseases and brain tumors. Monit...
Preprint
BACKGROUND Societal measures to contain the outspread of COVID-19 (e.g., lockdown, contact restrictions) have been associated with decreased health and well-being. A multitude of pre-pandemic studies identified the beneficial effects of physical exercise on both physical and mental health. OBJECTIVE Here, we report on the feasibility of a remote p...
Article
Background Societal measures to contain the spread of COVID-19 (eg, lockdown and contact restrictions) have been associated with decreased health and well-being. A multitude of prepandemic studies identified the beneficial effects of physical exercise on both physical and mental health. Objective We report on the feasibility of a remote physical e...
Article
Background COVID-19 is a worldwide pandemic caused by the highly infective SARS-CoV-2. There is a need for biomarkers not only for overall prognosis but also for predicting the response to treatments and thus for improvements in the clinical management of patients with COVID-19. Circulating cell-free DNA (cfDNA) has emerged as a promising biomarker...
Article
Full-text available
The search for monitoring tools that provide early indication of injury and illness could contribute to better player protection. The aim of the present study was to i) determine the feasibility of and adherence to our monitoring approach, and ii) identify variables associated with up-coming illness and injury. We incorporated a comprehensive set o...
Article
The search for monitoring tools that provide early indication of injury and illness could contribute to better player protection. The aim of the present study was to i) determine the feasibility of and adherence to our monitoring approach, and ii) identify variables associated with up-coming illness and injury. We incorporated a comprehensive set o...
Article
Full-text available
Background Sedentary behavior (SB) is highly prevalent among university students and has increased during COVID-19 pandemic. As SB is associated with negative health outcomes, appropriate prevention measures in the university setting are needed. Objective This pilot study aimed at investigating the effects of videos using different message strateg...
Preprint
Full-text available
Extracellular vesicles (EVs) derived from the CNS are potential liquid-biopsy markers for early detection and monitoring of neurodegenerative diseases and brain tumors. This study assessed the performance of a bead-based flow cytometry assay (EV Neuro) for multiparametric detection of CNS-derived EVs and identification of disease-specific markers....
Article
Full-text available
At present, various blood-based biomarkers have found their applications in the field of sports medicine. This current opinion addresses biomarkers that warrant consideration in future research for monitoring the athlete training load. In this regard, we identified a variety of emerging load-sensitive biomarkers, e.g., cytokines (such as IL-6), cha...
Article
This study aimed to examine the skin temperature (Tsk) variations in five regions of interest (ROI) to assess whether possible disparities between the ROI's Tsk could be associated with specific acute physiological responses during cycling. Seventeen participants performed a pyramidal load protocol on a cycling ergometer. We synchronously measured...
Article
Full-text available
Blood-based biomarkers can provide an objective individualized measure of training load, recovery, and health status in order to reduce injury risk and maximize performance. Despite enormous potentials, especially owing to currently evolving technology, such as point-of-care testing, and advantages, in terms of objectivity and non-interference with...
Article
Full-text available
Background: We examine the potential of behavioral activation by wearable devices in inpatients with late-life depression (LLD). Methods: In randomized order, 17 inpatients with LLD wore a GPS watch that either allowed monitoring their activity level or had a disabled activity display. The patients answered questionnaires repeatedly in addition to...
Poster
Full-text available
Societal measures to contain the outspread of COVID-19 (e.g., lockdown, contact restrictions) have been associated with decreased health and well-being. A multitude of pre-pandemic studies, however, identified the beneficial effects of physical exercise on both physical and mental health. Consequently, we investigated the buffering potential of a p...
Article
Full-text available
Background The present study aimed to (1) assess and compare sedentary time (ST) of university students before and during the COVID-19 pandemic, (2) examine risk groups with regard to ST and the “extent of change” in ST (from before to during the pandemic) in association with sociodemographic (gender, age), study-related (degree aspired to, field o...
Article
Full-text available
Background: Cancer-related fatigue (CRF) is one of the most common and distressing symptoms in paediatric oncology. Based on previous studies, physical activity interventions are considered to be effective in reducing CRF in adult cancer patients. Aim: The aim of this systematic review is to investigate whether physical activity interventions can r...
Article
Full-text available
Obstructive sleep apnea (OSA) has been associated with various acute and chronic inflammatory diseases, as has serum ferritin, an intracellular iron storage protein. Little is known about the relationship between severity of OSA and serum ferritin levels in otherwise healthy subjects. In this study, all polysomnographic recordings, serum levels of...
Article
Full-text available
Background Impaired respiratory and intestinal microbiome composition is linked to cystic fibrosis lung disease severity. In people with cystic fibrosis (pwCF), regular exercise is recommended to delay disease progression and preserve a stable lung function. An optimal nutritional status is vital for best clinical outcomes. Our study investigated w...
Article
Full-text available
Simple Summary Obstructive sleep apnea is the most common breathing-related sleep disorder. In addition to the quantitatively dominant obstructive apneas, patients may also be affected by central apneas. This study investigates the frequency of occurrence of central apneas in REM and NREM sleep in patients suffering from OSA of varying severity. Wh...
Article
Full-text available
Psychological stress affects the immune system and activates peripheral inflammatory pathways. Circulating cell-free DNA (cfDNA) is associated with systemic inflammation, and recent research indicates that cfDNA is an inflammatory marker that is sensitive to psychological stress in humans. The present study investigated the effects of acute stress...
Article
Non-invasive and contactless infrared thermography (IRT) measurements have been claimed to indicate acute neural, cardiovascular, and thermoregulatory adaptations during exercise. Due to challenging comparability, reproducibility, and objectivity, investigations considering different exercise types and intensities, and automatic ROI analysis are cu...
Article
Full-text available
Eine zu geringe Impfbereitschaft zählt zu den größten globalen Gesundheitsgefahren und war in der COVID-19-Pandemie auch in Deutschland eine der großen Herausforderungen der öffentlichen Gesundheit. Die Identifikation potenzieller Einflussfaktoren auf das Impfverhalten ist deshalb für eine zielgruppengerechte Gesundheitskommunikation von großer Bed...
Chapter
Die präoperative körperliche Leistungsfähigkeit ist ein modifizierbarer Risikofaktor. Dieser lässt sich durch ein gezieltes Training positiv beeinflussen. Zur Stabilisation der körperlichen Leistungsfähigkeit kann die präoperative Wartezeit effektiv genutzt werden und sich positiv auf das postoperative Komplikationsrisiko auswirken. Eine engmaschig...
Article
Full-text available
Evidence suggests an increasing apnea–hypopnea index (AHI) with aging. However, the effect of aging on sleep-related metrics, especially AHI, has been less frequently investigated within different gender-specific subpopulations by taking prominent confounding factors, e.g., obstructive sleep apnea (OSA)-related comorbidities and body mass index (BM...
Article
Full-text available
Physical activity impacts immune homeostasis and leads to rapid and marked increase in cell-free DNA (cfDNA). However, the origin of cfDNA during exercise remains elusive and it is unknown if physical activity could improve or interfere with methylation based liquid biopsy. We analyzed the methylation levels of four validated CpGs representing cfDN...
Article
Full-text available
Background As circulating DNA (cirDNA) is mainly detected as mononucleosome-associated circulating DNA (mono-N cirDNA) in blood, apoptosis has until now been considered as the main source of cirDNA. The mechanism of cirDNA release into the circulation, however, is still not fully understood. This work addresses that knowledge gap, working from the...
Article
Full-text available
The link between obstructive sleep apnea (OSA) and obesity, and their common comorbidities such as diabetes mellitus (DM) or cardiovascular diseases, is not fully understood. The aim of this study was to investigate the possible association of OSA severity in obese individuals with polysomnography-based sleep parameters, as well as C-reactive prote...
Article
Full-text available
Vaccination hesitancy has been a major challenge for health authorities and societies during the COVID-19 pandemic. The general determinants of vaccination intentions and behavior include sociodemographic and health-related, psychological, and communication-related factors, with varying relevance for different types of vaccinations, countries, and...
Presentation
Full-text available
Hormonelle Stoerungen in der sportlichen Leute
Article
Full-text available
Load management, i.e., prescribing, monitoring, and adjusting training load, is primarily aimed at preventing injury and maximizing performance. The search for objective monitoring tools to assess the external and internal load of athletes is of great interest for sports science research. In this 4-week pilot study, we assessed the feasibility and...
Preprint
Full-text available
Background: Because circulating DNA (cirDNA) are mainly detected as mononucleosome-associated circulating DNA (mono-N cirDNA) in blood apoptosis has until now been considered as the main source of cirDNA. The mechanism of cirDNA release into the circulation, however, is still not fully understood. This work addresses that knowledge gap, working fro...
Conference Paper
Full-text available
Background: Video-based health communication appears to be a promising approach to reduce sedentary behavior (SB) in the severely affected collective of university students, especially in times of online-lectures. More research is needed to identify effective video-based intervention strategies. Therefore, the aim of the present pilot study was to...
Article
Full-text available
Background: Education outside the classroom (EOtC) is considered beneficial to children's physical and mental health. Especially, stress resilience has been linked to nature experience. Aims: This study experimentally explored the effects of pupils' autonomy support (AUT) and physical activity (PA) on their biological stress responses and brain...
Preprint
Full-text available
Background: Impaired respiratory and intestinal microbiome composition is linked to cystic fibrosis lung disease severity. In people with cystic fibrosis (pwCF), regular exercise is recommended to delay disease progression and preserve a stable lung function. An optimal nutritional status is vital for best clinical outcomes. Our study investigated...
Article
Full-text available
Introduction The clinical course of patients with a SARS-CoV-2 (COVID-19) infection varies widely, from symptom-free to severe courses that can lead to death. Laboratory values of SARS-CoV-2 patients such as lymphocyte counts or C-reactive protein (CRP) do not allow a prediction of the actual course of the disease. To identify a possible predictive...
Article
Full-text available
Background Physical inactivity and sedentary behavior are modifiable risk factors for an unhealthy lifestyle in university students. The aim of this study was to identify subgroups among German university students with an increased risk for unhealthy behavior. For this purpose, differences in physical activity and sedentary behavior with respect to...
Article
Full-text available
Introduction: The clinical course of patients with a SARS-CoV-2 (COVID-19) infection varies widely, from symptom-free to severe courses that can lead to death. Laboratory values of SARS-CoV-2 patients such as lymphocyte counts or C-reactive protein (CRP) do not allow a prediction of the actual course of the disease. To identify a possible predicti...
Article
Full-text available
Job crafting has been established as a bottom-up work design instrument for promoting health and well-being in the workplace. In recent years, the concepts of job crafting have been applied to the university student context, proving to be positively related to student well-being. Building on person-centered analyses from the employment context, we...
Article
Full-text available
Circulating, cell-free DNA (cfDNA) has been discussed as an upcoming blood-based biomarker in exercise physiology, reflecting important aspects of exercise load. cfDNA blood sampling has evolved from elaborate venous to efficient capillary sampling from the fingertips. In this study, we aimed to evaluate the principal feasibility of cfDNA blood sam...
Article
Full-text available
Background Physical activity can have a strong impact on the concentration of several promising candidate biomarkers, including cell-free DNA (cfDNA). Content This narrative review describes the current understanding of how physical strain leads to increases of cfDNA and discusses how this interferes with attempts to standardize cfDNA analysis in...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...
Chapter
Welche Rolle haben Joseph Keul, Armin Klümper und andere Mediziner der Universität Freiburg jahrzehntelang bei der Organisation und Legitimierung des Dopings von Athleten in Westdeutschland und im vereinigten Deutschland gespielt? Die Autoren legen dazu eine eingehende Analyse vor und liefern überzeugende Erklärungen, indem sie die Ergebnisse der »...

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We have now done analysis on prevalence of doping in different collectives using alsmost the same randomized response technique.
Prevalence of "Cognitive enhancement", or illicit drug use, or a recreational misuse of prescription drugs for "hobby-doping purposes" in our general population tends to be roughly 15% in western societies.
Doping prevalence in junior elite sports is relatively low! Almost sero in the south-west german schools of elite sports (we only published a conference abstract on this; at that time we thought it is an unimportant information) and roughly 6.8% in national elite junior athletes.
Doping prevalence is very high in top-elite athletes (see link) to our recent study.
What do do?
Shall we put even more pressure on our elite athletes? Is it justified to use this result to infringe the personal rights of elite athletes even more? Is there a sense in extensive funding going into analytical attempts at all?
I would be interested in your opinion what science could possibly contribute to improve the fight against doping.
What is the most reasonable next step or shall we step out of the system and rather do something else?

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